Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. (Q35117306)

6 August 2017

title

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. (English)

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6 August 2017

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B H Zhang

1

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6 August 2017

K L Guan

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 October 2000

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6 August 2017

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6 August 2017

volume

19

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6 August 2017

issue

20

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6 August 2017

page(s)

5429-5439

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describes a project that uses

6 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC314015/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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9 July 2018

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B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

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p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

9 July 2018

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

9 July 2018

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9 July 2018

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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

9 July 2018

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14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo

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The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

9 July 2018

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Endothelial apoptosis in Braf-deficient mice

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9 July 2018

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9 July 2018

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Equilibrium and kinetic measurements reveal rapidly reversible binding of Ras to Raf.

9 July 2018

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Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

9 July 2018

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Protein kinase C alpha activates RAF-1 by direct phosphorylation

9 July 2018

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Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

9 July 2018

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Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

9 July 2018

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Phosphorylation of c-Raf-1 by protein kinase A interferes with activation

9 July 2018

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Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.

9 July 2018

1 reference

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Determination of v-Mos-catalyzed phosphorylation sites and autophosphorylation sites on MAP kinase kinase by ESI/MS.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

The ins and outs of Raf kinases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Transcriptional regulation by extracellular signals: mechanisms and specificity

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

The Raf-1 serine/threonine protein kinase.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Biochemical analysis of MEK activation in NIH3T3 fibroblasts. Identification of B-Raf and other activators

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Inhibition by cAMP of Ras-Dependent Activation of Raf

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Phosphorylation of Raf by ceramide-activated protein kinase

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Growth factor signaling by receptor tyrosine kinases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Genetics of RAS signaling in C. elegans.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314015

Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11032810

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate-dependent protein kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11032810

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/EMBOJ/19.20.5429

1 reference

6 August 2017

1 reference

6 August 2017

1 reference