Prelim Reviewer 2023
Prelim Reviewer 2023
Prelim Reviewer 2023
I. STANDARDS OF MATERNAL AND CHILD STANDARD 3: Every woman and newborn with
HEALTH NURSING PRACTICE condition(s) that cannot be dealt with effectively with the
available resources is appropriately referred.
Every woman and newborn is appropriately assessed
1. Health Promotion
on admission, during labour and in the early postnatal
Educating clients to be
aware of good health period to determine whether referral is required,
through teaching and and the decision to refer is made without delay.
role modeling. For every woman and newborn who requires referral,
the referral follows a pre-established plan that can be
implemented without delay at any time.
2. Health Maintenance
For every woman and newborn referred within or
Intervening to maintain health when risk of
illness is present between health facilities, there is appropriate
information exchange and feedback to relevant
health care staff.
3. Health Restoration
Promptly diagnosing
STANDARD 4: Communication with women and their
and treating illness
using interventions that families is effective and responds to their needs and
will return client to preferences.
wellness most rapidly. All women and their families receive information about
the care and have effective interactions with staff.
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All women and their families experience II. ADVANCED-PRACTICE ROLES FOR NURSES IN
coordinated care, with clear, accurate MATERNAL AND CHILD HEALTH
information exchange between relevant health CLINICAL NURSE SPECIALIST
and social care professionals. are nurses prepared at the master’s or doctorate
degree level who are capable of acting as consultants in
STANDARD 5: Women and newborns receive care their area of expertise, as well as serving as role models,
with respect and preservation of their dignity. researchers, and teachers of quality nursing care.
All women and newborns have privacy around a. Neonatal Nurse Specialists - manage the care of
the time of labour and childbirth, and their infants at birth and in intensive care settings; they
confidentiality is respected provide home follow-up care to ensure the newborn
No woman or newborn is subjected to remains well. Childbirth educators teach families
mistreatment, such as physical, sexual or about normal birth and how to prepare for labor and
verbal abuse, discrimination, neglect, birth.
detainment, extortion or denial of services. b. Childbirth Educators - teach families about normal
All women have informed choices in the birth and how to prepare for labor and birth.
services they receive, and the reasons for c. Lactation Consultants - educate women about
interventions or outcomes are clearly explained. breastfeeding and support them while they learn
how to do this.
STANDARD 6: Every woman and her family are d. Genetic Nurse Counselors - consult with families
provided with emotional support that is sensitive to about patterns of inheritance and offer support to
their needs and strengthens the woman’s capability. families with a child who has inherited a genetic
Every woman is offered the option to disorder.
experience labor and childbirth with the e. Case Manager – a graduate-level nurse who
companion of her choice. supervises a group of patients from the time they
Every woman receives support to strengthen enter a health care setting until they are discharged
her capability during childbirth. from the setting.
STANDARD 7: For every woman and newborn, NURSE PRACTITIONERS
competent, motivated staff are consistently available are nurses educated at the master’s or doctoral level.
to provide routine care and manage complications. Recent advances in technology, research, and
Every woman and child has access at all times knowledge have amplified the need for longer and more
to at least one skilled birth attendant and in-depth education for nurse practitioners as they play
support staff for routine care and management pivotal roles in today’s health care system.
of complications.
The skilled birth attendants and support staff a. Pediatric Nurse Practitioner (PNP)
have appropriate competence and skills mix with extensive skills in physical assessment,
to meet the requirements of labour, childbirth interviewing, and well-child counseling and care.
and the early postnatal period. Determines common illnesss – (Iron deficiency
Every health facility has managerial and clinical anemia) they can orders the necessary laboratory
leadership that is collectively responsible for tests and prescribes appropriate drugs for therapy.
developing and implementing appropriate Determines Major illness - Congenital subluxated hip,
policies and fosters an environment that kidney disease, heart disease, consults with an
supports facility staff in continuous quality associated pediatrician.
improvement.
b. Neonatal Nurse Practitioner
STANDARD 8: The health facility has an is an advanced-practice role for nurses who are
appropriate physical environment, with adequate skilled in the care of newborns, both well and ill.
water, sanitation and energy supplies, medicines, • Level 1 – Healthy babies
supplies and equipment for routine maternal and • Level 2 – infants with moderate health problems
newborn care and management of complications. • Level 3 – Neonatal ICU
Water, energy, sanitation, hand hygiene and • Newborn nurseries, neonatal follow-up clinics, or
waste disposal facilities are functional, reliable, physician groups.
safe and sufficient to meet the needs of staff,
women and their families. c. Family Nurse Practitioner (FNP)
Areas for labor, childbirth and postnatal care are • an advanced-practice that provides health
designed, organized and maintained so that care to women and children and
every woman and newborn can be cared for to the family as a whole.
according to their needs in private, to facilitate • FNP can provide prenatal care for a
the continuity of care. woman with an uncomplicated pregnancy
An adequate stock of medicines, supplies and
equipment is available for routine care and
management of complications
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d. Certified Nurse-Midwife 5. Adolescents who support themselves or who are
is an individual educated in the two disciplines of pregnant are termed “emancipated minors” or
nursing and midwifery and licensed. “mature minors” and have the right to sign for their
▪ plays an important role in assisting women with own health care.
pregnancy and childbearing either independently
or in association with a physician IV. ETHICAL CONSIDERATIONS OF PRACTICE
▪ Nurse-midwife assumes full responsibility for the
care and management of women with Some of the most difficult ethical quandaries in health
uncomplicated pregnancies. care today are those that involve children and their
families
III. LEGAL CONSIDERATIONS OF ▪ Ethics – concerned with determining what is good or
MATERNAL-CHILD PRACTICE valuable for individuals, groups, and society.
▪ acts that are ethical reflects a commitment to
• MCHN carries some legal concerns that extend standards that individuals, professionals,
above and beyond other areas of nursing, because societies strive to meet.
care is often given to an “unseen client”—the ▪ Difficult Ethical quandaries in Health care
fetus—or to clients who are not of legal age for involves children and their families
giving consent for medical procedures. Examples are:
• In addition, labor and birth of a neonate are 1. Conception issues -related to in-vitro fertilization,
considered “normal” events, so the risks for a embryo transfer, ownership of frozen oocytes or
lawsuit are greater when problems arise (O’Grady sperm, cloning, stem cell research, and surrogate
et al., 2007) mothers
2. Abortion, particularly Partial-birth abortions
1. Nurses are legally responsible for protecting the 3. Fetal rights versus rights of the mother
rights of their clients, including confidentiality and 4. Use of Fetal tissue for research
are accountable for the quality of their individual 5. Neonatal Resuscitation (for how long should it be
nursing care and that of other health care team continued?)
members. 6. Number of procedures or degree of pain that a child
▪ Confidentiality – protection of patients' personal should be asked to endure to achieve a degree of better
health information. health
▪ Accountability – ability to answer for one’s 7. Balance between modern technology and quality of life
professional actions.
V. NURSING THEORY
2. Understanding the scope of practice and
standards of care can help nurses practice within One of the requirements of a profession (together with
appropriate legal parameters. other critical determinants, such as member-set standards,
monitoring of practice quality, and participation in research)
3. Documentation is essential for protecting a is that the concentration of a discipline’s knowledge flows
nurse and justifying his or her actions. from a base of established theory.
Documentation – is a nursing action that produces Nursing theorists offer helpful ways to view clients so
a written account of patient data, nursing clinical that nursing activities can best meet client needs—for
decisions, and intervention and patient response example, by seeing a pregnant woman not simply as a
physical form but as a dynamic force with important
4. Nurses need to be conscientious about psychosocial needs, or by viewing children as extensions
obtaining informed consent for invasive or active members of a family as well as independent
procedures and determining that pregnant beings. Only with this broad theoretical focus can nurses
women are aware of any risk to the fetus appreciate the significant effect on a family of a child’s
associated with a illness or of the introduction of a new member.
procedure or test. Another issue most nursing theorist’s address is how
nurses should be viewed or what the goals of nursing care
Amniocentesis should be. Extensive changes in the scope of maternal
Informed Consent – and child health nursing have occurred as health
process of obtaining promotion, or keeping parents and children well, has
permission from a become a greater priority.
patient to perform a With health promotion as a major nursing goal, teaching,
specific test or counseling, supporting, and advocacy are also common
procedure after roles (Vonderheid et al., 2007). Nurses care for clients who
describing are more critically ill than ever before. Because care of
all risks, side effects, women during pregnancy and of children during their
and benefits. developing years helps protect not only current health but
also the health of the next generation, maternal-child
health nurses fill these expanded roles to a unique and
special degree.
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Maternal Mortality Rate: Philippines maternal
VI. PHILOSOPHY OF MATERNAL AND CHILD mortality ratio was at level of 121 deaths per
HEALTH NURSING
100,000 live births in 2017, down from 124 deaths per
1. Family – Centered 100,000 live births previous year, this is a change of
• assessment must include both family and 2.42%.
individual assessment data
2. Community – Centered VII. GOALS OF MATERNAL AND CHILD
▪ the health of families depends on the influences HEALTH NURSING
the health of communities
3. Evidenced – Based Practice The primary goal of maternal and child health nursing
▪ this is the means whereby critical knowledge care can be stated simply as the promotion and
increases maintenance of optimal family health to ensure cycles
4. MCH nurse serves as an advocate to protect the of optimal child- bearing and childrearing.
rights of all family members, including the fetus The goals of Maternal and Child Health Nursing care
5. MCH Nursing includes a high degree of are necessarily broad because the scope of practice.
independent nursing functions, because teaching
and counselling are major interventions The range of practice includes:
6. Promoting health and disease prevention are a. Preconceptual health care
important nursing roles because these to protect
the health of the next generation
7. MCH Nurse serve as an important resources for
family during childbearing and childbearing
8. Personal, cultural, and religious attitudes and
beliefs influence the meaning and impact of
childbearing and childbearing on families
9. Circumstances such as illness or pregnancy are
meaningful only in the context of a total life.
10. Maternal and child health nursing is a
challenging role for nurses and a major factor in
keeping families well and optimally functioning.
b. Care of women during three trimesters of pregnancy
STATISTICAL TERMS USED TO REPORT and the puerperium. (6 wks. After childbirth), sometimes
MATERNAL AND CHILD HEALTH termed the fourth trimester of pregnancy
Birth Rate: Number of births per 1000 c. Care of infants during the perinatal period (6 weeks
population. before conception to 6 weeks after birth)
Fertility rate: Number of pregnancies per 1000 d. Care of children from birth through young adolescence
women of childbearing age. e. Care in settings as varied as the birthing room, the
Fetal Death Rate: Number of fetal deaths pediatric intensive care unit, and the home
(weighing more 500 g) per 1000 live births.
Neonatal Death Rate: Number of deaths per VIII. WORLD HEALTH ORGANIZATION’S
1000 live births occurring at birth or in the first 17 SUSTAINABLE DEVELOPMENT GOALS
28 days of life.
Perinatal Death Rate: Number of deaths of
fetuses weighing more than 500 g and within
the first 28 days of life per 1000 live births.
Maternal Mortality Rate: Number of maternal
deaths per 100,000 live births that occur as a
direct result of the reproductive process.
Infant Mortality Rate: Number of deaths per
1000 live births occurring at birth or in the first
12 months of life.
Childhood Mortality Rate: Number of deaths
per 1000 population in children, 1 to 14 years of
age
Infant Mortality Rate: The infant mortality rate
for Philippines in 2019 was19.239deaths per TERMINOLOGIES:
1000 live births, a2.16% decline from 2018. • Infant Mortality rate - is the number of deaths among
The top three leading causes of infant mortality infants from birth to 1 year of age per 1000 live births.
were Pneumonia (3,146; 14.3%); Bacterial • Maternal Mortality Rate - is the number of resident
sepsis of newborn (2,731; 12.4%); and maternal deaths within 42 days of pregnancy termination
Respiratory distress of newborn (2,347; 10.7%). due to complications of pregnancy, childbirth, and the
puerperium in a specified geographic area.
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• Maternity Nursing – involves direct personal care feels as if he or she is of the opposite gender (Jain &
to maternity patients and their newborn infants or to Bradbeer, 2007). Such people may have sex change
related activities on their behalf during the various operations so that they appear cosmetically as the
phases of the child bearing experience gender they feel that they are.
EXCITEMENT
Occurs with physical and psychological
stimulation (i.e., sight, sound, emotion, or
thought) that causes parasympathetic nerve
stimulation. This leads to arterial dilation and
venous constriction in the genital area. The
resulting increased blood supply
DISORDERS OF SEXUAL FUNCTIONING
leads to vasocongestion and increasing 1. Inhibited Sexual Desire
muscular tension. Lessened interest in sexual relations is normal in
In women, this vasocongestion causes the some circumstances, such as after the death of a
clitoris to increase in size and mucoid fluid to family member, a divorce, or a stressful job change.
appear on vaginal walls as lubrication. The The support of a caring sexual partner or relief of the
vagina widens in diameter and increases in tension causing the stress allows a return to sexual
length. The nipples become erect. interest.
