The nuts and bolts of AGC protein kinases (Q29617465)

Europe PubMed Central

title

The nuts and bolts of AGC protein kinases (English)

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30 April 2017

author name string

Pearce LR

series ordinal

1

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30 April 2017

Komander D

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2

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30 April 2017

Alessi DR

series ordinal

3

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20027184

30 April 2017

language of work or name

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30 April 2017

publication date

January 2010

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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30 April 2017

volume

11

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issue

1

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30 April 2017

page(s)

9-22

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The protein kinase complement of the human genome

30 April 2017

cites work

1 reference

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

31 March 2020

1 reference

Active and inactive protein kinases: structural basis for regulation

31 March 2020

1 reference

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

31 March 2020

1 reference

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

31 March 2020

1 reference

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

31 March 2020

1 reference

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

31 March 2020

1 reference

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

31 March 2020

1 reference

Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

31 March 2020

1 reference

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

31 March 2020

1 reference

The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

31 March 2020

1 reference

Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation

31 March 2020

1 reference

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex

31 March 2020

1 reference

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

31 March 2020

1 reference

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

31 March 2020

1 reference

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

31 March 2020

1 reference

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

1 reference

Defining the role of mTOR in cancer

31 March 2020

1 reference

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

31 March 2020

1 reference

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

31 March 2020

1 reference

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

31 March 2020

1 reference

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

31 March 2020

1 reference

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

31 March 2020

1 reference

Bidirectional transport of amino acids regulates mTOR and autophagy

31 March 2020

1 reference

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

31 March 2020

1 reference

Regulation of TORC1 by Rag GTPases in nutrient response

31 March 2020

1 reference

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

31 March 2020

1 reference

TSC2 mediates cellular energy response to control cell growth and survival

31 March 2020

1 reference

AMPK phosphorylation of raptor mediates a metabolic checkpoint

31 March 2020

1 reference

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

31 March 2020

1 reference

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

31 March 2020

1 reference

Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.

31 March 2020

1 reference

Sgk kinases and their role in epithelial transport

31 March 2020

1 reference

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

31 March 2020

1 reference

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

31 March 2020

1 reference

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

31 March 2020

1 reference

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

31 March 2020

1 reference

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

31 March 2020

1 reference

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

31 March 2020

1 reference

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

31 March 2020

1 reference

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

31 March 2020

1 reference

Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase

31 March 2020

1 reference

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK

31 March 2020

1 reference

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

31 March 2020

1 reference

The RSK family of kinases: emerging roles in cellular signalling

31 March 2020

1 reference

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

31 March 2020

1 reference

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

31 March 2020

1 reference

MSK activation and physiological roles

31 March 2020

1 reference

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

31 March 2020

1 reference

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

31 March 2020

1 reference

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

31 March 2020

1 reference

The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.

31 March 2020

1 reference

Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling

31 March 2020

1 reference

The E3 ligase TRAF6 regulates Akt ubiquitination and activation

31 March 2020

1 reference

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

31 March 2020

1 reference

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

31 March 2020

1 reference

Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha

31 March 2020

1 reference

Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function.

31 March 2020

1 reference

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation

31 March 2020

1 reference

cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes

31 March 2020

1 reference

Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli

31 March 2020

1 reference

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

31 March 2020

1 reference

Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4

31 March 2020

1 reference

CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals

31 March 2020

1 reference

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

31 March 2020

1 reference

AKAP signalling complexes: focal points in space and time

31 March 2020

1 reference

PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I

31 March 2020

1 reference

Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase

31 March 2020

1 reference

Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation

31 March 2020

1 reference

G protein-coupled receptor kinases

31 March 2020

1 reference

Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo

31 March 2020

1 reference

Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.

31 March 2020

1 reference

Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.

31 March 2020

1 reference

Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation

31 March 2020

1 reference

Mammalian NDR protein kinases: from regulation to a role in centrosome duplication.

