SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease (Q35639816)

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scientific article published on 9 November 2011

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English	SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease	scientific article published on 9 November 2011

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scholarly article

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16 January 2020

SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease (English)

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16 January 2020

Alzheimer's disease

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3

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16 January 2020

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16 January 2020

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Kazuma Murakami

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16 January 2020

Nakaba Murata

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16 January 2020

Shoichi Tahara

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16 January 2020

Takao Kaneko

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16 January 2020

Noriaki Kinoshita

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16 January 2020

Hiroyuki Hatsuta

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16 January 2020

Shigeo Murayama

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16 January 2020

Kevin J Barnham

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16 January 2020

Takuji Shirasawa

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16 January 2020

Takahiko Shimizu

12

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16 January 2020

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9 November 2011

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16 January 2020

Journal of Biological Chemistry

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16 January 2020

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16 January 2020

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16 January 2020

44557-44568

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16 January 2020

Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23

1 reference

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12 July 2018

Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation

1 reference

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12 July 2018

Presenilin-2 mutation causes early amyloid accumulation and memory impairment in a transgenic mouse model of Alzheimer's disease

1 reference

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12 July 2018

Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production

1 reference

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12 July 2018

RAGE modulates hypoxia/reoxygenation injury in adult murine cardiomyocytes via JNK and GSK-3beta signaling pathways.

1 reference

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12 July 2018

Oxidative stress in the progression of Alzheimer disease in the frontal cortex

1 reference

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12 July 2018

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

1 reference

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12 July 2018

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

1 reference

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12 July 2018

Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis

1 reference

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12 July 2018

A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease

1 reference

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12 July 2018

Amyloid beta-protein assembly and Alzheimer disease

1 reference

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12 July 2018

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

1 reference

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12 July 2018

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

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12 July 2018

Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders

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12 July 2018

Oxidative stress and neurotoxicity

1 reference

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12 July 2018

Mitochondrial oxidative stress causes hyperphosphorylation of tau.

1 reference

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12 July 2018

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

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12 July 2018

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

1 reference

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12 July 2018

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

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12 July 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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12 July 2018

Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production

1 reference

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12 July 2018

Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration

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12 July 2018

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

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12 July 2018

Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers

1 reference

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12 July 2018

The potential role of amyloid beta in the pathogenesis of age-related macular degeneration

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12 July 2018

Oxidative stress and neurodegeneration

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12 July 2018

Synaptic localization of a functional NADPH oxidase in the mouse hippocampus

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12 July 2018

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

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12 July 2018

Neuropathological diagnostic criteria for Alzheimer's disease.

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12 July 2018

Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease.

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12 July 2018

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

1 reference

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12 July 2018

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

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12 July 2018

The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration

1 reference

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12 July 2018

Alzheimer's disease: role of aging in pathogenesis

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12 July 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 July 2018

Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria

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12 July 2018

Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice

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Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Free radicals in the genesis of Alzheimer's disease

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease

1 reference

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25 September 2018

Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice

1 reference

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25 September 2018

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo.

1 reference

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Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.

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25 September 2018

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

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25 September 2018

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.

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Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model

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1 reference

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25 September 2018

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25 September 2018

Neurodegenerative diseases and oxidative stress

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25 September 2018

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25 September 2018

Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type.

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Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation

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21 January 2018

CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity and sensitivity of the Abeta oligomer ELISA

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https://pubmed.ncbi.nlm.nih.gov/22072713

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking

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https://pubmed.ncbi.nlm.nih.gov/22072713

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based on heuristic

inferred from PubMed ID database lookup

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

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based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M111.279208

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22072713%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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Europe PubMed Central

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16 January 2020

PubMed publication ID

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Europe PubMed Central

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16 January 2020

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