Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias (Q28252023)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22045636%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias (English)

1 reference

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15 January 2020

3

1 reference

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15 January 2020

author name string

Silvie Foldynova-Trantirkova

series ordinal

1

1 reference

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15 January 2020

William R Wilcox

series ordinal

2

1 reference

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15 January 2020

language of work or name

English

0 references

publication date

16 November 2011

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15 January 2020

1 reference

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15 January 2020

volume

33

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15 January 2020

issue

1

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15 January 2020

page(s)

29-41

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Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

15 January 2020

cites work

1 reference

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Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1

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A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome

20 March 2017

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Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

20 March 2017

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Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

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A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse

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Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization

20 March 2017

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Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux

20 March 2017

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Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations

20 March 2017

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FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

20 March 2017

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Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

20 March 2017

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Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

20 March 2017

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Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

20 March 2017

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Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

20 March 2017

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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

20 March 2017

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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

20 March 2017

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

20 March 2017

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

20 March 2017

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Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

20 March 2017

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

20 March 2017

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Clinical and genetic heterogeneity of hypochondroplasia

20 March 2017

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PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth

20 March 2017

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Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

20 March 2017

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Fibroblast growth factor receptor 3 is a negative regulator of bone growth

20 March 2017

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Structural and functional diversity in the FGF receptor multigene family

20 March 2017

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VEGFA is necessary for chondrocyte survival during bone development

20 March 2017

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The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II

20 March 2017

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Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia

20 March 2017

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Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene

20 March 2017

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FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

20 March 2017

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

6 April 2017

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7 April 2017

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The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

29 September 2017

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29 September 2017

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29 September 2017

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Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia

29 September 2017

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29 September 2017

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STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes

29 September 2017

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C-natriuretic peptide: an important regulator of cartilage.

29 September 2017

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The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor

29 September 2017

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PTH has the potential to rescue disturbed bone growth in achondroplasia

29 September 2017

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29 September 2017

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Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins

29 September 2017

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BMP signaling in the cartilage growth plate.

29 September 2017

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CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice

29 September 2017

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Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi

29 September 2017

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Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes

29 September 2017

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K644E/M FGFR3 mutants activate Erk1/2 from the endoplasmic reticulum through FRS2 alpha and PLC gamma-independent pathways

29 September 2017

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The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells

29 September 2017

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Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling

29 September 2017

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Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis

29 September 2017

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FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

29 September 2017

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Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma.

29 September 2017

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Mechanisms underlying differential responses to FGF signaling

29 September 2017

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FGF signaling in the developing endochondral skeleton

29 September 2017

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Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF.

29 September 2017

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CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.

29 September 2017

1 reference

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The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling

29 September 2017

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FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells

29 September 2017

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Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

29 September 2017

1 reference

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Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

29 September 2017

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Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann/Schwartz-Jampel type 2 syndrome

29 September 2017

1 reference

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Insulin-like Growth Factor-1 Rescues the Mutated FGF Receptor 3 (G380R) Expressing ATDC5 Cells From Apoptosis Through Phosphatidylinositol 3-Kinase and MAPK

29 September 2017

1 reference

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A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

29 September 2017

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Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia--genetic short limbed dwarfism

29 September 2017

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

29 September 2017

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The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum

29 September 2017

1 reference

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FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation

29 September 2017

1 reference

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ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

29 September 2017

1 reference

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The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases

29 September 2017

1 reference

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Ten years of protein kinase B signalling: a hard Akt to follow

29 September 2017

1 reference

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Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240715

A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia

29 September 2017

1 reference

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Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240715

Integrating the MAP kinase signal into the G1 phase cell cycle machinery

29 September 2017

1 reference

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Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells

29 September 2017

1 reference

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The transmembrane mutation G380R in fibroblast growth factor receptor 3 uncouples ligand-mediated receptor activation from down-regulation

29 September 2017

1 reference

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Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis

29 September 2017

1 reference

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Clinical spectrum of fibroblast growth factor receptor mutations

29 September 2017

1 reference

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FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

