Adenomatous polyposis coli protein (Q21494863)

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mouse protein (annotated by UniProtKB/Swiss-Prot Q61315)
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Adenomatous polyposis coli protein
mouse protein (annotated by UniProtKB/Swiss-Prot Q61315)

    Statements

    instance of
    protein
    0 references
    part of
    molecular function
    beta-catenin binding
    determination method or standard
    IBA
    IDA
    IEA
    IPI
    ISO
    ISS
    6 references
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q61315
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    ISS
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IDA
    retrieved
    14 February 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IBA
    cell component
    biological process
    negative regulation of Wnt signaling pathway
    determination method or standard
    IGI
    IEA
    IMP
    9 references
    retrieved
    14 February 2019
    stated in
    Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Apc tumor suppressor gene is the "zonation-keeper" of mouse liver
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Disruption of early proximodistal patterning and AVE formation in Apc mutants
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Inactivation of Apc in the mouse prostate causes prostate carcinoma
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Deficiency of Mbd2 attenuates Wnt signaling
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IEA
    negative regulation of cell population proliferation
    determination method or standard
    ISS
    IGI
    IEA
    IMP
    ISO
    68 references
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q61315
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    ISS
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Inactivation of both APC alleles in human and mouse tumors
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    APC-dependent suppression of colon carcinogenesis by PPARgamma
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    In utero and neonatal sensitivity of ApcMin/+ mice to radiation-induced intestinal neoplasia
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    T cell status influences colon tumor occurrence in min mice fed short chain fructo-oligosaccharides as a diet supplement
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    APC inhibits ERK pathway activation and cellular proliferation induced by RAS
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Myc deletion rescues Apc deficiency in the small intestine
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Localized gene action controlling intestinal neoplasia in mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Gastro-intestinal tumorigenesis in Smad4 mutant mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Deficiency of Mbd2 attenuates Wnt signaling
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Meta-analysis of gene expression in mouse preimplantation embryo development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Alpha-catenin is essential in intestinal adenoma formation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Interleukin-6 and cachexia in ApcMin/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Functional PKC in vivo analysis using deficient mouse models
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    The H19 locus acts in vivo as a tumor suppressor
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IEA
    negative regulation of epithelial cell proliferation
    determination method or standard
    IGI
    IMP
    TAS
    5 references
    retrieved
    14 February 2019
    stated in
    Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    TAS
    retrieved
    14 February 2019
    stated in
    APC mutation and the crypt cycle in murine and human intestine
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IGI
    negative regulation of canonical Wnt signaling pathway
    determination method or standard
    IBA
    IMP
    ISO
    TAS
    6 references
    retrieved
    14 February 2019
    stated in
    Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    TAS
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315
    determination method or standard
    IBA

    Identifiers

     
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