Homing endonucleases: DNA scissors on a mission (Q27023722)

Georg Hausner

series ordinal

2

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L. Bonen

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3

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language of work or name

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August 2012

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55

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PubMed

issue

8

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PubMed

page(s)

553-69

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Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

PubMed

cites work

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The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy

21 January 2018

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Computational redesign of endonuclease DNA binding and cleavage specificity

21 January 2018

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Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

21 January 2018

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Successful Targeting and Disruption of an Integrated Reporter Lentivirus Using the Engineered Homing Endonuclease Y2 I-AniI

21 January 2018

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Homing endonucleases residing within inteins: evolutionary puzzles awaiting genetic solutions

21 January 2018

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Native homing endonucleases can target conserved genes in humans and in animal models

21 January 2018

1 reference

Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

21 January 2018

1 reference

Two for the price of one: a bifunctional intron-encoded DNA endonuclease-RNA maturase.

21 January 2018

1 reference

Homing endonucleases: keeping the house in order

21 January 2018

1 reference

I-TevI, the endonuclease encoded by the mobile td intron, recognizes binding and cleavage domains on its DNA target

21 January 2018

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Xanthomonas AvrBs3 family-type III effectors: discovery and function

21 January 2018

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Breaking the code of DNA binding specificity of TAL-type III effectors

21 January 2018

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TAL effectors: customizable proteins for DNA targeting

21 January 2018

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Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor

21 January 2018

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A likely pathway for formation of mobile group I introns

21 January 2018

1 reference

Structural modeling of TAL effector-DNA interactions

21 January 2018

1 reference

Site-specific selfish genes as tools for the control and genetic engineering of natural populations.

21 January 2018

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Evolution of the MAT locus and its Ho endonuclease in yeast species

21 January 2018

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Genome Engineering With Zinc-Finger Nucleases

21 January 2018

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21 January 2018

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Zinc-finger nucleases: the next generation emerges

21 January 2018

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Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

1 reference

Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster

21 January 2018

1 reference

A highly sensitive selection method for directed evolution of homing endonucleases

21 January 2018

1 reference

Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility

21 January 2018

1 reference

Design, activity, and structure of a highly specific artificial endonuclease

21 January 2018

1 reference

Targeting DNA double-strand breaks with TAL effector nucleases

21 January 2018

1 reference

Mobile group II intron targeting: applications in prokaryotes and perspectives in eukaryotes

21 January 2018

1 reference

Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family

21 January 2018

1 reference

Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family

21 January 2018

1 reference

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy

21 January 2018

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DNA nicks promote efficient and safe targeted gene correction

21 January 2018

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The population genetics of using homing endonuclease genes in vector and pest management

21 January 2018

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Requirements for effective malaria control with homing endonuclease genes

21 January 2018

1 reference

TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction

21 January 2018

1 reference

Directed evolution and substrate specificity profile of homing endonuclease I-SceI.

21 January 2018

1 reference

Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity

21 January 2018

1 reference

Group I introns as mobile genetic elements: facts and mechanistic speculations--a review

21 January 2018

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Mitochondrial genetics. XI. Mutations at the mitochondrial locus omega affecting the recombination of mitochondrial genes in Saccharomyces cerevisiae

21 January 2018

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Phylogenomic analysis of the GIY-YIG nuclease superfamily

21 January 2018

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Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

21 January 2018

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Coincidence of cleavage sites of intron endonuclease I-TevI and critical sequences of the host thymidylate synthase gene.

21 January 2018

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Mobile DNA elements in T4 and related phages.

21 January 2018

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Learning to live together: mutualism between self-splicing introns and their hosts

21 January 2018

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Developing a programmed restriction endonuclease for highly specific DNA cleavage

21 January 2018

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A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells

21 January 2018

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DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI

21 January 2018

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Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases.

21 January 2018

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Targeting DNA with triplexes

21 January 2018

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Heritable targeted mutagenesis in maize using a designed endonuclease

21 January 2018

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Invasion of a multitude of genetic niches by mobile endonuclease genes

21 January 2018

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Assessing the plasticity of DNA target site recognition of the PI-SceI homing endonuclease using a bacterial two-hybrid selection system

21 January 2018

1 reference

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

21 January 2018

1 reference

Inteins: structure, function, and evolution

21 January 2018

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Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

21 January 2018

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Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds

21 January 2018

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Group II intron endonucleases use both RNA and protein subunits for recognition of specific sequences in double-stranded DNA

21 January 2018

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Group II introns designed to insert into therapeutically relevant DNA target sites in human cells

21 January 2018

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The highly variable mitochondrial small-subunit ribosomal RNA gene of Ophiostoma minus

21 January 2018

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The spread of LAGLIDADG homing endonuclease genes in rDNA.

