High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells (Q34481639)

2 August 2017

title

High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells (English)

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2 August 2017

1 reference

Parvinder Hothi

1

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2 August 2017

Timothy J Martins

2

1 reference

2 August 2017

Liping Chen

3

1 reference

2 August 2017

Loic Deleyrolle

4

1 reference

2 August 2017

Jae-Geun Yoon

5

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2 August 2017

Brent Reynolds

6

1 reference

2 August 2017

Greg Foltz

7

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2 August 2017

language of work or name

English

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publication date

1 October 2012

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2 August 2017

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2 August 2017

volume

3

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2 August 2017

issue

10

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2 August 2017

page(s)

1124-1136

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Aldehyde dehydrogenases and cell proliferation.

2 August 2017

cites work

1 reference

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Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1.

6 July 2018

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The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance

6 July 2018

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Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.

6 July 2018

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The NFκB pathway: a therapeutic target in glioblastoma

6 July 2018

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Mouse Models to Interrogate the Implications of the Differentiation Status in the Ontogeny of Gliomas

6 July 2018

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Targeting glioma stem cells: A novel framework for brain tumors

6 July 2018

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Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells

6 July 2018

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Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme

6 July 2018

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Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

6 July 2018

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Eradicating cancer cells: struggle with a chameleon

6 July 2018

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Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy

6 July 2018

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miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis

6 July 2018

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Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype

6 July 2018

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Sumoylation of Vimentin354 Is Associated with PIAS3 Inhibition of Glioma Cell Migration

6 July 2018

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Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells

6 July 2018

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Targeting Metabolic Remodeling in Glioblastoma Multiforme

6 July 2018

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Molecular identification and targeting of colorectal cancer stem cells

6 July 2018

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p300- and Myc-mediated regulation of glioblastoma multiforme cell differentiation

6 July 2018

1 reference

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The role of human aldehyde dehydrogenase in normal and cancer stem cells

6 July 2018

1 reference

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NFκB inhibitors induce cell death in glioblastomas.

6 July 2018

1 reference

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Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

6 July 2018

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Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma

6 July 2018

1 reference

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Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo

6 July 2018

1 reference

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Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma

6 July 2018

1 reference

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Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis.

6 July 2018

1 reference

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Cancer stem cells: cell culture, markers, and targets for new therapies

6 July 2018

1 reference

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Suppressing glioblastoma stem cell function by aldehyde dehydrogenase inhibition with chloramphenicol or disulfiram as a new treatment adjunct: an hypothesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol

6 July 2018

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

6 July 2018

1 reference

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ALDH1 as a functional marker of cancer stem and progenitor cells

6 July 2018

1 reference

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Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with pro-apoptotic activity in human cancer cells.

6 July 2018

1 reference

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Chemoresistance in gliomas

6 July 2018

1 reference

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Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study

6 July 2018

1 reference

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Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Targeting of nuclear factor-kappaB and proteasome by dithiocarbamate complexes with metals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Pharmaceutical agents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain monoamines.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Long-term survival with glioblastoma multiforme

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

The proteasome and proteasome inhibitors in cancer therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Glioblastoma multiforme: the terminator

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

6 July 2018

1 reference

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Safety issues concerning the use of disulfiram in treating alcohol dependence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

The role of chemotherapy in recurrent malignant gliomas: an overview

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Absorption of pyrvinium pamoate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Serum ceruloplasmin and copper levels in patients with primary brain tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Disulfiram metabolites permanently inactivate the human multidrug resistance P-glycoprotein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Disulfiram induces apoptosis in human melanoma cells: a redox-related process.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Cu/Zn superoxide dismutase plays a role in angiogenesis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Overview--in vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717950

Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23165409

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Disulfiram and tumor inhibition

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23165409

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.707

0 references

PMC publication ID

3717950

1 reference

2 August 2017

1 reference