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    Hormone Replacement Therapy (HRT)

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    Lana
    This document discusses hormone replacement therapy (HRT) for menopause. It defines menopause and lists common symptoms. It then describes the types of supplemental hormones used in HRT, including estrogen, progesterone, and testosterone, which can be plant-based or synthetic. Different delivery methods are outlined, including pills, patches, creams, and implants. The document also covers the benefits of HRT in reducing menopausal symptoms, as well as some risks like increased chances of breast and endometrial cancers or blood clots.

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    Hormone Replacement Therapy (HRT)

    Uploaded by

    Lana
    54 views15 pages
    This document discusses hormone replacement therapy (HRT) for menopause. It defines menopause and lists common symptoms. It then describes the types of supplemental hormones used in HRT, including estrogen, progesterone, and testosterone, which can be plant-based or synthetic. Different delivery methods are outlined, including pills, patches, creams, and implants. The document also covers the benefits of HRT in reducing menopausal symptoms, as well as some risks like increased chances of breast and endometrial cancers or blood clots.

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    This document discusses hormone replacement therapy (HRT) for menopause. It defines menopause and lists common symptoms. It then describes the types of supplemental hormones used in HRT, including estrogen, progesterone, and testosterone, which can be plant-based or synthetic. Different delivery methods are outlined, including pills, patches, creams, and implants. The document also covers the benefits of HRT in reducing menopausal symptoms, as well as some risks like increased chances of breast and endometrial cancers or blood clots.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    54 views15 pages

    Hormone Replacement Therapy (HRT)

    Uploaded by

    Lana
    This document discusses hormone replacement therapy (HRT) for menopause. It defines menopause and lists common symptoms. It then describes the types of supplemental hormones used in HRT, including estrogen, progesterone, and testosterone, which can be plant-based or synthetic. Different delivery methods are outlined, including pills, patches, creams, and implants. The document also covers the benefits of HRT in reducing menopausal symptoms, as well as some risks like increased chances of breast and endometrial cancers or blood clots.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
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    of 15

    HORMONE

    REPLACEMENT
    THERAPY (HRT)
    WHAT IS MENOPAUSE?
    Cessation of menstruation as a result of the aging process
    of or surgical removal of the ovaries; change from
    fertility to infertility.
    Hormone levels change in female body; practically the
    production of estrogen.
    Menopause itself begins 12 months after a woman’s final
    period.
    SYMPTOMS OF
    PERIMENOPAUSE/MENOPA
    USE
    oCycles become irregular
    oErratic or heavy bleeding
    oDecrease in sexual response
    oIrritability/Mood Swings
    oFatigue
    oForgetfulness
    SYMPTOMS OF
    PERIMENOPAUSE/MENOPA
    USE
    Headache
    Hot flashes
    Night sweats
    Vaginal dryness
    Dry skin
    Bone loss
    Urinary incontinence
    HORMONE REPLACEMENT
    THERAPY
    Supplemental hormones: Estrogen, progesterone, and
    testosterone.

    Estrogen and progesterone can be made from plants of


    from synthetic chemicals.

    Delivery options: pills, patches, creams, inserted into


    vagina by means of creams, tablets or ring, placed under
    skin by implants or by injection; future: nasal spray.
    PROGESTOGENS
    19 NORTESTOSTERONE 17 HYDROXY-PROGESTERONE
    DERIVATIVES
    DERIVATIVES

    dydrogesterone
    norethisterone
    levonorgestrel medroxy progesterone acetate

    norgestrel
    PRESCRIPTION OF HRT:
    ROUTES

    Transdermal: patch or Oral


    gel

    Subcutaneous(implan Intra-uterine
    t) (Mirena)

    Intramuscular Intra-vaginal (tablets,


    (depot) ring or cream)
    PREPARATIONS OF HRT
    Oestrogen Only HRT (tablet, patch, gel, implant)

    Sequential Combined HRT - oestrogen and progestogens


    (tablets or patch)

    Continuous Combined HRT - oestrogen and progestogens


    (tablets or patch)
    OESTROGEN ONLY HRT
    Only to be used in women who have had a total
    hysterectomy

    If the hysterectomy was subtotal, then may need to


    use progestogens as well (some endometrium may be
    left behind)

    If the hysterectomy was for endometriosis, then


    progestogens continuously along with oestrogen
    should be used at least initially
    SEQUENTIAL COMBINED
    HRT
    Sequential oestrogen and progestogen

    estrogen for 28
    days
    Progesterone
    for 14 days
    The addition of the progestogen protects the endometrium and
    leads to a regular bleed

    Single named product available as patch or tablet but


    individualisation possible eg gel and IUS
    CONTINUOUS COMBINED
    HRT
    Continuous Combined HRT (CCT)
    Oestrogen
    combined with
    progestogen for
    28 days

    This should not be started until 1 year after the LMP or


    aged 54. Should also be used after 2 years of cyclical
    therapy if under the age of 54.

    No monthly bleed
    BENEFITS OF HRT
    Maintains thickness and vascularity of vaginal and
    urethral tissue for comfort and lubrication during sexual
    interaction.
    Reduces hot flashes and sleep disturbances from night
    sweats.
    Protects against osteoporosis and resultant fractures,
    particularly of the hip.
    Reduces risk of colon cancer
    RISKS OF HRT
    •Breast cancer
    • In 2003 there was 14,000 less cases of breast cancer possibly due to
    the decrease in women taking HRT
    • If a woman is diagnosed with breast cancer while taking HRT, she
    is advised to stop immediately.

    •Endometrial cancer
    •Cardiovascular disease
    •Stroke
    •Blood clots
    SIDE EFFECTS OF HRT
    •Weight gain
    •Bloating
    •Breast tenderness
    •Irregular bleeding

    •Mrscp
    THANK YOU

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