In men, penile erection occurs, as well as Decreased sexual desire can also be a side effect of
scrotal thickening and elevation of the testes. In many medicines. Chronic diseases, such as peptic
both sexes, there is an increase in heart and ulcers or chronic pulmonary disorders, that cause
respiratory rates and blood pressure. frequent pain or discomfort may interfere with a man’s
PLATEAU or a woman’s overall well-being and interest in sexual
The plateau stage is reached just before activity.
orgasm. In the woman, the clitoris is drawn Some women experience a decrease in sexual desire
forward and retracts under the clitoral prepuce; during perimenopause. Administration of androgen
the lower part of the vagina becomes extremely (testosterone) to women may be helpful at that time,
congested (formation of because it can improve interest in sexual activity.
the orgasmic platform), and there is increased 2. Failure to Achieve Orgasm
nipple elevation. The failure of a woman to achieve orgasm can be a
In men, the vasocongestion leads to distention result of poor sexual technique, concentrating too
of the penis. Heart rate increases to 100 to 175 hard on achievement, or negative attitudes toward
beats per minute and respiratory rate to sexual relationships.Treatment is aimed at relieving
approximately 40 respirations per minute. the underlying cause. It may include instruction and
ORGASM counseling for the couple about sexual feelings and
Orgasm occurs when stimulation proceeds needs.
through the plateau stage to a point at which the 3. Erectile Dysfunction
body suddenly discharges accumulated sexual Erectile dysfunction (ED), formerly referred to as
tension. impotence, is the inability of a man to produce or
A vigorous contraction of muscles in the pelvic maintain an erection long enough for vaginal
area expels or dissipates blood and fluid from penetration or partner satisfaction (Wessells et al.,
the area of congestion. The average number of 2007). Most causes of ED are physical, such as aging,
contractions for a woman is 8 to 15 contractions atherosclerosis, or diabetes, which limit blood supply.
at intervals of 1 every 0.8 seconds. It may also occur as a side effect of certain drugs.
In men, muscle contractions surrounding the Examples of drugs prescribed today for ED are
seminal vessels and prostate project semen into sildenafil (Viagra), tadalafil (Cialis), and vardenafil
the proximal urethra. These contractions are (Levitra), which are taken up to once a day to
followed immediately by three to seven stimulate penile erection.
propulsive ejaculatory contractions, occurring at a surgical implant to aid erection by the use of
the same time interval as in the woman, which vacuum pressure is a possible alternative (Hossein,
force semen from the penis. 2007). Testosterone injections may be helpful in some
RESOLUTION men.
Resolution is a 30-minute period during which 4. Premature Ejaculation
the external and internal genital organs return to Premature ejaculation is ejaculation before
an unaroused state. penile–vaginal contact (Docherty, 2007). The term
For the male, a refractory period occurs during also is often used to mean ejaculation before the
which further orgasm is impossible. sexual partner’s satisfaction has been achieved.
Women do not go through this refractory period, Premature ejaculation can be unsatisfactory and
so it is possible for women who are interested frustrating for both partners.
and properly stimulated to have additional
orgasms immediately after the first.
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The cause, like that of ED, can be psychological. gonadotropin-releasing hormone (GnRH), which in
Masturbating to orgasm (in which orgasm is turn triggers the anterior pituitary to begin the release
achieved quickly because of lack of time) may of follicle-stimulating hormone (FSH) and luteinizing
play a role. Other reasons suggested are doubt hormone (LH). FSH and LH initiate the production of
about masculinity and fear of impregnating a androgen and estrogen, which in turn initiate
partner, which prevent the man from sustaining secondary sex characteristics, the visible signs of
an erection. Sexual counseling for both partners maturity.
to reduce stress, as well as serotonergic Puberty is when the body starts to change, like
antidepressants such as Mirtazapine, may be growing hair and developing curves or muscles, and
helpful in alleviating the problem. these changes happen because a part in the brain
5. Persistent Sexual Arousal Syndrome (PSAS) releases signals that tell the body to make hormones,
is excessive and unrelenting sexual arousal in which then lead to these visible signs of growing up.
the absence of desire (Mahoney & Zarate, GnRH is a signal from the brain that starts the
2007). It may be triggered by medications or production of reproductive hormones.
psychological factors. When assessing FSH is a hormone that helps make eggs and sperm.
someone with the disorder, be certain to ask if LH is a hormone that triggers the release of eggs and
the person is taking any herbal remedies such the production of testosterone.
as Ginkgo biloba because some of these can Role of Androgen - Androgenic hormones are the
have arousal effects. hormones responsible for muscular development,
6. Vaginismus physical growth, and the increase in sebaceous gland
is involuntary contraction of the muscles at the secretions that causes typical acne in both boys and
outlet of the vagina when coitus is attempted girls. In males, androgenic hormones are produced by
that prohibits penile penetration (Engman, the adrenal cortex and the testes; in females, by the
Wijma, & Wijma, 2007). adrenal cortex and the ovaries.
Vaginismus may occur in women who have Androgen hormones help muscles grow, bodies get
been raped. Other causes are unknown, but it bigger, and skin glands make more oil that can lead to
could also be the result of early learning acne, and they are made in boys by testes and
patterns in which sexual relations were viewed adrenal cortex, and in girls by ovaries and adrenal
as bad or sinful. As cortex.
with other sexual problems, sexual or Role of Estrogen – When triggered at puberty by
psychological counseling to reduce this FSH, ovarian follicles in females begin to excrete a
response may be necessary. high level of the hormone estrogen.This hormone is
7. Dyspareunia and Vestibulitis actually not one substance but three compounds
Dyspareunia is pain during coitus. This can (estrone [E1], estradiol [E2], and estriol [E3]).
occur because of endometriosis (abnormal Estrogen, released when growing up, makes girls'
placement of endometrial tissue), vestibulitis bodies change and start making eggs, and it's actually
(inflammation of the vestibule), vaginal infection, three different things: estrone, estradiol, and estriol.
or hormonal changes such as those that occur Estrone is one type of the estrogen hormones that
with menopause and cause vaginal drying. A helps girls' bodies change during puberty.
psychological component may be present. Estradiol is another type of estrogen that also plays a
Treatment is aimed at the underlying cause. role in girls' body changes as they grow up.
Encouraging open communication between Estriol is the third type of estrogen hormone,
sexual partners can be instrumental in resolving contributing to the changes that happen in girls'
the problem. bodies during puberty.
PHYSIOLOGY OF ONSET
Puberty is initiated by hypothalamicpituitary –
gonad complex.
Puberty usually starts in Girls at 10-13 years old
and Boys starts at 12-14 years old.
A. EXTERNAL STRUCTURES
1. Scrotum - is a rugated, skin-covered,
muscular pouch suspended from the perineum. GLANS
Its functions are to support the testes and to The distal end of the organ is bulging sensitive ridge of
help regulate the temperature of sperm. tissue which has the external urinary meatus at its tip.
The scrotum is a wrinkled, skin-covered pouch CORONA
below the body that holds the testes and helps The proximal margin of the glans.
them stay at the right temperature for making PREPUCE
sperm, pulling them closer in cold weather and Also called the foreskin.
letting them hang away in hot weather or fever. Loose skin attached to the shaft, allowing for
expansion during erection.
2. Testes - are two ovoid glands, 2 to 3 cm wide, Retractable casing of skin that protects the nerve
that lie in the scrotum. Each testis is encased by sensitive glans at birth.Frenulum
a protective white fibrous capsule and is Ventral fold of tissue attaches the skin to the glans.
composed of several lobules, with each lobule Contains the urethra as well as 3 erectile bodies:
containing interstitial cells (Leydig’s cells) 2 dorsal erectile tissues known as the corpora
and a seminiferous tubule. cavernosa
Seminiferous tubules produce spermatozoa. 1 midventral tissue known as the corpus spongiosum
Leydig’s cells are responsible for the production Surrounds penile urethra
of testosterone. Expands distally to form the glans penis
Testes in a fetus first form in the pelvic cavity.
They descend, late in intrauterine life (about the
34th to 38th week), into the scrotal sac.
Because this descent occurs so late in
8
These glands secrete a viscous alkaline liquid that
has a high sugar, protein, and prostaglandin content.
Sperm become increasingly motile with this added
fluid, because it surrounds them with nutrients and a
more favorable pH.
Seminal vesicles are two pouches near the bladder
that connect to the urethra through small tubes and
release fluids during ejaculation. Seminal vesicles are
pouches near the bladder that release a thick fluid
into the tube where urine comes out, helping sperm
move better by giving them nutrients and a good pH.
B. INTERNAL STRUCTURES 4. Ejaculatory Ducts - The two ejaculatory ducts pass
1. Epididymis - the seminiferous tubule of each through the prostate gland and join the seminal
testis leads to a tightly coiled tube, the vesicles to the urethra.
epididymis, which is responsible for conducting 5. Prostate Gland - is a chestnut-sized gland that lies
sperm from the tubule to the vas deferens, the just below the bladder. The urethra passes through
next step in the passage to the outside. the center of it, like the hole in a doughnut.
Because each epididymis is so tightly coiled, its The prostate gland secretes a thin, alkaline fluid.
length is extremely deceptive: it is actually over When added to the secretion from the seminal
20 ft long. vesicles and the accompanying sperm from the
Some sperm are stored in the epididymis, and a epididymis, this alkaline fluid further protects sperm
portion of the alkaline fluid that will surround from being immobilized by the naturally low pH level
sperm at maturity (semen, or seminal fluid that of the urethra.
contains a basic sugar and mucin, a form of The prostate gland is a small gland near the bladder
protein) is produced by the cells lining the with a hole in the middle, and it makes a liquid that
epididymis. helps sperm move and survive in the body.
Sperm are immobile and incapable of 6. Bulbourethral Glands - two bulbourethral or
fertilization as they pass or are stored at the Cowper’s glands lie beside the prostate gland and
epididymis level. empty via short ducts into the urethra. Like the
It takes at least 12 to 20 days for them to travel prostate gland and seminal vesicles, they secrete an
the length of the epididymis and a total of 64 alkaline fluid that helps counteract the acid secretion
days for them to reach maturity. of the urethra and ensure the safe passage of
This is one reason that aspermia (absence of spermatozoa.
sperm) and oligospermia (20 million sperm/mL) The bulbourethral glands are two glands near the
are problems that do not appear to respond prostate that release a fluid into the urethra, like the
immediately to therapy but rather only 2 prostate and seminal vesicles, to balance the urethral
months. acid and help sperm move safely.
It is a coiled tube connected to each testis that 7. Urethra - is a hollow tube leading from the base of the
carries sperm from the testis to the vas bladder, which, after passing through the prostate
deferens. gland, continues to the outside through the shaft and
2. Vas Deferens (Ductus Deferens) - is an glans of the penis. It is approximately 8 in (18 to 20
additional hollow tube surrounded by arteries cm) long.
and veins and protected by a thick fibrous
coating. It carries sperm from the epididymis
through the inguinal canal into the abdominal
cavity, where it ens. ds at the seminal vesicles
and the ejaculatory ducts. Sperm mature as
they pass through the vas deferens.
Vasectomy (severing of the vas deferens to
prevent passage of sperm) is a popular means
of male birth control (Cook et al., 2009).
It is a tube that carries sperm from the testicles
to other parts of the body and helps sperm get
ready for fertilization as they travel through it.
3. Seminal Vesicles - are two convoluted
pouches that lie along the lower portion of the
posterior surface of the bladder and empty into
the urethra by way of the ejaculatory ducts.
after
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II. FEMALE REPRODUCTIVE SYSTEM Skene's glands, found on each side near the pee hole,
It produces the female egg cells necessary for have ducts that open into the urethra.
reproduction, called the ova or oocytes. 7. Bartholin’s glands (vulvovaginal glands) are
It is designed to transport the ova to the site of located just lateral to the vaginal opening on both
fertilization. sides. Their ducts open into the distal vagina.
If fertilization does not take place, the system is Bartholin's glands are found on each side of the
designed to menstruate. vaginal opening, and their tubes connect to the lower
It produces female sex hormone that maintain part of the vagina.
the reproductive cycle. Secretions from both of these glands help to lubricate
the external genitalia during coitus.
A. EXTERNAL STRUCTURES The alkaline pH of their secretions helps to improve
1. Mons Veneris - is a pad of adipose tissue sperm survival in the vagina.
located over the symphysis pubis, the pubic 8. Fourchette is the ridge of tissue formed by the
bone joint. It is covered by a triangle of coarse, posterior joining of the two labia minora and the labia
curly hairs. The purpose of the mons veneris is majora. This is the structure that is sometimes cut
to protect the junction of the pubic bone from (episiotomy) during childbirth to enlarge the vaginal
trauma. opening.
The mons veneris is a fatty pad above the pubic The fourchette is a tissue ridge where the back parts
bone covered with hair that protects the pubic of the inner and outer vaginal lips meet, and it might
bone joint from harm. be cut during childbirth to make the vaginal opening
2. Labia Minora - just posterior to the mons bigger.
veneris spread two hairless folds of connective 9. Hymen is a tough but elastic semicircle of tissue that
tissue, the labia minora. Before menarche, covers the opening to the vagina in childhood. It is
these folds are fairly small; by childbearing age, often torn during the time of first sexual intercourse.
they are firm and full; after menopause, they However, because of the use of tampons and active
atrophy and again become much smaller. sports participation, many girls who have not had
Behind the pubic mound, there are two smooth sexual relations do not have intact hymens at the time
folds of tissue called the labia minora, which are of their first pelvic examination.
small before a girl's first period, become larger The hymen is a stretchy piece of tissue that partly
during adulthood and pregnancy, and get covers the vagina's opening in the beginning, and it
smaller again after menopause. usually breaks during the first time someone has sex;
3. Labia Majora - are two folds of adipose tissue but sometimes, due to activities like using tampons or
covered by loose connective tissue and playing sports, the hymen can be broken before
epithelium that are positioned lateral to the labia having sex.
minora. Covered by pubic hair, the labia majora
serve as protection for the external genitalia and
the distal urethra and vagina.
The labia majora are two soft folds of skin with
fat underneath that are on the sides of the
smaller labia, and they have hair on them; they
help protect the
private parts and the openings of the urethra
and vagina.
4. Vestibule - is the flattened, smooth surface
inside the labia. The openings to the bladder
(the urethra) and the uterus (the vagina) both
arise from the vestibule
The vestibule is a flat, smooth area between the
labia, where the openings to the bladder
(urethra) and the uterus (vagina) are located.
B. INTERNAL STRUCTURES
5. Clitoris - is a small (approximately 1 to 2 cm),
1. Ovaries - are approximately 4 cm long by 2 cm in
rounded organ of erectile tissue at the forward
diameter and approximately 1.5 cm thick, or the size
junction of the labia minora. It is covered by a
and shape of almonds. They are grayish white and
fold of skin, the prepuce.The clitoris is sensitive
appear pitted, or with minute indentations on the
to touch and temperature and is the center of
surface.
sexual arousal and orgasm in a woman.
