CELL CYCLE AND CELL DIVISION

Meio is
1. At the end of meiosis-II, number of haploid cells formed are

a) Two b) Four c) Eight d) None of these

2. During, meiosis-I, the bivalent chromosomes clearly appear as tetrads during

a) Diakinesis b) Diplotene c) Leptotene d) Pachytene

3. Longest phase of meiosis, is

a) Prophase-I b) Prophase-II c) Anaphase-I d) Metaphase-II

4. Crossing over occurs during

a) Leptotene b) Diplotene c) Pachytene d) Zygotene

5. Select the event of cell cycle which shows the importance of synapsis and the formation of
chiasmata
a) An increase in the variation of progeny b) The DNA on homologous chromosomes
occurs mix
c) Reciprocal exchange of chromosomal d) All of the above
sections occurs

6. Which of the following stage of meiosis is responsible for deciding genetic constitution of
gametes?
a) Metaphase-II b) Anaphase-II c) Metaphase-I d) Anaphase-I

7. During which stage of meiosis, do the sister chromatids begin to move towards the poles?
a) Prophase-I b) Telophase-I c) Anaphase-II d) Anaphase-I

8. Identify the diagram and name the stage of meiosis correctly

a) Pachytene (crossing over) b) Zygotene

c) Leptotene d) Diplotene
9. Meiosis in AaBb will produce gametes
a) AB, aB, Ab, ab b) AB, ab c) Aa, bb d) Aa, Bb

10. Pick out the correct statements.

I.Synapsis of homologous chromosomes takes place during prophase-I of meiosis.
II.Division of centromeres takes place during anaphase-I of meiosis.
III.Spindle fibres disappear completely in telophase of mitosis.
IV.Nucleoli reappear at telophase-I of meiosis.
a) I only b) III only c) I and II only d) I, III and IV only

11. Which of the following specie’s haploid cell has maximum chromosome counts?
a) Ophioglossum b) Cat c) Allium d) Dog

12. Study the diagram showing meiosis carefully and choose the correct options for 𝐴 − 𝐸

𝐴 −Tetrad, 𝐵 −Bivalent, 𝐶 −Zygotene stage, 𝐷 −Sister chromatids, 𝐸 −Non-sister

a)
chromatids
𝐴 −Bivalent, 𝐵 −Tetrad, 𝐶 −Pachytene stage, 𝐷 −Crossing over, 𝐸 −Non-sister
b)
chromatids
𝐴 −Bivalent, 𝐵 −Tetrad, 𝐶 −Pachytene stage, 𝐷-Non-Sister chromatids, 𝐸-Sister
c)
chromatids
𝐴 −Bivalent, 𝐵 −Tetrad, 𝐶 −Pachytene stage, 𝐷 −Sister chromatids, 𝐸 −Non-Sister
d)
chromatids

13. In which stage of the first meiotic division, two sister chromatids are formed?
a) Leptotene b) Zygotene c) Pachytene d) Diplotene

14. Chiasma shows the sites of

a) Spindle formation b) Synapsis c) Crossing over d) None of these

15. Which is correct for meiotic metaphase-I?

a) Bivalents are arranged at equator
b) Univalents are arranged at equator
c) Non-homologous chromosomes forms pair
d) Spindle fibres are attached at chromomere
‘
16. Crossing over occurs at
a) Single strand stage
b) Two strand stage
c) Four strand stage
d) Eight strand stage

17. Crossing over is also an enzyme mediated process and the enzyme involved is called
a) Ligase b) Polymerase c) Recombinase d) Endonuclease

18. From the following, identify the two correct statements with reference to meiosis
I. Bead-like structures are absent on chromosomes
II. Displacement of chiasmata occurs in diakinesis
III. Separation of two basic sets of chromosomes
IV. No division of centromere
The correct option is
a) II and III b) II and IV c) III and IV d) I and III

19. What is the nature of cells formed at the end of meiosis-II?

a) Haploid b) Diploid c) Tetrad d) None of these

20. In meiosis, chromosome number becomes

a) Half of its parent chromosome
b) Same as that of parent chromosome
c) One fourth of its parent chromosome
d) None of the above

21. The two chromatids of a metaphase chromosome represent

a) Replicated chromosomes to be separated at anaphase
b) Homologous chromosomes of a diploid set
c) Non-homologous chromosomes joined at the centromere
d) Maternal and paternal chromosomes joined at the centromere

