Inventing new medicines: The FGF21 story (Q26823319)

Crossref

Andrew C. Adams

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

June 2014

1 reference

1 reference

3

1 reference

issue

3

1 reference

page(s)

221-9

1 reference

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo

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Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

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Different roles of N- and C- termini in the functional activity of FGF21

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FGF21 N- and C-termini play different roles in receptor interaction and activation

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betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

7 April 2017

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

7 April 2017

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

7 April 2017

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FGF-21 as a novel metabolic regulator

7 April 2017

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Identification of a novel FGF, FGF-21, preferentially expressed in the liver

7 April 2017

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Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor

7 April 2017

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FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

7 April 2017

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Fibroblast growth factor receptors, developmental corruption and malignant disease

7 April 2017

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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319

7 April 2017

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FGF21 requires βklotho to act in vivo

7 April 2017

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Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

7 April 2017

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Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?

7 April 2017

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Fundamentals of FGF19 & FGF21 action in vitro and in vivo

7 April 2017

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

7 April 2017

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Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like

7 April 2017

1 reference

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FGF21 regulates metabolism and circadian behavior by acting on the nervous system

28 September 2017

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FGF21 contributes to neuroendocrine control of female reproduction

28 September 2017

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LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

28 September 2017

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Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody

28 September 2017

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An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice

28 September 2017

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FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein

28 September 2017

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Role of fibroblast growth factor 21 in biology of glucagon

28 September 2017

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Fibroblast growth factor 21 mediates specific glucagon actions

28 September 2017

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Circulating fibroblast growth factors as metabolic regulators--a critical appraisal

28 September 2017

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Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis.

28 September 2017

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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

28 September 2017

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βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism

28 September 2017

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Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate

28 September 2017

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Adiponectin: mechanistic insights and clinical implications

28 September 2017

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Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

28 September 2017

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

28 September 2017

1 reference

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

28 September 2017

1 reference

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

28 September 2017

1 reference

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Metabolic Disease Drug Discovery— “Hitting the Target” Is Easier Said Than Done

28 September 2017

1 reference

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FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

28 September 2017

1 reference

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Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

28 September 2017

1 reference

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Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

28 September 2017

1 reference

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High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects

28 September 2017

1 reference

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FGF21 reloaded: challenges of a rapidly growing field

28 September 2017

1 reference

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Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease

28 September 2017

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Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo

28 September 2017

1 reference

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Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease

28 September 2017

1 reference

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Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats

28 September 2017

1 reference

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Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

28 September 2017

1 reference

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High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli

28 September 2017

1 reference

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Relevant use of Klotho in FGF19 subfamily signaling system in vivo

28 September 2017

1 reference

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Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis

28 September 2017

1 reference

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Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia

28 September 2017

1 reference

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Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

28 September 2017

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Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity

28 September 2017

1 reference

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FGF21 is an Akt-regulated myokine

28 September 2017

1 reference

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Fibroblast growth factor 21 corrects obesity in mice

28 September 2017

1 reference

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Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

28 September 2017

1 reference

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Does insulin detemir have a role in reducing risk of insulin-associated weight gain?

28 September 2017

1 reference

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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

28 September 2017

1 reference

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The effects of statins on high-density lipoproteins

28 September 2017

1 reference

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Dysregulation of the fibroblast growth factor system in major depression

28 September 2017

1 reference

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Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease

28 September 2017

1 reference

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The growing prevalence of type 2 diabetes: increased incidence or improved survival?

28 September 2017

1 reference

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Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones

31 May 2018

1 reference

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The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

31 May 2018

1 reference

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Increased FGF21 plasma levels in humans with sepsis and SIRS.

31 May 2018

1 reference

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Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states.

31 May 2018

1 reference

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FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity

31 May 2018

1 reference

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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho

31 May 2018

1 reference

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Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes

31 May 2018

1 reference

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Fibroblast growth factor 1: a key regulator of human adipogenesis.

31 May 2018

1 reference

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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

31 May 2018

1 reference

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Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?

28 November 2018

1 reference

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Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice

28 November 2018

1 reference

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Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

28 November 2018

1 reference

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Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation

28 November 2018

1 reference

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A novel approach to improve the function of FGF21.

28 November 2018

1 reference

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Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities

28 November 2018

1 reference

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Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.

28 November 2018

1 reference

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Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

28 November 2018

1 reference

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Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers

28 November 2018

1 reference

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Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin.

28 November 2018

1 reference

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Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity.

28 November 2018

1 reference

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Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice

28 November 2018

1 reference

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Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.

28 November 2018

1 reference

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Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.

28 November 2018

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The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

28 November 2018

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Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.

28 November 2018

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Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease.

28 November 2018

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Reliability of 'new drug target' claims called into question

28 November 2018

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12 December 2020

Investigation and treatment of type 2 diabetes in nonhuman primates

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12 December 2020

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

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12 December 2020

Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice

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12 December 2020

Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21

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12 December 2020

Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice

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12 December 2020

How to revive breakthrough innovation in the pharmaceutical industry

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12 December 2020

Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes

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12 December 2020

10.1016/J.MOLMET.2013.12.003

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

24749049

1 reference