Date of Issue:

28 January 2022

SAFETY DATA SHEET

1. SUBSTANCE AND SOURCE IDENTIFICATION
Product Identifier
SRM Number: 3289
SRM Name: Multivitamin Tablets
Other Means of Identification: Not applicable.
Recommended Use of This Material and Restrictions of Use
This Standard Reference Material (SRM) is intended primarily for use in evaluating methods for measurement of
vitamins in dietary supplement tablets and similar matrices and for assigning values to in-house control materials.
A unit of SRM 3289 consists of five bottles in individually sealed packets. Each bottle contains 30 tablets
weighing approximately 1.8 g per tablet.
Company Information
National Institute of Standards and Technology
Standard Reference Materials Program
100 Bureau Drive, Stop 2300
Gaithersburg, Maryland 20899-2300

Telephone: 301-975-2200 Emergency Telephone ChemTrec:

E-mail: [email protected] 1-800-424-9300 (North America)
Website: https://www.nist.gov/srm +1-703-527-3887 (International)

2. HAZARDS IDENTIFICATION
Note: This material is intended for laboratory use only; not for human consumption. SRM 3289 is supplied in tablet
form but may be ground during use. A small quantity of dust may be generated during processing.
Classification
Physical Hazard: Not classified.
Health Hazard: Not classified.
Label Elements
Symbol: No symbol.
Signal Word: No signal word.
Hazard Statement(s): No applicable hazard statements.
Precautionary Statement(s): No applicable precautionary statements.
Hazards Not Otherwise Classified: Not applicable.
Ingredients(s) with Unknown Acute Toxicity: Not applicable.

3. COMPOSITION AND INFORMATION ON HAZARDOUS INGREDIENTS

Substance: Multivitamin tablets
Other Designations: Not available.
Components are listed in compliance with OSHA 29 CFR 1910.1200. For actual values, see the Certificate of
Analysis.

Hazardous Component(s) CAS Number EC Number Nominal Mass Concentration

(EINECS) (%)
None -- -- --
Non-Hazardous Component(s)
Multivitamin tablets Not available Not available 100

SRM 3289 Page 1 of 6

 4. FIRST AID MEASURES
Description of First Aid Measures
Inhalation: If adverse effects occur, remove to well-ventilated (uncontaminated) area. If breathing is difficult,
qualified personnel may administer oxygen. If not breathing, qualified personnel should give artificial respiration.
Seek immediate medical attention.
Skin Contact: Rinse affected skin thoroughly with soap or mild detergent and water for at least 15 minutes. If
skin irritation persists, seek medical aid and bring the container or label.
Eye Contact: Immediately flush eyes, including under the eyelids, with copious amounts of water for at least
15 minutes. Seek immediate medical attention.
Ingestion: If a large amount is swallowed, seek medical attention.
Most Important Symptoms/Effects, Acute and Delayed: No information available.
Indication of any immediate medical attention and special treatment needed, if necessary: If any of the above
symptoms are present, seek immediate medical attention.

5. FIRE FIGHTING MEASURES

Fire and Explosion Hazards: Avoid generating dust. SRM 3289 is supplied in a small quantity and under normal
laboratory conditions it does not constitute a combustible dust hazard. The physical properties of this material indicate
that accumulated dust on surfaces generated where operations produce fine particulates may lead to combustible dust
concentrations in air, and in the presence of an ignition source may present a potential hazard.
Extinguishing Media
Suitable: Regular dry chemical, carbon dioxide, water, or regular foam.
Unsuitable: None listed.
Specific Hazards Arising from the Chemical: None listed.
Special Protective Equipment and Precautions for Fire-Fighters: Move container from fire area if it can be done
without personal risk. Avoid inhalation of material or combustion byproducts. Wear full protective clothing and
NIOSH approved self-contained breathing apparatus (SCBA).

6. ACCIDENTAL RELEASE MEASURES

Personal Precautions, Protective Equipment and Emergency Procedures: Any accumulated material on surfaces
should be removed and properly disposed of. Use suitable protective equipment; see Section 8, “Exposure Controls
and Personal Protection”.
Methods and Materials for Containment and Clean up: Notify safety personnel of spills. Collect spilled material
in appropriate container for disposal.