22. Dictyotene a is prolonged

a) Leptotene b) Pachytene c) Diplotene d) Zygotene

23. Crossing over is the exchange of genetic material between

a) Non-sister chromatids of the homologous chromosomes
b) Sister chromatids of the homologous chromosome
c) Chromatids of non-homologous chromosomes
d) The genes those are completely linked
24. Which of the following statement(s) is/are not correct about meiosis?
I. Meiosis involves pairing of homologous chromosomes and recombination between them
II. Two diploid cells are formed at the end of meiosis-II
III. Meiosis involves two sequential cycles of nuclear and cell division called meiosis-I and
meiosis-II, but only a single cycle of DNA replication
IV. Meiosis-I is initiated after the parental chromosome replication which produce identical
sister chromatids at the S-phase
The correct option is
a) I and III b) II only c) II and III d) I, II, III and IV

25. Synapsis occurs between

a) A male and a female gamete
b) mRNA and ribosomes
c) Spindle fibres and centromere
d) Two homologous chromosomes

26. Which of the following shows diplotene stage of cell cycle?

a) Separation of synapsed homologous chromosomes except at the site of cross overs
b) Degenecation of nucleolus
c) Chiasmata shift towards cheromosome ends
d) All of the above

27. The stage between two meiotic division is called

a) Interphase b) Cytokinesis c) Interkinesis d) Karyokinesis

28. Arrange the following events of meiosis in the correct sequence.

I. Terminalization
II. Crossing over
III. Synapsis
IV. Disjunction of genomes
The correct sequence is
a) 4, 3, 2, 1 b) 3, 2, 1, 4 c) 2, 1, 4, 3 d) 1, 4, 3, 2

29. During which stage of meiosis, do tetrads line up at the equator?

a) Prophase-I b) Telophase-I c) Metaphase-I d) Anaphase-I

30. Diakinesis is marked by

a) Terminalisation of chiasmata b) Degeneration of nucleolus
c) Chiasmata shift towards chromosome d) All of the above
ends
31. Give the name of the phases of meiosis, in which
I. the chromosome number is reduced to haploid state
II. the amount of DNA is reduced to haploid state
The correct option is
a) Anaphase-II; anaphase-I
b) Anaphase-I, metaphase-II
c) Anaphase-I, anaphase-II
d) Anaphase-II, metaphase-I

32. In meiosis, the chromosome number

a) Reduces by half b) Increase by twice
c) Increase by four times d) Reduces by one-fourth

33. The term ‘meiosis’ was given by

a) Rusk b) Flemming c) Johannsen d) Former and Moore

34. Synapsis occurs in ……….. phase of meiosis.

a) Zygotene
b) Diplotene
c) Pachytene
d) Leptotene

35. Meiosis in a plant occurs when there is a change

a) From gametophyte to sporophyte
b) From sporophyte to gametophyte
c) From gametophyte to gametophyte
d) From sporophyte to sporophyte

36. Meiosis occurs in which of the following cells?

a) Sperm cells b) Unicellular c) Liver cells d) All of these
organisms

37. What is the correct sequence of the steps given here?

Also work out the process depicted in the steps?
V. Homologous chromosomes move toward opposite poles of the cell; chromatids do not
separate.
VI. Chromosomes gather together at the two poles of the cell and the nuclear membrances
reform.
VII. Homologous chromosomes pair and exchanges segments.
 VIII. Homologous chromosomes align on a central plate.
IX. The haploid cells separate completely.
a) The correct sequence is III → IV → I → II → V and the process is meiosis-I
b) The correct sequence is II → I → V → IV → III and the process is mitosis
c) The correct sequence is IV → I → III → II → V and the process is meiosis-I
d) The correct sequence is II → V → IV → I → III and the process is mitosis

38. Identify the diagram and name the phase of meiosis carefully

a) Telophase-I b) Anaphase-I c) Metaphase-I d) Prophase-I

39. Arrange the following events of meiosis in a correct sequence and choose the correct option
I. Terminalisation
II. Crossing over
III. Synapsis
IV. Disjunction of genomes
a) IV, III, II and I b) III, II, I and IV c) II, I, IV and III d) I, IV, III and II

40. The number of chromosomes becomes half in

a) Anaphase-I b) Anaphase-II c) Telpohase-I d) Telophase-II

41. From the following, identify the two correct statements with reference to meiosis
I. Bead like reference to meiosis
II. Displacement of chaismata occurs in diakinesic
III. Separation of two basic sets of chromosomes
IV. No division of centromere
The correct option is
a) II, III b) II, IV c) III, IV d) I, III

