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    DRUG DOSAGES For Childrens

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    Asadullah Rawab
    This document provides drug dosages for various infusions, sedatives, analgesics, and other medications commonly used in PICU, PHDU, pediatric oncology, and general pediatric settings. It lists recommended dosage ranges for things like midazolam, morphine, dopamine, epinephrine, steroids, antibiotics, antiepileptics, and other classes of drugs. The dosages are organized by category and listed as milligrams per kilogram per hour or dose along with maximum doses when relevant.

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    DRUG DOSAGES For Childrens

    Uploaded by

    Asadullah Rawab
    15 views8 pages
    This document provides drug dosages for various infusions, sedatives, analgesics, and other medications commonly used in PICU, PHDU, pediatric oncology, and general pediatric settings. It lists recommended dosage ranges for things like midazolam, morphine, dopamine, epinephrine, steroids, antibiotics, antiepileptics, and other classes of drugs. The dosages are organized by category and listed as milligrams per kilogram per hour or dose along with maximum doses when relevant.

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    DRUG DOSAGES for childrens

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    This document provides drug dosages for various infusions, sedatives, analgesics, and other medications commonly used in PICU, PHDU, pediatric oncology, and general pediatric settings. It lists recommended dosage ranges for things like midazolam, morphine, dopamine, epinephrine, steroids, antibiotics, antiepileptics, and other classes of drugs. The dosages are organized by category and listed as milligrams per kilogram per hour or dose along with maximum doses when relevant.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    15 views8 pages

    DRUG DOSAGES For Childrens

    Uploaded by

    Asadullah Rawab
    This document provides drug dosages for various infusions, sedatives, analgesics, and other medications commonly used in PICU, PHDU, pediatric oncology, and general pediatric settings. It lists recommended dosage ranges for things like midazolam, morphine, dopamine, epinephrine, steroids, antibiotics, antiepileptics, and other classes of drugs. The dosages are organized by category and listed as milligrams per kilogram per hour or dose along with maximum doses when relevant.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 8

    DRUG DOSAGES PICU/PHDU/PEADS-ONCO/PEADS-GEN

    INFUSIONS

    SEDATION & RELAXATION


    Midazolam 0.05-0.1mg/kg/hr
    Morphine 0.05-0.1mg/kg/hr
    Atracurium 0.5-1mg/kg/hr
    Cisatracurium 0.06-0.18mg/kg/hr
    Dexmedetomidine 0.2-0.7 mic/kg/hr
    Rocuronium 1 mg/kg/hr
    Pancuromium 0.1mg/kg/hr
    Vecuronium 0.1mg/kg/hr
    Fentanyl 1-3 mic/kg/hr
    Thiopental 1-5 mg/kg/hr
    Propofol 1-3 mg/kg/hr
    CNS
    Valproic acid 3-5mg/kg/hr
    Midazolam 2-27mic/kg/min(status)
    Thiopental 3-5 mg/kg/hr
    CVS
    Dopamine 5-10mic/kg/min
    Epinephrine 0.01-0.05mic/kg/min
    0.01-0.3mic/kg/min
    Norepinephrine 0.03-0.3 mic/kg/min
    Dobutamine 1-10mic/kg/min
    Milrinone 0.3-0.8 mic/kg/min
    Vasopressin 0.2units/kg/hr
    Nitroglycerine 0.5-7 mic/kg/min
    Sodium nitroprusside 0.5-10mic/kg/min
    Lasix 0.1-0.4mg/kg/hr (CHF)
    1 mg/kg/hr (AKI)
    Amiodarone 5-15mic/kg/min
    Lidocaine 20-50 mic/kg/min
    Labetalol 0.5-3 mg/kg/hr
    Phenylephrine 0.1-2 mic/kg/min Max.4 mic/kg/min)
    Prostaglandin 0.01-0.1 mic/kg/min
    OTHERS
    Terbutaline 1-14 mic/kg/min
    Aminophylline 1 mg/kg/hr
    Hypertonic saline 0.1-1 ml/kg/hr
    1ml/age[yrs]/hr)
    Insulin 0.1-0.3mic/kg/min
    CaCl2 10-30mg/kg/hr
    Tranexamic acid 1-10mg/kg/hr
    15-25mg/kg/day
    Load 10mg/kg/dose then 1-2mg/kg/hr
    Heparin 20 units kg/hr
    Octreotide 1 mic/kg/hr (max 50mic/hr
    Omeprazole 2-4mg/kg/day
    0.1mg/kg/hr max.8mg/hr
    INTERMITTENT
    RELAXATION
    Atracurium 0.5-1mg/kg/dose
    Succinylcholine 1-2 mg/kg/dose (max 150 mg)
    Pancuronium 0.1 mg/kg/dose
    SEDATION & ANALGESIA
    Ketorolac 0.5 mg/kg/dose q8hrly (CI- ICB, AKI)
    Ketamine 0.5-2 mg/kg/dose
    Paracetamol 40-60mg/kg/day q4-6hrly(max 60mg/kg –
    4g/day
    Clonazepam PO 0.01-0.03mg/kg/day divided in BID/TDS

