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    Nucleated Red Blood Cell (NRBC) - QSP Newsletter Issue 44

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    Gaurav Maurya
    This document contains slides from a presentation on nucleated red blood cells (NRBCs). It includes slides on a case study showing abnormal red blood cell results, NRBC quick overview explaining erythropoiesis and the development of red blood cells, and information on manually counting and the diagnostic value of NRBCs. It finds that the presence of NRBCs in adult peripheral blood is rare but can indicate diseases and poorer prognosis. The slides are from a company providing medical diagnostic technologies.

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    Nucleated Red Blood Cell (NRBC) - QSP Newsletter Issue 44

    Uploaded by

    Gaurav Maurya
    48 views2 pages
    This document contains slides from a presentation on nucleated red blood cells (NRBCs). It includes slides on a case study showing abnormal red blood cell results, NRBC quick overview explaining erythropoiesis and the development of red blood cells, and information on manually counting and the diagnostic value of NRBCs. It finds that the presence of NRBCs in adult peripheral blood is rare but can indicate diseases and poorer prognosis. The slides are from a company providing medical diagnostic technologies.

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    Neucleated red cell

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    This document contains slides from a presentation on nucleated red blood cells (NRBCs). It includes slides on a case study showing abnormal red blood cell results, NRBC quick overview explaining erythropoiesis and the development of red blood cells, and information on manually counting and the diagnostic value of NRBCs. It finds that the presence of NRBCs in adult peripheral blood is rare but can indicate diseases and poorer prognosis. The slides are from a company providing medical diagnostic technologies.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    48 views2 pages

    Nucleated Red Blood Cell (NRBC) - QSP Newsletter Issue 44

    Uploaded by

    Gaurav Maurya
    This document contains slides from a presentation on nucleated red blood cells (NRBCs). It includes slides on a case study showing abnormal red blood cell results, NRBC quick overview explaining erythropoiesis and the development of red blood cells, and information on manually counting and the diagnostic value of NRBCs. It finds that the presence of NRBCs in adult peripheral blood is rare but can indicate diseases and poorer prognosis. The slides are from a company providing medical diagnostic technologies.