42. The given figure is the representation of a certain event at a particular stage of a type of cell
division. Identify the stage and choose the correct option?

a) Prophase-I during meiosis b) Prophase-II during meiosis

c) Prophase during meiosis d) Both prophase and metaphase of mitosis
Significance of Meioris
43. Which of the following stage is responsible for the appearance of Lampbrush
chromosomes?
a) Meiotic prophase b) Mitotic prophase c) Mitotic anaphase d) Mitotic metaphase

44. Significance of meiosis lies in

a) Reduction of chromosome number to one half
b) Maintaining consistency of chromosome number during sexual reproduction
c) Production of genetic variability
d) All of the above

Cell Cycle
45. Read the following statements and select the correct option
I. M-phase represents the phase when the actual cell division or mitosis occurs
II. Interphase represents the phase between two successive M-phases
III. In the 24 hrs average duration of cell cycle of a human cell, cell division proper lasts for
only about an hour
IV. The M-phase lasts more than 95% of the duration of cell cycle
a) I, II and III b) II and IV c) II, III and IV d) I and IV

46. If the cell has 14 chromosomes at interphase. Than how many chromosomes will the cell
have at G1 -phase of cell cycle?
a) 28 b) 14 c) 7 d) 21

47. …A…. mitotic cell division is only seen in the diploid somatic cells, while the …B… can show
mitotic divisions in both haploid and diploid cells.
Identify A and B form the options given below
a) A-Animals; B-plants b) A-Plants; B-animals c) A-Bacterial; B- d) None of these
viruses

48. Which of the following events occurs during G1 -phase?

a) DNA replication
b) Growth and normal function of cell
c) Mutation
d) Fertilization
49. The number of DNA strands in chromosome at G2 -stage is
a) One b) Two c) Four d) Eight

50. A cell in post reproductive stage remains in

a) G2 -phase b) S-phase c) G1 -phase d) M-phase

51. Mature nerve cells are incapable of cell division. These cell are probably considered in
a) G2 -phase b) S-phase c) Mitosis d) G0 -phase

52. The S-phase of cell cycle is characterized by

a) Duplication of chromosome
b) Shortening of chromosome
c) Duplication of DNA
d) Duplication of centriole

53. What change would occur in DNA content, during S-phase?

a) No change
b) The amount of DNA per cell doubles
c) The amount of DNA per cell increase four folds
d) The amount of DNA per cell decreases

54. What is the average duration for mitosis?

a) 3 min 30 min b) 3 hr to 5 hr c) 30 min to 3 hr d) 2 hr to 3 hr

55. Cell division can not be stopped in which phase of the cell cycle?
a) G1 -phase b) G2 -phase c) S-phase d) Prophase

56. Select the correct statements regarding S-phase of interphase

I. Occurs between G1 and G2
II. DNA replication begins in the nucleus
III. Centrioles duplicate in the cytoplasm
IV. As DNA is doubled, number of chromosomes also doubles
The option with correct statements is
a) IV and III b) I, II, III and IV c) II, III and IV d) I, II and III

57. RNA and proteins are formed in

a) G1 -phase b) G2 -phase c) S-phase d) G0 -phase
58. In …A…. phase, there is synthesis of RNAs and proteins that are needed for cell growth and
replication of DNA. While it is …B… phase, where synthesis of protein occur that is needed
for spindle formation and mitosis to continue.
Identify A and B to complete the given statement
a) A-G; B-S d) None of these
b) A-G2 ; B-S c) A-G; B-G2

59. An egg cell has 5pico gram of DNA in its nucleus. How much amount of DNA will be, in this
animal, at the end of G2 -phase of mitosis?
a) 2.5pico gram b) 5pico gram c) 5 g d) 20pico gram

60. Which of the following statements are correct for G1 -phase?

I. It is the last substage of interphase
II. Cell organelles do not increase in number
III. Both cell and nucleus grow in size
IV. It synthesizes RNAs, proteins and other biochemical for cell growth and subsequent
replication of DNA
Choose the correct option
a) I and II b) II and IV c) I and III d) II and III

61. The second check point in cell cycle occurs at

a) G0 − G1 b) G1 − G2 c) G1 −S d) G2 −M

62. In plant cell has 12 chromosomes at the end of mitosis. How many chromosomes would it
have in the G2 -phase of its next cell cycle?
a) 6 b) 8 c) 12 d) 24