21 January 2018

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The Evolution of Homing Endonuclease Genes and Group I Introns in Nuclear rDNA

21 January 2018

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Crystal structure of an archaeal intein-encoded homing endonuclease PI-PfuI

21 January 2018

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Mechanisms of DNA double strand break repair and chromosome aberration formation

21 January 2018

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Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space

21 January 2018

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High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

21 January 2018

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In vivo mobility of a group I twintron in nuclear ribosomal DNA of the myxomycete Didymium iridis

21 January 2018

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Retargeting mobile group II introns to repair mutant genes

21 January 2018

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DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI

21 January 2018

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Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria

21 January 2018

1 reference

Chemical and biological approaches to improve the efficiency of homologous recombination in human cells mediated by artificial restriction DNA cutter

21 January 2018

1 reference

Targeted genome engineering via zinc finger nucleases

21 January 2018

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Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

21 January 2018

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Infertility resulting from transgenic I-PpoI male Anopheles gambiae in large cage trials

21 January 2018

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Monomeric site-specific nucleases for genome editing

21 January 2018

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The discovery of zinc fingers and their development for practical applications in gene regulation and genome manipulation

21 January 2018

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Characterization of homing endonucleases

21 January 2018

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Evolution of T4-related phages

21 January 2018

1 reference

21 January 2018

Mobile group II introns

1 reference

I-BasI and I-HmuI: two phage intron-encoded endonucleases with homologous DNA recognition sequences but distinct DNA specificities.

21 January 2018

1 reference

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

21 January 2018

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Recurrent insertion of 5'-terminal nucleotides and loss of the branchpoint motif in lineages of group II introns inserted in mitochondrial preribosomal RNAs

21 January 2018

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Chromosomal double-strand break repair in Ku80-deficient cells

21 January 2018

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Creation of a type IIS restriction endonuclease with a long recognition sequence

21 January 2018

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The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

21 January 2018

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Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases

21 January 2018

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Homing endonucleases: from basics to therapeutic applications.

21 January 2018

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Group II intron-based gene targeting reactions in eukaryotes

21 January 2018

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A bacterial group II intron encoding reverse transcriptase, maturase, and DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron

21 January 2018

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Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

21 January 2018

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Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template

21 January 2018

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Structure and activities of group II introns

21 January 2018

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The ribozyme core of group II introns: a structure in want of partners

21 January 2018

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Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

21 January 2018

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Independent evolution of structural and coding regions in a Neurospora mitochondrial intron

21 January 2018

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Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence

21 January 2018

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The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity

21 January 2018

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Exon coconversion biases accompanying intron homing: battle of the nucleases.

21 January 2018

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A group II intron encodes a functional LAGLIDADG homing endonuclease and self-splices under moderate temperature and ionic conditions

21 January 2018

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Novel reporter systems for facile evaluation of I-SceI-mediated genome editing

21 January 2018

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Characterization of I-Ppo, an intron-encoded endonuclease that mediates homing of a group I intron in the ribosomal DNA of Physarum polycephalum

21 January 2018

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Regulating the HO endonuclease in yeast

21 January 2018

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Engineering variants of the I-SceI homing endonuclease with strand-specific and site-specific DNA-nicking activity

21 January 2018

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I-Ssp6803I: the first homing endonuclease from the PD-(D/E)XK superfamily exhibits an unusual mode of DNA recognition

21 January 2018

1 reference

Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy

21 January 2018

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Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

21 January 2018

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Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

21 January 2018

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Gene therapy for primary immunodeficiencies: Looking ahead, toward gene correction

21 January 2018

1 reference

GAL1-SceI directed site-specific genomic (gsSSG) mutagenesis: a method for precisely targeting point mutations in S. cerevisiae.

21 January 2018

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21 January 2018

Precision genome surgery

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Gene targeting using zinc finger nucleases

21 January 2018

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Insertion of a reversible redox switch into a rare-cutting DNA endonuclease

21 January 2018

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Molecular scissors for in situ cellular repair

21 January 2018

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Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

21 January 2018

1 reference

A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes

21 January 2018

1 reference

REBASE--a database for DNA restriction and modification: enzymes, genes and genomes

21 January 2018

1 reference

Targeted mutagenesis by homologous recombination in D. melanogaster

21 January 2018

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Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells

21 January 2018

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Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.

