Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. (Q43590657)

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6 November 2019

title

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family (English)

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6 November 2019

7

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6 November 2019

author name string

Maroney AC

1

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6 November 2019

Finn JP

2

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6 November 2019

Connors TJ

3

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6 November 2019

Durkin JT

4

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6 November 2019

Angeles T

5

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6 November 2019

Gessner G

6

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6 November 2019

Meyer SL

8

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6 November 2019

Savage MJ

9

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6 November 2019

Greene LA

10

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6 November 2019

Scott RW

11

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6 November 2019

Vaught JL

12

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6 November 2019

language of work or name

English

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publication date

26 April 2001

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Journal of Biological Chemistry

6 November 2019

number of pages

7

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based on heuristic

inferred from page(s)

published in

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volume

276

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6 November 2019

issue

27

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6 November 2019

page(s)

25302-25308

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6 November 2019

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The stress-activated protein kinase pathways

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JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

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Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

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Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

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Neuroprotection by the inhibition of apoptosis

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

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SKK4, a novel activator of stress‐activated protein kinase‐1 (SAPK1/JNK)

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Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

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Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

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Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase

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Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

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Signaling by the germinal center kinase family of protein kinases

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons

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The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

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Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

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1 reference

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CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.

21 January 2018

1 reference

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Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis.

21 January 2018

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A2-Pancortins (Pancortin-3 and -4) are the dominant pancortins during neocortical development

21 January 2018

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

21 January 2018

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Established insect cell line from the cabbage looper, Trichoplusia ni.

21 January 2018

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

21 January 2018

1 reference

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The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate

21 January 2018

1 reference

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Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2

21 January 2018

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Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains

21 January 2018

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Molecular Cloning and Functional Expression of a cDNA Encoding a New Member of Mixed Lineage Protein Kinase from Human Brain

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New insights into the control of MAP kinase pathways

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Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade

21 January 2018

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The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

21 January 2018

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Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

21 January 2018

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Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

21 January 2018

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Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

21 January 2018

1 reference

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Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

21 January 2018

1 reference

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Cloning of a novel putative protein kinase having a leucine zipper domain from human brain

21 January 2018

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Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site

21 January 2018

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

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Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol

21 January 2018

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MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase

21 January 2018

1 reference

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Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1

21 January 2018

1 reference

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Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but Is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylat

21 January 2018

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Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid

21 January 2018

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Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins

21 January 2018

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Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

21 January 2018

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21 January 2018

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NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

21 January 2018

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Inhibition of cell growth by overexpression of the ZPK gene

21 January 2018

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Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

21 January 2018

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The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo

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A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

21 January 2018

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K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.

21 January 2018

1 reference

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Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

21 January 2018

1 reference

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Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M011601200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11325962%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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