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    Plasma Proteins

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    nirilib
    The document discusses the main proteins found in plasma - albumin, globulins, and fibrinogen. It notes their origins in the liver and plasma cells/lymphocytes. The functions of plasma proteins include coagulation, maintaining colloid osmotic pressure, acid-base balance, immunity, transport, blood viscosity, and serving as a reservoir. Techniques for separating plasma proteins include salt precipitation, electrophoresis, Cohn's fractionation, ultracentrifugation, and gel filtration.

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    Plasma Proteins

    Uploaded by

    nirilib
    2K views11 pages
    The document discusses the main proteins found in plasma - albumin, globulins, and fibrinogen. It notes their origins in the liver and plasma cells/lymphocytes. The functions of plasma proteins include coagulation, maintaining colloid osmotic pressure, acid-base balance, immunity, transport, blood viscosity, and serving as a reservoir. Techniques for separating plasma proteins include salt precipitation, electrophoresis, Cohn's fractionation, ultracentrifugation, and gel filtration.

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    The document discusses the main proteins found in plasma - albumin, globulins, and fibrinogen. It notes their origins in the liver and plasma cells/lymphocytes. The functions of plasma proteins include coagulation, maintaining colloid osmotic pressure, acid-base balance, immunity, transport, blood viscosity, and serving as a reservoir. Techniques for separating plasma proteins include salt precipitation, electrophoresis, Cohn's fractionation, ultracentrifugation, and gel filtration.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    2K views11 pages

    Plasma Proteins

    Uploaded by

    nirilib
    The document discusses the main proteins found in plasma - albumin, globulins, and fibrinogen. It notes their origins in the liver and plasma cells/lymphocytes. The functions of plasma proteins include coagulation, maintaining colloid osmotic pressure, acid-base balance, immunity, transport, blood viscosity, and serving as a reservoir. Techniques for separating plasma proteins include salt precipitation, electrophoresis, Cohn's fractionation, ultracentrifugation, and gel filtration.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 11

    Plasma Proteins

    Dr. Niranjan Murthy H L


    Asst Prof of Physiology
    SSMC, Tumkur
    • Albumin
    • Globulin- α₁, α₂, β₁, β₂, γ
    • Fibrinogen

    Origin:
    Liver- Albumin & Fibrinogen
    Plasma cells, lymphocytes, tissue
    macrophages- Globulin
    S. Albumin: 3.5-5g/dL
    S. Globulin: 2-3g/dL
    S. Fibrinogen: 0.3g/dL
    Other proteins
    • Antithrombin-III
    • Haptoglobulin
    • Transferrin
    • Angiotensinogen
    • Apolipoprotein B
    • Clotting factors
    • Antithrombin C
    Separation Techniques

    1. Salt precipitation
    2. Electrophoresis
    3. Cohn’s fractionation
    4. Ultracentrifugation
    5. Gel filtration
    ELECTROPHORESIS
    Whipple’s Experiment
    • Relation of diet to plasma
    • Plasmapheresis

    3 types of cellular proteins:


    5 Fixed or Indispensible cell proteins
    6 Dispensable reserve proteins
    7 Labile reserve proteins
    Functions of plasma
    proteins
    1. Coagulation of Blood
    2. Maintain Colloid osmotic pressure
    3. Acid-Base balance
    4. Immunity
    5. Transport functions
    6. Maintenance of viscosity of blood
    7. Reservoir function
    Variations in plasma protein
    levels
    Reduced albumin:
    2 Infancy
    3 Pregnancy
    4 Hepatitis
    5 Cirrhosis
    6 Nephrosis
    7 burns
    Increased globulin:
    2 Cirrhosis of liver
    3 Tuberculosis
    4 Lymphatic leukemia
    Decreased Fibrinogen:
    6 Congenital
    7 DIC
    Increased Fibrinogen:
    9 Pregnancy
    10 malaria

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