Mechanisms of regulating the Raf kinase family (Q28183716)

Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins

Europe PubMed Central

title

Mechanisms of regulating the Raf kinase family (English)

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author name string

Huira Chong

series ordinal

1

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Haris G Vikis

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2

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Kun-Liang Guan

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3

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language of work or name

English

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publication date

May 2003

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published in

Cellular Signalling

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volume

15

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issue

5

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page(s)

463-9

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cites work

1 reference

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7 January 2021

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

1 reference

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7 January 2021

The complexity of Raf-1 regulation

1 reference

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7 January 2021

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

1 reference

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7 January 2021

Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Phosphorylation of Raf by ceramide-activated protein kinase

1 reference

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7 January 2021

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

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7 January 2021

Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice

1 reference

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7 January 2021

The raf oncogene is associated with a radiation-resistant human laryngeal cancer

1 reference

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7 January 2021

Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer

1 reference

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7 January 2021

Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Positive and negative regulation of Raf kinase activity and function by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Autoregulation of the Raf-1 serine/threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Mutational activation of c-raf-1 and definition of the minimal transforming sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

MEK kinase activity is not necessary for Raf-1 function

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

1 reference

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7 January 2021

Endothelial apoptosis in Braf-deficient mice

1 reference

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7 January 2021

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Isoform-specific localization of A-RAF in mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Ras signalling on the endoplasmic reticulum and the Golgi

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Function of the Rho family GTPases in Ras-stimulated Raf activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Mutations of the BRAF gene in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Protein kinase C alpha activates RAF-1 by direct phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Phosphorylation of c-Raf-1 by protein kinase A interferes with activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Phosphorylation by PKA of a site unique to B-Raf kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

KSR, a novel protein kinase required for RAS signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Kinase suppressor of Ras signals through Thr269 of c-Raf-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

KSR is a scaffold required for activation of the ERK/MAPK module

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Critical contribution of linker proteins to Raf kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

CNK, a RAF-binding multidomain protein required for RAS signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Functional analysis of CNK in RAS signaling

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Association of membrane-associated guanylate kinase-interacting protein-1 with Raf-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Spred is a Sprouty-related suppressor of Ras signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021

Sprouty, an intracellular inhibitor of Ras signaling.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900139-0

7 January 2021