Coordinating ERK/MAPK signalling through scaffolds and inhibitors (Q29618995)

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8 January 2020

review article

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title

Coordinating ERK/MAPK signalling through scaffolds and inhibitors (English)

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30 April 2017

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endosomal scaffold complex

8 January 2020

main subject

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Gene Ontology release 2020-05-02

1

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8 January 2020

author name string

Kolch W

series ordinal

1

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language of work or name

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publication date

1 November 2005

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Nature Reviews Molecular Cell Biology

8 January 2020

published in

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8 January 2020

volume

6

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8 January 2020

issue

11

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8 January 2020

page(s)

827-837

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The RAF proteins take centre stage

8 January 2020

cites work

1 reference

Mechanisms of regulating the Raf kinase family

1 May 2017

1 reference

MEK kinase activity is not necessary for Raf-1 function

1 May 2017

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 May 2017

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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

1 May 2017

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B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts

1 May 2017

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Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling

1 May 2017

1 reference

Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

1 May 2017

1 reference

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

1 May 2017

1 reference

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

1 May 2017

1 reference

CNK, a RAF-binding multidomain protein required for RAS signaling

1 May 2017

1 reference

Functional analysis of CNK in RAS signaling

1 May 2017

1 reference

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death

1 May 2017

1 reference

Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf

1 May 2017

1 reference

Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1

1 May 2017

1 reference

Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways

1 May 2017

1 reference

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

1 May 2017

1 reference

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

1 May 2017

1 reference

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

1 May 2017

1 reference

Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases

1 May 2017

1 reference

Identification of Sef, a novel modulator of FGF signalling

1 May 2017

1 reference

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

1 May 2017

1 reference

IQGAP proteins are integral components of cytoskeletal regulation

1 May 2017

1 reference

IQGAP1 binds ERK2 and modulates its activity

1 May 2017

1 reference

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 May 2017

1 reference

Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton

1 May 2017

1 reference

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

1 May 2017

1 reference

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

1 May 2017

1 reference

Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes

1 May 2017

1 reference

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

1 May 2017

1 reference

The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.

1 May 2017

1 reference

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

1 May 2017

1 reference

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

1 May 2017

1 reference

RKIP downregulates B-Raf kinase activity in melanoma cancer cells

1 May 2017

1 reference

Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation

1 May 2017

1 reference

Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2

1 May 2017

1 reference

Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation

1 May 2017

1 reference

Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation

1 May 2017

1 reference

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

1 May 2017

1 reference

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

1 May 2017

1 reference

A positive-feedback-based bistable 'memory module' that governs a cell fate decision

1 May 2017

1 reference

Guilty as charged: B-RAF is a human oncogene

1 May 2017

1 reference

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

1 May 2017

1 reference

Conferring specificity on the ubiquitous Raf/MEK signalling pathway

1 May 2017

1 reference

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

31 March 2020

1 reference

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

31 March 2020

1 reference

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

31 March 2020

1 reference

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

31 March 2020

1 reference

Raf-1 regulates Rho signaling and cell migration

31 March 2020

1 reference

Rho signalling at a glance

31 March 2020

1 reference

KSR modulates signal propagation within the MAPK cascade

31 March 2020

1 reference

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

31 March 2020

1 reference

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation

31 March 2020

1 reference

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

31 March 2020

1 reference

Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation

31 March 2020

1 reference

Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation

31 March 2020

1 reference

Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway

31 March 2020

1 reference

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

31 March 2020

1 reference

Bimodal regulation of RAF by CNK in Drosophila

31 March 2020

1 reference

Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism

31 March 2020

1 reference

Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.

31 March 2020

1 reference

CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation

31 March 2020

1 reference

CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation

31 March 2020

1 reference

Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells

31 March 2020

1 reference

Linking tumor suppression, DNA damage and the anaphase-promoting complex.

31 March 2020

1 reference

PEA-15 modulates TNFalpha intracellular signaling in astrocytes

31 March 2020

1 reference

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions

31 March 2020

1 reference

The death effector domain of PEA-15 is involved in its regulation of integrin activation

31 March 2020

1 reference

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

31 March 2020

1 reference

beta-arrestins: traffic cops of cell signaling

31 March 2020

1 reference

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

31 March 2020

1 reference

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation

31 March 2020

1 reference

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

31 March 2020

1 reference

'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors

31 March 2020

1 reference

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

31 March 2020

1 reference

Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.

31 March 2020

1 reference

Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.

31 March 2020

1 reference

Sef is a spatial regulator for Ras/MAP kinase signaling

31 March 2020

1 reference

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs

31 March 2020

1 reference

The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases

31 March 2020

1 reference

Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.

31 March 2020

1 reference

MAP kinases and cell migration

31 March 2020

1 reference

Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis

31 March 2020

1 reference

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

31 March 2020

1 reference

MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling

31 March 2020

1 reference

Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein

31 March 2020

1 reference

Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines.

31 March 2020

1 reference

RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis

31 March 2020

1 reference

Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis

31 March 2020

1 reference

Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab.

31 March 2020

1 reference

Differentiation induction of human keratinocytes by phosphatidylethanolamine-binding protein

31 March 2020

1 reference

Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice.

31 March 2020

1 reference

Congenital abnormalities and childhood cancer

31 March 2020

1 reference

Modulation of signalling by Sprouty: a developing story

31 March 2020

1 reference

FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity

31 March 2020

1 reference

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

31 March 2020

1 reference

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

31 March 2020

1 reference

The activating dual phosphorylation of MAPK by MEK is nonprocessive

31 March 2020

1 reference

Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability

31 March 2020

1 reference

Mathematical models of protein kinase signal transduction.

31 March 2020

1 reference

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

31 March 2020

1 reference

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31 March 2020

Identifiers

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30 April 2017

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Dimensions Publication ID

8 January 2020

1047623240

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30 April 2017

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