Pharmacology

Musculoskeletal system
(Options are shuffled so can test yourself)

Variant 1

1. Indicate preparation, a derivative of salicylic acid:

A. Aspirin
B. Diclofenac sodium
C. Flugalin
D. Butadion
E. Nimesulide

2. Which action of glucocorticoids are widely used in medical practice:

A. Hypoglycaemic
B. Diuretic
C. Anabolic
D. Anti-inflammatory
E. Analgesic

3. Show NSAIDs, a derivative of phenylacetic acid:

A. Piroxicam
B. Diazepam
C. Ibuprofen
D. Dexamethasone
E. Diclofenac sodium

4. Show a synthetic corticosteroid drug that does not contain fluorine atoms:
A. Hydrocortisone
B. Prednisolone
C. Flumethasone
D. Aldosterone
E. Glibenclamide

5. Which one of the following medications is a natural glucocorticoid:

A. Aldosterone
B. Prednisolone
C. Glucagon
D. Hydrocortisone
E. Flucortolone

6. Show NSAIDs a derivative of naphthylpropionic acid:

A. Flumethasone
B. Amidopyrine
C. Indomethacin
D. Aspirin
E. Naproxen

7. The earliest sign of hematological toxicity of methotrexate is:

A. decrease in red blood cell level
B. decrease in leukocyte level
C. decrease in platelet level
D. increased platelet level
E. increased white blood cell count

8. Compared with Indomethacin, Acctylsalicyis acid has more pronounced:

A. Activation of phagocytosis
B. Analgesic effect
C. Antipyretic effect
D. Antiplatelet effect on platelets
E. Anti-inflammatory effect

9.Steroidal anti-inflammatory drugs include:

A.Mineralocorticoids
B.Aniline derivatives
C.Salicylic acid derivatives
D.Pyrazolone derivatives
E.Glucocorticoids

10 Indicate a possible complication of dexamethasone application:

A. Accommodation paralysis
B.Aplastic anemia
C.Dysbacteriosis
D. Fluid retention
E.Hypoglycemia

11.Show the drug - indoleacetic acid derivative:

A. Diclofenac sodium
B. Butadion
C. Ibuprofen
D. Aspirin
E. Indomethacin

12.Side effects with the prescription of NSAIDs - selective COX-2 inhibitors:

A. Paroxysmal atrial fibrillation
B. Drug dependence
C. Hirsutism in women
D. Risk of blood clots
E. Arterial hypotension

13.The main regulator of phosphorus-calcium metabolism is:

A. Aldosterone
B.Calcium glycerophosphate
C.Tocopherol
D.Parathyroid hormone
E.Acetylsalicylic acid

14.The most serious complication of methotrexate is:

A.Cholangitis
B.Stomach ulcer
C.Duodenal ulcer
D.Intestinal amyloidosis
E.Liver fibrosis

15.Cyclophosphamide is a:
A. drug stimulating the regeneration of cartilage tissue cells
B.non-steroidal anti-inflammatory drug
C.steroidal anti-inflammatory drug
D.cytostatic antitumor chemotherapeutic drug
E.thyroid hormone, participates in the regulation of calcium metabolism

16.Specify non-selective COX inhibitors:

A.Meloxicam
B.Nimesulide
C.Dexamethasone
D.Celecoxib
E.Naproxen

17.Which method below improves methotrexate tolerability:

A. Prescribing the drug in the evening hours
B. Prescribing the drug before meals
C. Administration together with folic acid
D. Prescription of the drug after meals
E. Daily low-dose methotrexate

18.Inhibits dihydrofolate reductase, which is involved in the reduction of dihydrofolic acid to

tetrahydrofolic acid necessary for the synthesis of purine nucleotides and their derivatives, a
characteristic mechanism for:
A.Hingamin
B.Methotrexate
C.Dexamethasone
D. Celecoxib
E.D - penicillamine

19.What hormonal drug is used for osteoporosis?

