Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily (Q27667524)

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28 January 2020

title

Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily (English)

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5

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Peter Thompson

8

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28 January 2020

John A. Tainer

13

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28 January 2020

Binghui Shen

10

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Susan E Tsutakawa

object named as

Susan E Tsutakawa

1

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ORCID Public Data File 2021

author name string

Scott Classen

2

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28 January 2020

Brian R Chapados

3

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28 January 2020

Andrew S Arvai

4

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28 January 2020

Grant Guenther

6

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28 January 2020

Christopher G Tomlinson

7

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28 January 2020

Altaf H Sarker

9

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28 January 2020

Priscilla K Cooper

11

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Jane A Grasby

12

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28 January 2020

language of work or name

English

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publication date

1 April 2011

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28 January 2020

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28 January 2020

volume

145

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issue

2

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28 January 2020

page(s)

198-211

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The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis

28 January 2020

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Crystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substrates

20 March 2017

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20 March 2017

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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

20 March 2017

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20 March 2017

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Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG

20 March 2017

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Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination

20 March 2017

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DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

20 March 2017

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The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

20 March 2017

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Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity

20 March 2017

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Essential amino acids for substrate binding and catalysis of human flap endonuclease 1

20 March 2017

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XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair

20 March 2017

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Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

20 March 2017

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Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity

20 March 2017

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Identification of Holliday junction resolvases from humans and yeast

20 March 2017

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Human DNA ligase I completely encircles and partially unwinds nicked DNA

20 March 2017

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Flap endonuclease 1: a central component of DNA metabolism

20 March 2017

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20 March 2017

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Methionine or not methionine at the beginning of a protein

7 April 2017

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Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage

20 March 2017

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Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading

20 March 2017

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Substrate recognition and catalysis by flap endonucleases and related enzymes

29 September 2017

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Coordination of dual incision and repair synthesis in human nucleotide excision repair

29 September 2017

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A mutant allele of the transcription factor IIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae

29 September 2017

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Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity

29 September 2017

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29 September 2017

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Vertebrate cells lacking FEN-1 endonuclease are viable but hypersensitive to methylating agents and H2O2.

29 September 2017

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29 September 2017

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Human flap endonuclease-1: conformational change upon binding to the flap DNA substrate and location of the Mg2+ binding site

29 September 2017

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29 September 2017

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Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.

29 September 2017

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Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

29 September 2017

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The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair

29 September 2017

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Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates

2 June 2018

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Factors governing metal-ligand distances and coordination geometries of metal complexes

27 November 2018

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Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.

27 November 2018

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Fen1 mutations result in autoimmunity, chronic inflammation and cancers

27 November 2018

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Concerted action of exonuclease and Gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG)n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragments

27 November 2018

1 reference

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The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities

27 November 2018

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Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate.

27 November 2018

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Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c

27 November 2018

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Passing the baton in base excision repair

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21496641

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21496641

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phasercrystallographic software

1 reference

20 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1107/S0021889807021206

Identifiers

DOI

10.1016/J.CELL.2011.03.004

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21496641%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21496641%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

21496641

2 references