Ovaries are the two small organs in a girl's body that
The clitoris is a small, sensitive organ located at
make eggs and release hormones important for her
the front of the vaginal opening, covered by a
growth and development.
piece of skin; it plays a big role in women's
The function of the two ovaries (the female gonads) is
sexual feelings and pleasure.
to produce, mature, and discharge ova (the egg cells).
6. Skene’s glands (paraurethral glands) are
In the process, the ovaries produce estrogen and
located just lateral to the urinary meatus, one on
progesterone and initiate and regulate menstrual
each side. Their ducts open into the urethra.
cycles.
10
Ovarian function, therefore, is necessary for Isthmus
maturation and maintenance of secondary sex next distal portion
characteristics in females. 2 cm in length
At birth, each ovary contains approximately 2 this portion is cut and sealed in
million immature ova (oocytes), which were ubal ligation
formed during the first 5 months of intrauterine Ampulla
life. Longest portion
By age 7 years, only approximately 500,000 are 5 cm length
present in each ovary; by 22 years, there are Fertilization of ovum occurs4
approximately 300,000; and by menopause, Infundibular
none are left (all have either matured or Most distal segment
atrophied). 2 cm in length
Ovaries have three principal divisions: Funnel shape
Protective layer of surface epithelium The rim of the funnel is covered by fimbriae or small
Cortex, where the immature (primordial) hairs that
oocytes mature into ova and large amounts of Help to guide the ovum into the fallopian tube .
estrogen and progesterone are produced
Central medulla, which contains the nerves, The wall of the fallopian tube is made up of
blood vessels, lymphatic tissue, and some 4 layers :
smooth muscle tissue Peritoneal (serous) – covers the tubes.
2. Fallopian Tubes - arise from each upper corner Subserous ( adventitial ) – contains the blood and nerve
of the uterine body and extend outward and supply
backward until each opens at its distal end, next Muscular - responsible for the peristaltic movement of the
to an ovary. Fallopian tubes are approximately tube.
10 cm long in a mature woman. Their function is Mucosal – composed of ciliated and unciliated cells with
to convey the ovum from the ovaries to the the number of ciliated cells more abundant at the fimbria.
uterus and to provide a place for fertilization of
the ovum by sperm. The most proximal division, 3. Uterus - is a hollow, muscular, pear-shaped organ
the interstitial portion, is that part of the tube that located in the lower pelvis, posterior to the bladder
lies within the uterine wall. This portion is only and anterior to the rectum. During childhood, it is
about 1 cm in length; the lumen of the tube is approximately the size of an olive. An adolescent is
only 1 mm in diameter at this point. The isthmus closer to 17 years old before the uterus reaches its
is the next distal portion. It is approximately 2 adult size. With maturity, a uterus is approximately 5
cm in length and like the interstitial tube, is to 7 cm long, 5 cm wide, and, in its widest upper part,
extremely narrow. This is the portion of the tube 2.5 cm deep. In a nonpregnant state, it weighs
that is cut or sealed in a tubal ligation, or tubal approximately 60 g.
sterilization procedure. The ampulla is the third The function of the uterus is to receive the ovum from
and also the longest portion of the tube. It is the fallopian tube; provide a place for implantation
approximately 5 cm in length. It is in this portion and nourishment; furnish protection to a growing fetus;
that fertilization of an ovum usually occurs. The and, at maturity of the fetus, expel it from a woman’s
infundibular portion is the most distal segment body.
of the tube. It is approximately 2 cm long and is Anatomically, the uterus consists of three divisions:
funnel shaped. The rim of the funnel is covered a. The body of the uterus is the uppermost part and
by fimbria (small hairs) that help to guide the forms the bulk of the organ. During pregnancy, the
ovum into the fallopian tube body of the uterus is the portion of the structure that
Fallopian tubes are like pathways that come expands to contain the growing fetus. The portion of
from the upper corners of the uterus, and they the uterus between the points of attachment of the
carry eggs from the ovaries to the uterus, where fallopian tubes is termed the fundus.
fertilization can happen; they have different b. The isthmus of the uterus is a short segment
parts, and the one closest to the uterus is very between the body and the cervix. In the nonpregnant
tiny, while the one where fertilization usually uterus, it is only 1 to 2 mm in length. It is the portion of
happens is longer, and the end is shaped like a the uterus that is most commonly cut when a fetus is
funnel with little hairs that help guide the egg born by a cesarean birth.
inside. c. The cervix is the lowest portion of the uterus. It
represents approximately one third of the total uterus
PARTS OF THE FALLOPIAN TUBE size and is approximately 2 to 5 cm long. The opening
Interstital portion of the canal at the junction of the cervix and isthmus is
lies within the uterine wall the internal cervical os; the distal opening to the
approximately 1 cm in length lumen is 1 mm in vagina is the external cervical os. The level of the
the diameter external os is at the level of the ischial spines (an
important relationship in estimating the level of the
fetus in the birth canal).
11
LAYERS OF THE UTERUS nipples is darkly pigmented out to approximately 4 cm
Perimetrium – a part of visceral peritoneum and is termed the areola. The area appears rough on
Myometrium – bulk of uterus – three layers of the surface because it contains many sebaceous
muscle that contract under influence of oxytocin glands, called Montgomery’s tubercles.
during labor. Breasts start forming before birth, but they really grow
Endometrium – highly vascular mucosa bigger during puberty because of hormones like
Stratum functionalis – shed during estrogen, and they're important for feeding babies.
menstruation They have milk glands that make milk in small
Stratum basalis – deeper, permanent layer, sections, and the nipple can get bigger and send
gives rise to new stratum functionalis messages to release milk when a baby sucks. The
darker skin around the nipple is called the areola and
has tiny bumps called Montgomery's tubercles.
GYNECOMASTIA
14
OVARIAN CYCLE
1. The Follicular Phase: Days 1 through 13 • Change in vaginal mucus
• In response to follicle stimulating hormone (FSH) • Goodel’s sign
released from the pituitary gland in the brain, • Mood changes
ultimately one egg matures. • Breast tenderness
2. Ovulation: Day 14 • Increased levels of Progesterone
• At about day 14, in response to a surge of • Change in basal body temperature
luteinizing hormone, the egg is released from the
ovary.
• The egg travels through the fallopian tube toward ANTEPARTAL PERIOD
the uterus.
3. The Luteal Phase: Days 14 through 28 Ovum – from ovulation to fertilization
• The remains of the follicle become the corpus Zygote – from fertilization to
luteum which releases progesterone implantation
Embryo – from implantation to 5-8
UTERINE CYCLE weeks
Fetus – from 5-8 weeks until term
1. Proliferative Phase: Days 5 -14 Conceptus – Developing embryo or
• The uterine lining increases rapidly in thickness, fetus
and the uterine glands proliferate and grow. And placental structure throughout
2. Secretory Phase: Days 14 through 28 pregnancy
• When an egg is not fertilized, the corpus luteum
gradually disappears, estrogen and progesterone
levels drop, and the thickened uterine lining is shed.
This is menses (your period). PROCESS OF FERTILIZATION
IMPLANTATION
18
Common Chromosomal Disorders Resulting In responsibility between parents to determine and achieve
Physical Or Cognitive Developmental Disorders the desired number and timing of their children according
to their own aspirations. (RA 10354 Section 4v).These
1. Trisomy 13 Syndrome - also called Patau principles are based on the four (4) pillars of Responsible
syndrome, is a chromosomal condition associated Parenthood, Respect for Life, Birth Spacing, and
with severe intellectual disability and physical Informed Choice. Health services, including
abnormalities in many parts of the body. Reproductive Health services, are devolved by the Local
2. Trisomy 18 Syndrome - also called Edwards Government Code to the local government units
syndrome, is a chromosomal condition associated (Philippine Commission on Women, 2021).
with abnormalities in many parts of the body. Reproductive life planning includes all the decisions
Individuals with trisomy 18 often have slow growth an individual or couple make about whether and when to
before birth (intrauterine growth retardation) and a have children, how many children to have, and how they
low birth weight. are spaced.
3. Cri-du-Chat Syndrome- also known as 5p- Health teaching is necessary because some couples
syndrome and cat cry syndrome - is a rare genetic want counseling about how to avoid conception. Others
condition that is caused by the deletion (a missing need information on increasing fertility and their ability to
piece) of genetic material on the small arm (the p conceive. Others need counseling because contraception
arm) of chromosome 5. has failed. It is important for the health of children that as
4. Turner Syndrome - is a chromosomal condition many pregnancies as possible be intended, because when
related to the X chromosome that alters a pregnancy is unintended or mistimed, both short-term
development in females, though it is not usually and long-term consequences can result such as a woman
inherited in families. being less likely to seek prenatal care, being less likely to
5. Klinefeiter Syndrome - also known as the XXY breastfeed, and possibly being less careful to protect her
condition, is a term used to describe males who have fetus from harmful substances.
an extra X chromosome in most of their cells. A disproportionate share of women who bear
6. Fragile X Syndrome (FXS) is a genetic disorder children whose conception was unintended are unmarried;
characterized by mild-to-moderate intellectual such women are less apt to complete high school or
disability. college and more likely to require public assistance and to
7. Down Syndrome- (sometimes referred to as live in poverty than are their peers who are not mothers.
"Down's syndrome") or trisomy 21 is a common The child of such a pregnancy is at greater risk of low
genetic disorder that occurs when a person has birth weight, dying in the first year, being abused, and not
three copies of chromosome 21. receiving sufficient resources for healthy development
20
Cervical Mucus Changes: The cervix woman's urine. LH levels increase 12 to 24 hours before
produces mucus that changes throughout the ovulation.
menstrual cycle. Before ovulation, this mucus is These kits are really good at predicting ovulation, with
thick and doesn't stretch much when touched. an accuracy rate of 98% to 100%. While they can be a bit
Ovulation Approaches: As ovulation gets pricey, they're a convenient alternative to other methods
closer, the amount of mucus increases. On the like checking cervical mucus. Many women prefer using
day of ovulation (peak day), the mucus these kits, and some even combine them with cervical
becomes abundant, thin, watery, and clear. It mucus checks to improve accuracy. Overall, it's a popular
feels slippery and can stretch at least an inch choice for couples practicing natural family planning to
before breaking (called spinnbarkeit). help them know when it's more or less likely for the woman
Fertile Days: Any day with abundant cervical to get pregnant.
mucus and for at least one day afterward is
considered fertile. To prevent pregnancy, a LACTATION AMENORRHEA METHOD
woman should avoid having sex on these days. When a woman is
Consistency Matters: This method requires breastfeeding her
careful monitoring of daily vaginal secretions. baby, her body
It's not reliable to rely on how the mucus feels naturally reduces
after sex because seminal fluid can be similar to the chances of
ovulatory mucus. releasing an egg
(ovulation), which
SYMPTOTHERMAL METHOD can make it less
The symptothermal method of birth control likely for her to get
combines the cervical mucus and BBT methods. pregnant again
The woman takes her temperature daily, soon after giving
watching for the rise in temperature that marks birth. However, it's important to know that even
ovulation. She also analyzes her cervical mucus though she might not have her regular monthly period
every day and observes for other signs of while breastfeeding, she can still become fertile (able
ovulation such as mittelschmertz (midcycle to have a baby) because her body may release an
abdominal pain). The couple must abstain from egg without her noticing it.
intercourse until 3 days after the rise in If the baby is also getting other types of food or is not
temperature or the fourth day after the peak of breastfeeding very often, the effectiveness of
mucus change, because these are the woman’s breastfeeding as a birth control method becomes
fertile days. The symptothermal method is more uncertain. In such cases, it's important for the woman
effective than either the BBT or the cervical to consider using another form of birth control if she
mucus method alone (ideal failure rate, about wants to prevent pregnancy.
2%). As a rule, after 3 months of breastfeeding, the woman
Basal Body Temperature (BBT): The woman should be advised to choose another method of
takes her temperature every morning to notice a contraception (Burkman, 2007).
slight increase, which indicates ovulation (when
an egg is released). COITUS INTERRUPTUS
Cervical Mucus: She also observes changes in Coitus interruptus is an old method of contraception
the mucus from her cervix. As she gets closer to where a couple has sexual intercourse, but the man
ovulation, the mucus becomes clear, slippery, pulls out before ejaculation to prevent sperm from
and stretchy. entering the woman's vagina. However, this method is
By using both methods together, the couple can not very reliable because sometimes ejaculation
determine their fertile days, which are the days when happens too quickly or small amounts of sperm can
pregnancy is most likely. To prevent pregnancy, they be present in pre-ejaculation fluid, leading to a risk of
should avoid having intercourse on these fertile days pregnancy. It's only about 75% effective in preventing
and wait until a few days after the temperature rise or pregnancy.
the peak in cervical mucus changes.