A.Thyroidin
B.Calcitonin
C.Prednisolone
D.Insulin
E.Glucagon

20.After a long course of anti-inflammatory therapy, the patient developed Cushing's syndrome,
irritability, and pain in the epigastric region.
The correct option for the patient to take would be: A.Hydrocortisone
B.Acetylsalicylic acid
C.Naproxen
D.Piroxicam
E.indomethacin

Variant 2

1. Indicate one of the features of the pharmacological action of salicylates:

A. Stimulates thrombus formation
B. Depresses the breathing center
C. Excite the vasomotor center
D. Inhibits bile secretion
E. Have antiplatelet activity

2. Application of Acetylsalicylc acid:

A. For bleeding
B. Chronic alcoholism
C. Acute and chronic rheumatic diseases
D. Peptic ulcer of the stomach and duodenum
E. In the treatment of oncological diseases

3. Show the anti-inflammatory drug - pyrazolone derivative:

A. Prozerin
B. Diazolin
C. Butadion
D. Prednisolone
E. Pipolfen

4. Show the drug - anthranilic acid derivative:

A. Piroxicam
B. Flufenamic acid
C. Acetylsalicylic acid
 D. Amidopyrine
E. Actrapid

5. Non-steroidal anti-inflammatory drugs include:

A. Triamcinolone
B. Prednisolone
C. Hydrocortisone
D. Indomethacin
E. Dexamethasone

6. Which is correct?
A. Hydrocortisone is a pyrazolone derivative
B. Prednisolone is a steroidal anti-inflammatory drug
C. Acetylsalicylic acid is a steroidal anti-inflammatory agent
D. Ibuprofen is glucocorticoid
E. Dexamethasone is an anti-tuberculosis drug

7.Ulcerogenic effect is more pronounced with prescription of:

A.Celecoxib
B.Aspirin
C.Piroxicam
D.Naproxen
E.Ibuprofen

8.Glucocorticoids are indicated in:

A.Acute osteoporosis
B.Peptic ulcer
C.Diabetes mellitus
D.Collagenosis
E.Arterial hypertension

9.Note a non-steroidal anti-inflammatory drug that selectively competitively reversibly inhibits

COX-2 and has a lesser effect on cyclooxygenase-I (COX-I):
A.Diclofenac
B.Meloxicam
C.Naproxen
D.Moxilen
E.Indomethacin

10.Glucocorticoids are contraindicated in:

A.For chronic adrenal insufficiency
B.Eczema
C.For rheumatism and collagenosis
D.For bronchial asthma
E.Peptic ulcer of the stomach and duodenum

11.A patient with rheumatoid arthritis was treated with anti-inflammatory therapy.Six months
after treatment, he began to notice sleep disturbances, abdominal pain and weight gain.On
examination- arterial hypertension, hyperglycemia, glucosuria, lymphocytopenia,
eosinopenia.Solve the problem by answering the following questions:
What is the most likely group of drugs that could cause the complications described above?
A.Levothyroxine, Thiamazole
B.Paracetamol, Ibuprofen
C.Prednisolone, Dexamethasone
D.Cetirizine, Suprastin
E.Insulin, Glucagon

12.A specific immunosuppressive drug that selectively suppresses autoimmune reactions due to
specific binding to one of the immune cytokines - the so-called “tumor necrosis factor alpha",
TNF-a is:
A.Leflunomide
B.Infliximab
C.Cyclosporine
D.Mercaptopurine
E.Auranofin

13.Show the basic remedies for the treatment of rheumatoid arthritis:

A.NSAID
B.Glucocorticoids
C.Cytostatics, good preparations, immunomodulators
D.Antihistamines
E.Calcium preparations

14.A patient with rheumatoid arthritis has been prescribed methotrexate.How soon will the
effects of methotrexate appear?
A.In 2 hours after administration
B.In 1 month
C.After 1 year
D.Not earlier than 1 year
E.In a few months
F.In 2 years

15.Promotes the release of calcium from the bones and increases its contents in the blood,
enhances the absorption of calcium by the intestinal mucosa with the prescription of vitamin D:
A.Cholecalciferol
B.Parathyroidin
C.Ergocholecalciferol
D.Hingamin
E.Calcium gluconate

16.Calcium gluconate is indicated in:

A.Hyperparathyroidism, hypercalcemia, rickets, hypophosphatemia
B.Hypoparathyroidism, hypocalcemia, rickets, hyperphosphatemia
C.Hypercalciuria, thromboembolia, nephrourolithiasis
D.Sarcoidosis, severe renal failure, in combination with cardiac glycosides
E.Atherosclerosis, urolithiasis and cholelithiasis

17.Which one is a glucocorticoid:

