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Cell Cycle
by Regina Bailey
Updated January 17, 2019

The cell cycle is the complex sequence of events by which cells grow and divide. In eukaryotic cells, this process
includes a series of four distinct phases. These phases consist of the Mitosis phase (M), Gap 1 phase (G 1),
Synthesis phase (S), and Gap 2 phase (G 2). The G 1, S, and G 2 phases of the cell cycle are collectively
referred to as interphase. The dividing cell spends most of its time in interphase as it grows in preparation for cell
division. The mitosis phase of the cell division process involves the separation of nuclear chromosomes, followed
by cytokinesis (division of the cytoplasm forming two distinct cells). At the end of the mitotic cell cycle, two
distinct daughter cells are produced. Each cell contains identical genetic material.

The time it takes for a cell to complete one cell cycle varies depending on the type of cell. Some cells, such
as blood cells in bone marrow, skin cells, and cells lining the stomach and intestines, divide rapidly and
constantly. Other cells divide when needed to replaced damaged or dead cells. These cell types include cells of
the kidneys, liver, and lungs. Still other cell types, including nerve cells, stop dividing once mature.

Key Takeaways: Cell Cycle

The phases of the cell cycle include Interphase and the Mitotic phase. Interphase
consists of the Gap 1 phase (G 1), Synthesis phase (S), and Gap 2 phase (G 2).

Dividing cells spend most of their time in interphase, in which they increase in mass
and replicate DNA in preparation for cell division.

In mitosis, the contents of the dividing cell are equally distributed between two
daughter cells.

The cell cycle also occurs in the replication of sex cells, or meiosis. Upon completion
of the cell cycle in meiosis, four daughter cells are produced.

Phases of the Cell Cycle

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Darryl Leja, NHGRI

The two main divisions of the cell cycle are interphase and mitosis.

Interphase

During this segment of the cell cycle, a cell doubles its cytoplasm and synthesizes DNA. It is estimated that a
dividing cell spends about 90-95 percent of its time in this phase.

G1 phase: The period prior to the synthesis of DNA. In this phase, the cell increases in mass and
organelle number in preparation for cell division. Animal cells in this phase are diploid, meaning that
they have two sets of chromosomes.

S phase: The period during which DNA is synthesized. In most cells, there is a narrow window of time
during which DNA replication occurs. The chromosome content is doubled in this phase.

G2 phase: The period after DNA synthesis has occurred but prior to the start of mitosis. The cell
synthesizes additional proteins and continues to increase in size.

Stages of Mitosis

In mitosis and cytokinesis, the contents of the dividing cell are equally distributed between two daughter cells.
Mitosis has four phases: Prophase, Metaphase, Anaphase, and Telophase.

Prophase: In this stage, changes occur in both the cytoplasm and nucleus of the dividing cell. The
chromatin condenses into discrete chromosomes. The chromosomes begin to migrate toward the cell
center. The nuclear envelope breaks down and spindle fibers form at opposite poles of the cell.

Metaphase: In this stage, the nuclear membrane disappears completely. The spindle fully develops
and the chromosomes align at the metaphase plate (a plane that is equally distant from the two poles).

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Anaphase: In this stage, paired chromosomes (sister chromatids) separate and begin moving to
opposite ends (poles) of the cell. Spindle fibers not connected to chromatids lengthen and elongate the
cell.

Telophase: In this stage, the chromosomes are cordoned off into distinct new nuclei and the genetic
content of the cell is divided equally into two parts. Cytokinesis begins prior to the end of mitosis and
completes shortly after telophase.

Once a cell has completed the cell cycle, it goes back into the G 1 phase and repeats the cycle again. Cells in the
body can also be placed in a non-dividing state called the Gap 0 phase (G 0) at any point in their life. Cells may
remain in this stage for very long periods of time until they are signaled to progress through the cell cycle as
initiated by the presence of certain growth factors or other signals. Cells that contain genetic mutations are
permanently placed in the G 0 phase to ensure that they are not replicated. When the cell cycle goes wrong,
normal cell growth is lost. Cancer cells may develop, which gain control of their own growth signals and continue
to multiply unchecked.

Cell Cycle and Meiosis

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Lily Anther Microsporocyte in Telophase II of Meiosis. Ed Reschke/Photolibrary/Getty

Not all cells divide through the process of mitosis. Organisms that reproduce sexually also undergo a type of cell
division called meiosis. Meiosis occurs in sex cells and is similar in process to mitosis. After a complete cell cycle
in meiosis, however, four daughter cells are produced. Each cell contains one-half the number of chromosomes
as the original parent cell. This means that sex cells are haploid cells. When haploid male and
female gametes unite in a process called fertilization, they form one diploid cell called a zygote.

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