Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease. (Q34074765)

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English	Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease.	scientific article

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5 January 2020

Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease (English)

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5 January 2020

Parkinson's disease

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Maria G. Castro

7

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5 January 2020

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D Suwelack

1

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5 January 2020

A Hurtado-Lorenzo

2

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5 January 2020

E Millan

3

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5 January 2020

V Gonzalez-Nicolini

4

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5 January 2020

K Wawrowsky

5

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5 January 2020

P R Lowenstein

6

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publication date

1 December 2004

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5 January 2020

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5 January 2020

11

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24

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5 January 2020

1742-1752

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5 January 2020

Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration.

1 reference

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5 July 2018

Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats.

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Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus.

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5 July 2018

Gene therapy progress and prospects: Parkinson's disease

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5 July 2018

Neuroprotective strategies in Parkinson's disease : an update on progress

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5 July 2018

Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell

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5 July 2018

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

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5 July 2018

Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system

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Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer

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Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets.

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Hedgehog-Gli signalling and the growth of the brain.

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Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease

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5 July 2018

Gene therapy for Parkinson's disease: recent achievements and remaining challenges.

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5 July 2018

Regulatable and cell-type specific transgene expression in glial cells: prospects for gene therapy for neurological disorders

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5 July 2018

Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell line.

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5 July 2018

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

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Transducing the hedgehog signal

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5 July 2018

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

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Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

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Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

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Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain.

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Regional Distribution of Sonic Hedgehog, Patched, and Smoothened mRNA in the Adult Rat Brain

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Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

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Dopaminergic neurons protected from degeneration by GDNF gene therapy

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12 December 2020

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