Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation (Q35685580)

9 August 2017

title

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation (English)

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9 August 2017

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Hongbo Chi

6

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Peter Vogel

object named as

Peter Vogel

Thirumala-Devi Kanneganti

3

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object named as

Thirumala-Devi Kanneganti

4

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author name string

Gonghua Huang

1

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9 August 2017

Yanyan Wang

2

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9 August 2017

Kinya Otsu

5

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9 August 2017

language of work or name

English

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publication date

8 January 2012

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9 August 2017

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9 August 2017

volume

13

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9 August 2017

issue

2

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9 August 2017

page(s)

152-161

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Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis

9 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

The SYK tyrosine kinase: a crucial player in diverse biological functions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Regulation of adaptive immunity by the innate immune system

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Targeting protein kinases for the development of anti-inflammatory drugs

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

The selectivity of protein kinase inhibitors: a further update

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

27 July 2018

1 reference

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

21 January 2018

1 reference

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.

21 January 2018

1 reference

CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE.

21 January 2018

1 reference

Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses

21 January 2018

1 reference

IL-1β–Mediated Signals Preferentially Drive Conversion of Regulatory T Cells but Not Conventional T Cells into IL-17–Producing Cells

21 January 2018

1 reference

Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.

21 January 2018

1 reference

Induction of intestinal Th17 cells by segmented filamentous bacteria

21 January 2018

1 reference

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

21 January 2018

1 reference

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

21 January 2018

1 reference

Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.

21 January 2018

1 reference

The macrophage mannose receptor induces IL-17 in response to Candida albicans.

21 January 2018

1 reference

A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo

21 January 2018

1 reference

CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells

21 January 2018

1 reference

Noncanonical cAMP pathway and p38 MAPK mediate beta2-adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts.

21 January 2018

1 reference

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine

21 January 2018

1 reference

The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation.

21 January 2018

1 reference

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

21 January 2018

1 reference

Interferon-β exacerbates Th17-mediated inflammatory disease

21 January 2018

1 reference

Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.

21 January 2018

1 reference

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

21 January 2018

1 reference

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

21 January 2018

1 reference

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262925

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

25 September 2018

1 reference

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

21 January 2018

1 reference

12 December 2020

Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells

1 reference

12 December 2020

Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis

1 reference

12 December 2020

p38{alpha} MAP kinase controls IL-17 synthesis in vogt-koyanagi-harada syndrome and experimental autoimmune uveitis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.2207

1 reference

9 August 2017

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9 August 2017

1 reference