Chapter 1 IB Review 2017 - Extended Response [182 marks]

1a. Draw a labelled diagram of a prokaryotic cell. [5 marks]

Markscheme
a. cell wall – uniformly thick and drawn outside the plasma membrane;
b. plasma membrane – a continuous single line;
c. cytoplasm/cytosol;
d. nucleoid/(naked) DNA – shown as a tangle of thread or irregular shape without a nuclear membrane;
e. (70S) ribosomes – drawn as a small circle or dark dot;
f. pili – hair like structures / flagellum – shown to be longer than any pili;
g. plasmid – circular ring of DNA;
h. capsule – drawn outside the cell wall;
Award [1] for each structure clearly drawn and labelled which conforms to the italicized guidelines given above.

1b. Bacteria are prokaryotes that sometimes act as pathogens. Describe how the body can defend itself against
[7 marks]
pathogens.

Markscheme
Remember, up to TWO “quality of construction” marks per essay.

a. skin/mucus membranes act as barrier (to pathogens);

b. sebaceous glands secrete lactic acid/fatty acids/sebum / make surface of skin acidic;
c. (skin/stomach) acid prevents growth of many pathogens;
d. lysozyme in mucus can kill bacteria;
e. pathogens caught in sticky mucus and removed from body;
f. inflammatory response/inflammation can cause swelling/redness/fever (to inhibit the pathogen);
g. phagocytes/macrophages/leucocytes/white blood cells (non-specifically) identify (pathogens/bacteria/fungi/viruses)
as foreign;
h. (phagocytes macrophages/leucocytes/white blood cells) ingest pathogens;
i. specific lymphocytes recognize one specific antigen;
j. (antigen-specific) lymphocytes clone themselves;
k. lymphocytes/leucocytes produce antibodies;
l. antigen-antibody complex formed and stimulates destruction of pathogen;

1c. Explain the evolution of antibiotic resistance in bacteria. [6 marks]

Markscheme
a. antibiotics (are chemicals) used to treat bacterial diseases;
b. within populations, bacteria vary in their (genetic) resistance to antibiotics/fitness;
c. resistance arises by (random) gene mutation;
d. when antibiotics are used antibiotic-sensitive bacteria are killed;
e. (natural) selection favours those with resistance;
f. resistant bacteria survive, reproduce and spread the gene / increase allele frequency of resistant bacteria;
g. the more an antibiotic is used, the more bacterial resistance/the larger the population of antibiotic-resistant
bacteria;
h. genes can be transferred to other bacteria by plasmids;
i. doctors/vets use different antibiotics but resistance develops to these as well;
j. multiple-antibiotic resistant bacteria evolve/it becomes difficult to treat some infections;

(Plus up to [2] for quality)

2a. Draw a labelled diagram to show the structure of the plasma membrane. [5 marks]
 Markscheme
Remember, up to TWO “quality of construction” marks per essay.

Award [1] for each structure clearly drawn and correctly labelled.
a. phospholipid bilayer – with head and tails;
b. hydrophilic/phosphate/polar heads and hydrophobic/hydrocarbon/fatty acid/non-polar tails labelled;
c. integral/intrinsic protein – embedded in the phospholipid bilayer;
d. protein channel – integral protein showing clear channel/pore;
e. peripheral/extrinsic protein – not protruding into the hydrophobic region;
f. glycoprotein with carbohydrate attached – carbohydrate should be outside the bilayer;
g. cholesterol – positioned across one half of bilayer and not protruding;
h. thickness indicated (10 nm); (allow answers in the range of 7 nm to 13 nm)

The light-dependent reactions in photosynthesis take place on the thylakoid membranes. Explain the light- [8 marks]
2b.
dependent reactions.

Markscheme
Remember, up to TWO “quality of construction” marks per essay.

a. (chlorophyll/pigments/antenna complex) in photosystem II absorb light;

b. light/photoactivation produces an excited/high energy/free electron;
c. electrons pass from carrier to carrier/along electron transport chain/e.t.c.;
d. protons pumped across thylakoid membrane/into thylakoid space;
e. ATP produced (by the light dependent reactions);
f. ATP production by chemiosmosis/by ATP synthase/ATP synthetase;
g. electrons from photosystem II passed to photosystem I;
h. light/photoactivation excites electrons in photosystem I (to higher energy level);
i. production of NADPH/reduction of NADP(+) (using electrons from photosystem I); (reject NAD in place of NADP.
Accept reduced NADP instead of NADPH)
j. electrons from photolysis (needed) for photosystem II;
k. oxygen from photolysis is a waste product/by-product/passes out/excreted;
l. in cyclic photophosphorylation electrons from photosystem I return to it;

