Therapeutic potential of resveratrol: the in vivo evidence (Q29547413)

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28 January 2020

review article

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title

Therapeutic potential of resveratrol: the in vivo evidence (English)

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23 April 2017

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28 January 2020

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28 January 2020

David A. Sinclair

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2

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28 January 2020

author name string

Baur JA

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23 April 2017

Sinclair DA

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23 April 2017

publication date

26 May 2006

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Nature Reviews Drug Discovery

28 January 2020

published in

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28 January 2020

volume

5

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28 January 2020

issue

6

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28 January 2020

page(s)

493-506

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Chemical Constituents of Polygonaceous Plants. I

28 January 2020

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Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.

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Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene

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Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury

31 March 2020

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Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor

31 March 2020

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Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity

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Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity

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Toxicogenomics of resveratrol in rat liver.

31 March 2020

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Effect of resveratrol on cell cycle proteins in murine transplantable liver cancer

31 March 2020

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Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis

31 March 2020

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Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin

31 March 2020

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Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo

31 March 2020

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Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.

31 March 2020

1 reference

Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice

31 March 2020

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Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging

31 March 2020

1 reference

Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells.

31 March 2020

1 reference

Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol

31 March 2020

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Chemopreventive effect of trans-resveratrol--a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis

31 March 2020

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Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats

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Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries

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31 March 2020

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31 March 2020

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Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs

31 March 2020

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31 March 2020

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Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

31 March 2020

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An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

31 March 2020

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31 March 2020

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Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents.

31 March 2020

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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

31 March 2020

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Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

31 March 2020

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Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs

31 March 2020

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Evidence for the stimulatory effect of resveratrol on Ca(2+)-activated K+ current in vascular endothelial cells

31 March 2020

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The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption

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Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Immunosuppression by combined use of cyclosporine and resveratrol in a rat liver transplantation model

31 March 2020

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Resveratrol prolongs allograft survival after liver transplantation in rats

31 March 2020

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Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants

31 March 2020

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Effect of resveratrol on herpes simplex virus vaginal infection in the mouse

31 March 2020

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Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice

31 March 2020

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The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury

31 March 2020

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Myocardial protection with red wine extract

31 March 2020

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The protective effect of resveratrols on ischaemia-reperfusion injuries of rat hearts is correlated with antioxidant efficacy.

31 March 2020

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Pharmacological preconditioning with resveratrol: role of nitric oxide

31 March 2020

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Pharmacological preconditioning with resveratrol: an insight with iNOS knockout mice

31 March 2020

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Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes.

31 March 2020

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Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism

31 March 2020

1 reference

Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice

31 March 2020

1 reference

Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats

31 March 2020

1 reference

Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system

31 March 2020

1 reference

Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats

31 March 2020

1 reference

Differential response of immature rat uterine tissue to ethinylestradiol and the red wine constituent resveratrol

31 March 2020

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Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats

31 March 2020

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Effects of p-nonylphenol and resveratrol on body and organ weight and in vivo fertility of outbred CD-1 mice

31 March 2020

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Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring.

31 March 2020

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The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful

31 March 2020

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Resveratrol-associated renal toxicity

31 March 2020

1 reference

Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw.

31 March 2020

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Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test

31 March 2020

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The peripheral antinociceptive effect of resveratrol is associated with activation of potassium channels

31 March 2020

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Effects of Resveratrol on Acoustic Trauma

31 March 2020

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A role for cyclooxygenase-2 in lipopolysaccharide-induced anorexia in rats

31 March 2020

1 reference

Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3

31 March 2020

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Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys

31 March 2020

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In vivo inhibition of TNFalpha-induced vascular permeability by resveratrol

31 March 2020

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Protection from half-mustard-gas-induced acute lung injury in the rat.

31 March 2020

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Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats.

31 March 2020

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The role and interactions of nitric oxide (NO), carbon monoxide (CO), and prostanoids in the pathogenesis of postoperative ileus in rats

31 March 2020

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31 March 2020

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

31 March 2020

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

31 March 2020

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

31 March 2020

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

31 March 2020

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Calorie restriction--the SIR2 connection

31 March 2020

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How does calorie restriction work?

31 March 2020

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Substrate-specific activation of sirtuins by resveratrol

31 March 2020

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Mechanism of human SIRT1 activation by resveratrol

31 March 2020

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

31 March 2020

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

31 March 2020

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

31 March 2020

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

31 March 2020

1 reference

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

31 March 2020

1 reference

Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model

31 March 2020

1 reference

Inhibition of cancer growth by resveratrol is related to its low bioavailability

31 March 2020

1 reference

High absorption but very low bioavailability of oral resveratrol in humans

31 March 2020

1 reference

Bioavailability of trans-resveratrol from red wine in humans.

31 March 2020

1 reference

Resveratrol: from grapevines to mammalian biology

31 March 2020

1 reference

Resveratrol: a molecule whose time has come? And gone?