21 January 2018

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Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

21 January 2018

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Coevolution of a Homing Endonuclease and Its Host Target Sequence

21 January 2018

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Triplex-mediated gene modification

21 January 2018

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TAL effector-DNA specificity

21 January 2018

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Mutations altering the cleavage specificity of a homing endonuclease

21 January 2018

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Genes within genes: multiple LAGLIDADG homing endonucleases target the ribosomal protein S3 gene encoded within an rnl group I intron of Ophiostoma and related taxa

21 January 2018

1 reference

Purification and characterization of the SegA protein of bacteriophage T4, an endonuclease related to proteins encoded by group I introns

21 January 2018

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Identification of a family of bacteriophage T4 genes encoding proteins similar to those present in group I introns of fungi and phage

21 January 2018

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DNA binding and cleavage by the HNH homing endonuclease I-HmuI

21 January 2018

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Precise genome modification in the crop species Zea mays using zinc-finger nucleases

21 January 2018

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Catalytic activity control of restriction endonuclease--triplex forming oligonucleotide conjugates.

21 January 2018

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From monomeric to homodimeric endonucleases and back: engineering novel specificity of LAGLIDADG enzymes

21 January 2018

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Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy

21 January 2018

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Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells

21 January 2018

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A detailed study of the substrate specificity of a chimeric restriction enzyme.

21 January 2018

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A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences

21 January 2018

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Chimeras of the homing endonuclease PI-SceI and the homologous Candida tropicalis intein: a study to explore the possibility of exchanging DNA-binding modules to obtain highly specific endonucleases with altered specificity

21 January 2018

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Homing endonuclease structure and function

21 January 2018

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Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification

21 January 2018

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Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast

21 January 2018

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Recent advances in targeted genome engineering in mammalian systems

21 January 2018

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Double-strand break end resection and repair pathway choice

21 January 2018

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Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

21 January 2018

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

21 January 2018

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Structural, functional and evolutionary relationships between homing endonucleases and proteins from their host organisms

21 January 2018

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Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family

21 January 2018

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LAHEDES: the LAGLIDADG homing endonuclease database and engineering server

21 January 2018

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Exploitation of binding energy for catalysis and design

21 January 2018

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Identification of a family of group II introns encoding LAGLIDADG ORFs typical of group I introns

21 January 2018

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Homing endonucleases catalyze double-stranded DNA breaks and somatic transgene excision in Aedes aegypti.

21 January 2018

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

21 January 2018

1 reference

Permanent genome modifications in plant cells by transient viral vectors

21 January 2018

1 reference

Development of a markerless gene replacement system for Acidithiobacillus ferrooxidans and construction of a pfkB mutant

21 January 2018

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Medicine. Gene therapy--new challenges ahead

21 January 2018

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Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos

21 January 2018

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Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae

21 January 2018

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A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

21 January 2018

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Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya

21 January 2018

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Targeted genome editing across species using ZFNs and TALENs

21 January 2018

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Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.

21 January 2018

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Targeted mutagenesis in the progeny of maize transgenic plants

21 January 2018

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Gene targeting in gram-negative bacteria by use of a mobile group II intron ("Targetron") expressed from a broad-host-range vector

21 January 2018

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Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library

21 January 2018

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Zinc finger nuclease and homing endonuclease-mediated assembly of multigene plant transformation vectors

21 January 2018

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A free-standing homing endonuclease targets an intron insertion site in the psbA gene of cyanophages.

21 January 2018

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The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motif

21 January 2018

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Activity and specificity of the bacterial PD-(D/E)XK homing endonuclease I-Ssp6803I.

21 January 2018

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Targeted and random bacterial gene disruption using a group II intron (targetron) vector containing a retrotransposition-activated selectable marker

21 January 2018

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EcI5, a group IIB intron with high retrohoming frequency: DNA target site recognition and use in gene targeting

21 January 2018

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Linear group II intron RNAs can retrohome in eukaryotes and may use nonhomologous end-joining for cDNA ligation.

21 January 2018

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A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility

21 January 2018

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Phylogenetic relationships among group II intron ORFs

21 January 2018

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