29 September 2017

1 reference

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A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene

29 September 2017

1 reference

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A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors

29 September 2017

1 reference

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Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway

29 September 2017

1 reference

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Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

29 September 2017

1 reference

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Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

29 September 2017

1 reference

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Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

29 September 2017

1 reference

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Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

29 September 2017

1 reference

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Toward a molecular understanding of skeletal development

29 September 2017

1 reference

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Achondroplasia is defined by recurrent G380R mutations of FGFR3

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240715

Collagen gene expression during limb cartilage differentiation

29 September 2017

1 reference

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Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240715

Guanylate cyclase receptor family

29 September 2017

1 reference

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Flg-2, a new member of the family of fibroblast growth factor receptors

29 September 2017

1 reference

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Molecular biology and biochemistry of the natriuretic peptide system. I: Natriuretic peptides

29 September 2017

1 reference

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Hypochondroplasia: Clinical and Radiological Aspects in 39 cases

29 September 2017

1 reference

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Achondroplasia and hypochondroplasia. Comments on frequency, mutation rate, and radiological features in skull and spine

29 September 2017

1 reference

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Fibroblast growth factor receptor 3 (FGFR3) is a strong heat shock protein 90 (Hsp90) client: implications for therapeutic manipulation

29 September 2017

1 reference

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Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia.

2 June 2018

1 reference

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Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans

2 June 2018

1 reference

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Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias

2 June 2018

1 reference

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Platyspondylic lethal skeletal dysplasia, San Diego type, is caused by FGFR3 mutations

2 June 2018

1 reference

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Molecular, radiologic, and histopathologic correlations in thanatophoric dysplasia

2 June 2018

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Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

2 June 2018

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Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

2 June 2018

1 reference

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Stop codon FGFR3 mutations in thanatophoric dwarfism type 1

2 June 2018

1 reference

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A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheep

2 June 2018

1 reference

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Thanatophoric dysplasia type I with syndactyly

21 January 2018

1 reference

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Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

21 January 2018

1 reference

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Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias

21 January 2018

1 reference

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A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.

21 January 2018

1 reference

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Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21636

Structural and Functional Diversity in the FGf Receptor Multigene Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21636

Fibroblast growth factors 1, 2, 17, and 19 are the predominant FGF ligands expressed in human fetal growth plate cartilage

21 January 2018

1 reference

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New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells

21 January 2018

1 reference

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Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21636

Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21636

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

21 January 2018

1 reference

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Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

21 January 2018

1 reference

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The population-based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US.

21 January 2018

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FGF upregulates osteopontin in epiphyseal growth plate chondrocytes: implications for endochondral ossification

21 January 2018

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PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation

21 January 2018

1 reference

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21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21636

rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice

21 January 2018

1 reference

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STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2

27 November 2018

1 reference

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Lys650Met substitution in the tyrosine kinase domain of the fibroblast growth factor receptor gene causes thanatophoric dysplasia Type I. Mutations in brief no. 199. Online.

27 November 2018

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27 November 2018

[Thanatophoric dwarfism]

1 reference

12 December 2020

Abnormal FGFR 3 expression in cartilage of thanatophoric dysplasia fetuses

1 reference

12 December 2020

Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia

1 reference

12 December 2020

Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway

1 reference

12 December 2020

Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes

1 reference

12 December 2020

Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice

1 reference

12 December 2020

Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2

1 reference

12 December 2020

A common FGFR3 gene mutation in hypochondroplasia

1 reference

12 December 2020

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

1 reference

12 December 2020

Signal transduction by fibroblast growth factor receptors

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12 December 2020

Cbfa1 as a regulator of osteoblast differentiation and function

1 reference

12 December 2020

PTHrP and skeletal development

1 reference

12 December 2020

1 reference

12 December 2020

Organization of the Indian hedgehog--parathyroid hormone-related protein system in the postnatal growth plate

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12 December 2020

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

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12 December 2020

Identifiers

DOI

10.1002/HUMU.21636

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22045636%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22045636%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

22045636

2 references