Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia. (Q36255973)

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6 January 2020

review article

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title

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia (English)

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6 January 2020

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6 January 2020

Daniel G Tenen

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6 January 2020

author name string

Ulrich Steidl

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6 January 2020

Bronwyn M Owens

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6 January 2020

Steffen Koschmieder

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6 January 2020

publication date

1 June 2005

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International Journal of Hematology

6 January 2020

published in

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6 January 2020

volume

81

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6 January 2020

issue

5

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6 January 2020

page(s)

368-377

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PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer

6 January 2020

cites work

1 reference

Crossref

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CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1532%2FIJH97.05051

PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.

21 January 2018

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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

21 January 2018

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12 December 2020

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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12 December 2020

Purification and characterization of mouse hematopoietic stem cells

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12 December 2020

Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice

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12 December 2020

Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1

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12 December 2020

Overexpression of C/EBP -LIP, a Naturally Occurring, Dominant-Negative Transcription Factor, in Human Breast Cancer

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12 December 2020

Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

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12 December 2020

Down-modulation of the C/EBPalpha transcription factor in core binding factor acute myeloid leukemias

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12 December 2020

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

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12 December 2020

Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

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12 December 2020

Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1

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12 December 2020

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

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12 December 2020

c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.

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12 December 2020

Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations

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12 December 2020

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

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12 December 2020

Regulation of B lymphocyte and macrophage development by graded expression of PU.1.

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12 December 2020

PU.1 (Spi-1) autoregulates its expression in myeloid cells

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12 December 2020

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

1 reference

12 December 2020

FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation

1 reference

12 December 2020

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

1 reference

12 December 2020

PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells.

1 reference

12 December 2020

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

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12 December 2020

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1 reference

12 December 2020

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

1 reference

12 December 2020

Locus control regions

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12 December 2020

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors

1 reference

12 December 2020

Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells

1 reference

12 December 2020

Competitive repopulation: a new assay for long-term stem cell functional capacity

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12 December 2020

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

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12 December 2020

Mutation analysis of the transcription factor PU.1 in younger adults (16 to 60 years) with acute myeloid leukemia: a study of the AML Study Group Ulm (AMLSG ULM)

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12 December 2020

Disruption of differentiation in human cancer: AML shows the way.

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12 December 2020

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

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12 December 2020

The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds

1 reference

12 December 2020

Spi-1 is a putative oncogene in virally induced murine erythroleukaemias.

1 reference

12 December 2020

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein

1 reference

12 December 2020

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity

1 reference

12 December 2020

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1 reference

12 December 2020

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

1 reference

12 December 2020

SCL is required for normal function of short-term repopulating hematopoietic stem cells

1 reference

12 December 2020

Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)?

1 reference

12 December 2020

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

1 reference

12 December 2020

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias

1 reference

12 December 2020

Stepwise reprogramming of B cells into macrophages

1 reference

12 December 2020

CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge

1 reference

12 December 2020

Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

1 reference

12 December 2020

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.

1 reference

12 December 2020

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

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12 December 2020

Heterozygous PU.1 mutations are associated with acute myeloid leukemia

1 reference

12 December 2020

AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon.

1 reference

12 December 2020

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

1 reference

12 December 2020

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

1 reference

12 December 2020

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

1 reference

12 December 2020

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

1 reference

12 December 2020

Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia

1 reference

12 December 2020

Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1.

1 reference

12 December 2020

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator

1 reference

12 December 2020

Complementation of alpha-thalassaemia in alpha-globin knockout mice with a 191 kb transgene containing the human alpha-globin locus

1 reference

12 December 2020

PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors

1 reference

12 December 2020

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12

1 reference

12 December 2020

CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations

1 reference

12 December 2020

Making eosinophils through subtle shifts in transcription factor expression

1 reference

12 December 2020

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene

1 reference

12 December 2020

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

1 reference

12 December 2020

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

1 reference

12 December 2020

Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor

1 reference

12 December 2020

Prognostically useful gene-expression profiles in acute myeloid leukemia

1 reference

12 December 2020

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

1 reference

12 December 2020

CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing

1 reference

12 December 2020

Regulation of the PU.1 gene by distal elements

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12 December 2020

Reporter genes: application to the study of mammalian gene transcription

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12 December 2020

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

1 reference

12 December 2020

Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex

1 reference

12 December 2020

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium

1 reference

12 December 2020

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

1 reference

12 December 2020

Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.

1 reference

12 December 2020

GATA-1 Converts Lymphoid and Myelomonocytic Progenitors into the Megakaryocyte/Erythrocyte Lineages

1 reference

12 December 2020

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

1 reference

12 December 2020

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

1 reference

12 December 2020

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

1 reference

12 December 2020

1 reference

12 December 2020

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

1 reference

12 December 2020

Spi-1/PU.1 transgenic mice develop multistep erythroleukemias

1 reference

12 December 2020

c-Myc is a critical target for c/EBPalpha in granulopoiesis.

1 reference

12 December 2020

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

1 reference

12 December 2020