EISSN 2667-4440

twitter.com/turkjnephrol

Volume 32
Issue 1
January 2023

Page 4

“Nephrology”: An
Inquiry of How It
All Began and
Evolved into a
Discipline

Page 8

Autophagy and
Autosomal Dominant
Polycystic Kidney
Disease

turkjnephrol.org
Editor in Chief
Rümeyza Kazancıoğlu
Division of Nephrology, Bezmialem Vakif University School of Medicine, İstanbul, Türkiye

Editors Bioistatistics Editor Ethics Editor

Ali Düzova Gökmen Zararsız Berna Arda
Division of Pediatric Nephrology, Hacettepe Division of Biostatistics and Informatics, Erciyes Division of History of Medicine and Medical Ethics,
University, School of Medicine, Ankara, Türkiye University School of Medicine, Kayseri, Türkiye Ankara University School of Medicine, Ankara, Türkiye

Ferruh Artunç Editorial Board

Division of Nephrology, Tuebingen University,
Tuebingen, Germany Ali Abu-Alfa Fevzi Ersoy Siren Sezer
Division of Nephroloy, American University of Division of Nephrology, Akdeniz University Division of Nephrology, Atılım University School
Meltem Gürsu Beirut Faculty of Medicine, Beirut, Lebanon School of Medicine, Antalya, Türkiye of Medicine, Ankara, Türkiye
Division of Nephrology, Bezmialem Vakif
University School of Medicine, İstanbul, Türkiye
Demet Eğlenoğlu Alaygut Mohamed Hassanein Gültekin Süleymanlar
Division of Nephrology, İzmir Health Sciences Division of Nephrology and Hypertension, University Division of Nephrology, Akdeniz University
University, Tepecik Training and Research of Mississippi Medical Center, Jackson, MS, USA School of Medicine, Antalya, Türkiye
Özkan Güngör Hospital, İzmir, Türkiye
Talat Alp İkizler Peter Stenvinkel
Division of Nephrology, Kahramanmaraş
Sütçü İmam University School of Medicine,
Bülent Altun Division of Nephrology, Department of Medicine, Division of Renal Medicine, Karolinska Institutet,
Division of Nephrology, Hacettepe University Vanderbilt University Medical Center, Nashville, Solna, Sweden
Kahramanmaraş, Türkiye Tennessee, USA
School of Medicine, Ankara, Türkiye
Vladimir Tesar
Savaş Öztürk Mustafa Arıcı Mehmet Kanbay Department of Nephrology, 1st Faculty of
Division of Nephrology, Hacettepe University Division of Nephrology, Koç University School of Medicine and General University Hospital,
Division of Nephrology, İstanbul University Medicine, İstanbul, Türkiye
School of Medicine, Ankara, Türkiye Charles University, Prague, Czech Republic
School of Medicine, İstanbul, Türkiye
Turgay Arınsoy Norbert Lameire Bülent Tokgöz
Division of Nephrology, Ghent University School of
Sedat Üstündağ Division of Nephrology, Gazi University
School of Medicine, Ankara, Türkiye Medicine and Health Sciences, Ghent, Belgium
Division of Nephrology Erciyes University School
of Medicine, Kayseri, Türkiye
Division of Nephrology, Trakya University School
of Medicine, Edirne, Türkiye Kenan Ateş Bengt Lindholm Zeki Tonbul
Division of Nephrology, Ankara University Department of Clinical Sciences, Intervention Division of Nephrology, Necmettin Erbakan
and Technology (CLINTEC), Karolinska Institute,
Sena Ulu School of Medicine, Ankara, Türkiye
Solna, Sweden
University School of Medicine, Konya, Türkiye
Department of Nephrology, Jonas Axelsson Hüseyin Töz
Bahçeşehir University Faculty of Medicine, Division of Clinical Immunology, Karolinska Francesca Mallamaci Division of Nephrology, Ege University
Istanbul, Türkiye University Hospital, Stockholm, Sweden Division of Nephrology, Hypertension and Renal School of Medicine, Ankara, Türkiye
Transplantation, Ospedali Riuniti, Reggio Cal, Italy
Previous Editors in Chief Peter Barany Serhan Tuğlular
Division of Clinical Science, Intervention and Ercan Ok Division of Nephrology, Marmara University
Bülent Tokgöz Technology, Stockholm Sweden Division of Nephrology, Ege University School of Medicine, İstanbul, Türkiye
Division of Nephrology Erciyes University School School of Medicine, İzmir, Türkiye
Vecihi Batuman Aydın Türkmen
of Medicine, Kayseri, Türkiye
Division of Nephrology, Tulane Univeristy Alberto Ortiz Division of Nephrology, İstanbul University
School of Medicine, Los Angeles, USA Division of Nephrology, University Autonoma of School of Medicine, İstanbul, Türkiye
Ekrem Erek Juan Jesus Carrero
Madrid, Madrid, Spain
Kültigin Türkmen
İstanbul University Cerrahpaşa School of
Medicine, İstanbul, Türkiye Department of Medical Epidemiology and Nurhan Seyahi Division of Nephrology, Necmettin Erbakan Univer-
Biostatistics, Karolinska Institute, Solna, Sweden Division of Nephrology, İstanbul University sity, Meram School of Medicine, Konya, Türkiye
Cerrahpaşa School of Medicine, İstanbul, Türkiye
Emel Akoğlu Taner Çamsarı Raymond Vanholder
Marmara University School of Medicine, İstanbul, Division of Nephrology, Dokuz Eylül Kamil Serdengeçti Division of Nephrology, University Hospital
University School of Medicine, İzmir, Türkiye Emeritus Professor, Division of Nephrology, Ghent, Ghent, Belgium
Türkiye
İstanbul University Cerrahpaşa School of Medicine,
Ülver Derici İstanbul, Türkiye Abdulgaffar Vural
Cengiz Utaş Division of Nephrology, Gazi University
Mehmet Şükrü Sever
Emeritus Professor, Gülhane Military Academy
Erciyes University School of Medicine, Kayseri, School of Medicine, Ankara, Türkiye School of Medicine, Ankara, Türkiye
Department of Internal Medicine, Division of
Türkiye
Soner Duman Nephrology, İstanbul Faculty of Medicine, Alaattin Yıldız
Division of Nephrology, Ege University Istanbul University, İstanbul, Türkiye Division of Nephrology, İstanbul University
Bülent Altun School of Medicine, İzmir, Türkiye
Lale Sever School of Medicine, İstanbul, Türkiye
Hacettepe University School of Medicine, Ankara,
Türkiye
Tevfik Ecder Division of Pediatric Nephrology, Department Carmine Zoccali
Division of Nephrology, Istanbul Bilim University of Pediatrics, İstanbul University-Cerrahpaşa Nephrology, Dialysis and Transplantation Unit,
School of Medicine, İstanbul, Türkiye School of Medicine, İstanbul, Türkiye Ospedali Riuniti, Reggio Calabria, Italy