POSTCOITAL DOUCHING
OVULATION DETECTION Douching after sex, using any type of solution, is not an
This method effective way to prevent pregnancy. This is because sperm
uses an can reach the cervix (the entrance to the uterus) very
over-the-counter quickly, sometimes as fast as 90 seconds after ejaculation.
kit to help predict Douching won't remove the sperm fast enough to
when a woman is prevent pregnancy, so it's not a reliable method of
most likely to contraception. If someone wants to prevent pregnancy,
ovulate (release they should use a more proven and effective contraceptive
an egg from her method, like condoms or birth control pills, as advised by a
ovaries). The kit healthcare professional.
detects a
hormone called luteinizing hormone (LH) in a
21
HORMONAL CONTRACEPTION Beginning pills as soon as they are prescribed this
Hormonal contraceptives are medications that way (a Quick Start system) rather than have to wait
contain hormones. These hormones are designed to for a set day may increase compliance.
prevent a woman from releasing an egg (ovulation) After childbirth, a woman should start the
during her menstrual cycle. When you don't release contraceptive on the Sunday closest to 2 weeks after
an egg, it's much harder to get pregnant. These birth; after an elective termination of pregnancy, she
contraceptives can be taken in different forms, like should start on the first Sunday after the procedure.
pills, patches, vaginal rings, implants under the skin, Because COCs are not effective for the first 7 days,
or injections. They all work by controlling the advise women to use a second form of contraception
hormones in your body to stop ovulation and help during the initial 7 days on which they take pills.
prevent pregnancy A woman prescribed a 21-day cycle brand takes a pill
at the same time every day for 21 days. Pill taking by
ORAL ROUTE this regimen will end on a Saturday. The woman
Oral contraceptives, commonly known as the would then not take any pills for 1 week. She would
pill, OCs (for oral contraceptive), or COCs (for restart a new month’s supply of pills on the Sunday 1
combination oral contraceptives), are composed week after she stopped. A menstrual flow will begin
of varying amounts of synthetic estrogen about 4 days after the woman finishes a cycle of pills.
combined with a small amount of synthetic To eliminate having to count days between pill cycles,
progesterone (progestin). most brands of OCs are packaged with 28 pills—21
The estrogen acts to suppress follicle active pills and 7 placebo pills. With these brands, a
stimulating hormone (FSH) and LH, thereby woman starts a second dispenser of pills the day after
suppressing ovulation. The progesterone action finishing the first dispenser. There is no need to skip
complements that of estrogen by causing a days because of the placebo tablets. Menstrual flow
decrease in the permeability of cervical mucus, will begin during the 7 days on which she is taking the
thereby limiting sperm motility and access to placebo tablets.
ova. Progesterone also interferes with tubal For ovulation suppressants to be effective, women
transport and endometrial proliferation to such must take them consistently and conscientiously.
degrees that the possibility of implantation is Women who have difficulty remembering to take a
significantly decreased. contraceptive in the morning may find it easier to take
COCs must be prescribed by a physician, nurse a daily pill at bedtime or with a meal (the time of day
practitioner, or nurse-midwife after a pelvic makes no difference; it is the consistency that is
examination and a Papanicolaou (Pap) smear. important) (Box 6.5). Also, some women find that
When used correctly, they are 99.7% effective taking pills at bedtime rather than in the morning
in preventing conception. Women who forget to eliminates any nausea they otherwise experience.
take them as scheduled, however, experience a
failure rate of 95%. SIDE EFFECTS AND CONTRAINDICATIONS
Oral contraceptives have non-contraceptive Nausea
benefits such as decreased incidences of: Weight gain
Dysmenorrhea, because of lack of ovulation Headache
Premenstrual dysphoric syndrome and acne, Breast tenderness
because of the increased progesterone levels Breakthrough bleeding (spotting outside the
Iron deficiency anemia, because of the reduced menstrual period)
amount of menstrual flow Monilial vaginal infections
Acute pelvic inflammatory disease (PID) and the Mild hypertension
resulting tubal scarring Depression
Endometrial and ovarian cancer, ovarian cysts, COCs are not routinely prescribed for women with a
and ectopic pregnancies history of thromboembolic disease or a family history
Fibrocystic breast disease of cerebral or cardiovascular accident, who are over
Possibly osteoporosis, endometriosis, uterine 40 years of age, or who smoke because of the
myomata (fibroid uterine tumors), and increased tendency toward clotting as an effect of
progression of rheumatoid arthritis increased estrogen.
Colon cancer COCs can interfere with glucose metabolism. For this
COCs are reason, women with diabetes mellitus or a history of
packaged with liver disease, including hepatitis, are evaluated
21 or 28 pills individually before COCs are prescribed.
in a convenient COCs may interact with several drugs such as
dispenser. It is acetaminophen, anticoagulants, and some
generally anticonvulsants, reducing their therapeutic effect so
recommended women may be advised to temporarily change their
that the first pill method of birth control while prescribed these drugs.
be taken on a Sunday (the first Sunday after
the beginning of a menstrual flow), although a
woman may choose to begin on any day.
22
MINI-PILLS patch falls off, take it off and put on a new one right
Mini-pills are a away. If it was off for less than 24 hours, you don't
type of birth need extra birth control..
control pill that
contains only a VAGINAL INSERTION
hormone called The NuvaRing is a small
progestin. They silicone ring that a woman
work by inserts into her vagina. It
thickening the releases two hormones,
mucus in the estrogen and
cervix, which progesterone, slowly over
makes it harder for sperm to reach the uterus. three weeks. After three
While it's possible for ovulation to happen with weeks, she takes it out for
mini-pills, they also prevent the uterine lining one week. This is when she has her period. The
from fully developing, so a fertilized egg can't hormones are absorbed through the vaginal lining. It's
implant and result in pregnancy. a birth control method that helps prevent pregnancy.
However, mini-pills have a drawback of causing Fertility returns immediately after discontinuing using
more irregular bleeding than combination pills, the ring. Women may need to make out a calendar
which contain both progestin and estrogen. You that they post conspicuously to remind themselves to
have to take mini-pills every day, even during remove and replace the ring. Implantation
your period. The good thing is that they don't Five subdermal implants, rods the size of pencil lead
interfere with breastfeeding, so you can use are embedded just under the skin on the inside of the
them if you're nursing your baby. upper arm.
These rod-shaped implants contain a hormone called
EFFECT ON PREGNANCY etonogestrel, which is related to another hormone
If a woman is taking a birth control pill that called desogestrel used in the NuvaRing. When these
contains both estrogen and progestin and she thinks implants are put under the skin, they slowly release
she might be pregnant but wants to continue the this hormone over 3 to 5 years. This hormone
pregnancy, she should stop taking the pills. This is prevents pregnancy by stopping the release of eggs,
because having too much estrogen or progestin in thickening the cervical mucus, and making it hard for
the body during early pregnancy could potentially a fertilized egg to attach to the uterus.
harm the developing baby. So, it's a good idea to The implants are inserted with some numbing
stop the pills if she plans to have the baby. medicine. It's done either during a woman's period or
within the first week of her menstrual cycle to make
TRANSDERMAL ROUTE sure she's not already pregnant. They can also be put
Transdermal in shortly after an abortion or six weeks after giving
contraception is a birth. They are very effective, with a failure rate of less
birth control than 1%.
method that uses One big advantage of these implants is that they
patches to slowly eliminate the need to remember to take a daily birth
release hormones control pill. They are also a good option for women
(estrogen and who can't use birth control methods with estrogen, as
progesterone) into they don't contain estrogen. Unlike some other birth
the body. These control methods, they don't interfere with sexual
patches are applied to the skin once a week for enjoyment, and they can even be used while
three weeks. Then, during the fourth week, no breastfeeding without affecting milk production.
patch is used, and this is when a woman A disadvantage of the implant method is its cost ($500
typically has her period. After the patch-free on average) and side effects such as:
week, the cycle starts again with three weeks of Weight gain
patch use followed by one week without a patch. Irregular menstrual cycle such as spotting,
This method is as effective as birth control pills breakthrough bleeding, amenorrhea, or prolonged
for most women but may be slightly less periods
effective for women who weigh more than 90 kg Depression
(198 lb). Scarring at the insertion site
Patches can be put on four places: the upper Need for removal Injection
outer arm, upper torso (front or back, but not on A single intramuscular injection of
the breasts), abdomen (belly), or buttocks. Don't medroxyprogesterone acetate (DepoProvera [DMPA]),
place them where you'll use makeup, lotions, or a progesterone, given every 12 weeks inhibits
creams, or at the waist where they might come ovulation, alters the endometrium, and changes the
off when you bend. Also, avoid areas with red or cervical mucus (Box 6.8). The effectiveness rate of
irritated skin or any open sores. this method is almost 100%, making it an increasingly
You can wear contraceptive patches in the popular contraceptive method (Chrousos, 2008). Do
shower, while bathing, or while swimming. If a not massage the injection site after administration as
23
you want the drug to absorb slowly from the collapsed position, then enlarged to its final shape in
muscle. Because DepoProvera contains only the uterus when the inserter is withdrawn. The woman
progesterone, it can be used during may feel a sharp cramp as the device is passed
breastfeeding. through the internal cervical os, but she will not feel
Advantageous effects are reduction in ectopic the IUD after it is in place. Properly fitted, such
pregnancy, endometrial cancer, endometriosis, devices are contained wholly within the uterus,
and, for unknown reasons, reduction in the although the attached string protrudes through the
frequency of sickle cell crises (Burkman, 2007). cervix into the vagina.
Potential side effects are similar to those of IUDs have several advantages over other
subdermal implants: irregular menstrual cycle, contraceptives.
headache, weight gain, and depression. Only one insertion is necessary, so there is no
Depo-Provera may impair glucose tolerance in continuing expense.
women at risk for diabetes. Because there also The device does not require daily attention or interfere
may be an increase in the risk for osteoporosis with sexual enjoyment.
from loss of bone mineral density, advise It is appropriate for women who are at risk for
women to include an adequate amount of complications associated with COCs or who wish to
calcium in their diet (up to 1200 mg/day) and to avoid some of the systemic hormonal side effects.
engage in weight-bearing exercise daily to They may create lighter or fewer periods.
minimize this risk, rules that are good for all Teach women to regularly check after each menstrual
women. flow, to make sure the IUD string is in place, and to
Two disadvantages are that a woman must obtain a yearly pelvic examination.
return to a health care provider for a new
injection every 4 to 12 weeks for the method to SIDE EFFECTS AND CONTRAINDICATIONS
remain reliable, and the return to fertility is often A woman may notice some spotting or uterine
delayed by 6 to 12 months. cramping the first 2 or 3 weeks after IUD insertion; as
long as this is present, she should use an additional
INTRAUTERINE DEVICES form of contraception, such as vaginal foam.
An intrauterine device (IUD) Occasionally, a woman continues to have cramping
is a small plastic object that is and spotting after insertion; in such instances, she is
inserted into the uterus likely to expel the device spontaneously. Women with
through the vagina IUDs in place should take active steps to avoid toxic
(Postlethwaite et al., 2007). shock syndrome (TSS; a staphylococcal infection
IUDs became popular as a from the use of tampons), because infection might
method of birth control in the 1980s, and although travel by the IUD string into the uterus to cause
still a popular choice worldwide, IUDs are used by uterine infection.
only a small number of U.S. women. Few IUDs are not recommended for women with an
manufacturers continue to provide them since increased risk of contracting STIs, such as those who
several lawsuits were filed in association with the have multiple sexual partners, because this
increased incidence of pelvic inflammatory disease combination could lead to pelvic infection.
(PID) in women using one particular brand, now no They also are not recommended for women who have
longer available. never been pregnant (their small uterus could be
Today, the IUD is thought to prevent fertilization punctured with insertion) or who have a history of
as well as creating a local sterile inflammatory having had PID. If PID is suspected, the device
condition that prevents implantation. When should be removed and the woman should receive
copper is added to the device, sperm mobility antibiotic therapy to treat the infection.
appears to be affected as well. This decreases IUDs are also contraindicated in the woman whose
the possibility that sperm will successfully cross uterus is distorted in shape (the device might
the uterine space and reach the ovum. perforate an abnormally shaped uterus).
An IUD must be fitted by a physician, nurse They are not advised for women with severe
practitioner, or nurse-midwife, who first dysmenorrhea (painful menstruation), menorrhagia
performs a Pap test and pelvic examination. (bleeding between menstrual periods), or a history of
The device is inserted before a woman has had ectopic (tubal) pregnancy, because their use may
coitus after a menstrual flow, so the health care increase the symptoms or incidence of these
provider can be assured that the woman is not conditions.
pregnant at the time of insertion. Women with valvular heart disease may be advised
The insertion against the use of an IUD because the increased risk
procedure is of PID could lead to accompanying valve involvement
performed in an from bacterial endocarditis.
ambulatory setting
such as a
physician’s office or
a reproductive
planning clinic. The device is inserted in a
24
EFFECT ON PREGNANCY
If a woman with an IUD in place suspects that
she is pregnant, she should alert her primary health
care provider. Although the IUD may be left in place
during the pregnancy, it is usually removed vaginally
to prevent the possibility of infection or spontaneous
miscarriage during the pregnancy. The woman
should receive an early ultrasound to document
placement of the IUD. This can also rule out ectopic
pregnancy, which has an increased incidence
among IUD users who become pregnant with the
IUD in place. SIDE EFFECTS AND CONTRAINDICATIONS
Vaginally inserted spermicidal products are
BARRIER METHODS contraindicated in women with acute cervicitis, because
Barrier methods are forms of birth control that they might further irritate the cervix. They are generally
work by the placement of a chemical or other barrier inappropriate for couples who must prevent conception
between the cervix and advancing sperm so that (perhaps because the woman is taking a drug that would
sperm cannot enter the uterus or fallopian tubes and be harmful to a fetus or the couple absolutely does not
fertilize the ovum. A major advantage of barrier want the responsibility of children), because the overall
methods is that they lack the hormonal side effects failure rate of all forms of these products is about 20%.
associated with COCs. However, compared with Some women find the vaginal leakage after use of these
COCs, their failure rates are higher and sexual products bothersome. Vaginal suppositories, because of
enjoyment may be lessened. the cocoa butter or glycerin base, are the most
bothersome in this regard.