    Pethidine 0.5mg/kg/dose q4-6hrly


    Nelbuphine 0.2 mg/kg/dose q4-6hrly
    Morphine 0.02 – 0.05 mg /kg/dose q2-6 hrly
    Tramadol 1mg/kg/dose q8hrly

    CVS:
    Adenosine 100 mic/kg/dose ( x2)
    Atropine 0.02 mg/kg/dose (min 0.1mg;
    max 0.5-1 mg)
    Amiodarone 5 mg/kg (Antiarrhythmic)
    Amlodipine 0.1-0.3 mg/kg/dose q24hrly
    (max 10 mg/day)
    Captopril 0.05-0.3 mg/kg/dose q8hrly
    Digoxin 5-10 mic/kg/dose
    Dispirin 5 mg/kg/dose q24hrly (Antiplatelet)
    80-100 mg/kg/day q6hrly (Kawasaki)
    Enalapril 0.1-0.5mg/kg/day q12-24hrly
    Epinephrine 0.01mg/kg/dose
    Hydralazine 0.1-0.5 mg/kg/dose q4-6hrly (max 20
    mg/dose)
    Lidocaine 1 mg/kg/dose (max 3 mg/kg)
    Magnesium sulphate 25-50 mg/kg/dose (max 2 gms) torsades de
    pointes

    Phenytoin 1.25 mg/kg q5min (max 15mg/kg)


    Satolol 2-5 mg/kg/day (320-480mg/day)

    STEROIDS
    ASTHMA : Methyl prednisolone 2 mg/kg load then 2 mg/kg/day q6hrly
    Hydrocortisone 8 mg/kg load then 8 mg/kg/day q6hrly
    CROUP: Dexamethasone 0.6 mg/kg/dose
    MENINGITIS: Dexamethasone 0.15mg/kg/dose q6hrly (48hrs)
    TBM: Dexamethasone 4 mg/kg/day (max 16 mg) q6hrly
    POST EXTUBATION: Dexamethasone 0.5 mg/kg/dose q6hrly (48hrs)
    PULSE: Methyl prednisolone 25-30mg/kg/dose QD (max 1 grm)
    ARDS: Methyl prednisolone 2 mg/kg/day q6hrly
    Physiologic replacement
    Hydrocortisone PO : 12-18mg/m2/24hr divided Q8H
    PREDNISOLONE PO :2.5-3.5mg/m2/24hr divided Q12H

    Adrenal Insufficiency 50mg/m2/stat then 25-100mg/m2/24H as a


    Hydrocortisone (solu-cortif) continues infusion
    Severe Stress 25-100mg/m2/24H as a continues infusion
    Hydrocortisone Or 25mg/m2/dose I/M Q6H
    Anti-emetic: (chemo-induce ) Loading dose : 10mg/m2 (max:20mg)
    Dexamethasone Subsequent : 5mg/m2/dose Q6h
    Cerebral Edema : LD : 1-2mg/kg/dose
    Dexamethasone MD : 1-1.5mg/kg/day divided Q6H
    ITP : Pulse Therapy with Iv 20-25mg/m2/dose for 4 days
    DEXAMETHASONE
    Spinal Cord Injury 30mg/kg bolus over 15mint 45mint later
    Methyl Prednisolone 5.4mg/kg/hr for 23 hours as a continues infusion 
    should be initiated within 8hrs Of injury
    Enteric fever : Dexamethasone LD:2MG/KG
    MD 1mg/kg total 9dose 6H

    OSMOTHERAPY
    Mannitol 0.5-1 mg/kg (push)
    3% Hypertonic saline 2-5 ml/kg/dose q8hrly

