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    Histology 12: NSU Spring 2009 Taken By: Gregory Rodocker

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    Gregrodocker
    The skin is the largest organ of the body and consists of three layers - the epidermis, dermis, and hypodermis. The epidermis is stratified squamous epithelium containing keratinocytes, melanocytes, Langerhans cells, and Merkel's cells. It consists of several layers including the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum. The dermis lies below the epidermis and contains hair follicles, sebaceous glands, sweat glands, blood vessels, nerves, and connective tissue. The main types of skin cancer are squamous cell carcinoma, basal cell carcinoma

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    Histology 12: NSU Spring 2009 Taken By: Gregory Rodocker

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    Gregrodocker
    189 views35 pages
    The skin is the largest organ of the body and consists of three layers - the epidermis, dermis, and hypodermis. The epidermis is stratified squamous epithelium containing keratinocytes, melanocytes, Langerhans cells, and Merkel's cells. It consists of several layers including the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum. The dermis lies below the epidermis and contains hair follicles, sebaceous glands, sweat glands, blood vessels, nerves, and connective tissue. The main types of skin cancer are squamous cell carcinoma, basal cell carcinoma

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    Material for Test #3 Human Histology at N.S.U.

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    Skin

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    The skin is the largest organ of the body and consists of three layers - the epidermis, dermis, and hypodermis. The epidermis is stratified squamous epithelium containing keratinocytes, melanocytes, Langerhans cells, and Merkel's cells. It consists of several layers including the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum. The dermis lies below the epidermis and contains hair follicles, sebaceous glands, sweat glands, blood vessels, nerves, and connective tissue. The main types of skin cancer are squamous cell carcinoma, basal cell carcinoma

    Copyright:

    Attribution Non-Commercial (BY-NC)
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    Download as ppt, pdf, or txt
    189 views35 pages

    Histology 12: NSU Spring 2009 Taken By: Gregory Rodocker

    Uploaded by

    Gregrodocker
    The skin is the largest organ of the body and consists of three layers - the epidermis, dermis, and hypodermis. The epidermis is stratified squamous epithelium containing keratinocytes, melanocytes, Langerhans cells, and Merkel's cells. It consists of several layers including the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum. The dermis lies below the epidermis and contains hair follicles, sebaceous glands, sweat glands, blood vessels, nerves, and connective tissue. The main types of skin cancer are squamous cell carcinoma, basal cell carcinoma

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    Histology 12

    NSU
    Spring 2009
    Taken by: Gregory Rodocker
    Skin
     Largest and heaviest single organ of
    the body
     1.2-2.3 m2 surface area
     Outer epidermis
     Lower dermis and
     Underlying hypodermis (which is not
    actually considered part of the skin)
    Epidermis
     Stratified squamous epithelium
     Cells called keratinocytes
     Also contains
     Melanocytes
     Produce melanin
     Langerhans cells
     Merkel’s cells
    Thin vs. thick skin
     Thick skin or non-hairy
     Palms and soles
     Thin skin or hairy
     Found everywhere else
     What varies is the thickness of the
    epidermis
    Thin skin
    Epidermal layers
     Stratum basale
     Single layer of columnar to cuboidal cells
    on basement membrane
     Desmosomes and hemidesmosomes
     Intense mitotic activity (every 15-30 day
    replacement)
     Produce keratin
    Epidermal layers
     Stratum spinosum
     Cuboidal to flattened cells
     Spiny, studded appearance
     Thicker in areas of wear and tear
     Provides resistance to abrasion
    Epidermal layers
     Stratum granulosum
     3-5 layer of flattened polygonal cells
     Cells release lipid material that seals the
    cell layer
    Epidermal layers
     Stratum lucidum
     More obvious in thick skin
     Translucent
     Flattened cells
     Dying and dead cells
    Epidermal layers
     Stratum corneum
     15-20 layers (in thick skin)
     Flattened, non-nucleated keratinized cells
     Cells dead
     Cells lost to wear and tear
    Melanocytes
     Produce melanin
     Eumelanin – dark
    brown
     Pheomelanin – reddish
     Racial and individual
    differences in skin color
    result from the amount
    of melanin and not the
    number of melanocytes
    Melanin
    Sunscreen components
    Protection by melanin
     Note that the
    melanin granules
    are around the
    nucleus to protect it
    from solar radiation
     Skin color caused
    by melanin, blood
    vessels and blood
    flowing
    Langerhans and Merkel’s cells
     Langerhans cells are the APC’s of the
    skin
     Merkel’s cells may be sense organs
    for mechanoreception or serve a
    neuroendocrine role
    Dermis
     CT that supports the epidermis and
    connects it to the hypodermis
     Two layers
     Papillary layer that is thickest in wear and
    tear areas
     Reticular layer
    Dermis
     Contains
     Hair follicles
     Sebaceous glands
     Sweat glands
     All of epidermal origin
     Sympathetic but no parasympathetic
    innervation to skin structures
     Rich blood and lymph supply
    Sensory structures
     Pacinian corpuscles
     Meissner’s corpuscles
     Free nerve endings
    Meisner’s Corpuscles
    Hair follicles
     Hair is found everywhere except
     Palms
     Soles
     Lips
     Glans penis
     Clitoris
     Labia minora
    Hair follicle
    Sebaceous glands
     Acinar glands
     100 glands/cm2
     400-900 glands/cm2 on face, forehead
    and shoulders
     Produce sebum
     Lipids including triglycerides, waxes
    squalene and cholesterol
    Squalene
    (aka spinicene or supraene)
    Sweat gland
     Everywhere but in the glans penis
     Produce sweat
     Water, sodium chloride, urea, ammonia
    ad uric acid
    Ducts lined by stratified
    cuboidal epithelium
    Skin Cancer
     One third of all cancers are skin
    cancers
     Three types:
     Squamous cell carcinoma
     Basal cell carcinoma
     Malignant melanoma
    Squamous and basal cell Ca

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