2c. Outline two factors that affect the rate of photosynthesis. [5 marks]
 Markscheme
Remember, up to TWO “quality of construction” marks per essay.

a. (increase in) light (intensity) increases rate (of photosynthesis);

b. until a plateau is reached at higher light intensities/when another factor is limiting;
c. light needed for light dependent reactions/example of light dependent reaction;
d. (increase in) temperature/heat increases the rate (of photosynthesis);
e to an optimum temperature above which the rate drops;
f. temperature/heat affects rate of Calvin cycle/enzyme activity/rubisco activity;
g. (increase in) carbon dioxide (concentration) increases rate (of photosynthesis);
h. until a plateau is reached at higher CO2 levels/when another factor is limiting;
i. CO2 needed for light independent reactions/Calvin cycle/carboxylation of RuBP/production of glycerate phosphate;

If the candidate outlines more than two factors, only mark the first two.
Accept the first two points relating to each factor if clearly shown on a graph with both axes appropriately labelled.
Accept level instead of concentration, intensity or rate.
Do not accept enzyme denaturation as a reason for reductions in photosynthesis at higher temperatures.

Outline the stages of the cell cycle. [5 marks]

3a.

Markscheme
a. interphase is the longest phase;

b. interphase includes G1, S and G2;

c. in G1 and G2 /G phases, cell performs normal functions/protein synthesis/cell grows/organelles are replicated;

d. S/synthesis phase when the DNA replicates;

e. mitosis is when nucleus/genetic material divides;

f. named/described stages of mitosis;

g. cytokinesis: the division of the cytoplasm / formation of two daughter cells;

Award [3 max] if all three stages (interphase, mitosis and cytokinesis) are not mentioned.

Explain the process of translation in cells. [8 marks]

3b.
 Markscheme
a. translation is the conversion of base sequence on mRNA into an amino acid sequence / OWTTE;

b. messenger/mRNA attaches to ribosome (small unit);

c. many ribosome/polyribosomes bind to same mRNA;

d. (mRNA) carries codons/triplet of bases each coding for one amino acid;

e. transfer/tRNA each have specific anticodon;

f. tRNA carries specific amino acid;

g. tRNA anticodon binds to codon in the mRNA;

h. to corresponding triplet base/codon by complementary base pairing / OWTTE;

i. a second tRNA (anticodon) binds to next codon;

j. two amino acids bind together / peptide linkage is formed;

k. first tRNA detaches;

l. ribosome moves along mRNA;

m. another tRNA binds to next codon;

n. continues until stop codon is reached;

o. stop codon has no corresponding tRNA (anticodon)/amino acid/causes release of polypeptide;

Outline the production of a dipeptide by a condensation reaction, showing the structure of a generalized [5 marks]
3c.
dipeptide.

Markscheme
a. condensation is joining together two amino acids to form a dipeptide;

b. carboxyl/COOH group of one amino acid reacts with amine/NH 2 group of another / diagrams of two (generalized)
amino acids correctly shown;

c. water/H 2O is eliminated;

d. diagram of dipeptide correctly shown;

e. peptide/covalent bond is produced / peptide bond correctly labelled;

f. occurs at the ribosomes;

Describe four different types of transport of substances across a membrane. [4 marks]

4a.
 Markscheme
Must be description of types not a list.
a. (simple) diffusion when molecules move down a concentration gradient directly through membrane/unaided by
carrier molecule;
b. (passive transport by) facilitated diffusion through (specific) channel proteins;
c. osmosis of water via aquaporins/from area of low solute concentration to area of high solute concentration;
d. active transport against a concentration gradient using protein pumps/ATP;
e. vesicles attach to plasma membrane and release materials to exterior/ exocytosis;
f. cell membrane invaginates/pinches off to bring material to interior / endocytosis / phagocytosis;

Hormones such as FSH (follicle stimulating hormone) and LH (luteinizing hormone) affect the development of [6 marks]
4b.
certain cells by binding to receptors in the plasma membranes. Outline the role of FSH and LH in the menstrual cycle.

Markscheme
a. FSH stimulates estrogen secretion by follicle cells;
b. at start of menstrual cycle;
c. leading to development of endometrium;
d. (FSH and) LH (rise to a peak and) causes egg to be released/ovulation;
e. causes follicle cells to secrete less estrogen/more progesterone;
f. progesterone maintains endometrium/uterine lining
g. LH promotes change of follicle to corpus luteum;
h. secretion of LH and FSH regulated by negative feedback;
i. regulated/inhibited by high estrogen and progesterone levels;
j. low progesterone levels cause menstruation;

In the placenta, many substances are transported across membranes. Explain the structure and role of the [8 marks]
4c.
placenta.

