Lenti-GDNF gene therapy protects against Alzheimer's disease-like neuropathology in 3xTg-AD mice and MC65 cells (Q38966488)

25119316

8 September 2017

title

Lenti-GDNF gene therapy protects against Alzheimer's disease-like neuropathology in 3xTg-AD mice and MC65 cells (English)

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8 September 2017

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12

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14 May 2020

author name string

Susana Revilla

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493188&resulttype=core&format=json

14 May 2020

Suzanna Ursulet

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493188&resulttype=core&format=json

14 May 2020

María Jesús Álvarez-López

3

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14 May 2020

Marco Castro-Freire

4

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14 May 2020

Unai Perpiñá

5

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14 May 2020

Yoelvis García-Mesa

6

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14 May 2020

Analía Bortolozzi

7

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14 May 2020

Lydia Giménez-Llort

8

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14 May 2020

Perla Kaliman

9

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Rosa Cristòfol

10

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14 May 2020

Chamsy Sarkis

11

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14 May 2020

publication date

13 August 2014

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25119316

CNS Neuroscience & Therapeutics

8 September 2017

published in

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14 May 2020

volume

20

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issue

11

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14 May 2020

page(s)

961-972

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describes a project that uses

14 May 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6493188/fullTextXML

inferred from PubMed Central ID database lookup

1 reference

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

21 January 2018

1 reference

Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease

21 January 2018

1 reference

Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats.

21 January 2018

1 reference

GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases

21 January 2018

1 reference

BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β-induced toxicity in cultured rat septal neurons

21 January 2018

1 reference

N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor

21 January 2018

1 reference

Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells

21 January 2018

1 reference

Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation.

21 January 2018

1 reference

Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum

21 January 2018

1 reference

Pro-regenerative properties of cytokine-activated astrocytes.

21 January 2018

1 reference

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein

21 January 2018

1 reference

Carboxyl-terminal fragment of amyloid precursor protein and hydrogen peroxide induce neuronal cell death through different pathways.

21 January 2018

1 reference

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

21 January 2018

1 reference

Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death

21 January 2018

1 reference

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.

21 January 2018

1 reference

Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease

21 January 2018

1 reference

A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes

21 January 2018

1 reference

Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents

21 January 2018

1 reference

The effects of anisomycin (a protein synthesis inhibitor) on spatial learning and memory in CA1 region of rats hippocampus

21 January 2018

1 reference

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

21 January 2018

1 reference

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

21 January 2018

1 reference

Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease

21 January 2018

1 reference

Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease

21 January 2018

1 reference

Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice

21 January 2018

1 reference

The disturbance of hippocampal CaMKII/PKA/PKC phosphorylation in early experimental diabetes mellitus

21 January 2018

1 reference

Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.

21 January 2018

1 reference

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.

21 January 2018

1 reference

Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.

21 January 2018

1 reference

Effects of exercise on mitochondrial function, neuroplasticity and anxio-depressive behavior of mice

21 January 2018

1 reference

Resveratrol promotes neurotrophic factor release from astroglia

21 January 2018

1 reference

Progenitor proliferation in the adult hippocampus and substantia nigra induced by glial cell line-derived neurotrophic factor

21 January 2018

1 reference

GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3.

21 January 2018

1 reference

Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson's disease

21 January 2018

1 reference

Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicity

21 January 2018

1 reference

Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF

21 January 2018

1 reference

Upregulation of glutathione peroxidase-1 expression and activity by glial cell line-derived neurotrophic factor promotes high-level protection of PC12 cells against 6-hydroxydopamine and hydrogen peroxide toxicities

21 January 2018

1 reference

Increased expression of glial cell line-derived neurotrophic factor protects against oxidative damage-induced retinal degeneration

21 January 2018

1 reference

Glial cell line-derived neurotrophic factor protects against ischemia/hypoxia-induced brain injury in neonatal rat.

21 January 2018

1 reference

Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: role of antioxidation.

21 January 2018

1 reference

Ageing of enteric neurons: oxidative stress, neurotrophic factors and antioxidant enzymes

21 January 2018

1 reference

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress

21 January 2018

1 reference

Causes of oxidative stress in Alzheimer disease.

21 January 2018

1 reference

Mechanism of oxidative stress in neurodegeneration

21 January 2018

1 reference

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons

21 January 2018

1 reference

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

21 January 2018

1 reference

Neuronal Expression of β-Amyloid Precursor Protein Alzheimer Mutations Causes Intracellular Accumulation of a C-terminal Fragment Containing Both the Amyloid β and Cytoplasmic Domains

21 January 2018

1 reference

Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease

21 January 2018

1 reference

Mitochondrial oxidative stress causes hyperphosphorylation of tau.

21 January 2018

1 reference

The potential neuroprotection mechanism of GDNF in the 6-OHDA-induced cellular models of Parkinson's Disease.

21 January 2018

1 reference

Upregulation of glutamate-aspartate transporter by glial cell line-derived neurotrophic factor ameliorates cell apoptosis in neural retina in streptozotocin-induced diabetic rats.

21 January 2018

1 reference

Neuroprotection by GDNF in the ischemic brain

21 January 2018

1 reference

GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation

21 January 2018

1 reference

Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor.

21 January 2018

1 reference

Various roles of astrocytes during recovery from repeated exposure to different doses of lipopolysaccharide

21 January 2018

1 reference

The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS.

21 January 2018

1 reference

Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk

21 January 2018

1 reference

Ex vivo and in vitro studies of transgene expression in rat astrocytes transduced with lentiviral vectors

21 January 2018

1 reference

Optimized Quantities of GDNF Overexpressed by Engineered Astrocytes Are Critical for Protection of Neuroblastoma Cells Against 6-OHDA Toxicity

21 January 2018

1 reference

Gene-expression profile of the ageing brain in mice

21 January 2018

1 reference

12 December 2020

Neurotrophic factors in Alzheimer's and Parkinson's disease brain

1 reference

12 December 2020

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

1 reference

12 December 2020

Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway.

1 reference

12 December 2020

Loss of hippocampal CA1 pyramidal neurons correlates with memory impairment in rats with ischemic or neurotoxin lesions

1 reference

12 December 2020

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein

1 reference

12 December 2020

Role of oxidative stress in the progression of Alzheimer's disease

1 reference

12 December 2020

In vitro and in vivo activation of astrocytes by amyloid-beta is potentiated by pro-oxidant agents

1 reference

12 December 2020

Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?

1 reference

12 December 2020

Physical exercise protects against Alzheimer's disease in 3xTg-AD mice

1 reference

12 December 2020

Mechanisms of CaMKII action in long-term potentiation

1 reference

12 December 2020

Identifiers

DOI

10.1111/CNS.12312

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493188&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493188&resulttype=core&format=json

14 May 2020

25119316

1 reference