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    ISSUE

    ISSUE

    44
    oFebruary
    2024

    February Slides This issue


    Slide 1 February Slides P.1
    Nothing to report. Monthly Digital Case Study P.2
    Slide 2 NRBC Quick Overview P.2
    Intensive care unit.
    Anaemia.
    Neutrophilia + myelemia.
    Thrombocytopenia.
    cells (+++).
    Anaemia.
    Echinocytes/Burr
    Neutrophilia + myelemia.
    Thrombocytopenia.
    Monthly Digital Case Study Presentation
    Expert's comment: Echinocytes/Burr February 2024, Slide 3
    cells (+++) => probable metabolic
    cause.
    Slide 3 FBC Results
    See case study opposite. WBC 2.85* (10^3/mm3) Neutrophils 60.9%
    Slide 4 RBC 2.37* (10^6/mm3) Lymphocytes 28.1%
    Presence of a few activated HGB 8.2* (g/dL) Monocytes 9.4%
    lymphocytes (large lymphocytes
    HCT 24.4* (%) Basophils 1.6%
    with +/- irregular form and
    basophilic cytoplasm)?
    MCV 103 (fL) Normoblasts, Erythroblasts 58
    Expert's comment: MCH 34.6 (pg) Large Platelets 6
    See liver assessment MCHC 34.6 (g/dL)
    (transaminase assay). PLT 127 (10^3/mm3)
    Slide 5
    Pneumology unit.
    Multiple analyser flag on leukocyte Clinical Details
    differential. Haemodialysis unit.
    - Leukocytosis. Neutrophilia.
    - Hyposegmented neutrophils (band
    cells)/granular immature cells. Slide Information
    - Monocytosis, Eosinophilia. Leukopenia. Anaemia. Anisocytosis (+++). Hypochromic RBCs (+/-). Punctated
    - No blastosis associated with RBCs/Howell-Jolly bodies (+). Erythroblastosis (acidophilic erythroblasts).
    myelemia. Presence of macroplatelets.
    Presence of rare erythroblasts and
    some macro-platelets/giant Expert's comments: Punctated RBCs/Howell-Jolly bodies (+): Patient with
    platelets. splenectomy. Hypersegmented neutrophils: Patient on hydroxyurea?
    Expert's comment: Pathology of red blood cells: Abnormal Hb?
    Paraneoplastic syndrome (PNS) to
    look for first.
    Slide 6 Nucleated Red Blood Cell (NRBC) Erythroblasts
    Intensive care unit.
    Analyser flag on leukocyte
    differential.
    - Macrocytic anisocytosis (+).
    - Leukocytosis.
    - Neutrophilia.
    - Discreet myelemia.
    Cell Quiz
    Can you name a condition where
    NRBC Quick Overview
    this red cell picture would be
    Nucleated red blood cells are early precursors of red cells and in normal
    seen?
    healthy adults are rarely seen outside of the bone marrow. In a process
    known as Erythropoiesis various cytokines and growth factors
    cause progenitor cells such as the Pluripotent haemopoietic stem cells to
    form committed erythroid progenitor cells – burst forming unit – erythroid
    (BFU-E). BFU-E gives rise to a more mature progenitor cell the colony
    forming unit erythrocyte (CFU-E). The CFU-E is extremely responsive to
    erythropoietin and causes the CFU-S to produce the erythroid precursor
    known as the Proerythroblast. The proerythroblast is a large cell, with a
    large round nucleus, finely stippled cytoplasm, deeply basophilic cytoplasm
    and one or more nucleoli. As the cell matures it decreases in size along with
    Last Month's Quiz changes to the size of the nucleus and alongside changes to the cytoplasm
    Can you name the cell below? (see below). After the cell reaches the late (orthochromatic) erythroblast
    stage, the nucleus is extruded from the cell producing a reticulocyte, the
    reticulocyte is then released into the blood stream where it matures to a
    red cell within 24 - 48 hours. It is remarkable to think that every second the
    human body generates 2 million red cells.

    Right answer:
    Blast cell
    Bibliography
    Erythropoiesis: insights into
    pathophysiology and
    treatments in 2017

    Diagnostic Value and Prognostic


    Significance of Nucleated Red Manual counting of NRBC
    Blood Cells (NRBCs) in Selected The traditional way of enumerating Nucleated Red Blood cells and therefore
    Medical Conditions providing a Corrected White Cell Count (most automated cell counters
    produce a Total Nucleated Cell Count (TNC) that may include NRBC as well
    Frequency of Nucleated Red as WBC) is when performing the differential and the total number of NRBC
    Blood Cells in the Peripheral seen per 100 WBC is counted. The Corrected WBC may then be calculated
    Blood of ICU-Admitted Patients with the following formula:
    Corrected WBC = TNC x [100 / (NRBC +100)]
    Editorial Team
    Kelly Duffy Automated analysers like the HORIBA Yumizen series of analysers are able
    Andrew Fisher to enumerate NRBC on every sample with a high degree of accuracy.

    About us In adults the presence of NRBC is rare and if found in numbers has been
    shown to indicate the presence of numerous diseases e.g. solid tumours,
    HORIBA UK Limited
    haematological malignancies, haemolysis, hypoxia, nutritional anaemia,
    Kyoto Close, Moulton Park
    blood loss, septicaemia, myocardial infarct, chronic lung disease, and
    Northampton, UK, NN3 6FL
    myelodysplasia. In studies it has been shown that the presence of NRBC in
    HORIBA Medical the peripheral blood of adults is a marker for poor prognosis.
    Parc Euromédecine, Rue du
    Caducée, BP 7290, 34184 NRBC are found in healthy neonates and disappear after approx. one month
    Montpellier Cedex 4, France of life.

    www.horiba.com/medical

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