Markscheme
a. disc shaped structure
b. embedded in uterus wall;
c. connected to fetus by umbilical cord;
d. contains fetal and maternal structures/tissues;
e. placental villi/maternal intervillous space provide large surface area for exchange of materials;
f. blood of fetus and mother flow close to each other (but no mixing);
g. materials exchanged/diffuse (through membranes) between mother and fetal blood;
h. oxygen/nutrients/antibodies/other substances diffuse (through membranes) to fetus;
i. CO2 and wastes diffuse (through membranes) to mother;
j. caffeine/drugs/alcohol/viruses from mother may damage fetal development;
k. takes over role of corpus luteum (to produce hormones);
l. produces hormones/estrogen/progesterone/HCG;

State the functions of the following organelles of a eukaryotic animal cell: lysosome, Golgi apparatus, free [5 marks]
5a.
ribosomes, plasma membrane, rough endoplasmic reticulum.
 Markscheme
lysosome:
a. (from Golgi apparatus) with digestive enzymes / break down food/organelles/ cell;

Golgi apparatus:
b. site that processes/modifies/packages and releases proteins;

free ribosomes:
c. site of synthesis of proteins (released to cytoplasm);

plasma membrane:
d. controls entry and exit of materials/substances in cell;

rough endoplasmic reticulum:

e. synthesis and transport of proteins; (both needed)

Distinguish between anaerobic and aerobic cell respiration in eukaryotes. [4 marks]

5b.

Markscheme

Award [1] for each contrasting characteristic.

Table format is not necessary for the marks.

Explain the mechanism of ventilation in the lungs in order to promote gas exchange for cell respiration. [9 marks]
5c.

Markscheme
a. inspiration/inhalation brings air into lungs;
b. external intercostal muscles contract;
c. and move rib cage upwards and outwards;
d. diaphragm flattens/contracts;
e. increasing thoracic volume;
f. pressure decreases from atmospheric pressure so air rushes into lungs;
g. expiration/exhalation forces air out;
h. internal intercostal muscles contract / external intercostal muscles and diaphragm relax;
i. abdominal/abdomen wall muscles contract and push diaphragm upwards;
j. decreasing thoracic volume;
k. increasing pressure in lungs so air is forced out;
l. a concentration gradient between air sacs and blood needs to be maintained;

Draw a labelled diagram to show the molecular structure of a membrane. [4 marks]

6a.
 Markscheme
Award [1] for each of the following clearly drawn and correctly labelled.

phospholipid bilayer; (double row of opposing phospholipids, tails to inside)

hydrophilic/phosphate/polar (heads) and hydrophobic/hydrocarbon/fatty acid/nonpolar (tails) labeled;

integral protein; (embedded in the phospholipid bilayer)

protein channel/channel protein; (integral protein showing clear channel/pore)

peripheral protein; (shown on surface or slightly embedded on either side)

glycoprotein; (with carbohydrate attached on outer side)

cholesterol; (shown embedded in bilayer and smaller than the hydrophobic tail)

Some proteins in membranes act as enzymes. Outline enzyme-substrate specificity. [6 marks]

6b.

Markscheme
enzyme shape is specific to (particular) substrate;
lock and key analogy/model;
example of specific enzyme and substrate;
has specific 3-D/tertiary configuration/3-D/tertiary shape essential to functioning;
active site on enzyme binds to substrate;
substrate and active site complementary/fit together;
(substrate and active site) are complementary due to structure/chemical attraction;
enzyme-substrate complex forms;
denaturation changes enzyme’s binding ability (to specific substrate);
Award [6] for the above points clearly shown in an annotated diagram.

Membranes of pre-synaptic and post-synaptic neurons play an important role in transmission of nerve impulses. [8 marks]
6c.
Explain the principles of synaptic transmission.