1. CHEMICAL BARRIERS
A spermicide is an agent that causes the death 2. MECHANICAL BARRIERS
of spermatozoa before they can enter the cervix. Mechanical barriers,
Such agents are not only actively spermicidal such as a diaphragm, work
but also change the vaginal pH to a strong acid by blocking the entrance of
level, a condition not conducive to sperm sperm into the cervix.
survival. They do not protect against STIs. A diaphragm is a circular
In addition to the general benefits for barrier rubber disk that is placed
contraceptives, the advantages of spermicides over the cervix before
include: intercourse. A Lea’s Shield,
They may be purchased without a prescription made of silicone rubber and bowl shaped, is a new design.
or an appointment with a health care provider, Although use of a spermicide is not required for
so they allow for greater independence and diaphragms, use of a spermicidal gel with a diaphragm
lower costs. combines a barrier and a chemical method of
When used in conjunction with another contraception. With this, the failure rate of the diaphragm
contraceptive, they increase the other method’s is as low as 6% (ideal) to 16% (typical use).
effectiveness. A diaphragm is prescribed and fitted initially by a
Various preparations are available, including physician, nurse practitioner, or nurse-midwife to
gels, creams, sponges, films, foams, and ensure a correct fit. Because the shape of a woman’s
suppositories. cervix changes with pregnancy, miscarriage, cervical
Another form of spermicidal protection is a film surgery (dilatation and curettage [D&C]), or elective
of glycerin impregnated with a spermicidal termination of pregnancy, teach
agent that is folded and inserted vaginally. On women to return for a second
contact with vaginal secretions or precoital fitting if any of these
penile emissions, the film dissolves and a circumstances occur. A woman
carbon dioxide foam forms to protect the cervix should also have the fit of the
against invading spermatozoa. diaphragm checked if she gains
Sponges are foam-impregnated synthetic or loses more than 15 lb,
sponges that are moistened to activate the because this could also change
impregnated spermicide and then inserted her pelvic and vaginal contours.
vaginally to block sperm access to the cervix. A diaphragm is inserted into the
Well liked by most users, they are easy to insert vagina, after first coating the rim
and have an efficiency rate of 80% (ideal) and a and center portion with a
typical use failure rate of about 60% spermicide gel, by sliding it
(Cunningham et al., 2008). They should remain along the posterior wall and pressing it up against the
in place for 6 hours after intercourse to ensure cervix so that it is held in place by the vaginal fornices.
sperm destruction. A woman should check her diaphragm with a finger
after insertion to be certain that it is fitted well up over
25
the cervix; she can palpate the cervical os A history of cervical cancer
through the diaphragm. An undiagnosed vaginal bleeding
A diaphragm should remain in place for at least A condom is a latex
6 hours after coitus, because spermatozoa rubber or synthetic sheath
remain viable in the vagina for that length of that is placed over the
time. It may be left in place for as long as 24 erect penis before coitus
hours. If it is left in the vagina longer than this, to trap sperm. Condoms
the stasis of fluid may cause cervical have an ideal failure rate
inflammation (erosion) or urethral irritation. of 2% and a typical failure
After use, a diaphragm should be washed in rate of about 15%, because breakage or spillage
mild soap and water, dried gently, and stored in occurs in up to 15% of uses (Kaplan & Love-Osborne,
its protective case. With this care, a diaphragm 2007).
will last for 2 to 3 years. A major advantage of condoms is that they are one of
the few “male responsibility” birth control measures
SIDE EFFECTS AND CONTRAINDICATIONS available, and no health care visit or prescription is
Diaphragms may not be effective if the uterus is needed. Latex condoms have the additional potential
prolapsed, retroflexed, or anteflexed to such a of preventing the spread of STIs, and their use has
degree that the cervix is also displaced in relation to become a major part of the fight to prevent infection
the vagina. Intrusion on the vagina by a cystocele or with human immunodeficiency virus (HIV).
rectocele, in which the walls of the vagina are Recommend them for any partners who do not
displaced by bladder or bowel, may make insertion maintain a monogamous relationship.
of a diaphragm difficult. Users of diaphragms may To be effective, condoms must be applied before any
experience a higher number of urinary tract penilevulvar contact, because even preejaculation
infections (UTIs) than nonusers, probably because of fluid may contain some sperm. A condom should be
pressure on the urethra. positioned so that it is loose enough at the penis tip to
Other contraindications include: collect the ejaculate without placing undue pressure
History of toxic shock syndrome (TSS; on the condom. The penis (with the condom held
staphylococcal infection introduced through the carefully in place) must be withdrawn before it begins
vagina) to become flaccid after ejaculation. If it is not
Allergy to rubber or spermicides withdrawn at this time, sperm may leak from the now
History of recurrent UTIs loosely
A cervical cap is yet fitting sheath into the vagina.
another barrier method of Some men find that condoms
contraception. Caps are dull their enjoyment of coitus;
made of soft rubber, are Condoms for females are latex
shaped like a thimble with a sheaths made of polyurethane
thin rim, and fit snugly over and prelubricated with a
the uterine cervix. The spermicide. The inner ring (closed end) covers the
failure rate is estimated to cervix, and the outer ring (open end) rests against the
be as high as 26% (ideal) to 32% (typical use). vaginal opening. The sheath may be inserted any
The precautions for use are the same as for time before sexual activity begins and then removed
diaphragm use except they can be kept in place after ejaculation occurs. Like male condoms, they are
longer. intended for one-time use and offer protection against
Many women cannot use cervical caps because both conception and STIs
their cervix is too short for the cap to fit properly. Male and female
Also, caps tend to dislodge more readily than condoms should not be
diaphragms during coitus. An advantage is that used together. The failure
cervical caps can remain in place longer than rate is somewhat greater
diaphragms, because they do not put pressure than the failure rate for
on the vaginal walls or urethra; however, this male condoms, 12% to
time period should not exceed 48 hours, to 22%. Most failures occur because of incorrect or
prevent cervical irritation. Cervical caps, like inconsistent use.
diaphragms, must be fitted individually by a
health care provider. SURGICAL METHODS OF REPRODUCTIVE
LIFE PLANNING
They are contraindicated in any woman who Surgical methods of reproductive life planning, often
has: called sterilization, include tubal ligation for women and
An abnormally short or long cervix vasectomy for men. Tubal ligation is chosen by about
A previous abnormal Pap smear 28% of all women in the United States of childbearing age
A history of TSS as their contraceptive of choice. Vasectomy is the
An allergy to latex or spermicide contraceptive method of choice for about 11% of men,
A history of pelvic inflammatory disease, making these two procedures the most frequently used
cervicitis, or papillomavirus infection
26
methods of contraception in the United States for for the future can have it stored in a sperm bank
couples older than 30 years of age. before vasectomy.
Counseling should be especially intensive for Tubal ligation, where the fallopian tubes are occluded
men and women by cautery, crushing, clamping, or blocking, thereby
younger than 25 years of preventing passage of both sperm and ova. A
age, because the fimbriectomy, or removal of the fimbria at the distal
possibility of divorce, end of the tubes, is another possible but little used
death of a sexual partner, technique. Tubal ligation has a 99.5% effectiveness
loss of a child, or rate (Cunningham et al., 2008). Although the reason
remarriage could change is not clear, tubal ligation is associated with a
a person’s philosophy decreased incidence of ovarian cancer.
toward childbearing in the future. In addition, The most common operation to achieve tubal ligation
sterilization is not recommended for is laparoscopy. After a menstrual flow and before
individuals whose fertility is important to their ovulation, an incision as small as 1 cm is made just
self-esteem. under the woman’s umbilicus with the woman under
In a vasectomy, a small incision or puncture general or local anesthesia. A lighted laparoscope is
wound is made on each side of the scrotum. inserted through the incision. Carbon dioxide is then
The vas deferens at that point is then located, pumped into the incision to lift the abdominal wall
cut and tied, cauterized, or plugged, blocking upward and out of the line of vision. The surgeon
the passage of spermatozoa. Vasectomy can locates the fallopian tubes by viewing the field through
be done under local anesthesia in an a laparoscope.
ambulatory setting, such as a physician’s office The procedure can also be done by culdoscopy (a
or a reproductive life planning clinic. The man tube inserted through the posterior fornix of the
experiences a small amount of local pain vagina) or colpotomy (incision through the vagina),
afterward, which can be managed by taking a but the incidence of pelvic infection is higher with
mild analgesic and applying ice to the site. these procedures and visualization is less. The
The procedure is 99.5% woman is discharged from the hospital a few hours
effective (MacKay, after the procedure. She may notice abdominal
2009). Spermatozoa bloating for the first 24 hours, until the carbon dioxide
that were present in the infused at the beginning of the procedure is absorbed.
vas deferens at the time This can also cause sharp diaphragmatic or shoulder
of surgery can remain pain if some of the carbon dioxide escapes under the
viable for as long as 6 diaphragm and presses on ascending nerves.
months. Therefore, A woman may return to having coitus as soon as 2 to
although the man can resume sexual 3 days after the procedure. Be certain that they
intercourse within 1 week, an additional birth understand. that tubal ligation, unlike a hysterectomy,
control method should be used until two does not affect the menstrual cycle, so they will still
negative sperm reports have been obtained have a monthly menstrual flow. Be certain that
(proof that all sperm in the vas deferens have women know to have no unprotected coitus before a
been eliminated, usually requiring 10 to 20 tubal ligation (sperm trapped in the tube could fertilize
ejaculations). an ovum there and cause an ectopic pregnancy).
They can be assured that vasectomy does not
interfere with the production of sperm; the FAMILY PLANNING
testes continue to produce sperm as always,
The concept of enhancing the quality of families w/c
but the sperm simply do not pass beyond the
includes:
severed vas deferens
• Regulating & spacing childbirth
and are absorbed at
• Helping subfertile couples beget children
that point. The man will
• Counseling parents and would-be parents
still have full erection
It means it is essentially says that it's the
capacity. Because he
responsibility and choice of a married couple to
also continues to form
decide, with love, when and how many children they
seminal fluid, he will
want to have. However, this decision should have a
ejaculate seminal
good reason behind it and should be made using
fluid—it will just not contain sperm.
ethical methods. It's a personal decision that takes
A few men develop chronic pain after
into account each person's background, experiences,
vasectomy (postvasectomy pain syndrome);
and cultural beliefs. To make this decision, careful
having the procedure reversed relieves this pain.
planning is needed to ensure that the chosen method
Some men develop autoimmunity or form
is suitable and can be used effectively.
antibodies against sperm, so that even if
reconstruction of the vas deferens is successful,
the sperm they produce do not have good
mobility and are incapable of fertilization. Men
who feel a need to have their sperm available
27
FUNCTION OF THE HEALTH PROFESSIONAL • Ogino-knaus formula:
IN FAMILY PLANNING 1. Determine the shortest and longest cycle
To providing support, guidance, and information ex. Shortest cycle = 28 days
to help someone or a couple make their own Longest cycle = 36 days
decisions based on their personal beliefs, values, 2. If the cycle is irregular, subtract 18 from the shortest and
and preferences. It involves offering reassurance 11 from the longest
and letting them choose what they think is best for ex. 28-18=10 ex. 25-18=7
themselves, considering their individual, societal, 36-11=25 29-11=18
and religious beliefs. 3. The difference between the shortest cycle and 18
FAMILY PLANNING SERVICES determines the earliest time when ovulation occur.
4. The difference between the longest cycle and 11
TEMPORARY CONCEPTION CONTROL determines the last day when ovulation can occur
• Methods used to prevent conception 5. OVULATION CAN OCCUR ANYTIME IN BETWEEN.
• Methods used to prevent ovulation 6. In a regular 28 day cycle, abstinence should be
• Methods used to prevent implantation observed from day 9 to day 17. (count 5 days before the
earliest ovulation and 3 days after the last day
STERILIZATION / PERMANENT
CONCEPTION CONTROL
• Tubal Occlusion / Bilateral Tubal Ligation
• Vasectomy or Vas Ligation
WITHDRAWAL
• Removal of penis from the vagina before
ejaculation occurs
• NOT a sufficient method of birth control by itself
• Effectiveness rate is 80% (very unpredictable in
teens, wide variation)
• 1 of 5 women practicing withdrawal become
pregnant
• Very difficult for a male to ‘control’
COITUS RESERVATUS
• Male does not reach orgasm and therefore no
ejaculation occurs
• Requires considerable control over the sexual urge PHASES OF WETNESS / DRYNESS
RHYTHMIC ABSTINENCE 1. Wet – menstruation
• Identification of the periods of fertility and the 2. Dry – basic infertile pattern
periods of sterility in the menstrual cycle of a woman - sequence of dry days (or days of unchanging mucus)
and the restriction of sexual intercourse to the sterile indicating low level of estrogen and present infertility
periods or the time when the pregnancy is unlikely - duration is invariable, could be days, weeks,months
because the woman is biologically unprepared to or zero (if cycle is short)
conceive.
• Also known as “safe or infertile period” technique 1. Wet – days of possible fertility
and “natural birth control” or NFP because there is - changing mucus; non-slippery at first later becoming
nothing artificial used to prevent conception. slippery
• These methods are based on the ff. principles: - peak: last day of slippery mucus
• The human ovum is susceptible to fertilization for - days 1-3 after the peak are part of fertile period
approx. 18-24 hours after ovulation 2. Dry – infertile days
• The sperms deposited in the vagina are - day 4 after the peak till the end of the cycle
ordinarily capable of fertilizing the ovum for no more - ends about 2 weeks after the peak
than 72 hours
• Present methods of determining ovulation time EMERGENCY CONTRACEPTION (ECP)
are inexact and seldom sufficiently predictive (by at Emergency contraception pills can reduce the chance
least 48 hours) so that in practice, it is necessary to of a pregnancy by 75% if taken within 72 hours of
avoid intercourse for a far longer period of time than unprotected sex!
72 hours before ovulation and 24 hours after • Must be taken within 72 hours of the act of unprotected
ovulation intercourse or failure of contraception method
• Must receive ECP from a physician
CALENDAR METHOD • 75 – 84% effective in reducing pregnancy
• The use of mathematical calculations to predict the • Floods the ovaries with high amount of hormone and
probable time of ovulation. “Ovulation most often prevents ovulation
takes place 14 days before the onset of the next • Alters the environment of the uterus, making it disruptive
menstruation.” to the egg and sperm
• Two sets of pills taken exactly 12 hours apart
28
FEMALE CONDOM 1. Decidua basalis, the part of the endometrium that lies
The female condom is a lubricated polyurethane directly under the embryo (or the portion where the
sheath, similar in appearance to a male condom. It is trophoblast cells establish communication with maternal
inserted into the vagina. The closed end covers the blood vessels).
cervix. Like the male condom, it is intended for 2. Decidua capsularis, the portion of the endometrium
one-time use and then discarded. The sponge is that stretches or encapsulates the surface of the
inserted by the woman into the vagina and covers trophoblast
the cervix blocking sperm from entering the cervix. 3. Decidua vera, the remaining portion of the uterine lining.
