Beyond chemotherapy: targeted therapies in ovarian cancer (Q37399899)

20 August 2017

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title

Beyond chemotherapy: targeted therapies in ovarian cancer (English)

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20 August 2017

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Timothy A Yap

1

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20 August 2017

Craig P Carden

series ordinal

2

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20 August 2017

Stan B Kaye

series ordinal

3

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20 August 2017

language of work or name

English

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publication date

1 March 2009

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20 August 2017

published in

Nature Reviews Cancer

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20 August 2017

volume

9

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20 August 2017

issue

3

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20 August 2017

page(s)

167-181

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Global cancer statistics, 2002

20 August 2017

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Folate receptor alpha as a tumor target in epithelial ovarian cancer

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Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway

31 March 2020

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Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

31 March 2020

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

31 March 2020

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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An immunomagnetic-based method for the purification of ovarian cancer cells from patient-derived ascites

31 March 2020

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31 March 2020

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Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens

31 March 2020

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A phase Ib and pharmacokinetic trial of patupilone combined with carboplatin in patients with advanced cancer

31 March 2020

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Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia

31 March 2020

1 reference

A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer

31 March 2020

1 reference

A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer

31 March 2020

1 reference

Gefitinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy--a phase II trial of the AGO Ovarian Cancer Study Group (AGO-OVAR 2.6)

31 March 2020

1 reference

Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II multicenter study

31 March 2020

1 reference

A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers.

31 March 2020

1 reference

A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer

31 March 2020

1 reference

Phase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: a Gynecologic Oncology Group study

31 March 2020

1 reference

A phase II trial of EMD72000 (matuzumab), a humanized anti-EGFR monoclonal antibody, in patients with platinum-resistant ovarian and primary peritoneal malignancies

31 March 2020

1 reference

Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status

31 March 2020

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Multicenter, randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer

31 March 2020

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Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase

31 March 2020

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12 December 2020

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

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12 December 2020

Optimal therapy of advanced ovarian cancer: carboplatin and paclitaxel vs. cisplatin and paclitaxel (GOG 158) and an update on GOG0 182-ICON5

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12 December 2020

Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics.

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12 December 2020

Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.

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12 December 2020

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor

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12 December 2020

A randomized phase II study evaluating the combination of carboplatin-based chemotherapy with pertuzumab versus carboplatin-based therapy alone in patients with relapsed, platinum-sensitive ovarian cancer

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12 December 2020

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

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12 December 2020

Mechanisms underlying the synergistic effect of SU5416 and cisplatin on cytotoxicity in human ovarian tumor cells

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12 December 2020

Pathogenesis of ascites tumor growth: fibrinogen influx and fibrin accumulation in tissues lining the peritoneal cavity

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12 December 2020

EGFR and steroid receptors in ovarian carcinoma: comparison with prognostic parameters and outcome of patients

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12 December 2020

A novel technique for the enrichment of primary ovarian cancer cells.

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12 December 2020

The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

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12 December 2020

Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer

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12 December 2020

Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy

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12 December 2020

Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases

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12 December 2020

Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash

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12 December 2020

Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model

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12 December 2020

Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

1 reference

12 December 2020

Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells

1 reference

12 December 2020

The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically

1 reference

12 December 2020

Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

1 reference

12 December 2020

Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-alpha

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12 December 2020

Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms

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12 December 2020

Systemic treatment policies in ovarian cancer: the next 10 years

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12 December 2020

Identifiers

DOI

10.1038/NRC2583

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20 August 2017

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