    HEMATOLOGY
    DDAVP 0.3 mic/k/dose (max 20 mic/dose)
    Enoxaparin 1 mg/kg/dose q12hrly
    Tranexamic acid 10 mg/kg/dose q6-12hrly(max 1gm/dose)
    Cryoprecipitate 1 unit/5 kg
    Platelets 1 unit/5 kg
    Factor VIIa 90 mic/kg/dose
    FFP 10ml/kg
    Pack cells 10ml/kg
    CNS
    Dexamethasone 0.3-0.5 mg/kg/day q6hrly (Raised ICP)
    Lidocaine 1-2 mg/kg/dose (raised ICP in intubation)
    Lorazepam IV/PO 0.05-0.1 mg/kg/dose q1hrly prn
    Phenobarbital 15-20 mic/kg load the 3-5 mg/kg HS
    Phenytoin 15-20 mg/kg load then 7 mg/kg/day Q12H
    Epival 15-20mg/kg load then 10-20 mg/kg/dose q8h
    If Divalproic acid use then administerd in BD
    dose i-e 10-30mg/kg/dose BD
    Lerace 15mg/kg/dose q6h max.60mg/kg/day
    PO 10-15mg/kg/dose BID
    Topiramate 1-3mg/kg/day QHS for 7day (max.25mg)
    Maintance :5-9mg/kg/day Divided BD
    Lacosamide 1-2mg/kg/day BD
    Max:4-5mg/kg/dose
    Diazepam 0.1-0.3mg/kg/dose

    GIT
    N Acetylcystiene for FHF I/V 150mg/kg over 1 hr then
    I/V 50 mg/kg over 4 hrs then
    I/V 100 mg/kg over 16 hrs
    PO 70mg/kg q4hrly 17 doses
    Kayhexalate 0.5-1 gm/kg/dose q4-6hrly (max 30-60g/dose
    Dimenhydrinate 1 mg/kg/dose q4-6hrly (max 50 mg/dose)
    Domperidone 0.1-0.5mg/kg/dose q8hrly
    Glycopyrolate 5-10 mic/kg/dose q6hrly
    Lactulose 1ml/kg/dose q8-24hrly (max 30 ml/dose)
    Omeprazole 0.7-1.4mg/kg/day q12-24hrly
    Ranitidine 2-6 mg/kg/day q6-12hrly (max 50 mg/dose)
    Sucralfate 40-80mg/kg/day q6hrly(max 1 gm/dose)
    Ondansetron 0.15mg/kg/dose q8hrly
    RENAL
    Acetazolamide: PO 5-10mg/kg/day q8-24hrly (max 1gm/day)
    Lasix 1-2 mg/kg/day q6-8hrly
    Metolazone 0.2-0.4mg/kg/day q12-24hrly (max
    10mg/dose)
    Spironolactone 1-3 mg/kg/day q12-24hrly
    Vasopressin 0.0003-0.002 units/kg/dose (DI)
    ANTIBIOTICS
    Acyclovir: Neonates 20mg/kg/dose Q8H
    Child:
    10mg/kg/dose q8hrly (immunocompetent pt)
    750-1500mg/m2/day q8hrly (immunocompromised
    pt)
    Augmentin Iv 30 mg/kg/dose q8hrly
    PO 25-50mg/kg/day or severe
    80-90mg/kg/day (in S.pneumonia
    resistance)
    Amphotericin B : 0.5 mg/kg/dose QD (day1) then 1
    mg/kg/dose QD
    Azithromycin 10 mg/kg/dose q24hrly(3DAYS)
    10mg/kg stat then 5mg/kg/day for four days
    Cefazolin 50-150 mg/kg/day q8hrly (max 6 gm/day)
    Cefotaxime (m) 200mg/kg/day q6hrly (max 8 gm/day)
    Others 100-150 mg/kg/day q8-6hrly (max
    6gm/day)
    Cefoperazone+sulbactum Mild infection 20-40mg/kg/day
    Moderate infection 60-80mg/kg/day
    Severe infection 100-150mg/kg/day
    Cefpodoxime Proxtil PO: 10mg/kg/day divided 12-24H
    Ceftazidime Mild-Moderate Infection 90-120mg/kg/day
    Cyctic fibrosis & Meningitis 50mg/kg/dose
    Q8H
    Cefuroxime IV 75-150mg/kg/day Q8H
    PO 20-30mg/kg/day Q12H
    Ceftriaxone (m) 100mg/kg/day q12-24hrly (max 2
    gm/dose)
    Others 65-75mg/kg/day q24hrly (max 2
    gm/day)
    Ciprofloxacin 20-30mg/kg/day q12hrly (max 400mg/dose)
    Levofloxicin PO/IV : 10mg/kg/dose OD
    Clarithromycin 15 mg/kg/day q12hrly
    Erythromycin 10mg/kg/dose Q12H
    Ertapenem 15mg/kg/dose Q12H (max500mg/dose)
    Clindamycin 30-40 mg/kg/day q8hrly

