Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis. (Q35203637)

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English	Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.	scientific article

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31 January 2020

Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis (English)

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31 January 2020

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cancer metastasis

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31 January 2020

Marcus E. Peter

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31 January 2020

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31 January 2020

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Thomas Krausz

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31 January 2020

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Marion Zillhardt

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31 January 2020

Sun-Mi Park

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31 January 2020

Kenjiro Sawada

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31 January 2020

Anthony Montag

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31 January 2020

S Diane Yamada

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31 January 2020

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6 May 2011

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31 January 2020

Clinical Cancer Research

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31 January 2020

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31 January 2020

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31 January 2020

4042-4051

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31 January 2020

Ovarian cancer development and metastasis

1 reference

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13 July 2018

c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.

1 reference

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13 July 2018

An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis

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13 July 2018

Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases

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13 July 2018

Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.

1 reference

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13 July 2018

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

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13 July 2018

p21 in cancer: intricate networks and multiple activities

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13 July 2018

Beyond chemotherapy: targeted therapies in ovarian cancer

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13 July 2018

A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings

1 reference

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13 July 2018

The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169439

13 July 2018

Angiogenesis as a strategic target for ovarian cancer therapy

1 reference

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13 July 2018

Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169439

13 July 2018

CDC25 phosphatases in cancer cells: key players? Good targets?

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13 July 2018

The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169439

13 July 2018

Cancer of the ovary

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169439

13 July 2018

RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169439

13 July 2018

A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169439

13 July 2018

Met, metastasis, motility and more

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3169439

13 July 2018

Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models

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13 July 2018

Regulation of the G2/M transition by p53.

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13 July 2018

Mitochondrial control of apoptosis: an overview

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13 July 2018

Comparison of c-met expression in ovarian epithelial tumors and normal epithelia of the female reproductive tract by quantitative laser scan microscopy

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13 July 2018

Expression of the C-Met/HGF receptor in human breast carcinoma: Correlation with tumor progression

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13 July 2018

Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor

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13 July 2018

Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network

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13 July 2018

A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2.

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26 September 2018

Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

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26 September 2018

Overexpression of the Met/HGF receptor in ovarian cancer.

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26 September 2018

c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion

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12 December 2020

based on heuristic

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Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21551255

12 December 2020

based on heuristic

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10.1158/1078-0432.CCR-10-3387

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31 January 2020

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31 January 2020

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31 January 2020

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