Publisher Publication Coordinators Finance Coordinators Contact

İbrahim KARA Arzu ARI Elif YILDIZ ÇELİK Address: Büyükdere Cad.
Deniz KAYA 105/9 34394 Mecidiyeköy,
General Manager Irmak BERBEROĞLU Web Coordinators Şişli, İstanbul, Türkiye
Ali ŞAHİN Alara ERGIN Sinem Fehime KOZ Phone: +90 212 217 17 00
Publishing Director Hira GIZEM FIDAN Doğan ORUÇ Fax: +90 212 217 22 92
İrem SOYSAL Vuslat TAŞ E-mail: [email protected]
Gökhan ÇİMEN İrem ÖZMEN

Editor
Bahar ALBAYRAK

I
Aims and Scope

Turkish Journal of Nephrology (Turk J Nephrol) is a double- at www.turkjnephrol.org. The journal guidelines, technical
blind peer-reviewed, open access, an international online-only information, and the required forms are available on the journal’s
publication of the Turkish Society of Nephrology. The journal is a web page.
quarterly publication, published in January, April, July and October.
The publication language of the journal is English. All expenses of the journal are covered by the Turkish Society of
Nephrology. Potential advertisers should contact the Editorial
Turkish Journal of Nephrology aims to contribute to the literature Office. Advertisement images are published only upon the Editor-in-
by publishing manuscripts at the highest scientific level in the Chief’s approval.
fields of nephrology, dialysis and transplantation. The journal
publishes original articles, rare case reports, reviews, and letters Statements or opinions expressed in the manuscripts published in
to the editor that are prepared in accordance with the ethical the journal reflect the views of the author(s) and not the opinions of
guidelines. the Turkish Society of Nephrology, editors, editorial board, and/or
publisher; the editors, editorial board, and publisher disclaim any
The scope of the journal includes but not limited to; remarkable responsibility or liability for such materials.
clinical and experimental investigations conducted in all fields of
nephrology. The target audience of the journal includes specialists Turkish Journal of Nephrology is an open-access publication and
and professionals working and interested in all disciplines of the journal’s publication model is based on the Budapest Open
nephrology and kidney care. Access Initiative (BOAI) declaration. Journal’s archive is available
online, free of charge at www.turkjnephrol.org. Turkish Journal
The editorial and publication processes of the journal are shaped of Nephrology’s content is licensed under a Creative Commons
in accordance with the guidelines of the International Committee Attribution 4.0 International License.
of Medical Journal Editors (ICMJE), World Association of Medical
Editors (WAME), Council of Science Editors (CSE), Committee on You can find the current version of the Instructions to Authors at
Publication Ethics (COPE), European Association of Science Editors https://turkjnephrol.org/en/instructions-to-authors-1013
(EASE), and National Information Standards Organization (NISO).
The journal is in conformity with the Principles of Transparency and Editor in Chief: Rümeyza Kazancıoğlu
Best Practice in Scholarly Publishing (doaj.org/bestpractice). Address: Division of Nephrology, Bezmialem Vakif University School
of Medicine, İstanbul, Türkiye
Turkish Journal of Nephrology is currently indexed in Web of E-mail: [email protected]
Science-Emerging Sources Citation Index, DOAJ, Scopus, EBSCO,
Gale, China National Knowledge Infrastructure (CNKI) and TUBITAK Publisher: AVES
ULAKBIM TR Index. Address: Büyükdere Cad. 105/9 34394 Mecidiyeköy, Şişli, İstanbul,
Türkiye
Processing and publication are free of charge with the journal. Phone: +90 212 217 17 00
No fees are requested from the authors at any point throughout Fax: +90 212 217 22 92
the evaluation and publication process. All manuscripts must be E-mail: [email protected]
submitted via the online submission system, which is available Web page: avesyayincilik.com

