Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease (Q35197124)

25666182

7 August 2017

title

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease (English)

1 reference

7 August 2017

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3

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2 June 2020

Holger Cynis

8

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2 June 2020

author name string

Maike Hartlage-Rübsamen

1

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2 June 2020

Alexander Waniek

2

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2 June 2020

Markus Morawski

4

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2 June 2020

Stephan Schilling

5

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2 June 2020

Carsten Jäger

6

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2 June 2020

Martin Kleinschmidt

7

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2 June 2020

Astrid Kehlen

9

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2 June 2020

Thomas Arendt

10

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2 June 2020

Hans-Ulrich Demuth

11

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2 June 2020

Steffen Rossner

12

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2 June 2020

publication date

11 February 2015

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25666182

7 August 2017

published in

Acta Neuropathologica

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2 June 2020

volume

129

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2 June 2020

issue

4

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2 June 2020

page(s)

565-583

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Creative Commons Attribution 4.0 International

2 June 2020

copyright license

start time

11 February 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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13 July 2018

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13 July 2018

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An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes

13 July 2018

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Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides

13 July 2018

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13 July 2018

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13 July 2018

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Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

13 July 2018

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Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease

26 September 2018

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Bindarit, inhibitor of CCL2 synthesis, protects neurons against amyloid-β-induced toxicity.

26 September 2018

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Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study

26 September 2018

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Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease

26 September 2018

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Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

26 September 2018

1 reference

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Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics

26 September 2018

1 reference

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Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

26 September 2018

1 reference

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N-terminal truncated pyroglutamyl beta amyloid peptide Abetapy3-42 shows a faster aggregation kinetics than the full-length Abeta1-42.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4366547

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

26 September 2018

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Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease.

26 September 2018

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Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury

26 September 2018

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Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

26 September 2018

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26 September 2018

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Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

26 September 2018

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Presenilin-1 mutations in Alzheimer's disease.

26 September 2018

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Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

26 September 2018

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On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25666182

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00401-015-1395-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25666182%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25666182%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

25666182

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25666182%20AND%20SRC:MED&resulttype=core&format=json