Markscheme
synapse is gap between adjacent neurons;
(arriving) action potential depolarizes pre-synaptic membrane;
opens (voltage-gated) calcium channels in membrane;
causes influx of calcium ions;
causes synaptic vesicles to fuse with pre-synaptic membrane;
vesicles release/exocytose neurotransmitter into the synaptic cleft;
neurotransmitter diffuses/moves across synaptic cleft;
neurotransmitter binds to receptors on post-synaptic membrane;
opens channels allowing sodium ions/potassium ions to diffuse;
initiation of action potential/depolarization in post-synaptic membrane;
removal/breakdown of neurotransmitter stops effect on post-synaptic membrane;
Award any of the above points for a clearly drawn correctly annotated diagram.
(Plus up to [2] for quality)

Draw a labelled diagram of Escherichia coli as an example of a prokaryote. [4 marks]

7a.
 Markscheme
Award [1] for each structure clearly drawn and correctly labeled.
cell wall; (with some thickness)
plasma membrane; (shown as single line or very thin)
cytoplasm;
pilus/pili; (shown as single lines coming from the cell wall)
flagellum/flagella; (thicker and longer than pili and embedded in cell wall)
70S ribosomes; (shown as small dots)
nucleoid / naked DNA;
approximate width 0.5 μm / approximate length 2.0 μm;
Award [3 max] if the bacterium drawn does not have the shape of a bacillus (rounded-corner rectangle with length
approximately twice its width).
Award [3 max] if any eukaryotic structures included.

Explain the process of transcription in prokaryotes. [8 marks]

7b.

Markscheme
transcription, synthesis of RNA identical to one strand/coding strand of DNA;
antisense stand acts as template/is transcribed;
RNA polymerase attaches to sequence of DNA known as promoter (region);
RNA polymerase separates the two strands of DNA;
(unwinding) exposes (10–20) DNA bases for pairing with RNA nucleotides;
RNA nucleotides matched to complementary bases;
adenine with uracil and cytosine with guanine / uracil replaces thymine;
H bonds between RNA nucleotide and complementary base on DNA strand;
(RNA) nucleoside triphosphates used;
hydrolysis of (two) phosphate molecules provides energy for reaction;
adds nucleotides to the 3′ end of RNA molecule/in 5′ → 3′ direction;
terminator is sequence of DNA signaling end of transcription;
RNA molecule separates completely from DNA;
Award any of the above points for a clearly drawn correctly annotated diagram.

Some prokaryotes cause infectious diseases which stimulate the body’s immune system. Outline the principles [6 marks]
7c.
that form the basis of immunity.

Markscheme
skin and mucous membranes form barriers to pathogens as first line of defence;
macrophage recognizes antigens and ingests pathogen (in blood/body tissues);
presents antigen/MHC on cell surface;
macrophage activates helper T-cells that are complementary to antigen;
complementary B-cell becomes activated/stimulated by T-helper cells;
activated B-cell increases in size and divides by mitosis / creates clone of B-cells;
B-cells differentiate into plasma cells and memory cells; (both needed) plasma cells secrete specific antibodies;
memory cells remain/form basis of long-term immunity;
polyclonal response / multiple B-cells activated by different molecules of antigen;
Award any of the above points for a clearly drawn correctly annotated diagram.
(Plus up to [2] for quality)

Discuss the endosymbiotic theory for the origin of eukaryotes. [6 marks]

8.
 Markscheme
eukaryotes evolved from prokaryotes;
mitochondria/chloroplasts evolved from (independent) prokaryotic cells;
taken in by larger (heterotrophic) cell by endocytosis;
theory supported by characteristics of chloroplasts/mitochondria;

[2 max] for mitochondria/chloroplast characteristics:

mitochondria/chloroplasts have naked DNA;
mitochondria/chloroplasts divide/carry out fission;
mitochondria/chloroplasts have 70S ribosomes / synthezise own proteins;
mitochondria/chloroplasts have double membranes;
cristae similar to mesosomes / thylakoid have similar structures in prokaryotes;

but theory cannot be falsified as it predicts something occurring in the past;

theory does not explain the origins of cilia/flagella/linear chromosomes/meiosis;
weaker evidence that cilia/flagella evolved from attached bacteria/spirochetes;

Describe the characteristics of stem cells that make them potentially useful in medicine. [5 marks]
9a.

Markscheme
(stem cells) have/retain the capacity to divide;
can be used to produce cell cultures/large number of identical cells;
can be used to repair/replace damaged/lost cells/tissue;
(stem cells) are undifferentiated / have not yet differentiated/specialized;
can differentiate/specialize in different ways / are pluripotent/totipotent;
can be used to form a variety of different tissues / form organs;
used in medical research;
used in treatment of (named) disease;

Outline the inheritance of a named sex-linked condition in humans. [5 marks]

9b.