7. HANDLING AND STORAGE

Safe Handling Precautions: Minimize dust generation and accumulation on surfaces. See Section 8, “Exposure Controls
and Personal Protection”.
Storage and Incompatible Materials: Store and handle in accordance with all current regulations and standards.
Keep separated from incompatible substances (see Section 10, “Stability and Reactivity”). See the Certificate of
Analysis for specific storage conditions.

SRM 3289 Page 2 of 6

 8. EXPOSURE CONTROLS AND PERSONAL PROTECTION
Exposure Limits: No occupational exposure limits established for multivitamin tablet powder. The following
exposure limits for Particles Not Otherwise Regulated are applicable.
OSHA (PEL): 15 mg/m3 (TWA, total particulates)
5 mg/m3 (TWA, respirable particulates)

Engineering Controls: Provide local exhaust or process enclosure ventilation system. Ensure compliance with
applicable exposure limits.
Personal Protection: In accordance with OSHA 29 CFR 1910.132, subpart I, wear appropriate Personal Protective
Equipment (PPE) to minimize exposure to this material.
Respiratory Protection: If workplace conditions warrant a respirator, a respiratory protection program that
meets OSHA 29CFR 1910.134 must be followed. Refer to NIOSH 42 CFR 84 for applicable certified respirators.
Eye Protection: Splash resistant safety goggles with a face shield is recommended. An eye wash station should
be readily available near areas of use.
Skin and Body Protection: Personal protective equipment for the body should be selected based on the task
being performed and the risks involved and should be approved by a specialist before handling this product.
Chemical-resistant gloves should be worn at all times when handling chemicals.

9. PHYSICAL AND CHEMICAL PROPERTIES

Descriptive Properties
Appearance (physical state, color, etc.): tablet
Molar Mass (g/mol): not applicable
Molecular Formula: not applicable
Odor: not available
Odor threshold: not available
pH: not available
Evaporation rate: not applicable
Melting point/freezing point (ºC): not available
Relative Density (g/L): not available
Vapor Pressure (mmHg): not applicable
Vapor Density (air = 1): not applicable
Viscosity (cP): not applicable
Solubility(ies): not available
Partition coefficient (n-octanol/water): not available
Thermal Stability Properties:
Autoignition Temperature (ºC): not available
Thermal Decomposition (ºC): not available
Initial boiling point and boiling range (ºC): not available
Explosive Limits, LEL (Volume %) not available
Explosive Limits, UEL (Volume %): not available
Flash Point (ºC): not available
Flammability (solid, gas): not available

SRM 3289 Page 3 of 6

 10. STABILITY AND REACTIVITY
Reactivity: Stable at normal temperatures and pressure.
Stability: X Stable Unstable
Possible Hazardous Reactions: None listed.
Conditions to Avoid: Avoid generating dust. Avoid heat, flames, sparks and other sources of ignition. Avoid contact
with incompatible materials.
Incompatible Materials: Oxidizing materials.
Fire/Explosion Information: See Section 5, “Fire Fighting Measures”.
Hazardous Decomposition: Thermal decomposition will produce oxides of carbon and nitrogen.
Hazardous Polymerization: Will Occur X Will Not Occur

11. TOXICOLOGICAL INFORMATION

Route of Exposure: X Inhalation X Skin X Ingestion

Symptoms Related to the Physical, Chemical and Toxicological Characteristics: No data available.
Potential Health Effects (Acute, Chronic, and Delayed)
Inhalation: No data available.
Skin Contact: No data available; skin exposure may result in mechanical irritation.
Eye Contact: No data available; may cause mechanical irritation.
Ingestion: Large quantities may cause gastrointestinal distress; no other adverse effects identified.
Numerical Measures of Toxicity
Acute toxicity: Not classified; no data available.
Skin Corrosion/Irritation: Not classified; no data available.
Serious Eye Damage/Irritation: Not classified; no data available.
Respiratory Sensitization: Not classified; no data available.
Skin Sensitization: Not classified; no data available.
Germ Cell Mutagenicity: Not classified; no data available.
Carcinogenicity: Not classified.
Listed as a Carcinogen/Potential Carcinogen Yes X No
Multivitamin tablets are not listed by IARC, NTP or OSHA as a carcinogen.
Reproductive Toxicity: Not classified; no data available.
Specific Target Organ Toxicity, Single Exposure: Not classified; no data available.
Specific Target Organ Toxicity, Repeated Exposure: Not classified; no data available.
Aspiration hazard: Not applicable.

