Genetically modified animal models recapitulating molecular events altered in human hepatocarcinogenesis (Q37452220)

20 August 2017

1 reference

title

Genetically modified animal models recapitulating molecular events altered in human hepatocarcinogenesis (English)

1 reference

20 August 2017

Aránzazu Sánchez

1

0 references

Isabel Fabregat

object named as

Isabel Fabregat

series ordinal

2

0 references

publication date

1 April 2009

1 reference

Clinical and Translational Oncology

20 August 2017

published in

1 reference

20 August 2017

volume

11

1 reference

20 August 2017

issue

4

1 reference

20 August 2017

page(s)

208-214

1 reference

Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis

20 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS12094-009-0342-X

Emerging multipotent aspects of hepatocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-009-0342-X

Acceleration of c-myc-induced hepatocarcinogenesis by Co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-009-0342-X

Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-009-0342-X

Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-009-0342-X

Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes.

21 January 2018

1 reference

12 December 2020

The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes

1 reference

12 December 2020

SF/HGF-c-Met autocrine and paracrine promote metastasis of hepatocellular carcinoma.

1 reference

12 December 2020

Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice.

1 reference

12 December 2020

The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma

1 reference

12 December 2020

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

1 reference

12 December 2020

Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers

1 reference

12 December 2020

Clonal cosegregation of tumorigenicity with overexpression of c-myc and transforming growth factor alpha genes in chemically transformed rat liver epithelial cells

1 reference

12 December 2020

The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis

1 reference

12 December 2020

Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

1 reference

12 December 2020

Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis

1 reference

12 December 2020

Apoptosis Induced by Transforming Growth Factor- in Fetal Hepatocyte Primary Cultures

1 reference

12 December 2020

Overexpression of transforming growth factor-alpha causes liver enlargement and increased hepatocyte proliferation in transgenic mice

1 reference

12 December 2020

Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype

1 reference

12 December 2020

Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor

1 reference

12 December 2020

Autocrine production of TGF-β confers resistance to apoptosis after an epithelial–mesenchymal transition process in hepatocytes: Role of EGF receptor ligands

1 reference

12 December 2020

Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas

1 reference

12 December 2020

1 reference

12 December 2020

Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha

1 reference

12 December 2020

Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.

1 reference

12 December 2020

Molecular and genetic analysis of liver oncogenesis in transforming growth factor alpha transgenic mice

1 reference

12 December 2020

Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model

1 reference

12 December 2020

Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.

1 reference

12 December 2020

Elevated levels of transforming growth factor beta messenger RNA and its polypeptide in human hepatocellular carcinoma

1 reference

12 December 2020

Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha

1 reference

12 December 2020

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

1 reference

12 December 2020

Met, metastasis, motility and more

1 reference

12 December 2020

Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis.

1 reference

12 December 2020

Investigation of the cooperative effects of transforming growth factor α and c‐myc overexpression in rat liver epithelial cells

1 reference

12 December 2020

TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer

1 reference

12 December 2020

Experimental models of hepatocellular carcinoma

1 reference

12 December 2020

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

1 reference

12 December 2020

Development of liver tumors in transforming growth factor alpha transgenic mice.

1 reference

12 December 2020

Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA

1 reference

12 December 2020

Hepatocellular carcinoma pathogenesis: from genes to environment

1 reference

12 December 2020

Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade

1 reference

12 December 2020

Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.

1 reference

12 December 2020

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

1 reference

12 December 2020

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes

1 reference

12 December 2020

Met receptor tyrosine kinase: enhanced signaling through adapter proteins

1 reference

12 December 2020

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1

1 reference

12 December 2020

Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

1 reference

12 December 2020

Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer

1 reference

12 December 2020

Growth Inhibition and Induction of Apoptosis by HGF in Transformed Rat Liver Epithelial Cells

1 reference

12 December 2020

Disregulation of E-cadherin in transgenic mouse models of liver cancer

1 reference

12 December 2020

Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism

1 reference

12 December 2020

Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis

1 reference

12 December 2020

Application of comparative functional genomics to identify best-fit mouse models to study human cancer

1 reference

12 December 2020

Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis

1 reference

12 December 2020

Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.

1 reference

12 December 2020

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1 reference

12 December 2020

Invasive growth: a genetic program

1 reference

12 December 2020

Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes

1 reference

12 December 2020

Oncogene-induced liver neoplasia in transgenic mice.

1 reference

12 December 2020

Hepatocyte growth factor transforms immortalized mouse liver epithelial cells

1 reference

12 December 2020

Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine

1 reference

12 December 2020

Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.

1 reference

12 December 2020

Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma

1 reference

12 December 2020

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

1 reference

12 December 2020

Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas

1 reference

12 December 2020

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

1 reference

12 December 2020

Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes

1 reference

12 December 2020

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

1 reference

12 December 2020

Epithelial-mesenchymal transitions in development and pathologies

1 reference

12 December 2020

Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3

1 reference

12 December 2020

Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha

1 reference

12 December 2020

Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells

1 reference

12 December 2020

Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas

1 reference

12 December 2020

Molecular mechanisms of liver carcinogenesis in the mdr2-knockout mice

1 reference

12 December 2020

Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest.

1 reference

12 December 2020

Regulatory mechanisms for transforming growth factor beta as an autocrine inhibitor in human hepatocellular carcinoma: implications for roles of smads in its growth

1 reference

12 December 2020

Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression

1 reference

12 December 2020

Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells

1 reference

12 December 2020

Adenoviral delivery of recombinant DNA into transgenic mice bearing hepatocellular carcinomas

1 reference

12 December 2020

Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers

1 reference

12 December 2020

Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

1 reference

12 December 2020

10.1007/S12094-009-0342-X

Identifiers

DOI

1 reference

20 August 2017

1 reference