ATM and related protein kinases: safeguarding genome integrity (Q29547735)

Europe PubMed Central

title

ATM and related protein kinases: safeguarding genome integrity (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612651

23 April 2017

author name string

Shiloh Y

series ordinal

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612651

23 April 2017

language of work or name

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23 April 2017

publication date

March 2003

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612651

23 April 2017

published in

Nature Reviews Cancer

1 reference

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23 April 2017

volume

3

1 reference

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23 April 2017

issue

3

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23 April 2017

page(s)

155-68

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612651

Modelling the molecular circuitry of cancer

23 April 2017

cites work

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Caretaker tumour suppressor genes that defend genome integrity

31 March 2020

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Genome maintenance mechanisms for preventing cancer

31 March 2020

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Endogenous mutagenesis and cancer

31 March 2020

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DNA damage processing defects and disease

31 March 2020

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Recombinational DNA repair and human disease

31 March 2020

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Immunological disorders and DNA repair

31 March 2020

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Interfaces between the detection, signaling, and repair of DNA damage

31 March 2020

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Sensing and repairing DNA double-strand breaks

31 March 2020

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DNA double-strand breaks: signaling, repair and the cancer connection

31 March 2020

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Chromosomal stability and the DNA double-stranded break connection

31 March 2020

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Mammalian G1- and S-phase checkpoints in response to DNA damage

31 March 2020

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Integrating stress-response and cell-cycle checkpoint pathways

31 March 2020

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Induction of gene expression as a monitor of exposure to ionizing radiation

31 March 2020

1 reference

Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes

31 March 2020

1 reference

Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays

31 March 2020

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ATM and ATR: networking cellular responses to DNA damage

31 March 2020

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ATM: genome stability, neuronal development, and cancer cross paths

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Cell cycle checkpoint signaling through the ATM and ATR kinases

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

31 March 2020

1 reference

ATM, a central controller of cellular responses to DNA damage.

31 March 2020

1 reference

The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

31 March 2020

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TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins

31 March 2020

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Regulation of mammalian translation factors by nutrients

31 March 2020

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Quick guide: target of rapamycin

31 March 2020

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

31 March 2020

1 reference

31 March 2020

Ataxia telangiectasia

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Substrate specificities and identification of putative substrates of ATM kinase family members

31 March 2020

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Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

31 March 2020

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

31 March 2020

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

31 March 2020

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

31 March 2020

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ATM associates with and phosphorylates p53: mapping the region of interaction

31 March 2020

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

31 March 2020

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Regulation of p53 function and stability by phosphorylation

31 March 2020

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

31 March 2020

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Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

31 March 2020

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CHK2 kinase--a busy messenger.

31 March 2020

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Regulation and function of the p53 tumor suppressor protein

31 March 2020

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RETRACTED: Regulation of p53: intricate loops and delicate balances

31 March 2020

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

31 March 2020

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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

31 March 2020

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

31 March 2020

1 reference

Cancer susceptibility and the functions of BRCA1 and BRCA2

31 March 2020

1 reference

Homologous repair of DNA damage and tumorigenesis: the BRCA connection

31 March 2020

1 reference

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

31 March 2020

1 reference

Transactivation of repair genes by BRCA1

31 March 2020

1 reference

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

31 March 2020

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Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

31 March 2020

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

31 March 2020

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

31 March 2020

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Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

31 March 2020

1 reference

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

31 March 2020

1 reference

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

31 March 2020

1 reference

ATM-dependent phosphorylation of nibrin in response to radiation exposure

31 March 2020

1 reference

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

31 March 2020

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

31 March 2020

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

31 March 2020

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

31 March 2020

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Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

31 March 2020

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Rapid destruction of human Cdc25A in response to DNA damage

31 March 2020

1 reference

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

31 March 2020

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

31 March 2020

1 reference

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

31 March 2020

1 reference

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

31 March 2020

1 reference

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

31 March 2020

1 reference

Increasing evidence that germline mutations inCHEK2 do not cause Li-Fraumeni syndrome

31 March 2020

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Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

31 March 2020

1 reference

A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

31 March 2020

1 reference

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

31 March 2020

1 reference

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage

31 March 2020

1 reference

A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins.