12. ECOLOGICAL INFORMATION

Ecotoxicity Data: No data available.
Persistence and Degradability: No data available.
Bioaccumulative Potential: No data available.
Mobility in Soil: No data available.
Other Adverse effects: No data available.

13. DISPOSAL CONSIDERATIONS

Waste Disposal: Dispose of waste in accordance with all applicable federal, state, and local regulations.

SRM 3289 Page 4 of 6

 14. TRANSPORTATION INFORMATION
U.S. DOT and IATA: This material is not regulated by DOT or IATA.

15. REGULATORY INFORMATION

U.S. Regulations
CERCLA Sections 102a/103 (40 CFR 302.4): Not regulated.
SARA Title III Section 302 (40 CFR 355.30): Not regulated.
SARA Title III Section 304 (40 CFR 355.40): Not regulated.
SARA Title III Section 313 (40 CFR 372.65): Not regulated.
OSHA Process Safety (29 CFR 1910.119): Not regulated.
SARA Title III Sections 311/312 Hazardous Categories (40 CFR 370.21)
ACUTE HEALTH: No
CHRONIC HEALTH: No
FIRE: No
REACTIVE: No
PRESSURE: No
State Regulations:
California Proposition 65: Not listed.
U.S. TSCA Inventory: Not listed.
TSCA 12(b), Export Notification: Not listed.
Canadian Regulations:
WHMIS Information: Not provided for this material.

16. OTHER INFORMATION

Issue Date: 28 January 2022
Sources: 29 CFR Occupational Health and Safety Office (OSHA) 1910.1000, Limits for Air Contaminants,
Table Z-1; available at
https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1000TABLEZ1
(accessed Jan 2022).

CDC; NIOSH; NIOSH Pocket Guide to Chemical Hazards; Department of Health and Human
Services (DHHS), Centers for Disease Control and Prevention (CDC), National Institute for Safety and
Health; Particulates Not Otherwise Regulated, 30 October 2019; available at
https://www.cdc.gov/niosh/npg/npgd0480.html (accessed Jan 2022).

Key of Acronyms:
ACGIH American Conference of Governmental Industrial NRC Nuclear Regulatory Commission
Hygienists
ALI Annual Limit on Intake NTP National Toxicology Program
CAS Chemical Abstracts Service OSHA Occupational Safety and Health Administration
CERCLA Comprehensive Environmental Response, PEL Permissible Exposure Limits
Compensation, and Liability Act
CFR Code of Federal Regulations RCRA Resource Conservation and Recovery Act
DOT Department of Transportation REL Recommended Exposure Limit
EC50 Effective Concentration, 50 % RM Reference Material
EINECS European Inventory of Existing Commercial Chemical RQ Reportable Quantity
Substances
EPCRA Emergency Planning and Community Right-to-Know RTECS Registry of Toxic Effects of Chemical Substances
Act
IARC International Agency for Research on Cancer SARA Superfund Amendments and Reauthorization Act
IATA International Air Transport Association SCBA Self-Contained Breathing Apparatus
IDLH Immediately Dangerous to Life and Health SRM Standard Reference Material
LC50 Lethal Concentration, 50 % STEL Short Term Exposure Limit
LD50 Lethal Dose, 50 % TLV Threshold Limit Value
LEL Lower Explosive Limit TPQ Threshold Planning Quantity
MSDS Material Safety Data Sheet TSCA Toxic Substances Control Act
NIOSH National Institute for Occupational Safety and Health TWA Time Weighted Average
NIST National Institute of Standards and Technology UEL Upper Explosive Limit
n.o.s. Not Otherwise Specified WHMIS Workplace Hazardous Materials Information System

SRM 3289 Page 5 of 6

Disclaimer: The NIST SDS information is specific to the NIST product and is believed to be correct, based upon
our current knowledge. The SDS may not necessarily be all inclusive and should be used only as a guide. NIST does
not guarantee the accuracy or completeness of this information. The only official source for specific values and
uncertainties is the certificate or information sheet.

Users of this SRM should ensure that the SDS in their possession is current. This can be accomplished by contacting
the SRM Program: telephone (301) 975-2200; e-mail [email protected]; or via the Internet at
https://www.nist.gov/srm.

SRM 3289 Page 6 of 6