Receptor editing in lymphocyte development and central tolerance. (Q34568574)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16998507%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

review article

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title

Receptor editing in lymphocyte development and central tolerance (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16998507%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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1

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30 December 2019

author name string

David Nemazee

series ordinal

1

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3 August 2017

publication date

1 October 2006

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16998507%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

30 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16998507%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

volume

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16998507%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

issue

10

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30 December 2019

page(s)

728-740

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Receptor selection in B and T lymphocytes

30 December 2019

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Revising B cell receptors

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Receptor revision in T cells: an open question?

21 January 2018

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Analysis of B cell receptor production and rearrangement. Part I. Light chain rearrangement.

21 January 2018

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T-cell antigen receptor genes and T-cell recognition

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Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoire

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Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production

21 January 2018

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Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

21 January 2018

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The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

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Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains

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Analysis of the B-cell progenitor compartment at the level of single cells.

21 January 2018

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The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire

21 January 2018

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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

21 January 2018

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A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly.

21 January 2018

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Structure and function of the pre-T cell receptor

21 January 2018

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A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein

21 January 2018

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Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate

21 January 2018

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Positive selection of thymocytes

21 January 2018

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Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice

21 January 2018

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Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands

21 January 2018

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T-cell receptor delta gene rearrangements in early thymocytes

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Frequency and characterization of phenotypic Ig heavy chain allelically included IgM-expressing B cells in mice.

21 January 2018

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Intra- and inter-allelic ordering of T cell receptor beta chain gene assembly.

21 January 2018

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Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion

21 January 2018

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T cell receptor specificity is critical for the development of epidermal gammadelta T cells

21 January 2018

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Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus

21 January 2018

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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

21 January 2018

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Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene

21 January 2018

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Antisense intergenic transcription in V(D)J recombination

21 January 2018

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T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

21 January 2018

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Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes

21 January 2018

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Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure

21 January 2018

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Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters

21 January 2018

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Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies

21 January 2018

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Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development

21 January 2018

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Kappa chain monoallelic demethylation and the establishment of allelic exclusion

21 January 2018

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OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes

21 January 2018

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Tracing the pre-B to immature B cell transition in human leukemia cells reveals a coordinated sequence of primary and secondary IGK gene rearrangement, IGK deletion, and IGL gene rearrangement

21 January 2018

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Receptor editing: an approach by autoreactive B cells to escape tolerance

21 January 2018

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B lymphocytes may escape tolerance by revising their antigen receptors

21 January 2018

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Receptor editing in self-reactive bone marrow B cells

21 January 2018

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BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro

21 January 2018

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Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo

21 January 2018

1 reference

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

21 January 2018

1 reference

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

21 January 2018

1 reference

Contribution of Receptor Editing to the Antibody Repertoire

21 January 2018

1 reference

Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance

21 January 2018

1 reference

Light chain replacement: a new model for antibody gene rearrangement

21 January 2018

1 reference

Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes

21 January 2018

1 reference

The human kappa deleting element and the mouse recombining segment share DNA sequence homology

21 January 2018

1 reference

B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.

21 January 2018

1 reference

Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes

21 January 2018

1 reference

Receptor editing is the main mechanism of B cell tolerance toward membrane antigens

21 January 2018

1 reference

Editors and editing of anti-DNA receptors.

21 January 2018

1 reference

Human autoantibody silencing by immunoglobulin light chains

21 January 2018

1 reference

Regulation of anti-phosphatidylserine antibodies

21 January 2018

1 reference

The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow

21 January 2018

1 reference

An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system

21 January 2018

1 reference

B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.

21 January 2018

1 reference

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

21 January 2018

1 reference

Split tolerance in peripheral B cell subsets in mice expressing a low level of Igkappa-reactive ligand

21 January 2018

1 reference

Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development

21 January 2018

1 reference

The Cellular Location of Self-antigen Determines the Positive and Negative Selection of Autoreactive B Cells

21 January 2018

1 reference

The scope of receptor editing and its association with autoimmunity

21 January 2018

1 reference

Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion

21 January 2018

1 reference

Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction.

21 January 2018

1 reference

Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

21 January 2018

1 reference

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.

