The Failing Heart Relies on Ketone Bodies as a Fuel (Q36614537)

15 August 2017

The Failing Heart Relies on Ketone Bodies as a Fuel (English)

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Correction to: The Failing Heart Relies on Ketone Bodies as a Fuel

15 August 2017

corrigendum / erratum

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Gregory Aubert

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Peter A Crawford

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Peter A Crawford

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Deborah M Muoio

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Deborah M Muoio

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Stephen J Gardell

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object named as

Stephen J Gardell

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15 August 2017

Ola J Martin

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15 August 2017

Julie L Horton

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15 August 2017

Ling Lai

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15 August 2017

Rick B Vega

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15 August 2017

Teresa C Leone

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15 August 2017

Timothy Koves

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15 August 2017

Marcus Krüger

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15 August 2017

Charles L Hoppel

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15 August 2017

E Douglas Lewandowski

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15 August 2017

Daniel P Kelly

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15 August 2017

language of work or name

English

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publication date

27 January 2016

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15 August 2017

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15 August 2017

133

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15 August 2017

8

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15 August 2017

698-705

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Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.

15 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Dietary fat supply to failing hearts determines dynamic lipid signaling for nuclear receptor activation and oxidation of stored triglyceride

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Single exhaled breath metabolomic analysis identifies unique breathprint in patients with acute decompensated heart failure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Targeting myocardial substrate metabolism in heart failure: potential for new therapies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Reciprocal Transcriptional Regulation of Metabolic and Signaling Pathways Correlates With Disease Severity in Heart Failure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

A mitochondrial protein compendium elucidates complex I disease biology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

The failing heart--an engine out of fuel

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Deranged energy substrate metabolism in the failing heart

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Nuclear receptor signaling and cardiac energetics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Is the failing heart energy starved? On using chemical energy to support cardiac function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Linking gene expression to function: metabolic flexibility in the normal and diseased heart

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Energy metabolism in the hypertrophied heart

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Role of ketone bodies in perinatal myocardial energy metabolism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Cardiac fatty acid uptake and transport in health and disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Regulation of fatty acid oxidation in the mammalian heart in health and disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Ketone bodies disturb fatty acid handling in isolated cardiomyocytes derived from control and diabetic rats

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Global protein quantification of mouse heart tissue based on the SILAC mouse

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Exhaled acetone as a new biomaker of heart failure severity

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Down-regulated energy metabolism genes associated with mitochondria oxidative phosphorylation and fatty acid metabolism in viral cardiomyopathy mouse heart

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Total-body and myocardial substrate oxidation in congestive heart failure.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopy

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766035

Activation of a novel metabolic gene regulatory pathway by chronic stimulation of skeletal muscle

20 September 2018

1 reference

12 December 2020

Myocardial Phosphocreatine-to-ATP Ratio Is a Predictor of Mortality in Patients With Dilated Cardiomyopathy

1 reference

12 December 2020

The creatine kinase system in normal and diseased human myocardium

1 reference

12 December 2020

Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration

1 reference

12 December 2020

Blood ketone bodies in congestive heart failure

1 reference

12 December 2020

Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism

1 reference

12 December 2020

Fatty acid oxidation enzyme gene expression is downregulated in the failing heart

1 reference

12 December 2020

Urinary ketone is associated with the heart failure severity

1 reference

12 December 2020

Altered glucose and fatty acid oxidation in hearts of the spontaneously hypertensive rat

1 reference

12 December 2020

Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts

1 reference

12 December 2020

Effects of moderate hypertension on cardiac function and metabolism in the rabbit

1 reference

12 December 2020

Increased glycolytic metabolism in cardiac hypertrophy and congestive failure

1 reference

12 December 2020

The metabolism of the heart

1 reference

12 December 2020

ON THE SIGNIFICANCE OF ACETOACETATE AND BETA-HYDROXYBUTYRATE IN HUMAN MYOCARDIAL METABOLISM

1 reference

12 December 2020

Myocardial fatty acid metabolism: independent predictor of left ventricular mass in hypertensive heart disease

1 reference

12 December 2020

Validated method for the quantification of free and total carnitine, butyrobetaine, and acylcarnitines in biological samples

1 reference

12 December 2020

Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts

1 reference

12 December 2020

Breath acetone in congestive heart failure

1 reference

12 December 2020

Depletion of Energy Reserve via the Creatine Kinase Reaction During the Evolution of Heart Failure in Cardiomyopathic Hamsters

1 reference

12 December 2020

10.1161/CIRCULATIONAHA.115.017355

Identifiers

DOI

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release_lhfemsedcrgxllgcxiwlv2v37m

15 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/lhfemsedcrgxllgcxiwlv2v37m

24 November 2022

mapped directly with Wikidata item

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15 August 2017

PubMed publication ID

26819376

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