Markscheme
genes that are located on just one of the sex chromosomes/X or Y are sex-linked;
(sex-linked) genes present on the X chromosome are absent from the Y chromosome / vice versa;
named recessive X-linked condition (e.g. colour blindness / haemophilia / other valid example);
sex-linked conditions tend to be more commonly expressed in males;
female can be homozygous or heterozygous/carrier for a sex-linked/X-linked condition;
affected males have only one copy of the gene / have carrier daughters but cannot pass the condition on to sons;
carrier/heterozygous females can have affected sons/carrier daughters;
for a female to be affected (homozygous recessive) the father must be affected;

If the example used is of a recessive X-linked condition, use marking points c–h.
Make appropriate adjustments if the example is of a dominant X-linked trait or a Y-linked trait.
Accept any of the above points shown in a suitable diagram/chart/Punnett square/pedigree.

Explain the use of karyotyping in human genetics. [8 marks]

9c.
 Markscheme
Definition and construction of karyotypes:
karyotype is the number and type / image of chromosomes in a cell;
cells collected from chorionic villus / by amniocentesis;
requires cells in metaphase / stimulate cells to divide and reach metaphase;
burst cells and spread chromosomes / photo taken of chromosomes;
chromosomes are arranged in pairs;
according to size/structure/position of centromere/banding pattern;

Uses for karyotypes:

karyotypes used to identify sex/gender;
male is XY and female XX;
used to identify chromosome mutations/abnormal numbers/non-disjunction;
Down syndrome due to extra chromosome 21 / other trisomy/aneuploidy example;
used for pre-natal diagnosis of chromosome abnormalities;
may lead to a decision to abort the fetus;
prepare for consequences of abnormality in offspring;

Outline, with an example, the process of exocytosis. [5 marks]

10a.

Markscheme
vesicles carry material to plasma membrane;
vesicle fuses with membrane;
(by joining of) phospholipid bilayers;
aided by the fluidity of the membrane;
material released/expelled from the cell;
membrane flattens;
name of example e.g. exocytosis of neurotransmitter / exocrine secretion/endocrine secretion / hormone secretion /
release of cortical granules;
outline of example: (in the presence of calcium), neurotransmitter vesicles release their contents into the synapse /
hormones released from one cell have an effect on another cell etc.;
Accept these points if clearly made in an annotated diagram. [4 max] if no example given.

Translation occurs in living cells. Explain how translation is carried out, from the initiation stage onwards. [9 marks]
10b.

Markscheme
translation involves initiation, elongation/translocation and termination;
mRNA binds to the small sub-unit of the ribosome;
ribosome slides along mRNA to the start codon;
anticodon of tRNA pairs with codon on mRNA:
complementary base pairing (between codon and anticodon);
(anticodon of) tRNA with methionine pairs with start codon / AUG is the start codon;
second tRNA pairs with next codon;
peptide bond forms between amino acids;
ribosome moves along the mRNA by one codon;
movement in 5' to 3' direction;
tRNA that has lost its amino acid detaches;
another tRNA pairs with the next codon/moves into A site;
tRNA activating enzymes;
link amino acids to specific tRNA;
stop codon (eventually) reached;

Compare simple diffusion with facilitated diffusion as mechanisms to transport solutes across membranes. [5 marks]
11a.
 Markscheme
Award [1] for each linked set of answers.

Describe the process of endocytosis. [5 marks]

11b.

Markscheme
endocytosis occurs when a membrane encloses a target particle;
fluidity of membrane permits movement of membrane;
membrane sinks inwardly/forms pit/invaginates to enclose particle;
membrane seals back on itself / edges fuse;
one membrane layer / two phospholipid layers enclose particle making vesicle;
inner phospholipid layer of (original) membrane becomes outer phospholipid layer of vesicle membrane;
outer phospholipid layer of (original) membrane becomes inner phospholipid layer of vesicle membrane;
vesicle breaks away from membrane/moves into cytoplasm;
changes in membrane shape require energy;
specific example of endocytosis (e.g. pinocytosis, phagocytosis);
Accept any of the above points in an annotated diagram.

Explain how an impulse passes along the membrane of a neuron. [8 marks]

11c.
 Markscheme
resting membrane is polarized;
interior is –70 mV/negative relative to outside;
more sodium ions outside than inside;
more potassium ions inside than outside;
disturbance of membrane opens sodium ion channels;
sodium ions rush to inside of cell;
causing depolarization;
sodium ion channels shut;
potassium ion channels open;
potassium ions rush out;
helping to restore polarized state of membrane;
sodium-potassium pumps maintain polarity;
process repeated along the length of neuron / sodium ions diffuse between region with an action potential and the
region at resting potential;

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