    Cloxacillin 100-200 mg/kg/day q6hrly


    Metronidazole 30 mg/kg/day q8hrly
    Meropenem (m) 40mg/kg/dose q8hrly (max 6 g/day)
    Others 20mg/kg/dose q8hrly
    Imipenem- 15-25mg/kg/dose Q6h (max 1g/dose)
    Pip/Tazocin 300mg/kg/day q8hrly (max 4.5 gm/dose)
    Fluconazole 6-12 mg/kg/day QD
    Voriconazole Empirical dose : 9mg/Kg/dose BD
    Itraconazole 3-5mg/kg/day divided Q12-24H
    Ketoconazole 3-6mg/kg/day OD
    Collistin (IV)15000-25000/KG/DOSE Q8HRLY
    (Neb ) 1.2 million-2.25million iu per/day
    divided 3 doses 0r 50-70mg/day (6.25-8.75lac
    IU/day )

    Vancomycin (m) 60mg/kg/day q8-6hrly


    Others 45 mg/kg/day q8hrly
    Tiecoplanin 10mg/kg/dose 1st 3dose at Q12H Then OD
    Linezolid 10mg/kg/dose Q8H-Q12H (MAX 1.2g/day)
    Anti-
    Anti-Hypertensive agent
    Amlodpine PO 0.1mg/kg/dose initially max 5mg
    May increase upto 0.6mg/kg/day maximum
    20mg/day (10 mg bid)
    Atenolol PO 0.5-1mg/kg/dose OD-BID
    Carvedilol PO 0.015-0.2mg/kg/24H divided in BD
    Captopril PO 0.3-0.5mg/kg/dose MAX.2MG/KG/DOSE
    Clonidine PO 5-10mic/kg/day divided in BD/TDS
    Diltiazem PO 1.5-2MG/KG/DAY divided in tds/qid
    Esmolol 500mic/kg stat
    50-250mic/kg/min as cont. infusion
    Hydralazine 0.1-0.2mg/kg/dose Q4-6H (max.20mg/dose)
    Labetalol PO :1-3MG/KG/DAY
    IV :
    intermittent dose= 0.2-1mg/kg/dose
    infusion dose =0.4-1mg/kg/hr (max3mg/kg/hr)
    Linsopril PO 0.07-0.1mg/kg/dose OD
    Losartan PO 0.7MG/KG/DOSE OD
    Methyl-dopa PO = 10mg/kg/day in Q6-12H
    IV = 2-4mg/kg/dose
    Metoprolol PO 1-2mg/kg/day divided in BID
    Propronalol PO 0.5-1MG/KG/24H divided in 6-12H
    Sildenafil (pulmonary HTN) PO 0.25-2MG/KG/DOSE Q6-8H

    VITAMINS
    Vit A PO 50,000-200,000IU/DOSE
    Vit B1 (THIAMIN)  BERIBERI IV-IM : 10-25MG/DOSE OD
    PO : 10-50MG/DOSE OD

    Wernicki’s encephalopathy 100MG IV STAT  50-100MG/DAY


    Vit B2 (RIBOFLAVIN) 2.5MG-10MG/24HR OD
    Vit B3 ( NIACIN) 50-100MG/DOSE TID
    Vit B6 (PYRIDOXINE) 5-25MG/24HR
    Vit B12 (Cynocobalmmin) 100MCG/DAY
    Vit C ( Ascorbic Acid) 100-300MG/24HR OD
    Vit D2 ( Ergocalciferol) 400-800 iu/day
    25-OH vit D= 4000-8000 iu/day
    Malabsorption =10,000-25,000 iu/day
    Vit D3 (Cholecalciferol) 200-800 iu/day
    Vit E (a-tocopherol) 10 iu/kg
    Cystic fibrosis : 5-10iu/kg/day max 400iu
    Vit k (Phytonadione ) Iv 1-2mg/day or
    age will be the dose max 10mg
    OTHERS
    L-Carnitine 50-100 mg/kg/dose q6-12hrly (max
    300mg/kg/day)
    Clemastine 0.025mg/kg/dose q6-8hrly
    Calcium gluconate 100-400 mg/kg/day q6hrly (max 1 gm/dose)
    Baclofen 10-20mg/24H
    Pralidoxime Intermittent dose 20-50mg/kg/dose
    Continues infusion 10-20mg/kg/hr

    Raza Ullah (Rph)


    Critical Care Clinical Pharmacist
    The Indus Hospital Karachi

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