21 January 2018

1 reference

Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus

21 January 2018

1 reference

21 January 2018

A quasi-monoclonal mouse

1 reference

Molecular mechanisms involved in receptor editing at the Ig heavy chain locus

21 January 2018

1 reference

Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.

21 January 2018

1 reference

Contribution of Vh gene replacement to the primary B cell repertoire

21 January 2018

1 reference

Antigen receptor 'capacity' and the sensitivity of self-tolerance.

21 January 2018

1 reference

Receptor editing occurs frequently during normal B cell development.

21 January 2018

1 reference

Predominant autoantibody production by early human B cell precursors

21 January 2018

1 reference

Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse

21 January 2018

1 reference

Negative selection in the thymus includes semimature T cells

21 January 2018

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Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression

21 January 2018

1 reference

Exclusion and inclusion of α and β T cell receptor alleles

21 January 2018

1 reference

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production

21 January 2018

1 reference

The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement

21 January 2018

1 reference

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

1 reference

Positive and negative selection of an antigen receptor on T cells in transgenic mice.

21 January 2018

1 reference

Post-transcriptional regulation of early T cell development by T cell receptor signals

21 January 2018

1 reference

Antigen receptor selection by editing or downregulation of V(D)J recombination.

21 January 2018

1 reference

Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation.

21 January 2018

1 reference

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

21 January 2018

1 reference

The timing of TCR alpha expression critically influences T cell development and selection

21 January 2018

1 reference

Characterization of a germline Vk gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus

21 January 2018

1 reference

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus

21 January 2018

1 reference

Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern

21 January 2018

1 reference

Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells

21 January 2018

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

21 January 2018

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The evolutionary and structural 'logic' of antigen receptor diversity

21 January 2018

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Mechanisms Controlling Termination of V-J Recombination at the TCR Locus: Implications for Allelic and Isotypic Exclusion of TCR Chains

21 January 2018

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Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

21 January 2018

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Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

21 January 2018

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Antibody response elicited by T-dependent and T-independent antigens in gene targeted kappa-deficient mice

21 January 2018

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Chance, necessity and antibody gene dynamics

31 March 2020

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Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu

31 March 2020

1 reference

The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

31 March 2020

1 reference

Precursor B Cells Showing H Chain Allelic Inclusion Display Allelic Exclusion at the Level of Pre-B Cell Receptor Surface Expression

31 March 2020

1 reference

VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus

31 March 2020

1 reference

TCR signal strength influences alphabeta/gammadelta lineage fate

31 March 2020

1 reference

T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination

31 March 2020

1 reference

A change in the structure of Vbeta chromatin associated with TCR beta allelic exclusion

31 March 2020

1 reference

Conserved sequence elements in K promoters from mice and humans: implications for transcriptional regulation and repertoire expression

31 March 2020

1 reference

Re-evaluation of the probabilities for productive rearrangements on the κ andλloci

31 March 2020

1 reference

Editing disease-associated autoantibodies

31 March 2020

1 reference

The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status

31 March 2020

1 reference

Altered selection processes of B lymphocytes in autoimmune NZB/W mice, despite intact central tolerance against DNA

31 March 2020

1 reference

Stochastic pairing of Ig heavy and light chains frequently generates B cell antigen receptors that are subject to editing in vivo

31 March 2020

1 reference

In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance

31 March 2020

1 reference

Positive selection of natural autoreactive B cells

31 March 2020

1 reference

A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro

31 March 2020

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Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens

31 March 2020

1 reference

Development and selection of edited B cells in B6.56R mice

31 March 2020

1 reference

Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing

31 March 2020

1 reference

V(H) replacement is unlikely to contribute significantly to receptor editing due to an ineffectual embedded recombination signal sequence

31 March 2020

1 reference

How diverse should the immune system be?

31 March 2020

1 reference

Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells

31 March 2020

1 reference

Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus.

31 March 2020

1 reference

T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms

31 March 2020

1 reference

Receptor editing in developing T cells

31 March 2020

1 reference

Autoimmune NZB/NZW F1 mice utilize B cell receptor editing for generating high-affinity anti-dsDNA autoantibodies from low-affinity precursors

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1939

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16998507%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference