The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease (Q26783362)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26425388%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Josiane Budni

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26425388%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Tatiani Bellettini-Santos

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26425388%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Francielle Mina

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26425388%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Alexandra Ioppi Zugno

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26425388%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

language of work or name

English

0 references

publication date

September 2015

0 references

2 references

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4 June 2020

volume

6

1 reference

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4 June 2020

issue

5

1 reference

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4 June 2020

page(s)

331-341

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26425388%20AND%20SRC:MED&resulttype=core&format=json

New insights into brain BDNF function in normal aging and Alzheimer disease

4 June 2020

cites work

1 reference

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Parkinson's disease: clinical features and diagnosis

7 April 2017

1 reference

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Sortilin is essential for proNGF-induced neuronal cell death

7 April 2017

1 reference

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Neurotrophins: roles in neuronal development and function

7 April 2017

1 reference

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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

7 April 2017

1 reference

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Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

7 April 2017

1 reference

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A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP

7 April 2017

1 reference

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Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

7 April 2017

1 reference

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Neuroinflammation in the normal aging hippocampus

7 April 2017

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Optimizing neurotrophic factor combinations for neurite outgrowth

7 April 2017

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Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor

7 April 2017

1 reference

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Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats

7 April 2017

1 reference

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ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury

7 April 2017

1 reference

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Decision making in the ageing brain: changes in affective and motivational circuits.

7 April 2017

1 reference

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Hippocampal plasticity during the progression of Alzheimer's disease

28 September 2017

1 reference

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Decreased Neurotrophic Support is Associated with Cognitive Decline in Non-Demented Subjects

28 September 2017

1 reference

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Effects of senescence on the expression of BDNF and TrkB receptor in the lateral geniculate nucleus of cats

28 September 2017

1 reference

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Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: a meta-analysis

28 September 2017

1 reference

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Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice.

28 September 2017

1 reference

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BDNF val66met polymorphism affects aging of multiple types of memory

28 September 2017

1 reference

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Lenti-GDNF gene therapy protects against Alzheimer's disease-like neuropathology in 3xTg-AD mice and MC65 cells

28 September 2017

1 reference

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IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice

28 September 2017

1 reference

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Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques.

28 September 2017

1 reference

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Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3β, neurotrophin-3 and CREB signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Short-term exercise increases GDNF protein levels in the spinal cord of young and old rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

GDNF, NGF and BDNF as therapeutic options for neurodegeneration.

28 September 2017

1 reference

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BDNF transcripts, proBDNF and proNGF, in the cortex and hippocampus throughout the life span of the rat.

28 September 2017

1 reference

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Diminished trkA receptor signaling reveals cholinergic-attentional vulnerability of aging

28 September 2017

1 reference

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Hippocampal proNGF signaling pathways and β-amyloid levels in mild cognitive impairment and Alzheimer disease

28 September 2017

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Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology

28 September 2017

1 reference

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The ageing cortical synapse: hallmarks and implications for cognitive decline

28 September 2017

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The neurotrophin family of neurotrophic factors: an overview

28 September 2017

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Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease

28 September 2017

1 reference

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Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's disease

28 September 2017

1 reference

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The Mechanism of Memory Impairment Induced by A&#946; Chronic Administration Involves Imbalance between Cytokines and Neurotrophins in the Rat Hippocampus

28 September 2017

1 reference

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ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Neural mechanisms of ageing and cognitive decline

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Decreased serum brain-derived neurotrophic factor levels in elderly korean with dementia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

A metabolic and functional overview of brain aging linked to neurological disorders.

28 September 2017

1 reference

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Development of a non invasive NGF-based therapy for Alzheimer's disease.

28 September 2017

1 reference

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Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats.

28 September 2017

1 reference

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Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis

28 September 2017

1 reference

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Involvement of neurotrophic factors in aging of noradrenergic innervations in hippocampus and frontal cortex

28 September 2017

1 reference

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ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

28 September 2017

1 reference

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Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR.

28 September 2017

1 reference

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Physiology of BDNF: focus on hypothalamic function

28 September 2017

1 reference

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Ability of GDNF to diminish free radical production leads to protection against kainate-induced excitotoxicity in hippocampus

28 September 2017

1 reference

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From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning

28 September 2017

1 reference

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GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation

28 September 2017

1 reference

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The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor.

28 September 2017

1 reference

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Neuroprotective effects of GDNF against 6-OHDA in young and aged rats

28 September 2017

1 reference

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Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

28 September 2017

1 reference

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Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: role of antioxidation.

28 September 2017

1 reference

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TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

28 September 2017

1 reference

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p75 and Trk: a two-receptor system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro

28 September 2017

1 reference

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Functional receptor for GDNF encoded by the c-ret proto-oncogene

28 September 2017

1 reference

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GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo

28 September 2017

1 reference

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Brain changes in Alzheimer's disease patients with implanted encapsulated cells releasing nerve growth factor

28 September 2017

1 reference

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Enhancement of the nonamyloidogenic pathway by exogenous NGF in an Alzheimer transgenic mouse model

31 May 2018

1 reference

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Serum brain-derived neurotrophic factor levels in different neurological diseases.

31 May 2018

1 reference

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Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

31 May 2018

1 reference

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Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism

31 May 2018

1 reference

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Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

31 May 2018

1 reference

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The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

31 May 2018

1 reference

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Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system

31 May 2018

1 reference

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Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones.

31 May 2018

1 reference

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Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain

31 May 2018

1 reference

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Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation

31 May 2018

1 reference

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Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning

31 May 2018

1 reference

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Social interaction rescues memory deficit in an animal model of Alzheimer's disease by increasing BDNF-dependent hippocampal neurogenesis.

28 November 2018

1 reference

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Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Age-dependent effects of valproic acid in Alzheimer's disease (AD) mice are associated with nerve growth factor (NGF) regulation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Role of nuclear receptor on regulation of BDNF and neuroinflammation in hippocampus of β-amyloid animal model of Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

BDNF, TNFα, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer's disease or mild cognitive impairment.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Val66Met polymorphism and BDNF levels in Alzheimer's disease patients in North Indian population

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment.

28 November 2018

1 reference

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Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Brain-derived neurotrophic factor (BDNF) has proliferative effects on neural stem cells through the truncated TRK-B receptor, MAP kinase, AKT, and STAT-3 signaling pathways

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Effect of aging on brain-derived neurotrophic factor, proBDNF, and their receptors in the hippocampus of Lou/C rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Effect of aging on the expression of BDNF and TrkB isoforms in rat pituitary

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementias

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

BDNF is necessary for maintenance of noradrenergic innervations in the aged rat brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

NGF content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Reciprocal changes in expression of mRNA for nerve growth factor and its receptors TrkA and LNGFR in brain of aged rats in relation to maze learning deficits

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

NGF level of is not decreased in the serum, brain-spinal fluid, hippocampus, or parietal cortex of individuals with Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4567216

Effects of BDNF infusion on the axon terminals of locus coeruleus neurons of aging rats

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26425388

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26425388

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Region-Specific Neurotrophin Imbalances in Alzheimer Disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26425388

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.14336/AD.2015.0825

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26425388%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26425388%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

26425388

2 references