Regulatory T cells: Mechanisms of suppression and impairment in autoimmune liver disease (Q26827787)

Charlotte R. Grant

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Maria Serena Longhi

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Giorgina Mieli-Vergani

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Diego Vergani

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language of work or name

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February 2015

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67

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PubMed

issue

2

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PubMed

page(s)

88-97

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

PubMed

cites work

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

1 reference

A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 January 2018

1 reference

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

21 January 2018

1 reference

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene

21 January 2018

1 reference

Cytokines and autoimmunity

21 January 2018

1 reference

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

1 reference

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

1 reference

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

21 January 2018

1 reference

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

21 January 2018

1 reference

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

21 January 2018

1 reference

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

21 January 2018

1 reference

Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells

21 January 2018

1 reference

Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

21 January 2018

1 reference

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

1 reference

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

21 January 2018

1 reference

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

21 January 2018

1 reference

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

21 January 2018

1 reference

Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells

21 January 2018

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Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

21 January 2018

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TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice

21 January 2018

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Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

21 January 2018

1 reference

Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis

21 January 2018

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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.

21 January 2018

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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

21 January 2018

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CD39 and control of cellular immune responses

21 January 2018

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T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine

21 January 2018

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Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells

21 January 2018

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

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Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other

21 January 2018

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CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

21 January 2018

1 reference

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

21 January 2018

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A two-step process for thymic regulatory T cell development.

21 January 2018

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Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

21 January 2018

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

21 January 2018

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Antigen presentation in the thymus for positive selection and central tolerance induction

21 January 2018

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Activation-threshold tuning in an affinity model for the T-cell repertoire

21 January 2018

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Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

21 January 2018

1 reference

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

21 January 2018

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Control of regulatory T cell lineage commitment and maintenance

21 January 2018

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IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

21 January 2018

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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

21 January 2018

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FOXP3+ regulatory T cells in the human immune system

21 January 2018

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How regulatory T cells work

21 January 2018

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

21 January 2018

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Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

21 January 2018

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Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells

21 January 2018

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Mechanisms of foxp3+ T regulatory cell-mediated suppression

21 January 2018

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

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CTLA-4 control over Foxp3+ regulatory T cell function

21 January 2018

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Dynamics of peripheral tolerance and immune regulation mediated by Treg.

21 January 2018

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

21 January 2018

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Inhibition of T cell proliferation by macrophage tryptophan catabolism

21 January 2018

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Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.

21 January 2018

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Role of LAG-3 in regulatory T cells.

21 January 2018

1 reference

Neuropilin-1: the glue between regulatory T cells and dendritic cells?

21 January 2018

1 reference

Neuropilin-1: a surface marker of regulatory T cells

21 January 2018

1 reference

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

21 January 2018

1 reference

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

21 January 2018

1 reference

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

21 January 2018

1 reference

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

21 January 2018

1 reference

Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

21 January 2018

1 reference

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

21 January 2018

1 reference

The 'danger' sensors that STOP the immune response: the A2 adenosine receptors?

21 January 2018

1 reference

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

21 January 2018

1 reference

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

21 January 2018

1 reference

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

21 January 2018

1 reference

CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner

21 January 2018

1 reference

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

21 January 2018

1 reference

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

21 January 2018

1 reference

Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease

21 January 2018

1 reference

Natural regulatory T cells in infectious disease

21 January 2018

1 reference

Regulatory T cells in cancer

21 January 2018

1 reference

Regulatory T cells in immunologic self-tolerance and autoimmune disease

21 January 2018

1 reference

Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro

21 January 2018

1 reference

Primary biliary cirrhosis

21 January 2018

1 reference

Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis.

21 January 2018

1 reference

CD4+CD25+ but not CD4+Foxp3+ T cells as a regulatory subset in primary biliary cirrhosis

21 January 2018

1 reference

Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population

21 January 2018

1 reference

Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis

21 January 2018

1 reference

Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis

21 January 2018

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Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis

21 January 2018

1 reference

Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease.

21 January 2018

1 reference

Autoimmune hepatitis: a comprehensive review

21 January 2018

1 reference

Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis

21 January 2018

1 reference

A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis

21 January 2018

1 reference

Dysfunctional CD39(POS) regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis.

21 January 2018

1 reference

Expansion and de novo generation of potentially therapeutic regulatory T cells in patients with autoimmune hepatitis.

21 January 2018

1 reference

Anti-liver kidney microsome antibody recognizes a cytochrome P450 from the IID subfamily

21 January 2018

1 reference

Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease.

21 January 2018

1 reference

Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2.

21 January 2018

1 reference

Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes

21 January 2018

1 reference

Reduced FOXP3+ regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms

21 January 2018

1 reference

FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency

21 January 2018

1 reference

Foxp3-dependent programme of regulatory T-cell differentiation

21 January 2018

1 reference

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

21 January 2018

1 reference

7 January 2021

Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells

1 reference

7 January 2021

Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis

1 reference

7 January 2021

The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9/tim-3 pathway

1 reference

7 January 2021

From vanilla to 28 flavors: multiple varieties of T regulatory cells

1 reference

7 January 2021

Regulatory T cells and autoimmune hepatitis: Defective cells or a hostile environment?

1 reference

7 January 2021

Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

1 reference

7 January 2021

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

7 January 2021

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

1 reference

7 January 2021

Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells

1 reference

7 January 2021

Inhibition of interleukin-17 promotes differentiation of CD25⁻ cells into stable T regulatory cells in patients with autoimmune hepatitis

1 reference

7 January 2021

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7 January 2021

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

1 reference

7 January 2021

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

1 reference

7 January 2021

CD4+CD25high regulatory cells in human peripheral blood

1 reference

7 January 2021

CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses

1 reference

7 January 2021

Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T cells

1 reference

7 January 2021

Identifiers

DOI

10.1002/IUB.1349

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

25850692

1 reference

Consolidated OpenCitations Corpus – April 2017