Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys (Q33819946)

29 July 2017

title

Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys (English)

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29 July 2017

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7

John Bringas

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Philip Pivirotto

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object named as

Philip Pivirotto

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Eric J Huang

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Eric J Huang

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ORCID Public Data File 2021

Piotr Hadaczek

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object named as

Piotr Hadaczek

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29 July 2017

Xiaomin Su

1

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Adrian P Kells

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29 July 2017

Han S Lee

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29 July 2017

Janine Beyer

6

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29 July 2017

John Bringas

7

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29 July 2017

Philip Pivirotto

8

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29 July 2017

Janine Penticuff

9

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29 July 2017

Jamie Eberling

10

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Howard J Federoff

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John Forsayeth

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Krystof S Bankiewicz

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29 July 2017

publication date

1 December 2009

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29 July 2017

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29 July 2017

volume

20

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29 July 2017

issue

12

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29 July 2017

page(s)

1627-1640

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Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease

29 July 2017

cites work

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Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

4 July 2018

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Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys

4 July 2018

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Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys

4 July 2018

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Efficient gene therapy-based method for the delivery of therapeutics to primate cortex

4 July 2018

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Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented.

4 July 2018

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Targeted activation of astrocytes: a potential neuroprotective strategy.

4 July 2018

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Absolute requirement of GDNF for adult catecholaminergic neuron survival

4 July 2018

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Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain

4 July 2018

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Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF in rhesus monkeys

4 July 2018

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The role of astrocytes and complement system in neural plasticity.

4 July 2018

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Ubiquitin-proteasome system and Parkinson's disease

4 July 2018

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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

4 July 2018

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Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity

4 July 2018

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Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease.

4 July 2018

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Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain

4 July 2018

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Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV.

4 July 2018

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Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys

4 July 2018

1 reference

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Immune function of astrocytes

4 July 2018

1 reference

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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Dose response to intraventricular glial cell line-derived neurotrophic factor administration in parkinsonian monkeys

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Glial cell line-derived neurotrophic factor: the lateral cerebral ventricle as a site of administration for stimulation of the substantia nigra dopamine system in rats

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo

4 July 2018

1 reference

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Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Striatal 6-hydroxydopamine induces apoptosis of nigral neurons in the adult rat.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Significant up-regulation of nestin protein in the neostriatum of MPTP-treated mice. Are the striatal astrocytes regionally activated after systemic MPTP administration?

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861959

Two types of dopaminergic nerve terminals in the rat neostriatum. An ultrastructural study

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19671001

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1089/HUM.2009.103

1 reference

29 July 2017

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29 July 2017

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