31 March 2020

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Prospective study of alcohol consumption and risk of dementia in older adults

31 March 2020

1 reference

Wine, beer and spirits and the risk of myocardial infarction: a systematic review

31 March 2020

1 reference

Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum

31 March 2020

1 reference

Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene.

31 March 2020

1 reference

Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration

31 March 2020

1 reference

Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells.

31 March 2020

1 reference

Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway

31 March 2020

1 reference

Antioxidant effects of resveratrol and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles

31 March 2020

1 reference

Synergistic protection of PC12 cells from beta-amyloid toxicity by resveratrol and catechin.

31 March 2020

1 reference

Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol

31 March 2020

1 reference

Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats

31 March 2020

1 reference

Caloric restriction mimetics: the next phase

31 March 2020

1 reference

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

31 March 2020

1 reference

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

31 March 2020

1 reference

Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.

31 March 2020

1 reference

Small molecules that regulate lifespan: evidence for xenohormesis

31 March 2020

1 reference

2-Deoxy-D-Glucose Feeding in Rats Mimics Physiologic Effects of Calorie Restriction

31 March 2020

1 reference

Hormesis: from marginalization to mainstream

31 March 2020

1 reference

Aging, anti-aging, and hormesis

31 March 2020

1 reference

Apparently beneficial effect of low to intermediate doses of A-bomb radiation on human lifespan

31 March 2020

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Hormesis and the antiaging action of dietary restriction

31 March 2020

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Phenotypic plasticity and selection in Drosophila life-history evolution. I. Nutrition and the cost of reproduction

31 March 2020

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

31 March 2020

1 reference

An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster

31 March 2020

1 reference

Liquid chromatography-electrospray tandem mass spectrometry of cis-resveratrol and trans-resveratrol: development, validation, and application of the method to red wine, grape, and winemaking byproducts

31 March 2020

1 reference

Determination of Stilbenes (trans-Astringin,cis- andtrans-Piceid, andcis- andtrans-Resveratrol) in Portuguese Wines

31 March 2020

1 reference

Plant foods and herbal sources of resveratrol

31 March 2020

1 reference

A validated HPLC method for the quantitative analysis of trans-resveratrol and trans-piceid in Hungarian wines

31 March 2020

1 reference

Determination of stilbenes (delta-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, epsilon-viniferin) in Brazilian wines.

31 March 2020

1 reference

Resveratrol, pterostilbene, and piceatannol in vaccinium berries

31 March 2020

1 reference

Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content.

31 March 2020

1 reference

Piceid, the major resveratrol derivative in grape juices

31 March 2020

1 reference

An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine

31 March 2020

1 reference

Resveratrol in raw and baked blueberries and bilberries

31 March 2020

1 reference

Occurrence of resveratrol in edible peanuts

31 March 2020

1 reference

Determination of the phytoalexin resveratrol (3,5,4'-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS).

31 March 2020

1 reference

trans-resveratrol content in commercial peanuts and peanut products

31 March 2020

1 reference

Resveratrol and Piceid Levels in Natural and Blended Peanut Butters

31 March 2020

1 reference

Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages

31 March 2020

1 reference

Hop as an interesting source of resveratrol for brewers: optimization of the extraction and quantitative study by liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

31 March 2020

1 reference

Determination of stilbenes in hop pellets from different cultivars

31 March 2020

1 reference

Phenolic Constituents of Gnetum klossii

31 March 2020

1 reference

Anti-platelet effects of different phenolic compounds from Yucca schidigera Roezl. bark.

31 March 2020

1 reference

Peanut roots as a source of resveratrol

31 March 2020

1 reference

Isolation of resveratrol from Festuca versuta and evidence for the widespread occurrence of this stilbene in the poaceae

31 March 2020

1 reference

Phenanthrene and stilbenes from Pterolobium hexapetallum

31 March 2020

1 reference

Stilbene Synthase and Chalcone Synthase : Two Different Constitutive Enzymes in Cultured Cells of Picea excelsa

31 March 2020

1 reference

Hydroxystilbenes of Eucalyptus wandoo

31 March 2020

1 reference

Pacharin: a new dibenzo(2,3-6,7)oxepin derivative from bauhinia racemosa lamk

31 March 2020

1 reference

Effect of Postharvest Ultraviolet Irradiation on Resveratrol and Other Phenolics of Cv. Napoleon Table Grapes

31 March 2020

1 reference

Postharvest induction modeling method using UV irradiation pulses for obtaining resveratrol-enriched table grapes: a new "functional" fruit?

31 March 2020

1 reference

Postharvest stilbene-enrichment of red and white table grape varieties using UV-C irradiation pulses

31 March 2020

1 reference

Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice

31 March 2020

1 reference

Determination oftrans-Resveratrol in Plasma by HPLC

31 March 2020

1 reference

Human, rat, and mouse metabolism of resveratrol.

31 March 2020

1 reference

Absorption of three wine-related polyphenols in three different matrices by healthy subjects

31 March 2020

1 reference

Hydroxystilbenes in the roots of Rheum rhaponticum

31 March 2020

1 reference

12 April 2024

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28 January 2020

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