Clusterin is a potential molecular predictor for ovarian cancer patient's survival: targeting clusterin improves response to paclitaxel. (Q35780679)

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19 January 2020

title

Clusterin is a potential molecular predictor for ovarian cancer patient's survival: targeting clusterin improves response to paclitaxel (English)

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19 January 2020

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8

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19 January 2020

2

Hidemichi Watari

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19 January 2020

author name string

Mohamed K Hassan

1

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19 January 2020

Yimin Han

3

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19 January 2020

Takashi Mitamura

4

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19 January 2020

Masayoshi Hosaka

5

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19 January 2020

Lei Wang

6

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19 January 2020

Shinya Tanaka

7

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19 January 2020

publication date

20 December 2011

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Journal of Experimental & Clinical Cancer Research

19 January 2020

published in

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19 January 2020

volume

30

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19 January 2020

page(s)

113

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Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells

19 January 2020

cites work

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Clusterin and chemoresistance

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Roles of clusterin in progression, chemoresistance and metastasis of human ovarian cancer

27 July 2018

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Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup

27 July 2018

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Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer

27 July 2018

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Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy

27 July 2018

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Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J.

27 July 2018

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Antisense oligodeoxynucleotide therapy targeting clusterin gene for prostate cancer: Vancouver experience from discovery to clinic

27 July 2018

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Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

27 July 2018

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Clusterin regulates drug-resistance in melanoma cells

27 July 2018

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Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer

27 July 2018

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Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor.

27 July 2018

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Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

27 July 2018

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Intracellular clusterin induces G2-M phase arrest and cell death in PC-3 prostate cancer cells1.

27 July 2018

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Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo.

27 July 2018

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Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress

27 July 2018

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Clear cell tumors have higher mRNA levels of ERCC1 and XPB than other histological types of epithelial ovarian cancer

27 July 2018

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Chemistry and chemical biology of taxane anticancer agents.

27 July 2018

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Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy

27 July 2018

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Overexpression of clusterin in human breast carcinoma

27 July 2018

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Chemically modified oligonucleotides exhibit decreased immune stimulation in mice.

27 July 2018

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Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer.

27 July 2018

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Cellular adaptation to drug exposure: evolution of the drug-resistant phenotype

27 July 2018

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Gp80 (clusterin; TRPM-2) mRNA level is enhanced in human renal clear cell carcinomas.

27 July 2018

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Clear cell adenocarcinoma of the ovary: a clinical analysis and comparison with serous carcinoma

27 July 2018

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Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death

27 July 2018

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Low proliferation activity may be associated with chemoresistance in clear cell carcinoma of the ovary.

27 July 2018

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Modulation of different clusterin isoforms in human colon tumorigenesis

21 January 2018

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Clusterin expression predicts survival of invasive cervical cancer patients treated with radical hysterectomy and systematic lymphadenectomy.

21 January 2018

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A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer

21 January 2018

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Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas.

21 January 2018

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Clusterin expression inversely correlates with chemosensitivity and predicts poor survival in patients with locally advanced cervical cancer treated with cisplatin-based neoadjuvant chemotherapy and radical hysterectomy.

21 January 2018

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Response to a lethal dose of heat shock by a transient up-regulation of clusterin expression followed by down-regulation and apoptosis in prostate and bladder cancer cells.

21 January 2018

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Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer.

21 January 2018

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Overexpression of clusterin in ovarian cancer is correlated with impaired survival.

25 September 2018

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An association between clusterin over-expression and taxol-resistance in ovarian cancer

25 September 2018

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Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry.

25 September 2018

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Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy

25 September 2018

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Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins

25 September 2018

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Up-regulated expression of cytoplasmic clusterin in human ovarian carcinoma

21 January 2018

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Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer

21 January 2018

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12 December 2020

Expression of clusterin in prostate cancer correlates with Gleason score but not with prognosis in patients undergoing radical prostatectomy without neoadjuvant hormonal therapy

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12 December 2020

Clusterin is highly expressed in pancreatic endocrine tumours but not in solid pseudopapillary tumours

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12 December 2020

Prognostic significance of clusterin immunoreactivity in breast cancer

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12 December 2020

Cytoplasmic clusterin expression is associated with longer survival in patients with resected non small cell lung cancer

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12 December 2020

Detection of differentially expressed genes in lymphomas using cDNA arrays: identification of clusterin as a new diagnostic marker for anaplastic large-cell lymphomas

1 reference

12 December 2020

Over expression of clusterin is an independent prognostic factor for nonpapillary renal cell carcinoma

1 reference

12 December 2020

Clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy in stage III disease

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12 December 2020

Identifiers

DOI

10.1186/1756-9966-30-113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22185350%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 January 2020

0 references

1 reference

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19 January 2020

PubMed publication ID

22185350

1 reference