The sponge also contains a spermicide that kills As the embryo continues to grow, it pushes the decidua
sperm. It is available without a prescription. capsularis before it like a blanket. Eventually, the embryo
enlarges so much that this action brings the decidua
How to use the female condoms capsularis into contact with the opposite uterine wall (the
• Open the Female condom package carefully; tear decidua vera). Here, the two decidua areas fuse, which is
at the notch on the top right of the package. Do not why, at birth, the entire inner surface of the uterus is
use scissors or a knife to open. stripped away, leaving the organ highly susceptible to
• The outer ring covers the area around the opening hemorrhage and infection
of the vagina. The inner ring is used for insertion and
to help hold the sheath in place during Intercourse B. CHORIONIC VILLI
• While holding the Female condom at the closed After implantation, the
end, grasp the flexible inner ring and squeeze it with trophoblastic cells in the
the thumb and second or middle finger so it becomes blastocyst start growing
long and narrow finger-like structures
• Choose a position that is comfortable for called chorionic villi, which
insertion – squat, raise one leg, sit or lie reach into the uterus and
down. eventually become the
• Gently insert the inner ring into the vagina. Feel the placenta, with around 200
inner ring go up and move into place. of these structures forming by the end of pregnancy.
• Place, the index finger on the inside of the condom, Chorionic villi are structures
and push the inner ring up as far as it will go. Be sure in the placenta that contain a
the sheath is not twisted. The outer ring should core of fetal blood vessels
remain on the outside of the vagina. surrounded by two layers of
• To remove the Female condom, twist the outer ring cells, with the outer layer called
and gently pull the condom out. the syncytiotrophoblast, which
• Wrap the condom in the package or in tissue, and produces important hormones for pregnancy.
throw it in the garbage. Do not put it into the toilet. The middle layer of the placenta, called the
cytotrophoblast or Langhans' layer, is present early in
VAGINAL DIAPHRAGM pregnancy and helps protect the growing embryo from
• A shallow,dome-shaped rubber device with a certain infections like syphilis, but it disappears between
flexible wire rim that covers the cervix; maybe the 20th and 24th weeks, so syphilis becomes more
inserted several hours before intercourse and left in harmful to the fetus after this point. However, this layer
place for at least 6 hours after the last intercourse doesn't offer much protection against viral infections
• Initially fitted by a health professional throughout pregnancy.
• Weight loss/gain of 15 lbs may require re-fitting
• Inserted before intercourse with the woman in THE PLACENTA
squatting or supine position, or with one leg elevated The placenta, which
on a chair gets its name from its
• May cause cervicitis if left in place for too long pancake-like shape,
• Washed with mild soap & water, lasts for 2-3 years develops from trophoblast
• 97% efficiency tissue and grows alongside
the fetus, eventually
PRENATAL CARE FOR THE MOTHER becoming a 15 to 20 cm
EMBRYONIC STRUCTURE wide, 2 to 3 cm thick organ
A. THE DECIDUA that covers about half of
After fertilization, a hormone called hCG keeps the inside of the uterus during pregnancy.
the corpus luteum in the ovary active, preventing it
from shrinking. This allows the lining of the uterus to CIRCULATION
keep thickening and preparing for pregnancy instead As early as the 12th day of pregnancy, during the third
of shedding during a regular menstrual cycle. The week of pregnancy, nutrients from the mother's blood start
endometrium is now termed the decidua (the Latin moving into the embryo through tiny structures called
word for “falling off”), because it will be discarded chorionic villi, nourishing the developing baby.
after the birth of the child. Placental osmosis allows most substances, including
The decidua has three separate areas: drugs, to pass from the mother to the fetus, so it's crucial
29
for pregnant women to avoid unnecessary drugs, 3. Progesterone
alcohol, and nicotine to protect the baby's health. Estrogen is often referred to as the “hormone of
During pregnancy, the baby's and mother's blood women”; progesterone as the “hormone of mothers.” This
do not directly mix thanks to osmosis, but tiny breaks is because, although estrogen influences afemale
in the outer chorionic villi layer after the third appearance, progesterone is necessary to maintain the
trimester can occasionally allow fetal cells and endometrial lining of the uterus during pregnancy. It is
enzymes to enter the mother's bloodstream. present in serum as early as the fourth week of pregnancy,
About 100 maternal uterine arteries supply the as a result of the continuation of the corpus luteum. After
mature placenta. To provide enough blood for placental synthesis begins (at about the 12th week), the
exchange, the rate ofuteroplacental blood flow in level of progesterone rises progressively during the
pregnancy increases from about 50 mL/min at 10 remainder of the pregnancy. This hormone also appears to
weeks to 500 to 600 mL/min at term. The woman’s reduce the contractility of the uterus during pregnancy,
heart rate, total cardiac output, and blood volume preventing premature labor.
increase to supply blood to the placent 4. Human Placental Lactogen (Human Chorionic
Lying on the left side during pregnancy helps Somatomammotropin)
blood flow to the placenta by preventing the uterus hPL is a hormone with both growth-promoting and
from pressing on a major blood vessel, which can lactogenic (milk-producing) properties. It is produced by
lead to low blood pressure and poor circulation if the placenta beginning as early as the sixth week of
lying on the back. pregnancy, increasing to a peak level at term. It can be
At term, the placental circulatory network has assayed in both maternal serum and urine. It promotes
grown so extensively that a placenta weighs 400 to mammary gland (breast) growth in preparation for lactation
600 g (1 lb), onesixth the weight of the baby. If a in the mother. It also serves the important role of regulating
placenta is smaller than this, it suggests that maternal glucose, protein, and fat levels so that adequate
circulation to the fetus may have been inadequate. A amounts of these nutrients are always available to the
placenta larger than this may also indicate that fetus (Taylor & Lebovic, 2007).
circulation to the fetus was threatened, because it
suggests that the placenta was forced to spread out 5. Placental Proteins
in an unusual manner to maintain a sufficient blood The placenta also produces several plasma proteins.
supply. The fetus of a woman with diabetes may also The function of these has not been well documented, but it
develop a larger-than-usual placenta from excess is thought that they may contribute to decreasing the
fluid collected between cells. immunologic impact of the growing placenta through being
part of the complement cascade (Knuppel, 2007).
ENDOCRINE FUNCTION
Aside from serving as the conduit for oxygen and C. THE AMNIOTIC MEMBRANES
nutrients for the fetus, the syncytial (outer) layer of The chorionic villi inside the uterus gradually become a
the chorionic villi develops into a separate, important smooth surface called the chorion laeve, which later
hormone-producing system becomes the outermost fetal membrane, holding amniotic
fluid, while another membrane, the amniotic membrane,
1. Human Chorionic Gonadotropin forms beneath it. These
The hormone hCG, which is checked in membranes merge during
pregnancy tests, can be detected in a woman's pregnancy and cover the
blood and urine shortly after a missed period until placenta's fetal side,
about the 100th day of pregnancy, and a negative making it shiny. They have
result can occur before or after this time. After giving no nerve supply, so when
birth, hCG disappears from the blood within 1 to 2 they break during birth,
weeks, confirming that the placenta is no longer neither the mother nor the
present. baby feels pain.
The purpose of hCG is to act as a fail-safe The amniotic membrane not only supports the amniotic
measure to ensure that the corpus luteum of the fluid but also creates it, and it produces a substance that
ovary continues to produce progesterone and can start contractions and possibly kickstart labor.
estrogen. This is important because, if the corpus
luteum should fail and the level of progesterone fall, D. THE AMNIOTIC FLUID
the endometrial lining will slough and the pregnancy Amniotic fluid is constantly being newly formed and
will be lost. hCG also may play a role in suppressing reabsorbed by the amniotic membrane, so it never
the maternal immunologic response so that placental becomes stagnant. Some of it is absorbed by direct
tissue is not detected and rejected as a foreign contact with the fetal surface of the placenta. The major
substance. method of absorption, however, occurs because the fetus
2. Estrogen continually swallows the fluid. In the fetal intestine, it is
Estrogen, mainly estriol, is made by placental absorbed into the fetal bloodstream. From there, it goes to
cells and helps a woman's breasts get ready for milk the umbilical arteries and to the placenta, and it is
production and makes her uterus grow to support the exchanged across the placenta. At term, the amount of
growing baby amniotic fluid has increased so much it ranges from 800 to
1200 mL
30
If for any reason the fetus is unable to swallow cord that contains only a single vein and artery. From 15%
(esophageal atresia or anencephaly are the two to 20% of these infants are found to have accompanying
most common reasons), excessive amniotic fluid,or chromosomal disorders or congenital anomalies,
hydramnios(more than 2000 mL in total, or pockets particularly of the kidney and heart (Lubusky et al.,
of fluid larger than 8 cm on ultrasound), will result. 2007).Blood can bewithdrawn from the umbilical vein or
Hydramnios also tends to occur in women with transfused into the vein during intrauterine life for fetal
diabetes, because hyperglycemia causes excessive assessment or treatment (termed percutaneous umbilical
fluid shifts into the amniotic space (Bush & Pernoll, blood sampling [PUBS]).
2007). >> The umbilical cord typically has one vein and two
Early in fetal life, as soon as the fetal kidneys arteries, but some infants have only one vein and artery,
become active, fetal urine adds to the quantity of the which can indicate potential health issues, like
amniotic fluid. A disturbance of kidney function may chromosomal disorders or kidney and heart problems in
cause oligohydramnios, or a reduction in the amount about 15% to 20% of cases, and the umbilical vein can be
of amniotic fluid (less than 300 mLin total, or no used for fetal assessments or treatments.
pocket on ultrasound larger than 1 cm) (Knuppel, In about 20% of all births, a loose loop of cord is found
2007). around the fetal neck (nuchal cord) at birth. If this loop of
The most important purpose of amniotic fluid is to cord is removed before the newborn’s shoulders are born,
shield the fetus against pressure or a blow to the so that there is no traction on it, the oxygen supply to the
mother’s abdomen. Because liquid changes fetus remains unimpaired (Jackson, Melvin, & Downe,
temperature more slowly than air, it also protects the 2007). Because the umbilical cord contains no nerve
fetus from changes in temperature. As yet another supply, it can be cut at birth without discomfort to either the
function, it aids in muscular development, because it child or woman
allows the fetus freedom to move. Finally, it protects
the umbilical cord from pressure, protecting the fetal F. PRIMARY GERM LAYERS
oxygen supply. Even if the amniotic membranes At the time of
rupture before birth and the bulk of amniotic fluid is implantation, a blastocyst
lost, some will always surround the fetus in utero, already has differentiated
because new fluid is constantly formed. Amniotic to a point at which two
fluid is slightly alkaline, with a pH of about 7.2. separate cavities appear in
Checking the pH of the fluid at the time of rupture the inner structure: (1) a
helps to differentiate it from urine, which is acidic (pH large one, the amniotic
5.0–5.5). cavity, which is lined with a
distinctive layer of cells, the
E. THE UMBILICAL CORD ectoderm, and (2) a smaller
The umbilical cord is formed from the fetal cavity, the yolk sac, which
membranes (amnion and chorion) and provides a is lined with entoderm
circulatory pathway that connects the embryo to cells.In humans, the yolk
thechorionic villi of the placenta. Its function is to sac appears to supply
transport oxygen and nutrients to the fetus from the nourishment only until
placenta and to return waste products from the fetus implantation. After that, its main purpose is to provide a
to the placenta. It is about 53 cm (21 in) in length at source of red blood cells until the embryo’s hematopoietic
term and about 2 cm (3 ⁄4 in) thick. The bulk of the system is mature enough to perform this function (at about
cord is a gelatinous mucopolysaccharide called the 12th week of intrauterine life). The yolk sac then
Wharton’s jelly, which gives the cord body and atrophies and remains only as a thin white streak
prevents pressure on the vein and arteries that pass discernible in the cord at birth. Between the amniotic cavity
through it. The outer surface is covered with amniotic and the yolk sac, a third layer of primary cells, the
membrane. mesoderm, forms. The embryo will begin to develop at the
>> The umbilical cord is like a lifeline that connects a point where the three cell layers (ectoderm, entoderm, and
developing baby to the placenta in the mother's mesoderm) meet, called the embryonic shield. Each of
womb, allowing it to get food and oxygen and get rid these germ layers of primary tissue.
of waste, and it's made of a jelly-like substance to Understanding the origins of body structures helps
protect the important blood vessels inside. doctors determine which screenings to perform on
An umbilical cord contains onlyone vein (carrying newborns with birth defects, like checking the kidneys for a
blood from the placental villi to the fetus) but two baby born with a heart problem or looking for reproductive
arteries (carrying blood from the fetus back to the issues in a child with urinary tract abnormalities, because
placental villi). The number of veins and arteries in all organ systems start forming by 8 weeks of pregnancy,
the cord is always assessed and recorded at birth and this early development stage is most susceptible to
because about 1% to 5% of infants are born with a harmful factors like smoking.
31
G. FETAL CIRCULATION II. End of 8th Gestational Week
As early as the third week of intrauterine life, fetal Length: 2.5 cm (1 in)
blood begins to exchange nutrients with the maternal Weight: 20 g
circulation across the chorionic villi. Fetal circulation Organogenesis is complete.
differs from extrauterine circulation because the The heart, with a septum and valves, is beating
fetus derives oxygen and excretes carbon dioxide rhythmically.
not from gas exchange in the lung but from gas Facial features are definitely discernible.
exchange in the placenta. Arms and legs have developed.
Blood arriving at the External genitalia are forming, but sex is not yet
fetus from the placenta is distinguishable by simple observation.
highly oxygenated. This The primitive tail is regressing.
blood enters the fetus The abdomen bulges forward because the fetal
through the umbilical vein intestine is growing so rapidly.