A.Dexamethasone
B.Ibufen
C.Spironolactone
D.Diclofenac
E.Aspirin

18.Side effects on the central nervous system are more pronounced upon application of:
A.Piroxicam
B. Indomethacin
C.Ibuprofen
D.Meloxicam
E.Diclofenac

19.Application of which NSAID can mask important symptoms of infection, which can delay
diagnosis and initiation of adequate therapy and worsen outcome of infectious disease.
A.Glucosamine
B.Ibuprofen
C.Chondroitin
D.Prednisolone
E.Methotrexate

20.A 30 years old patient was admitted to clinic with gastric bleeding.From anamnesis it became
known that patient had been suffering from peptic ulcer of stomach and duodenum for 10
years.A week before hospitalization he took NSAIDs to reduce fever:
What drug could patient take?
A. Indomethacin
B. Ergocalciferol
C. Chondroitin sulfate
D. Prednisolone
E. Dexamethasone
 Variant 3

1. Calcitonin is:
A. lowers the content of calcium ions in the blood
B. reduces HDL levels in the blood
C. parathyroid hormone
D. increases osteoclast activity
E. stimulates osteolysis

2. Ergocalciferol is:
A. thyroid hormone preparation
B. anti-tuberculosis drug
C. steroidal anti-inflammatory drug
D. formed in the body under the influence of ultraviolet rays
E. increases the permeability of the intestinal epithelium to calcium

3. Calcium preparation:
A. calcitonin
B. myacalcic
C. calcium gluconate
D. cholecalciferol
E. ergocalciferol

4. Indicate a drug that is a conjugate of 5-aminosalicylic acid and sulfapyridine, which

has anti-inflammatory, antimicrobial activities, and is used in the treatment of
rheumatoid arthritis (RA)
A. Sulfocamphocaine
B. Favipiravir
C. Sulperazon
D. Sulfasalazine
E. Pyridoxine hydrochloride

5. Replenishes the deficiency of Ca2+, which is necessary for the transmission of nerve
impulses, contraction of skeletal and smooth muscles, myocardial activity, bone tissue
formation, and blood clotting. Choose the correct answer to which drug the
above-described pharmacological effects relate to.
A. Sodium chloride
B. Dexamethasone
C. Calamine
D. Calcium gluconate
E. Magnesium sulfate

6. Indicate the most common side effect of NSAIDs - non-selective COX inhibitors
application.
A. Damage to the gastrointestinal tract in the form of ulceration
B. Arterial hypotension
C. Onychomycosis (fungal infection of the nail plates)
D. Hirsutism (excessive male pattern hair growth) in women
E. Paroxysmal atrial fibrillation

7. Ergocalciferol is indicated, all above mentioned are correct, EXCEPT

A. Osteomalacia
B. Rickets
C. Tetany
D. Atherosclerosis
E. Osteoporosis

8. Reye's syndrome, a rare but serious illness characterized by acute encephalopathy

and fat deposits in the liver, can occur in children or adolescents with the application of
NSAIDs for fever or cold symptoms, indicate the drug which is associated with the
syndromes described above.
A. Prednisolone
B. Nimesulide
C. Paracetamol
D. Acetylsalicylic acid
E. Levamisole

9. Calcitonin:
A. stimulates bone decalcification
B. produced by the pancreas
C. contraindicated in nephrocalcinosis
D. calcium preparation
E. inhibits bone decalcification

10. Mechanism of action of Chondroprotectors?

A. inhibition of osteoclast function and reduction of their formation from precursor cells
B. inhibition of prostaglandin synthesis by inhibition of cyclooxygenase
C. stimulate the regeneration of cartilage tissue cells, increase resistance to oxidation,
inhibit cartilage-degrading enzymes
D. regulates the exchange of phosphorus and calcium in the body, promotes their
absorption in the intestine by increasing the permeability of its mucous membrane and
adequate deposition in bone tissue.
E. inhibition of bacterial cell wall synthesis