31 March 2020

1 reference

Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes

31 March 2020

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The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9

31 March 2020

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Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event

31 March 2020

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ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation

31 March 2020

1 reference

Histone H2A variants H2AX and H2AZ

31 March 2020

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Genomic instability in mice lacking histone H2AX

31 March 2020

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

31 March 2020

1 reference

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

31 March 2020

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Chk2 activation dependence on Nbs1 after DNA damage

31 March 2020

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Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

31 March 2020

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

31 March 2020

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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

31 March 2020

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53BP1, a mediator of the DNA damage checkpoint

31 March 2020

1 reference

NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage

31 March 2020

1 reference

NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

31 March 2020

1 reference

NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

31 March 2020

1 reference

Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl

31 March 2020

1 reference

The controlling role of ATM in homologous recombinational repair of DNA damage

31 March 2020

1 reference

Regulation of Rad51 function by c-Abl in response to DNA damage

31 March 2020

1 reference

Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation

31 March 2020

1 reference

Interaction between ATM protein and c-Abl in response to DNA damage

31 March 2020

1 reference

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

31 March 2020

1 reference

Regulation of DNA-dependent protein kinase activity by ionizing radiation-activated abl kinase is an ATM-dependent process

31 March 2020

1 reference

Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation

31 March 2020

1 reference

ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage

31 March 2020

1 reference

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

31 March 2020

1 reference

ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks

31 March 2020

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The role of ATM in telomere structure and function

31 March 2020

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Connecting chromosomes, crisis, and cancer

31 March 2020

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Telomeres, aging and cancer: in search of a happy ending

31 March 2020

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New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

31 March 2020

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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

31 March 2020

1 reference

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

31 March 2020

1 reference

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

31 March 2020

1 reference

A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells

31 March 2020

1 reference

Sensing of intermediates in V(D)J recombination by ATM.

31 March 2020

1 reference

Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability

31 March 2020

1 reference

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

31 March 2020

1 reference

The emerging genetic and molecular basis of Fanconi anaemia

31 March 2020

1 reference

Interaction of FANCD2 and NBS1 in the DNA damage response

31 March 2020

1 reference

DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein

31 March 2020

1 reference

Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM

31 March 2020

1 reference

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

31 March 2020

1 reference

A role for ATR in the DNA damage-induced phosphorylation of p53

31 March 2020

1 reference

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

31 March 2020

1 reference

Hypoxia links ATR and p53 through replication arrest

31 March 2020

1 reference

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

31 March 2020

1 reference

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

31 March 2020

1 reference

Preferential binding of ATR protein to UV-damaged DNA.

31 March 2020

1 reference

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

31 March 2020

1 reference

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

31 March 2020

1 reference

Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

31 March 2020

1 reference

ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint

31 March 2020

1 reference

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

31 March 2020

1 reference

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

31 March 2020

1 reference

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

31 March 2020

1 reference

ATR and ATRIP: partners in checkpoint signaling

31 March 2020

1 reference

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

31 March 2020

1 reference

ATR Regulates Fragile Site Stability

31 March 2020

1 reference

A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins

31 March 2020

1 reference

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

31 March 2020

1 reference

Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms

31 March 2020

1 reference

Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae

31 March 2020

1 reference

Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo

31 March 2020

1 reference

Quality control of mRNA function

31 March 2020

1 reference

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

31 March 2020

1 reference

Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein

31 March 2020

1 reference

The DNA-dependent protein kinase

31 March 2020

1 reference

Synapsis of DNA ends by DNA-dependent protein kinase

31 March 2020

1 reference

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

31 March 2020

1 reference

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

31 March 2020

1 reference

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

31 March 2020

1 reference

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

31 March 2020

1 reference

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

31 March 2020

1 reference

Cancer risk and the ATM gene: a continuing debate

31 March 2020

1 reference

ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer

31 March 2020

1 reference

Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations

31 March 2020

1 reference

Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer

31 March 2020

1 reference

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

31 March 2020

1 reference

ATM mutations in sporadic lymphoid tumours.

31 March 2020

1 reference

The Fanconi anaemia/BRCA pathway

31 March 2020

1 reference

Biallelic inactivation of BRCA2 in Fanconi anemia

31 March 2020

1 reference

V(D)J recombination: RAG proteins, repair factors, and regulation

31 March 2020

1 reference

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

31 March 2020

1 reference

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

31 March 2020

1 reference

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

31 March 2020

1 reference

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

31 March 2020

1 reference

ATM in lymphoid development and tumorigenesis

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612651

23 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1026716666

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612651

PubMed publication ID

2 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017