DI-VS.-SIADH

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Diabetes

Insipidus
vs.
SIADH
Difference of DI and SIADH
FEATURE DIABETES INSIPIDUS (DI) (SIADH)

ADH LEVEL Increased Decreased or ineffective


URINE OUTPUT Decreased Increased

FLUID BALANCE Water Retention Water Loss

BLOOD SODIUM Decreased (hyponatremia) Increased (hypernatremia)


LEVEL

SYMPTOMS Confusion, lethargy, Excessive thirst, frequent


seizures, weight gain urination, dehydration

TREATMENT Fluid restriction, diuretics, Fluid replacement,


Medication to block ADH medications to increase ADH
(desmopressin)
Diabetes
Insipidus (DI)
DEFINITION
Diabetes Insipidus:

• Excretion of large amounts of dilute


urine and increased
thirst(POLYDIPSIA).
• problem of vasopressin
hormone(ADH)
TYPES:
Two types of DIABETES INSIPIDUS:

1. CENTRAL DIABETES INSIPIDUS


- due to damage of Hypothalamus or
Pituitary Gland

2. NEPHROGENIC DIABETES INSIPIDUS


- due to kidney disease.
PATHOPHYSIOLOGY:
-Diabetes Insipidus (DI) refers to a group of
disorders that result in an inability of the kidneys to
concentrate urine, leading to excessive urination
(polyuria) and thirst (polydipsia).
-The disease process depends on the underlying
cause, but generally involves a disruption in the
normal action or production of antidiuretic
hormone (ADH), also known as vasopressin,
which plays a crucial role in regulating the body’s
water balance.
Diagnostic Evaluation
and Laboratory Test
To confirm the diagnosis of DI and differentiate between its
forms:
 Water deprivation test:(primary diagnosis): A test
where water intake is rbestricted, and urine output is
monitored.
 ADH levels: Measurement of ADH in the blood helps
determine if the cause is central (low ADH) or nephrogenic
(normal or high ADH).
Vasopressin (ADH) challenge test: Administering
synthetic ADH (desmopressin) can differentiate between
central and nephrogenic DI.
CLINICAL MANIFESTATION 3P’s
• POLYDIPSIA

• POLYURIA

• POLYPHAGIA
Management:
Central DI: Desmopressin (synthetic ADH) is
used to replace the missing hormone.
Nephrogenic DI: Treatment focuses on
managing the underlying cause and may include
the use of thiazide diuretics, low-salt diet, and
sometimes prostaglandin inhibitors to help the
kidneys concentrate urine.
Dipsogenic DI: Managed with fluid restriction
and addressing the underlying cause.
Gestational DI: Treated with desmopressin
Syndrome of
nappropriate Antidiuretic
Hormone Secretion
(SIADH)
DEFINITION
Syndrome of Inappropriate Antidiuretic
Hormone Secretion:

• A condition characterized by
excessive secretion of
antidiuretic hormone (ADH),
leading to water retention and
hyponatremia.
SIGN AND SYMPTOMS:

Neurological: Confusion, Lethargy, Headache,


Seizures, Coma
Gastrointestinal: Anorexia, Nausea, Vomiting
Other: Weight gain without edema
Muscle weakness

Hallmark: Hyponatremia
Management:
Mild Hyponatremia:
• Fluid restriction
• Moderate to Severe Hyponatremia:
• Fluid restriction
• Hypertonic saline administration
• Diuretics (e.g., loop diuretics)
Underlying Cause Treatment:
Addressing underlying conditions like lung cancer,
brain tumors, or medications
Management:
Mild Hyponatremia:
• Fluid restriction
• Moderate to Severe Hyponatremia:
• Fluid restriction
• Hypertonic saline administration
• Diuretics (e.g., loop diuretics)
Underlying Cause Treatment:
Addressing underlying conditions like lung cancer,
brain tumors, or medications
Nursing Intervention:
• Assessment:
-Monitor for neurological changes, fluid intake and
output, and electrolyte levels.
• Fluid Restriction:
-Restrict fluid intake as prescribed.
• Medication Administration:
-Administer diuretics or hypertonic saline as ordered.
Safety Measures:
-Implement fall precautions due to potential neurological
changes.
Patient Education:
- Educate the patient and family about the condition,
treatment plan, and the importance of fluid restriction.
Health Teaching:

-Explain the condition and its causes


Discuss the importance of fluid restriction
-Instruct on recognizing symptoms of
hyponatremia
-Teach self-care measures, such as monitoring
fluid intake and weight
-Encourage regular follow-up with healthcare
provider
THANK
YOU!

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