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    Heme Catabolism

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    TARIQ
    1. Heme from senescent red blood cells is broken down through a process called catabolism of heme. 2. During catabolism, heme oxygenase oxidizes heme to form biliverdin, which is then converted to bilirubin. 3. Bilirubin is transported to the liver where it undergoes further three-step metabolism: uptake by liver cells, conjugation to make it water-soluble, and excretion into bile through active transporters like MRP-2.

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    Heme Catabolism

    Uploaded by

    TARIQ
    3K views13 pages
    1. Heme from senescent red blood cells is broken down through a process called catabolism of heme. 2. During catabolism, heme oxygenase oxidizes heme to form biliverdin, which is then converted to bilirubin. 3. Bilirubin is transported to the liver where it undergoes further three-step metabolism: uptake by liver cells, conjugation to make it water-soluble, and excretion into bile through active transporters like MRP-2.

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    hematology

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    1. Heme from senescent red blood cells is broken down through a process called catabolism of heme. 2. During catabolism, heme oxygenase oxidizes heme to form biliverdin, which is then converted to bilirubin. 3. Bilirubin is transported to the liver where it undergoes further three-step metabolism: uptake by liver cells, conjugation to make it water-soluble, and excretion into bile through active transporters like MRP-2.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    3K views13 pages

    Heme Catabolism

    Uploaded by

    TARIQ
    1. Heme from senescent red blood cells is broken down through a process called catabolism of heme. 2. During catabolism, heme oxygenase oxidizes heme to form biliverdin, which is then converted to bilirubin. 3. Bilirubin is transported to the liver where it undergoes further three-step metabolism: uptake by liver cells, conjugation to make it water-soluble, and excretion into bile through active transporters like MRP-2.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 13

    Catabolism of Heme

    Intro
    The largest repository of Heme in
    the human body is in red blood cells.
    There is turnover of about 6 g/day
    of hemoglobin,
    Porphyrin ring is hydrophobic
    Iron must be conserved for new
    Heme synthesis.
    Senescent RBCs are engulfed by RE
    cells
    Globin is recycled
    Heme is oxidized by Heme oxygenase
    to form biliverdin
    Biliverdin is acted upon by biliverdin
    reductase to form bilirubin
    Bilirubin formed in peripheral tissues
    is transported to Liver
    Further metabolism proceeds in
    three steps
    1. Uptake of bilirubin by liver
    2. Conjugation of bilirubin
    3. Secretion of conjugated bilirubin
    1. Liver takes up Bilirubin
    Bilirubin is sparingly soluble in water
    Bounded by Albumin non covalently
    Albumin contains two sites
    High affinity site (25mg/100ml Plasma)
    Low affinity site
    Drugs and antibiotics can compete for high
    affinity site
    Contd..
    Albumin is removed from bilirubin at
    sinusoidal surface of hepatocytes
    Carrier mediated saturable system
    Once it enters hepatocytes, its
    bound temporarily to cytosolic
    proteins
    Ligandin and Y proteins
    2.Conjugation
    Takes place in hepatocytes
    UDP Glucuronic acid is involved
    Catalyzed by Glucuronosyl
    transferase
    Forms Bilirubin Diglucuronide and
    excreted
    3.Secretion into bile
    Occurs by an active transport
    mechanism
    Rate limiting for entire hepatic
    bilirubin metabolism
    MRP-2 (Multidrug Resistance like
    protein) or MOAT (Multispecific
    organic anion Transporter)
    Contd..
    Located in Bile canalicular membrane
    Hepatic transport is induced by
    number of drugs
    E.g.. Phenobarbital
    Disturbance in the catabolism of
    Heme causes variety of clinical
    conditions
    When conjugated bilirubin reaches
    terminal ileum or large intestine
    glucuronide is removed

    Intestinal Bacterias can reduce


    bilirubin to urobilinogen (colourless)
    In terminal ileum, a small portion of
    urobilinogen is reabsorbed and
    reexcreted to constitute the
    Enterohepatic urobilinogen cycle

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