Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells (Q22011159)

Europe PubMed Central

title

Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells (English)

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D Huylebroeck

2

D

Huylebroeck

1 reference

PubMed

PubMed publication ID

7 February 2023

K Verschueren

1

K

Verschueren

1 reference

PubMed

PubMed publication ID

10647776

7 February 2023

language of work or name

English

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publication date

1999

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Cytokine and Growth Factor Reviews

PubMed

published in

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volume

10

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issue

3-4

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page(s)

187-99

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cites work

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SMADs: mediators and regulators of TGF-β signaling

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TGF-beta signal transduction

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Intracellular signaling: Fleshing out the TGFbeta pathway

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Smads and early developmental signaling by the TGFbeta superfamily

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The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation

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Determinants of specificity in TGF-beta signal transduction.

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The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

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Identification of two Smad4 proteins in Xenopus. Their common and distinct properties

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Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

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Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp.

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The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development.

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Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals

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The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway

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Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

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Regulation of Smad signalling by protein associations and signalling crosstalk

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Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

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A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

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Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

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MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

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7 January 2021

Regulation of immune responses by TGF-beta

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7 January 2021

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

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7 January 2021

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

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7 January 2021

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

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7 January 2021

Human Smad3 and Smad4 are sequence-specific transcription activators

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7 January 2021

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

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A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3

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Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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7 January 2021

Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen activator inhibitor-1 promoter

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7 January 2021

Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation

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7 January 2021

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

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7 January 2021

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

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7 January 2021

A transcriptional partner for MAD proteins in TGF-beta signalling

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7 January 2021

Smad4 and FAST-1 in the assembly of activin-responsive factor

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Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

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7 January 2021

Characterization of human FAST-1, a TGF beta and activin signal transducer

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7 January 2021

FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals

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7 January 2021

A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis

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7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

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7 January 2021

Smads bind directly to the Jun family of AP-1 transcription factors

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7 January 2021

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

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Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene

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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

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7 January 2021

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

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7 January 2021

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

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7 January 2021

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells

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7 January 2021

Physical and functional interaction of SMADs and p300/CBP

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TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein

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7 January 2021

Role of p300, a transcriptional coactivator, in signalling of TGF-beta

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7 January 2021

A function of CBP as a transcriptional co-activator during Dpp signalling.

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7 January 2021

Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

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7 January 2021

A Smad transcriptional corepressor

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7 January 2021

Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling

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7 January 2021

SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes

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7 January 2021

The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation.

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7 January 2021

Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker

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7 January 2021

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.

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7 January 2021

Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators

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7 January 2021

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

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7 January 2021

Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expression

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7 January 2021

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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7 January 2021

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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7 January 2021

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

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Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

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7 January 2021

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

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7 January 2021

A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction

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7 January 2021

Interaction of Drosophila Inhibitors of Apoptosis with Thick Veins, a Type I Serine/Threonine Kinase Receptor for Decapentaplegic

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7 January 2021

Carboxy-terminally truncated Gli3 proteins associate with Smads

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7 January 2021

The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

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7 January 2021

Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

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7 January 2021

Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity

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7 January 2021

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

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7 January 2021

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.

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7 January 2021

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

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7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

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7 January 2021

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

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7 January 2021

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

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7 January 2021

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

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7 January 2021