II
Contents

Editorial 1
Acknowledgement of Reviewers 2
Reviews
“Nephrology”: An Inquiry of How It All Began and Evolved into a Discipline 4
Garabed Eknoyan

Autophagy and Autosomal Dominant Polycystic Kidney Disease 8

Özgür Akın Oto, Charles L. Edelstein

Original Articles
Association of the Left Ventricular Hypertrophy and Red Cell Distribution Width in Newly Diagnosed Hypertensive
Patients 16
Onur Tunca, Sinan Kazan, Elif Dizen Kazan, Alper Sarı, Serkan Gökaslan, Sena Ulu

The Utility of Unenhanced Renal Artery Magnetic Resonance Angiography Using Inhance Sequence in Depiction of
Renal Vasculature and Related Abnormalities in Patients with Suspected Renovascular Hypertension 22
Filiz Taşçı, Yavuz Metin, Nurgül Orhan Metin, Maksude Esra Kadıoğlu, Eda Beykoz Çetin, Melih Gaffar Gözükara

Management of Common Medical Conditions in End-Stage Kidney Disease by the General Practitioner 30
Emran El-Alali, Emad Al-Jaber

Dialysis Symptoms on Exercise Perception of Hemodialysis Patients 39

Züleyha Kılıç, Nurcan Uzdil

Affecting Factors in Medication Adherence in Kidney Transplant Recipients 48

Yaprak Sarıgöl Ordin, Özgül Karayurt, Nermin Ertan, Aylin Durmaz Edeer, Serkan Yıldız

COVID-19 in Kidney Transplant Recipients: A Single-Center Experience 55

Mehmet Mert, Ahmet Kutluay, Belda Dursun, Murat Özban, Hande Şenol, Mevlüt Çeri

Evaluation of Phenotypes and CLDN16 Variants in 2 Different Familial Hypomagnesemia with Hypercalciuria and
Nephrocalcinosis Families: Phenotypic Differences in Siblings and Phenotypic Similarity in Monozygotic Twins 63
Muhammet Akif Güler, Çiğdem Yüce Kahraman

Trends in Antimicrobial Resistance and Demographics of Urinary Tract Infections Regarding Impacts of Urological
Comorbidities in Children in a Single Institution Over a 4-Year Period 73
Behçet Şimşek, Seniha Şenbayrak, Recep Balık

Case Reports
Persistent Hyponatremia due to Sodium Wasting via External Biliary Drainage 81
Cihan Uysal, Tuğba Yılmaz, Rıfkı Sarıca, Hafsa Koçyiğit, Güven Kahriman, Oktay Oymak

Two Different Presentation of C3 Glomerulonephritis Treated with Eculizumab: Two Cases and Brief Overview 86
Yasin Öztürk, Hakan Özer, İsmail Baloğlu, Kültigin Türkmen

A Rare Case: Improved Heart Failure with Anti-Complement Therapy in Complement-Dependent Hemolytic Uremic
Syndrome 90
Hakan Özer, Yasin Öztürk, Kültigin Türkmen, Zeki Halil Tonbul, Nedim Yılmaz Selçuk

III
Slowly Progressive Immunoglobulin A Nephropathy With Isomorphic Hematuria and Without Significant Proteinuria:
A Case Report and Follow-Up for 9 Years 94
Rukiye Kübra Kaynar, Sevdegül Mungan

Successful Kidney Transplantation in a Patient with Marfan’s Syndrome with a History of Aortic Dissection Operation
and a Dissection Flap Up to the Iliac Bifurcation Level 98
Vural Taner Yılmaz, Abdullah Kısaoğlu, Ali Avanaz, İsmail Demiryılmaz, Fahri Uçar, Bülent Aydınlı, Hüseyin Koçak

IV