31 March 2020

1 reference

The Hippo-YAP pathway: new connections between regulation of organ size and cancer

31 March 2020

1 reference

Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases

31 March 2020

1 reference

Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein

31 March 2020

1 reference

Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation

31 March 2020

1 reference

Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins

31 March 2020

1 reference

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

31 March 2020

1 reference

Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

31 March 2020

1 reference

Rassf family of tumor suppressor polypeptides.

31 March 2020

1 reference

Regulation and functions of Rho-associated kinase

31 March 2020

1 reference

Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron

31 March 2020

1 reference

Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1.

31 March 2020

1 reference

Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

31 March 2020

1 reference

PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation

31 March 2020

1 reference

The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.

31 March 2020

1 reference

Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase

31 March 2020

1 reference

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

31 March 2020

1 reference

Rho-associated kinase of chicken gizzard smooth muscle

31 March 2020

1 reference

The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity

31 March 2020

1 reference

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.

31 March 2020

1 reference

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

31 March 2020

1 reference

Emerging roles of pseudokinases

31 March 2020

1 reference

Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein

31 March 2020

1 reference

Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae

31 March 2020

1 reference

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

31 March 2020

1 reference

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

31 March 2020

1 reference

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

31 March 2020

1 reference

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

31 March 2020

1 reference

PDK1, the master regulator of AGC kinase signal transduction

31 March 2020

1 reference

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

31 March 2020

1 reference

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

31 March 2020

1 reference

3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma

31 March 2020

1 reference

AKT/PKB signaling: navigating downstream

31 March 2020

1 reference

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

31 March 2020

1 reference

Brick by brick: metabolism and tumor cell growth

31 March 2020

1 reference

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

31 March 2020

1 reference

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

31 March 2020

1 reference

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

31 March 2020

1 reference

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

31 March 2020

1 reference

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

31 March 2020

1 reference

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

31 March 2020

1 reference

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

31 March 2020

1 reference

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

31 March 2020

1 reference

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

31 March 2020

1 reference

Targeting the phosphoinositide 3-kinase pathway in cancer

31 March 2020

1 reference

Small-molecule inhibitors of PDK1.

31 March 2020

1 reference

Inhibitor hijacking of Akt activation

31 March 2020

1 reference

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

31 March 2020

1 reference

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

31 March 2020

1 reference

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

31 March 2020

1 reference

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

31 March 2020

1 reference

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

31 March 2020

1 reference

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

31 March 2020

1 reference

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

31 March 2020

1 reference

Regulating insulin signaling and beta-cell function through IRS proteins

31 March 2020

1 reference

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

31 March 2020

1 reference

Inflammatory mechanisms in the regulation of insulin resistance

31 March 2020

1 reference

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

31 March 2020

1 reference

PKC-theta knockout mice are protected from fat-induced insulin resistance

31 March 2020

1 reference

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

31 March 2020

1 reference

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

31 March 2020

1 reference

Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness

31 March 2020

1 reference

Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man

31 March 2020

1 reference

Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14.

31 March 2020

1 reference

Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma

31 March 2020

1 reference

Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

31 March 2020

1 reference

Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.

31 March 2020

1 reference

Clinical and molecular aspects of the myotonic dystrophies: a review.

31 March 2020

1 reference

Myotonic dystrophy: emerging mechanisms for DM1 and DM2.

31 March 2020

1 reference

MAST3: a novel IBD risk factor that modulates TLR4 signaling

31 March 2020

1 reference

FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10

31 March 2020

1 reference

Guanylyl cyclases and signaling by cyclic GMP.

31 March 2020

1 reference

12 December 2020

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1 reference

12 December 2020

Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

1 reference

12 December 2020

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

1 reference

12 December 2020

RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains

1 reference

12 December 2020

GSK3 takes centre stage more than 20 years after its discovery

1 reference

12 December 2020

Posttranslational modification of MDM2

1 reference

12 December 2020

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1 reference

7 January 2021

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20027184

30 April 2017

Consolidated OpenCitations Corpus – April 2017

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1030815156

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20027184

PubMed publication ID

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30 April 2017

Consolidated OpenCitations Corpus – April 2017