WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies. (Q34120466)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Martín C. Abba

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

author name string

Brent W Ferguson

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

language of work or name

English

0 references

publication date

14 June 2014

1 reference

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20 March 2020

number of pages

13

1 reference

Biochimica et Biophysica Acta

inferred from page(s)

published in

1 reference

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20 March 2020

volume

1846

1 reference

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20 March 2020

issue

1

1 reference

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20 March 2020

page(s)

188-200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json

The WWOX gene modulates high-density lipoprotein and lipid metabolism

20 March 2020

cites work

1 reference

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Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks

5 July 2018

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WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications

5 July 2018

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Comprehensive molecular characterization of urothelial bladder carcinoma

5 July 2018

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The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration

5 July 2018

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The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation

5 July 2018

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The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding

5 July 2018

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Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase

5 July 2018

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Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population

5 July 2018

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miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene

5 July 2018

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Comprehensive molecular characterization of clear cell renal cell carcinoma

5 July 2018

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Integrated genomic characterization of endometrial carcinoma

5 July 2018

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Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

5 July 2018

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Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

5 July 2018

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5 July 2018

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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

5 July 2018

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5 July 2018

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5 July 2018

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Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

5 July 2018

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Comprehensive genomic characterization of squamous cell lung cancers

5 July 2018

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Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways

5 July 2018

1 reference

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Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality

5 July 2018

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A landscape of driver mutations in melanoma

5 July 2018

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Comprehensive molecular characterization of human colon and rectal cancer

5 July 2018

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Sequence analysis of mutations and translocations across breast cancer subtypes

5 July 2018

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5 July 2018

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Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches.

5 July 2018

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Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study

5 July 2018

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Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

5 July 2018

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Functional and Clinical Characterization of the Putative Tumor Suppressor WWOX in Non-small Cell Lung Cancer

5 July 2018

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The mutational landscape of head and neck squamous cell carcinoma

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Wwox inactivation enhances mammary tumorigenesis

5 July 2018

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The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol

5 July 2018

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WWOX gene is associated with HDL cholesterol and triglyceride levels.

5 July 2018

1 reference

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TGF- Biology in Mammary Development and Breast Cancer

5 July 2018

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ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

5 July 2018

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Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcome

5 July 2018

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The landscape of somatic copy-number alteration across human cancers

5 July 2018

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Signatures of mutation and selection in the cancer genome

5 July 2018

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WWOX gene and gene product: tumor suppression through specific protein interactions

5 July 2018

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Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene

5 July 2018

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5 July 2018

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5 July 2018

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Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein

5 July 2018

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WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Roles of TGFbeta in metastasis

5 July 2018

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Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis

5 July 2018

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WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels

5 July 2018

1 reference

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Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours

5 July 2018

1 reference

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Conserved co-expression for candidate disease gene prioritization

5 July 2018

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Newly identified loci that influence lipid concentrations and risk of coronary artery disease

5 July 2018

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Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

5 July 2018

1 reference

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Association between decreased WWOX protein expression and thyroid cancer development

5 July 2018

1 reference

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Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

5 July 2018

1 reference

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WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.

5 July 2018

1 reference

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Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas

5 July 2018

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Targeted deletion of Wwox reveals a tumor suppressor function

5 July 2018

1 reference

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STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review).

5 July 2018

1 reference

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Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression

5 July 2018

1 reference

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In vivo enhancer analysis of human conserved non-coding sequences

5 July 2018

1 reference

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WWOX protein expression in normal human tissues.

5 July 2018

1 reference

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A role for the WWOX gene in prostate cancer

5 July 2018

1 reference

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Expression profiling in primates reveals a rapid evolution of human transcription factors

5 July 2018

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Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox

5 July 2018

1 reference

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WWOX gene restoration prevents lung cancer growth in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status

5 July 2018

1 reference

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Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma

5 July 2018

1 reference

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Loss of WWOX expression in gastric carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

WWOX, the common chromosomal fragile site, FRA16D, cancer gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

A gene-coexpression network for global discovery of conserved genetic modules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

WWOX, the FRA16D gene, behaves as a suppressor of tumor growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Chromosome translocations in multiple myeloma

5 July 2018

1 reference

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WWOX: a candidate tumor suppressor gene involved in multiple tumor types

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

NeW wrinkles for an old domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Reversible inhibition of mammary gland growth by transforming growth factor-beta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide gene dosage effect

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

A new form of childhood onset, autosomal recessive spinocerebellar ataxia and epilepsy is localized at 16q21-q23.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151823

Deletion map of chromosome 16q in ductal carcinoma in situ of the breast: refining a putative tumor suppressor gene region

28 October 2018

1 reference

12 December 2020

WWOX Expression in Different Histologic Types and Subtypes of Non-Small Cell Lung Cancer

1 reference

12 December 2020

Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

1 reference

12 December 2020

Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping

1 reference

12 December 2020

A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value

1 reference

12 December 2020

10.1016/J.BBCAN.2014.06.001

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

24932569

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24932569%20AND%20SRC:MED&resulttype=core&format=json