Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs (Q36085634)

12 August 2017

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title

Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs (English)

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12 August 2017

Chikashi Nakanishi

1

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12 August 2017

Masakazu Toi

series ordinal

2

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12 August 2017

language of work or name

English

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publication date

1 April 2005

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12 August 2017

published in

Nature Reviews Cancer

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12 August 2017

volume

5

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12 August 2017

issue

4

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12 August 2017

page(s)

297-309

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

12 August 2017

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Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide

31 March 2020

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Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

31 March 2020

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Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models

31 March 2020

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31 March 2020

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NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells

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26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer

31 March 2020

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Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors

31 March 2020

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The proteasome: a suitable antineoplastic target

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NF-kappa B as a therapeutic target in multiple myeloma

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Combined histone deacetylase and NF-kappaB inhibition sensitizes non-small cell lung cancer to cell death

31 March 2020

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Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

31 March 2020

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Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway

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31 March 2020

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

31 March 2020

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Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells.

31 March 2020

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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

31 March 2020

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Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents?

31 March 2020

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

31 March 2020

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Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

31 March 2020

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Aspirin-like molecules that covalently inactivate cyclooxygenase-2.

31 March 2020

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Sulindac inhibits activation of the NF-kappaB pathway

31 March 2020

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Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis

31 March 2020

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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

31 March 2020

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Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta

31 March 2020

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Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity

31 March 2020

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The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro--from cytotoxic synergy to complete inhibition of apoptosis

31 March 2020

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The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway

31 March 2020

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Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol

31 March 2020

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Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

31 March 2020

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Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol

31 March 2020

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Inhibition of NF-kappa B activation by panepoxydone

31 March 2020

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Synthesis of NF-kappaB activation inhibitors derived from epoxyquinomicin C

31 March 2020

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Inhibition of tumor necrosis factor-alpha -induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicin

31 March 2020

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Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma

31 March 2020

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HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma

31 March 2020

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HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo

31 March 2020

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Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line

31 March 2020

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Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit

31 March 2020

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Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells

31 March 2020

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Treatment of multiple myeloma

31 March 2020

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Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: an inhibitor of AP-1 and NF-kappaB mediated gene expression

31 March 2020

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BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

31 March 2020

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A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

31 March 2020

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Interferon-alpha sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation

31 March 2020

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In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13

31 March 2020

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Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes.

31 March 2020

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Alpha-MSH inhibits inflammatory signalling in Schwann cells.

31 March 2020

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Human chorionic gonadotropin decreases proliferation and invasion of breast cancer MCF-7 cells by inhibiting NF-kappaB and AP-1 activation

31 March 2020

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Potentiation of tumour apoptosis by human growth hormone via glutathione production and decreased NF-kappaB activity

31 March 2020

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Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells

31 March 2020

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Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

31 March 2020

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Inhibition of JNK activation through NF-kappaB target genes

31 March 2020

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Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability

31 March 2020

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IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy

31 March 2020

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Ionizing radiation induces expression and binding activity of the nuclear factor kappa B

31 March 2020

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The anti-angiogenic basis of metronomic chemotherapy

31 March 2020

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Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

31 March 2020

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NF-kappaB/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors.

31 March 2020

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Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C.

31 March 2020

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Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells

31 March 2020

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

31 March 2020

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Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B

31 March 2020

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Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancer

31 March 2020

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Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway

31 March 2020

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Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha

31 March 2020

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Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells

31 March 2020

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Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells

31 March 2020

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Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B

31 March 2020

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Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells

31 March 2020

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Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells

31 March 2020

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Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

31 March 2020

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Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling

31 March 2020

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Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.

31 March 2020

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Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis

31 March 2020

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Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB.

31 March 2020

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Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells

31 March 2020

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Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.

31 March 2020

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Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis

31 March 2020

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Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB

31 March 2020

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Cycloepoxydon, 1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene and 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene, new inhibitors of eukaryotic signal transduction

31 March 2020

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The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1588

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12 August 2017

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