63. Chromatid formation takes place in

a) S-phase b) Metaphase c) G1 -phase d) G2 -phase

64. DNA replicates

a) Twice in each cell cycle
b) Only once in each cell cycle
c) Once in mitotic cell cycle, once in meiotic-I (reductional division) and once in meiotic-II
(equational division)
d) None of the above
65. Interphase nucleus is enclosed by
a) Non-porous nuclear membrane
b) Porous double nuclear membrane
c) Non-porous double discontinuous nuclear membrane
d) A single porous unit membrane

66. Which of the following statement is true for cells in G0 stage of cell cycle?
a) Cells in G0 stage are metabolically more active
b) Cells are metabolically inactive
c) Cells are metabolically active but no longer proliferate in normal condition
d) None of the above

67. The anaphase promoting complex is activated by

a) M cdk cyclin b) G1 cdk cyclin c) S cdk cyclin d) Transaction factor

68. In G1 -phase of cell cycle, what would be the change in DNA content of the cell?
a) DNA content increases to double b) DNA content gets reduced
c) Four fold increase of DNA content d) No change in DNA content

69. I. The cells that do not divide further, exit G1 -phase to enter an inactive stage called …A…
phase of the cell cycle
II. The cells that are in G2 -phase definitely continue with the …B… phase.
Identify A and B to complete the given NCERT statements
a) A-G0 ; B-S b) A-S; B-G0 c) A-M; B-G0 d) A-G0 ; B-M

70. Which of the following type of cell cycle is known as equational division?
a) Amitosis b) Mitosis c) Meiosis d) None of the above

71. During cell cycle, RNA and non-histone proteins are synthesized in
a) S-phase b) G0 -phase c) G1 -phase d) M-phase

72. Chromosome number can be doubled by using which of the following?

a) Indole acetic acid
b) GA
c) Zeatin
d) Colchicines
73. What would be the change in the chromosome number, during S-phase?
a) No change
b) The number of chromosome doubles
c) The number of chromosome doubles only in case of diploid cell
d) The number of chromosome doubles only in case of haploid cell

74. Select the matched ones.

I . S-phase - DNA replication
II. Zygotene - Synapsis
III. Diplotene - Crossing over
IV. Meiosis - Both haploid and diploid cells
V 𝐺2 -phase - Quiescent stage
a) I and II only b) III and IV only c) III and V only d) I,III and V only

75. During the G1 -phase of cell division

a) RNA and proteins are synthesized
b) DNA and proteins are synthesized
c) Cell prepares for M-phase
d) Cell undergoes duplication

M phase
76. Pick out the correct statements.
I.Mitosis takes place in the somatic cells and meiosis takes place in the germ cells
II.During mitosis, the DNA replicates once for one cell division and in meiosis the DNA
replicates twice for two cell divisions.
III.Mitosis and meiosis occur both in sexually and asexually reproducing organisms.
a) I only b) II only c) III only d) I and II only

77. Cleavage is a unique form of mitotic cell division in which

a) There is no growth of cells
b) The nucleus does not participate
c) No spindle developers to guide the cells
d) The plasma membranes of daughter cells do not separate

78. Phragmoplast is
a) Proplasted in cytoplasm of dividing cells
b) Cell plate formed by vesicles ER and dictyosomes during cytokinesis
c) Cell plate formed by ER, dictyosomes, secretory vesicles and spindle fibre
d) None of the above
79. A diploid living organism develops from zygote by which type of the following repeated cell
divisions?
a) Meiosis b) Amitosis c) Mitosis d) Segmentation

80. The spindles are formed of

a) Chromosome b) Actin c) Microtubules d) Myosin

81. In animal cell has, cytokinesis involves

a) The separation of sister chromatids
b) The contraction of the contractile ring of micro filament
c) Depolymerization of kinetochore microtubules
d) A protein kinase that phosphorylaes other enzymes

82. Mitosis is characterized by

a) Reduction division b) Equal division
c) Both (a) and (b) d) Absence of spindle formation

83. Spindle fibre is made up of

a) Humulin
b) Intermediate filament
c) Flagellin
d) Tubulin

84. If you are provided with root-tips of onion in your class and are asked to count the
chromosomes, which of the following stages can you most conveniently look into?
a) Metaphase b) Telophase c) Anaphase d) Prophase

85. Which of the following character is related with telophase?

a) Formation of nuclear membrane
b) Formation of nucleolus
c) Elongation of chromosome
d) Formation of two daughter nuclei