(called a vein even though An ultrasound shows a gestational sac, diagnostic of
it carries oxygenated pregnancy (Fig. 9.8).
blood, because the
direction of the blood is III. End of 12th Gestational Week (First Trimester)
toward the fetal Length: 7–8 cm
heart).Blood flows from Weight: 45 g
the umbilical vein to the ductus venosus, an Nail beds are forming on fingers and toes.
accessory vessel that directs oxygenated blood Spontaneous movements are possible, although they
directly to the fetal liver. are usually too faint to be felt by the mother.
Blood then empties into the fetal inferior vena Some reflexes, such as the Babinski reflex, are
cava so oxygenated blood is directed to the right present.
side of the heart. Because there is no need for the Bone ossification centers begin to form.
bulk of blood to pass through the lungs, it is shunted, Tooth buds are present.
as it enters the right atrium, into the left atrium Sex is distinguishable by outward appearance.
through an opening in the atrial septum, called the Urine secretion begins but may not yet be evident in
foramen ovale. From the left atrium, it follows the amniotic fluid.
course of adult circulation into the left ventricle and The heartbeat is audible through Doppler technology.
into the aorta. A small amount of blood that returns to
the heart via the vena cava does leave the right IV. End of 16th Gestational Week
atrium via the adult circulatory route—that is, through Length: 10–17 cm
the tricuspid valve into the right ventricle, and then Weight: 55–120 g
into the pulmonary artery and lungs to service the Fetal heart sounds are audible by an ordinary
lung tissue. However, the larger portion of even this stethoscope.
blood is shunted away from the lungs through an Lanugo is well formed
additional structure, the ductus arteriosus, directly Liver and pancreas are functioning.
into the aorta, Fetus actively swallows amniotic fluid, demonstrating
an intact but uncoordinated swallowing reflex; urine is
MILESTONES OF FETAL GROWTH AND present in amniotic fluid.
DEVELOPMENT Sex can be determined by ultrasound.
I. End of 4th Gestational Week
At the end of the fourth week of gestation, the V. End of 20th Gestational Week
human embryo is a group of rapidly growing cells but Length: 25 cm
does not yet resemble a human being. Weight: 223 g
Length: 0.75–1 cm Spontaneous fetal movements can be sensed by the
Weight: 400 mg mother.
The spinal cord is formed and fused at the Antibody production is possible.
midpoint. The hair forms on the head, extending to include
Lateral wings that will form the body are folded eyebrows.
forward to fuse at the midline. Meconium is present in the upper intestine.
The head folds forward and becomes prominent, Brown fat, a special fat that will aid in temperature
representing about one-third of the entire regulation at birth, begins to be formed behind the
structure. kidneys, sternum, and posterior neck.
The back is bent so that the head almost Vernix caseosa begins to form and cover the skin.
touches the tip of the tail. • Passive antibody transfer from mother to fetus begins.
The rudimentary heart appears as a prominent Definite sleeping and activity patterns are
bulge on the anterior surface. distinguishable (the fetus has developed biorhythms
Arms and legs are budlike structures. • that will guide sleep/wake patterns throughout life)
Rudimentary eyes, ears, and nose are
discernible
32
VI. End of 24th Gestational Week Fetus kicks actively, hard enough to cause the mother
(Second Trimester) considerable discomfort.
Length: 28–36 cm Fetal hemoglobin begins its conversion to adult
Weight: 550 g hemoglobin. The conversion is so rapid that, at birth,
Meconium is present as far as the rectum about 20% of hemoglobin will be adult in character.
Active production of lung surfactant begins. Vernix caseosa is fully formed.
Eyebrows and eyelashes become well defined. Fingernails extend over the fingertips.
Eyelids, previously fused since the 12th week, Creases on the soles of the feet cover at least two
now open. thirds of the surface
Pupils are capable of reacting to light.
When fetuses reach 24 weeks, or 601 g, they PREVENTING FETAL EXPOSURE TO TERATOGENS
have achieved a practical low-end age of A teratogen is any factor, chemical or physical, that
viability (earliest age at which fetuses could adversely affects the fertilized ovum, embryo, or fetus. At
survive if born at that time), if they are cared for one time, it was assumed that a fetus in utero was
after birth in a modern intensive care facility. protected from chemical or physical injury by the presence
Hearing can be demonstrated by response to of the amniotic fluid and by the absence of any direct
sudden sound. placental exchange between mother and fetus. When
infants were born with disorders, it was attributed to the
VII. End of 28th Gestational Week influence of fate, bad luck, or, in some cultures, evil spirits.
Length: 35–38 cm Today, it is acknowledged that a fetus is extremely
Weight: 1200 g vulnerable to environmental injury.
Lung alveoli begin to mature, and surfactant can
be demonstrated in amniotic fluid. EFFECTS OF TERATOGENS ON A FETUS
Testes begin to descend into the scrotal sac Several factors influence the amount of damage a
from the lower abdominal cavity. teratogen can cause. The strength of the teratogen is one
The blood vessels of the retina are formed but of these. For example, radiation is a known teratogen. In
thin and extremely susceptible to damage from small amounts (everyone is exposed to some radiation
high oxygen concentrations (an important every day, such as from sun rays), it causes no damage.
consideration when caring for preterm infants However, in large doses (e.g., the amount of radiation
who need oxygen) necessary to treat cancer of the cervix), serious fetal
defects or death can occur.
VIII. End of 32nd Gestational Week The timing of the teratogenic insult makes a significant
Length: 38–43 cm impact on damage done to the fetus. If a teratogen is
Weight: 1600 g introduced before implantation, either the zygote is
Subcutaneous fat begins to be deposited (the destroyed or it appears unaffected. If the insult occurs
former stringy, “little old man” appearance is when the main body systems are being formed (in the
lost) second to eighth weeks of embryonic life), a fetus is very
Fetus responds by movement to sounds outside vulnerable to injury. During the last trimester, the potential
the mother’s body. for harm again decreases because all the organs of a fetus
Active Moro reflex is present. are formed and are merely maturing.
Iron stores, which provide iron for the time Two exceptions to the rule that deformities usually
during which the neonate will ingest only milk occur in early embryonic life are the effects caused by the
after birth, are beginning to be developed. organisms of syphilis and toxoplasmosis. These two
Fingernails grow to reach the end of fingertips. infections can cause abnormalities in organs that were
originally formed normally.
IX. End of 36th Gestational Week A third factor determining the effects of a teratogen is
Length: 42–48 cm the teratogen’s affinity for specific tissue. Lead and
Weight: 1800–2700 g (5–6 lb) mercury, for example, attack and disable nervous tissue.
Body stores of glycogen, iron, carbohydrate, Thalidomide, a drug once used to relieve nausea in
and calcium are deposited. pregnancy, causes limb defects. Tetracycline, a common
Additional amounts of subcutaneous fat are antibiotic, causes tooth enamel deficiencies and, possibly,
deposited. long-bone deformities. The rubella virus can affect many
Sole of the foot has only one or two crisscross organs: the eyes, ears, heart, and brain are the four most
creases, compared with the full crisscross commonly attacked.
pattern that will be evident at term.
Amount of lanugo begins to diminish. TERATOGENIC MATERNAL INFECTIONS
Most babies turn into a vertex (head down) 1. TOXOPLASMOSIS
presentation during this month. Toxoplasmosis, a protozoan infection, is spread most
commonly through contact with uncooked meat,
X. End of 40th Gestational Week although it may, also be contracted through handling
(Third Trimester) cat stool in soil or cat litter (Friars, 2007).
Length: 48–52 cm (crown to rump, 35–37 cm) As many as 1 in 900 pregnancies may be affected by
Weight: 3000 g (7–7.5 lb) toxoplasmosis.
33
A woman experiences almost no symptoms of 3. CYTOMEGALOVIRUS
the disease except for a few days of malaise Cytomegalovirus (CMV), a member of the herpes
and posterior cervical lymphadenopathy. Even virus family, is another teratogen that can cause
in light of these mild symptoms, extensive damage to a fetus while causing few
if the infection crosses the placenta, the infant symptoms in a woman (Lilleri et al.,2007).
may be born with central nervous system It is transmitted from person to person by droplet
damage, hydrocephalus, microcephaly, infection such as occurs with sneezing.
intracerebral calcification, and retinal If a woman acquires a primary CMV infection during
deformities. pregnancy and the virus crosses the placenta, the
Prepregnancy serum analysis can be done to infant may be born severely neurologically challenged
identify women who have never had the disease (hydrocephalus, microcephaly, spasticity) or with eye
and so are susceptible (about 50% of women). damage (optic atrophy, chorioretinitis), hearing
Instruct pregnant women to avoid undercooked impairment, or chronic liver disease. The child’s skin
meat and also not to change a cat litter box or may be covered with large petechiae
work in soil in an area where cats may defecate (“blueberry-muffin” lesions).
to avoid exposure to the disease. However, diagnosis in the mother or infant can be
If the diagnosis is established by serum analysis established by the isolation of CMV antibodies in
during pregnancy, therapy with sulfonamides blood serum.
may be prescribed. Unfortunately, there is no treatment for the infection
Pyrimethamine, an antiprotozoal agent, may even if it presents in the mother with enough
also be used. This drug is an antifolic acid drug, symptoms to allow detection. Because there is no
so it is administered with caution early in treatment or vaccine for the disease, routine
pregnancy to prevent reducing folic acid levels. screening for CMV during pregnancy is not
recommended.
2. RUBELLA Women can help prevent exposure by thorough
The rubella virus usually causes only a mild handwashing before eating and avoiding crowds of
rash and mild systemic illness in a woman, but young children at daycare or nursery settings.
the teratogenic effects on a fetus can be
devastating (Johnson & Ross, 2007). 4. HERPES SIMPLEX VIRUS
Fetal damage from maternal infection with (GENITAL HERPES INFECTION)
rubella (German measles) includes hearing The first time a woman contracts a genital herpes
impairment, cognitive and motor challenges, infection, systemic involvement occurs. The virus
cataracts, cardiac defects (most commonly spreads into the bloodstream (viremia) and crosses
patent ductus arteriosus and pulmonary the placenta to a fetus posing substantial fetal risk
stenosis), intrauterine growth restriction (IUGR), (ACOG, 2007).
thrombocytopenic purpura, and dental and If the infection takes place in the first trimester, severe
facial clefts, such as cleft lip and palate. congenital anomalies or spontaneous miscarriage
Typically, a rubella titer from a pregnant woman may occur.
is obtained on the first prenatal visit. A titer If the infection occurs during the second or third
greater than 1:8 suggests immunity to rubella. A trimester, there is a high incidence of premature birth,
titer of less than 1:8 suggests that a woman is intrauterine growth restriction, and continuing
susceptible to viral invasion. A titer that is infection of the newborn at birth. Unless recognized
greatly increased over a previous reading or is and treated, the fetal mortality and morbidity rates are
initially extremely high suggests that a recent as high as 80% (ACOG, 2007).
infection has occurred. If a woman has had herpes simplex virus type 1
A woman who is not immunized before infections before the genital herpes invasion or if the
pregnancy cannot be immunized during genital herpes (type 2) infection is a recurrence,
pregnancy because the vaccine uses a live antibodies to the virus in her system prevent spread of
virus that would have effects similar to those the virus to a fetus across the placenta.
occurring with a subclinical case of rubella. After If genital lesions are present at the time of birth,
a rubella immunization, a woman is advised not however, a fetus may contract the virus from direct
to become pregnant for 3 months, until the exposure during birth. For women with a history of
rubella virus is no longer active. genital herpes and existing genital lesions, cesarean
All pregnant women should avoid contact with birth is often advised to reduce the risk of this route of
children with rashes. Infants who are born infection. This awareness of the
tomothers who had rubella during pregnancy Placental spread of herpes simplex virus has
may be capable of transmitting the disease for a increased the importance of obtaining information
time after birth. Because of this, an infant may about exposure to genital herpes or any painful
be isolated from other newborns during the perineal or vaginal lesions that might indicate this
newborn period. infection at prenatal visits.
34
Intravenous or oral acyclovir (Zovirax) can be 2007). When the baby’s primary teeth come in, they are
administered to women during pregnancy oddly shaped (Hutchinson teeth).
(Karch, 2009). The primary mechanism for
protecting a fetus, however, focuses on disease B. LYME DISEASE
prevention. Urging women to practice safe sex Lyme disease, a multisystem disease caused by the
is important to lessen their exposure to this and spirochete Borrelia burgdorferi, is spread by the bite of a
other sexually deer tick. The highest incidence occurs in the summer and
Transmitted infections. Advising adolescents to early fall. The largest outbreaks of the disease are found
obtain a vaccine against HPV (Gardasil) should on the east coast of the United States (Mullen, 2007). After
lessen the incidence of genital herpes infection a tick bite, a typical skin rash, erythema chronicum
in the future. migrans (large, macular lesions with a clear center),
develops. Pain in large joints such as the knee may
5. OTHER VIRAL DISEASES develop. Infection in pregnancy can result in spontaneous
It is difficult to demonstrate other viral miscarriage or severe congenital anomalies.
teratogens, but rubeola (measles), To spread the spirochete, the tick must be present on
coxsackievirus, infectious parotitis (mumps), the body possibly as long as 24 hours. After returning
varicella (chickenpox), poliomyelitis, influenza, home from an outing, therefore, a woman should inspect
and viral hepatitis all may be teratogenic. her body carefully and immediately remove any ticks found.
Parvovirus B19, the causative agent of If she has any symptoms that suggest Lyme disease or
erythema infectiosum (also called fifth disease), knows she has been bitten, she should contact her primary
a common viral disease in school age children, health care provider immediately.
if contractedduring pregnancy, can cross the Treatment of Lyme disease for pregnant women differs
placenta and attack the red blood cells of a from that for nonpregnant women. The drugs used for
fetus. Infection with the virus during early nonpregnant adults, tetracycline and doxycycline, cannot
pregnancy is associated with fetal death. If the be used during pregnancy because they cause tooth
infection occurs late in pregnancy, the infant discoloration and, possibly, long-bone malformation in a
may be born with severe anemia and congenital fetus. A course of penicillin will be prescribed to reduce
heart disease (Barankin, 2008). symptoms in the pregnant woman.
