Mitochondria are required for pro-ageing features of the senescent phenotype. (Q34046100)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26848154%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

Mitochondria are required for pro-ageing features of the senescent phenotype (English)

1 reference

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7 March 2020

1 reference

1 reference

7

1 reference

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7 March 2020

Diana Jurk

13

1 reference

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7 March 2020

Stephen Tait

14

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7 March 2020

Rafal Czapiewski

15

1 reference

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Laura C Greaves

16

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7 March 2020

Glyn Nelson

17

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7 March 2020

Antonio Vidal-Puig

20

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Gabriele Saretzki

22

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Giovanni Quarato

23

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Douglas R. Green

24

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7 March 2020

Thomas von Zglinicki

26

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7 March 2020

Viktor Korolchuk

27

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Joao F Passos

28

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7 March 2020

4

Graeme Hewitt

1 reference

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7 March 2020

8

Satomi Miwa

1 reference

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7 March 2020

1

Clara Correia-Melo

1 reference

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7 March 2020

author name string

Francisco D M Marques

2

1 reference

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7 March 2020

Rhys Anderson

3

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7 March 2020

Rachael Hewitt

5

1 reference

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7 March 2020

John Cole

6

1 reference

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7 March 2020

Jodie Birch

9

1 reference

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7 March 2020

Alina Merz

10

1 reference

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7 March 2020

Michael D Rushton

11

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7 March 2020

Michelle Charles

12

1 reference

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7 March 2020

Mohammad Bohlooly-Y

18

1 reference

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7 March 2020

Sergio Rodriguez-Cuenca

19

1 reference

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7 March 2020

Derek Mann

21

1 reference

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7 March 2020

Peter D Adams

25

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7 March 2020

language of work or name

English

0 references

publication date

4 February 2016

1 reference

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7 March 2020

1 reference

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7 March 2020

volume

35

1 reference

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7 March 2020

issue

7

1 reference

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7 March 2020

page(s)

724-742

1 reference

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describes a project that uses

7 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4818766/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

1 reference

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

5 July 2018

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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

5 July 2018

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Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

5 July 2018

1 reference

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Endothelial PGC-1α mediates vascular dysfunction in diabetes.

5 July 2018

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Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?

5 July 2018

1 reference

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Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

5 July 2018

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mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

5 July 2018

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

5 July 2018

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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

5 July 2018

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TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

5 July 2018

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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

5 July 2018

1 reference

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Differential analysis of gene regulation at transcript resolution with RNA-seq

5 July 2018

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Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis

5 July 2018

1 reference

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Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

5 July 2018

1 reference

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The effect of long term calorie restriction on in vivo hepatic proteostatis: a novel combination of dynamic and quantitative proteomics

5 July 2018

1 reference

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mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

5 July 2018

1 reference

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Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

5 July 2018

1 reference

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Suppression of replicative senescence by rapamycin in rodent embryonic cells

5 July 2018

1 reference

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Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

mTOR signaling in growth control and disease

5 July 2018

1 reference

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Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

5 July 2018

1 reference

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A senescent cell bystander effect: senescence-induced senescence

5 July 2018

1 reference

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Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

5 July 2018

1 reference

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

5 July 2018

1 reference

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High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

5 July 2018

1 reference

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IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α.

5 July 2018

1 reference

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A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.

5 July 2018

1 reference

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Does calorie restriction induce mitochondrial biogenesis? A reevaluation.

5 July 2018

1 reference

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Adult-onset, short-term dietary restriction reduces cell senescence in mice.

5 July 2018

1 reference

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S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

5 July 2018

1 reference

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

5 July 2018

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

5 July 2018

1 reference

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A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

5 July 2018

1 reference

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

5 July 2018

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Mitochondrial dysfunction contributes to oncogene-induced senescence.

5 July 2018

1 reference

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Senescence-messaging secretome: SMS-ing cellular stress

5 July 2018

1 reference

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Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks

5 July 2018

1 reference

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

A mitochondrial protein compendium elucidates complex I disease biology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Chemokine signaling via the CXCR2 receptor reinforces senescence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

The efficiency and plasticity of mitochondrial energy transduction.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

A DNA damage checkpoint response in telomere-initiated senescence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Superoxide dismutase 1 knock-down induces senescence in human fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Oxidative stress shortens telomeres

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

TRF2 Protects Human Telomeres from End-to-End Fusions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818766

Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26848154

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMBJ.201592862

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26848154%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26848154%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

26848154

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26848154%20AND%20SRC:MED&resulttype=core&format=json