11. The mother of a one-year-old child contacted the pediatrician with complaints of
curvature of the lower limbs and missing teeth. The examination revealed deformation
of the spine and chest, muscle hypotonia, and a delay in the general development of the
child. What vitamin deficiency in the body leads to the development of the above
symptoms and what drug should be prescribed for treatment?
A. Hypovitaminosis of vitamin B 12 requires prescribing an intramuscular solution of
Cyanocobolamine
B. Vitamin C hypovitaminosis must be prescribed Ascorbic acid tablets
C. Vitamin A hypovitaminosis must be prescribed dragee Retinol acetate orally
D. Hypovitaminosis vitamin B9 must be prescribed Folic acid tablets.
E. Vitamin D hypovitaminosis - it is necessary to prescribe oral drops Aguadetrim
(Colecalciferol)

12. A 44-year-old woman with rheumatoid arthritis was recently treated with
methotrexate. Her doctor recently added another drug that inhibits dihydroorotate
dehydrogenase, an enzyme involved in pyrimidine synthesis. What drug was added to
the patient's treatment regimen?
A. Dexamethasone
B. D-penicillamine
C. Leflunomide
D. Prednisolone
E. Piroxicam

13. The mother of a 6-month old child consulted a pediatrician with complaints of
curvature of the lower extremities and restless sleep: trembling. convulsions, crying,
sweating. The examination revealed deformation of the spine and chest, muscle
hypotonia, and a delay in the general development of the child. What vitamin deficiency
in the body leads to the development of the above symptoms and what drug should be
prescribed for treatment?
A. Vitamin A hypovitaminosis must be prescribed dragse Retinol acetate orally
B. Vitamin C hypovitaminosis must be prescribed Ascorbic acid tablets.
C. Vitamin D hypovitaminosis - it is necessary to prescribe oral drops Aguadetrim
(Colecalciferol)
D. Hypovitaminosis vitamin B9 must be prescribed Folic acid tablets
E. Hypovitaminosis of vitamin B 12 requires prescribing an intramuscular solution of
Cyanocobolamine

14. A 57-year-old man who was recently diagnosed with rheumatoid arthritis
complained to his physician of joint pain despite ongoing ibuprofen therapy. The doctor
decided to add to the treatment a disease-modifying antirheumatic drug (DMARD)
which has antimalarial properties and also has anti-inflammatory and
immunosuppressive effects What drug was prescribed to the patient?
A. dihydrofolate reductase inhibitor - Methotrexate
B. Indoleacetic acid derivative - Ketorolac
C. complexing compound - D penicillamine
D. inhibition of dihydroorotate dehydrogenase, an enzyme involved in the synthesis of
pyrimidines - Leflunomide
E. 4-aminoquinoline derivative - Hydroxychloroquine

15. A 30 years old patient was admitted to the clinic with gastric bleeding. From the
anamnesis it became known that the patient had been suffering from the peptic ulcer of
the stomach and duodenum for 10 years. A week before hospitalization, he took
NSAIDs to reduce fever. What drug could the patient take?
A. Chondroitin sulfate
B. Ergocalciferol
C. Indomethacin
D. Prednisolone
E. Dexamethasone

16. Which medication mostly used in the basic therapy of rheumatoid arthritis:
A. genetically engineered biological products
B. high doses glucocorticoids
C. non-steroidal anti-inflammatory drugs
D. methotrexate
E. calcium supplements

17. Most nonsteroidal anti-inflammatory drugs (NSAIDs) show combined effects of:
A. Immunosuppressive, antipyretic, antimicrobial
B. Antihistamine, analgesic, anti-inflammatory
C. Anti-inflammatory, analgesic, antipyretic
D. Analgesic, immunosuppressive, antipyretic
E. Antiallergic, hypotensive, diuretic

18. The effects of NSAIDs can be mediated by:

A. Inhibition of prostaglandin synthesis by inhibition of phospholipase A2
B. Inhibition of prostaglandin synthesis by inhibition of cyclooxygenase
C. Inhibition of leukotriene synthesis by inhibition of 5-lipoxygenase
D. Inhibition of the release of bradykinin, histamine, and serotonin from blood cells
E. Stimulates the synthesis of leukotrienes at the site of inflammation

19. The most effective basic drug for the treatment of rheumatoid arthritis is:
A. Amikacin
B. calcium preparations
C. Methotrexate
D. Chondroitin
E. Osteogenon

20. Indicate the steroidal anti-inflammatory drug that is used intra-articular, which has
the longest-lasting effect:
A. Hydrocortisone
B. Celecoxib
C. Methylprednisolone
D. Indomethacin
E. Betamethasone