Optimization of the Tet-On system for regulated gene expression through viral evolution (Q28242232)

1

0 references

M Vink

2

0 references

B Klaver

3

0 references

B Berkhout

4

0 references

A T Das

The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies

5

0 references

language of work or name

English

0 references

publication date

October 2006

0 references

published in

Gene Therapy

0 references

volume

13

0 references

issue

19

0 references

page(s)

1382-90

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

A single lentivirus vector mediates doxycycline-regulated expression of transgenes in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Viral evolution as a tool to improve the tetracycline-regulated gene expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

A conditionally replicating virus as a novel approach toward an HIV vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

In vitro evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Efficient human immunodeficiency virus replication requires a fine-tuned level of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Constitutively dead, conditionally live HIV-1 genomes. Ex vivo implications for a live virus vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Conditional virus replication as an approach to a safe live attenuated human immunodeficiency virus vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Conditional live virus as a novel approach towards a safe live attenuated HIV vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Conformational changes of the Tet repressor induced by tetracycline trapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Structure-based design of Tet repressor to optimize a new inducer specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Mechanism of Tet repressor induction by tetracyclines: length compensates for sequence in the alpha8-alpha9 loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Identification of a stability determinant on the edge of the Tet repressor four-helix bundle dimerization motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

A general and fast method to generate multiple site directed mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Factor correction as a tool to eliminate between-session variation in replicate experiments: application to molecular biology and retrovirology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Single-chain Tet transregulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Raster3D: photorealistic molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

Characterization of non-inducible Tet repressor mutants suggests conformational changes necessary for induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780

inferred from DOI database lookup

7 January 2021

based on heuristic

A conserved hairpin motif in the R-U5 region of the human immunodeficiency virus type 1 RNA genome is essential for replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302780