Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 (Q24318639)

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English	Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21	scientific article

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1 January 2020

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 (English)

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1 January 2020

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fibroblast growth factor receptor 4

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GOA release 2020-03-11

Fibroblast growth factor 21

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GOA release 2020-03-11

Fibroblast growth factor 19

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GOA release 2020-03-11

positive regulation of ERK1 and ERK2 cascade

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GOA release 2020-03-11

3

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1 January 2020

Moosa Mohammadi

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Kevin P. Rosenblatt

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Kevin P Rosenblatt

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Makoto Kuro-o

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Hiroshi Kurosu

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Anna V Eliseenkova

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Anna V Eliseenkova

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Mihwa Choi

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Addie S Dickson

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1 January 2020

Steven A Kliewer

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10 July 2007

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1 January 2020

Journal of Biological Chemistry

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26687-26695

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

Suppression of aging in mice by the hormone Klotho

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

FGF-21 as a novel metabolic regulator

1 reference

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19 March 2017

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

1 reference

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19 March 2017

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

Receptor specificity of the fibroblast growth factor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity

1 reference

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19 March 2017

Klotho converts canonical FGF receptor into a specific receptor for FGF23

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23

1 reference

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19 March 2017

Regulation of fibroblast growth factor-23 signaling by klotho

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

19 March 2017

Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4

1 reference

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19 March 2017

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

1 reference

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

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7 April 2017

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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7 April 2017

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

7 April 2017

Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

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Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase

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27 September 2017

Structural basis for fibroblast growth factor receptor activation

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Evolution of the Fgf and Fgfr gene families

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The phosphatonin pathway: new insights in phosphate homeostasis

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27 September 2017

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

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27 September 2017

Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2496965

27 September 2017

Identification of a hormonal basis for gallbladder filling.

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21 January 2018

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

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21 January 2018

The role of regulated CFTR trafficking in epithelial secretion

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https://api.crossref.org/works/10.1074%2FJBC.M704165200

21 January 2018

Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704165200

21 January 2018

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process

1 reference

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21 January 2018

Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.

1 reference

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21 January 2018

Redundant pathways for negative feedback regulation of bile acid production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704165200

21 January 2018

Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

1 reference

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21 January 2018

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10.1074/JBC.M704165200

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