Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells (Q24300842)

sequence-specific DNA binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Mesenchyme homeobox 1

1 reference

GOA release 2020-03-11

Jeffrey T Wigle

5

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author name string

Josette M Douville

1

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David Y C Cheung

2

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Krista L Herbert

3

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Teri Moffatt

The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences

4

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language of work or name

English

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publication date

2011

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published in

PLOS One

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volume

6

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issue

12

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page(s)

e29099

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cites work

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Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter

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VentX trans-Activates p53 and p16ink4a to Regulate Cellular Senescence

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Estrogen regulated expression of the p21 Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells

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A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a

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Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter

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Angiogenesis during exercise and training

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Molecular mechanisms of replicative senescence in endothelial cells

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Inhibition of endothelial cell activation by the homeobox gene Gax.

27 September 2017

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The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter

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Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation

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Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein

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Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.

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27 September 2017

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Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells

27 September 2017

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27 September 2017

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27 September 2017

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C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

27 September 2017

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eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization

30 May 2018

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Androgen induction of cyclin-dependent kinase inhibitor p21 gene: role of androgen receptor and transcription factor Sp1 complex

30 May 2018

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c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.

30 May 2018

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Reduction of Nitric Oxide Producing Activity Associated with in Vitro Aging in Cultured Human Umbilical Vein Endothelial Cell

30 May 2018

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Embryonic expression of the Gax homeodomain protein in cardiac, smooth, and skeletal muscle.

30 May 2018

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Meox1Cre: a mouse line expressing Cre recombinase in somitic mesoderm

21 January 2018

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Developmental origin of smooth muscle cells in the descending aorta in mice

21 January 2018

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Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2.

21 January 2018

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Intracellular localization of homopolymeric amino acid-containing proteins expressed in mammalian cells

21 January 2018

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Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis

21 January 2018

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Transcriptional Regulation of the p21(WAF1/CIP1)Gene

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Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide

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