86. In which stage of cell division, chromosomes are most condensed?

a) Prophase b) Metaphase c) Anaphase d) Telophase
87. Choose the correct sequence of two main events in mitosis
a) Karyokinesis followed by cytokinesis
b) Cytokinesis followed by karyokinesis
c) Karyokinesis followed by separation of the daughter cells
d) Cytokinesis followed by separation of the daughter cells

88. Replication of centriole occurs during

a) Interphase b) Prophase c) Late prophase d) Late telophase

89. Which of the following occurs more than one and less than five in a chromosome?
a) Chromatid b) Chromomere c) Centromere d) Telomere

90. Which stages of cell division do the following figures ‘A’ and ‘B’ represent respectively?

a) Metaphase - Telophase
b) Telophase - Metaphase
c) Late anaphase - Prophase
d) Prophase - Anaphase

91. In cell cycle, during which phase chromosomes are arranged at equatorial plate?
a) Metaphase b) Anaphase c) Telophase d) Prophase

92. Which of the following statements (events) is/are true for mitotic telophase?
a) Nucleolus, GB and ER form
b) NM assembles around each chromosomes clusters
c) Arrival of chromosomes cluster at opposite poles and loss of their identity as discrete
elements
d) All of the above

93. Congression is a phenomenon of

a) Movement of sister chromatids towards the poles
b) Pairing of homologous chromosomes
c) Separation of paired chromosomes
d) Bringing the chromosomes on equator of spindle apparatus

94. Chromosome reaches their respective poles in which of the following stages of mitosis?
a) Cytokinesis b) Interphase c) S-phase d) Telophase
95. Colchicine arrests which of the following stage of cell division?
a) Prophase b) Anaphase c) Telophase d) Metaphase

96. Choose the correct combination of options to select the correct statement for prophase
I. Chromosomal material condenses to form compact mitotic chromosomes
II. The assembly of mitotic spindle is initiated by the microtubules
III. Cells do not show organelles when viewed under the prophase
IV. The nucleolus or nucleoli degenerate completely
a) I only b) II and III c) I and II d) All of these

97. The major event that occurs during the anaphase of mitosis, which brings about the equal
distribution of chromosomes is
a) Replication of the genetic material
b) Splitting of the chromatids
c) Splitting of the centromeres
d) Condensation of the chromatin

98. Which of the following is unique to mitosis and not a part of meiosis?
a) Homologous chromosomes behave independently
b) Chromatids are separated during anaphase
c) Homologous chromosomes pair and form bivalents
d) Homologous chromosomes crossover

99. The morphology of chromosomes can be studied most easily in

a) Prophase b) Metaphase c) Anaphase d) Telophase

100.During mitosis, number of chromosomes gets

a) Change
b) No change
c) May be change if cell is mature
d) May be change if cell is immature

101.The complete disintegration of nuclear envelope in a cell cycle marks the

a) Start of prophase of mitosis b) Start of metaphase of mitosis
c) End of anaphase of mitosis d) Start of telophase of mitosis

102.The division of the cytoplasm is termed as

a) Karyokinesis b) Mitosis c) Cytokinesis d) Meiosis

103.Which of the protein is found in spindle fibre?

a) Tubulin b) Albumin c) Mucin d) Haemoglobin
104.The plane of alignment of chromosome at the metaphase stage of cell cycle is referred to as
the
a) Prophase plate b) Metaphase plate c) Anaphase plate d) Telophase plate

105.Small disc-shaped structures at the surface of the centromeres that appear during
metaphase are
a) Kinetochores b) Metaphase plate c) Spindle fibres d) Chromatid

106.The proteins involved in the movement of chromosomes towards the poles during cell
division are
a) Actin b) Myosin c) Tubulin d) Elastin

107.The term, mitosis was coined by

a) Flemming b) Strasburger c) Remak d) Moore

108.Which stages of mitosis is known for occurrence of cytokinesis?

a) Metaphase b) Telophase c) Anaphase d) None of these

Significance of mitosis
109.Which of the following statements are correct for multicellular cell division?
I. Cell division brings about embryonic development and growth
II. It plays a role in repair and maintenance of the body
III. It is important for reproduction
The correct option is
a) Only I b) I and III c) Only II d) I, II and III

110.Mitosis or the equational division is usually restricted to …A… cells. However, in some lower
plants and in some social insects …B… cells also divide by mitosis.
Choose the correct option for A and B from the given options
A B
a) Haploid; diploid b) Haploid; haploid c) Diploid; diploid d) Diploid; haploid

111.Which type of cell division helps in regeneration of cells?

a) Mitosis b) Amitosis c) Meiosis d) Karyokinesis