Human POLB gene is mutated in high percentage of colorectal tumors (Q36078847)

12 August 2017

Human POLB gene is mutated in high percentage of colorectal tumors (English)

1 reference

12 August 2017

8

Joann B Sweasy

1 reference

12 August 2017

Katherine A Donigan

1

1 reference

12 August 2017

Ka-wai Sun

2

1 reference

12 August 2017

Antonia A Nemec

3

1 reference

12 August 2017

Drew L Murphy

4

1 reference

12 August 2017

Xiangyu Cong

5

1 reference

12 August 2017

Veronika Northrup

6

1 reference

12 August 2017

Daniel Zelterman

7

1 reference

12 August 2017

language of work or name

English

0 references

publication date

10 May 2012

1 reference

Journal of Biological Chemistry

12 August 2017

1 reference

12 August 2017

287

1 reference

12 August 2017

28

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12 August 2017

23830-23839

1 reference

describes a project that uses

12 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3390656/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair

2 October 2017

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Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis

2 October 2017

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MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers

2 October 2017

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A method and server for predicting damaging missense mutations

2 October 2017

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Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

2 October 2017

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Population-specific variation in haplotype composition and heterozygosity at the POLB locus

2 October 2017

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The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient

2 October 2017

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Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1

2 October 2017

1 reference

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Halting a cellular production line: responses to ribosomal pausing during translation

2 October 2017

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Patterns of somatic mutation in human cancer genomes

2 October 2017

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The consensus coding sequences of human breast and colorectal cancers

2 October 2017

1 reference

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Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

The colorectal microRNAome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation

2 October 2017

1 reference

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Role of DNA mismatch repair in apoptotic responses to therapeutic agents

2 October 2017

1 reference

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Fast and effective prediction of microRNA/target duplexes

2 October 2017

1 reference

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Is there a link between DNA polymerase beta and cancer?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Mutational analysis of the tyrosine phosphatome in colorectal cancers

2 October 2017

1 reference

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A DNA polymerase beta mutant from colon cancer cells induces mutations

2 October 2017

1 reference

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Prediction of mammalian microRNA targets

2 October 2017

1 reference

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DNA repair defects in colon cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Clinical relevance of MGMT in the treatment of cancer

2 October 2017

1 reference

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A novel role of XRCC1 in the functions of a DNA polymerase beta variant

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Impaired repair activity of a truncated DNA polymerase beta protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Codon usage tabulated from international DNA sequence databases: status for the year 2000

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Genetic susceptibility to non-polyposis colorectal cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

DNA polymerase beta expression differences in selected human tumors and cell lines

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

A variant of DNA polymerase β acts as a dominant negative mutant

2 October 2017

1 reference

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Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

2 October 2017

1 reference

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

2 October 2017

1 reference

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Instability and decay of the primary structure of DNA

2 October 2017

1 reference

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Conformational coupling in DNA polymerase fidelity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

DNA polymerase beta mutations in human colorectal cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Functional mutation of DNA polymerase beta found in human gastric cancer--inability of the base excision repair in vitro.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

The role of DNA mismatch repair in drug resistance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Hypermutability and mismatch repair deficiency in RER+ tumor cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

27 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.324947

MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.324947

The relative distribution of membranous and cytoplasmic met is a prognostic indicator in stage I and II colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.324947

A Triad Interaction in the Fingers Subdomain of DNA Polymerase Beta Controls Polymerase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.324947

The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Cancer risk associated with germline DNA mismatch repair gene mutations

23 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.324947

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390656

Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22577134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22577134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.324947

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22577134

1 reference