Because the symptoms of Lyme disease are chronic
A. SYPHILIS but not dramatic (a migratory rash and joint pain), women
Syphilis, a sexually transmitted infection, is of may not report them at a prenatal visit unless they are
great concern for the maternal–fetal population educated about their importance and are asked at prenatal
despite the availability of accurate screening tests visits if such symptoms are present.
and proven medical treatment, as it is growing in
incidence and places a fetus at risk for intrauterine or 6. POTENTIALLY TERATOGENIC VACCINES
congenital syphilis (Walker, 2009). Early in Live virus vaccines, such as measles, HPV, mumps,
pregnancy, when the cytotrophoblast layer of the rubella, and poliomyelitis (Sabin type), are
chorionic villi is still intact, the causative spirochete of contraindicated during pregnancy because they may
syphilis, Treponema pallidum, cannot cross the transmit the viral infection to a fetus (Rojas, Wood, &
placenta and damage the fetus. When this layer Blakemore, 2007). Care must be taken in routine
atrophies at about the 16th to 18th week of immunization programs to make sure that
pregnancy, however, the spirochete then can cross adolescents about to be vaccinated are not pregnant.
and cause extensive damage. If syphilis is detected Women who work in biologic laboratories where
and treated with an antibiotic such as benzathine vaccines are manufactured are well advised not to
penicillin in the first trimester, a fetus is rarely work with live virus products during pregnancy.
affected. If left untreated beyond the 18th week of
gestation, hearing impairment, cognitive challenge, 7. TERATOGENIC DRUGS
osteochondritis, and fetal death are possible. Many women, assuming that the rule of being
For this reason, serologic screening (by either a cautious with drugs during pregnancy applies only to
VDRL or a rapid plasma reagin test) should be done prescription drugs, take over-the-counter drugs or
at a first prenatal visit; the test may then be repeated herbal supplements freely. Although not all drugs
again close to term (the 8th month) if exposure is a cross the placenta (heparin, for example, does not
concern. Even when a woman has been treated with because of its large molecular size), most do. Also,
appropriate antibiotics, the serum titer remains high even though most herbs are safe, ginseng, for
for more than 200 days; an increasing titer, however, example, used to improve general well-being, or
suggests that reinfection has occurred. In an infant senna, used to relieve constipation, may not be safe
born to a woman with syphilis, the serologic test for (Der Marderosian & Beutler, 2007).
syphilis may remain positive for up to 3 months even Any drug or herbal supplement, under certain
though the disease was treated during pregnancy. circumstances, may be detrimental to fetal welfare.
The newborn with congenital syphilis may have Therefore, during pregnancy, women should not take
congenital anomalies, extreme rhinitis (sniffles), and any drug or supplement not specifically prescribed or
a characteristic syphilitic rash, all of which identify approved by their physician or nurse-midwife.
the baby as high risk at birth (Chakraborty & Luck,
35
A woman of childbearing age and ability should 9. TERATOGENICITY OF CIGARETTES
not take any drug other than one prescribed by Cigarette smoking is associated with infertility in
a physician or nurse-midwife to avoid exposure women. Cigarette smoking by a pregnant woman has
to a drug should she become pregnant. been shown to cause fetal growth restriction
The use of recreational drugs during pregnancy (Lawrence & Haslam, 2007). In addition, a fetus may
puts a fetus at risk in two ways: the drug may be at greater risk for being stillborn (Hogberg &
have a direct teratogenic effect, and intravenous Cnattingius, 2007) and, after birth, may be at greater
drug use risks exposure to diseases such as risk than others for sudden infant death syndrome.
HIV and hepatitis B (Donnelly et al., 2008). Low birth weight in infants of smoking mothers results
Narcotics such as meperidine (Demerol) and from vasoconstriction of the uterine vessels, an effect
heroin have long been implicated as causing of nicotine. This limits the blood supply to a fetus.
intrauterine growth restriction (IUGR). The use Another contributory effect may be related to inhaled
of marijuana alone apparently does not, carbon monoxide. Secondary smoke, or inhaling the
although the long-term effects of marijuana smoke of another person’s cigarettes, may be as
during pregnancy are still unstudied. Cocaine, harmful as actually smoking the cigarettes. All
particularly its crack form, is potentially harmful prenatal healthcare settings should be smoke-free
to a fetus because it causes severe environments for this reason.
vasoconstriction in the mother, compromising The best way to urge women to discontinue smoking
placental blood flow and perhaps dislodging the is to educate them about the risks to themselves and
placenta. Its use is associated with their fetus at a first prenatal visit. It may be effective to
spontaneous miscarriage, preterm labor, encourage women to sign a contract with a health
meconium staining, and IUGR (Rojas, Wood, & care provider to try to stop or to join a
Blakemore, 2007). smoking-cessation program.
An area of recreational drug use that needs to
be examined is that of inhalant abuse (“huffing”). 10. RADIATION
Substances frequently used as inhalants Rapidly growing cells are extremely vulnerable to
include gasoline, butane lighter fluid,Freon, glue, destruction by radiation. That makes radiation a
and nitrous oxide (NIOSH, 2007). potent teratogen to unborn children because of their
high proportion of rapidly growing cells. Radiation
8. TERATOGENICITY OF ALCOHOL produces a range of malformations depending on the
Evidence over the years has shown that when stage of development of the embryo or fetus and the
women consume a large quantity of alcohol strength and length of exposure. If the exposure
during pregnancy, their babies show a high occurs before implantation, the growing zygote
incidence of congenital deformities and apparently is killed. If the zygote is not killed, it
cognitive impairment. It was assumed in the survives apparently unharmed. The most damaging
past that these defects were the result of the time for exposure and subsequent damage is from
mother’s poor nutritional status (drinking alcohol implantation to 6 weeks after conception (when many
rather than eating food), not necessarily the women are not yet aware that they are pregnant). The
direct result of the alcohol. nervous system, brain, and retinal innervation are
However, alcohol has now been firmly isolated most affected.
as a direct teratogen. Fetuses cannot remove As a rule, therefore, all women of childbearing age
the breakdown products of alcohol from their should be scheduled for pelvic x-ray examinations
body. The large buildup of this leads to vitamin only in the first 10 days of a menstrual cycle (when
B deficiency and accompanying neurologic pregnancy is unlikely be-cause ovulation has not yet
damage. occurred), except in emergency situations. A serum
Women during pregnancy should be screened pregnancy test can be done on all women who have
for alcohol use because an infant born with fetal reason to believe they might be pregnant before
alcohol syndrome (FAS) not only is small for diagnostic tests involving x-rays are scheduled.
gestational age but can be cognitively
challenged (Shankar, Ronis, & Badger, 2007). PRENATAL CARE FOR THE FETUS
Women are best advised, therefore, to abstain OBSTETRIC DATA
from alcohol completely. Be certain to ask about Gravida - Number of pregnancy regardless of
binge drinking (consuming more than five duration as long as the mother becomes pregnant
alcohol drinks in an evening) as women may even abnormal.
refer to this as only “occasional drinking.” Refer Para/Parity- number of viable pregnancy or the total
women with alcohol addiction to an alcohol number of pregnancies in which the fetus has
treatment program as early in pregnancy as reached the age of viability and subsequently
possible to help them reduce their alcohol delivered whether dead or alive at birth.
intake. Viability- Ability of the fetus to live outside the uterus
at the earliest possible gestational age.
36
Primigravida - Woman who is pregnant for the LEOPOLD’S MANEUVER
first time 1st MANEUVER: Purpose: to determine the fetal
Primipara - Woman who has given birth to one presentation/lie through fundal palpation
child past age of viability; woman who has If palpated a round, hard and movable - BREECH
completed one pregnancy to age of viability and presentation
subsequently delivered the fetus, whether alive If palpated round, soft and immovable -
or dead at birth. HEAD/CEPHALIC presentation
Multigravida - Woman who has been pregnant 2nd MANEUVER: Purpose: to determine the back of fetus
previously; 2 or more pregnancy to hear the fetal heart sound
Grandmultigravida - woman who has had six If smooth hard and resistant surface - FETAL BACK
or more pregnancies If angular nodulations - KNEES AND ELBOWS
Multipara - Woman who has carried two or
more pregnancies to viability; woman who has 3rd MANEUVER: Purpose: to determine the degree of
carried two or more pregnancies of stage of engagement by palpating the lower uterine segment
viability and subsequently born alive or dead. If the presenting part is movable: NOT ENGAGED
Nulligravida - Woman who has never been and If the presenting part is immovable: ENGAGED
is not currently pregnant >> HARD: HEAD
Nullipara - woman who has not carried a >> SOFT, GLOBULAR, LARGE: BUTTOCKS
pregnancy beyond 20 weeks 4th MANEUVER: Purpose: to determine the fetal attitude
Grandmultipara - woman who has had 6 or –relationship of fetus to each part or degree of flexion by
more viable deliveries, whether, the fetuses grasping the lower quadrant of abdomen. It is done only if
were alive or dead. the fetus is in cephalic presentation.
Full Flexion if the fetal chin touches chest
PRINCIPLES IN IDENTIFYING PARITY PSYCHOLOGICAL CHANGES OF PREGNANCY
1. Number of pregnancies is counted and not the ● Pregnancy is such a huge change in a woman’s life and
number of fetuses. brings about more psychological
2. Abortion is not included in parity count changes than any other life event beside puberty.
3. Live birth or stillbirth is counted in parity count. ● A woman’s attitude towards a pregnancy depends a
great deal on psychological aspects: such as:
OB SCORING o The environment in which she was raised
T - Term: Number of full-term infants born 37 weeks o The messages about pregnancy her family
P - Pre-term: Number of preterm infants born 20 – 36 communicated to her as a child
weeks o The society and culture in which she lives as an adult
A - Abortion: termination of pregnancy before the o Whether the pregnancy has come at a good time in her
age of viability (less than 20 weeks) life
L - Number of Currently Living Children 1. Social Influences
M - Multiple Pregnancy 2. Cultural Influences
3. Family Influences
NAGELE’S RULE 4. Individual Differences
Use to determine expected date of delivery 5. Partners Adaptation
(EDD or EDB). It is important to determine the
SOCIAL INFLUENCES
mother’s LMP.
If Jan – March = +9 +7 FROM THE PAST TODAY
If Apr – Dec = -3 +7 +1 The pregnancy was Pregnancy is viewed as a
conveyed as a 9-month healthy span of time best
MC DONALD’S RULE shared with supportive
Use to determine age of gestation in weeks long illness
partner and or family
using FUNDIC HEIGHT
FORMULA: The pregnant woman The woman brings their
AOG in WKS = FUNDIC HEIGHT x 8/7 went alone to a families for prenatal care
FORMULA: physician’s office for care visits as well as to watch
AOG in MONTHS = FUNDIC HEIGHT x 2/7 the birth
At the time of birth, she The woman chooses
BARTHOLOMEW’S RULE was separated from her what level of pain
Use to determine age of gestation by proper family management they want
location of fundus at abdominal cavity to use for labor and birth
< 12 weeks = not palpable/pelvic cavity The woman was
3 months = above symphysis hospitalized in seclusion
5 months = level of umbilicus from visitors and even They expect to breastfed
7 months = bet. Umbilicus and xyphoid from the new baby for 1 their newborn
9 months = touching/below xyphoid week afterward so the
10 months = level of 9 months due to lightening; newborn could be fed by
about 4 cm nurses
37
● The woman and her partner feel during pregnancy NURSE’S ROLE
and prepared to meet the challenges: are related to 1. Assessing and counselling pregnant woman
them: 2. Fill the role of an attentive listener
a. Cultural background
b. Personal beliefs PARTNER’S ADAPTATION
c. Experiences reported by friends and relatives ● The more emotionally attached a partner is to a pregnant
d. Current plethora of information available woman, the closer the partner’s attachment is apt to be to
the child.
NURSE’S ROLE Factors that affect the pregnant woman’s decision
1. Teaching the woman about their health care making:
option a. Cultural background
2. Continue to work with other health care provider to b. Past experience
“demedicalize” childbirth c. Relationships with the family members
38
● Feeling close to jealousy of the growing baby who Assessing events that could contribute to difficulty
although not yet physically apparent, seems to be accepting Pregnancy:
taking up a great deal of the woman’s time and 1. Pregnancy is unintended
though 2. Learning the pregnancy is a multiple, not a single one
HEALTH CARE PLAN: 3. Learning the fetus has developmental abnormality
o Prenatal visit or fetal testing – provide an outlet 4. Pregnancy is less than 1 year after the previous one
for both male and female partners to discuss 5. Family has to relocate during pregnancy (Involves a
concerns and offer parenting information. need to find new support people
6. The main family support person suffers a job loss
2. SECOND TRIMESTER: Accepting the Baby 7. The woman’s relationships end because of partner’s
● Task: Accepting the baby - Woman and partner infidelity
move through emotions such as narcissism and 8. There is a major illness in self, partner, or a relative
introversion as they concentrate on what it will feel 9. Complications of pregnancy occur (Hypertension)
like to be a parent. Roleplaying and increased 10. The woman has a series of developing experiences
dreaming are common (failure in school work)
42
The test requires the use of an ultrasound and Purposes of Amniotic Fluid Analysis:
the electronic fetal monitor and the observation Detection of fetal abnormalities early in pregnancy
time takes about 30 minutes. To determine fetal lung maturity
Lecithin/Sphingomyelin ratio
Five Parameters: Lung Profile
1. Fetal reactivity Amniotic Fluid Bilirubin
2. Fetal breathing movements Rh incompatibility
3. Fetal body movements For detection of certain infections
4. Fetal tone Detection of fetal abnormalities early in pregnancy
5. Amniotic fluid volume
RESULTS: Nursing Care During Amniocentesis:
8 - 10 fetus is considered to be doing well Assist client to empty her bladder before the
6 – 7 is considered suspicious procedure
4 - denotes a fetus probably in jeopardy Place in supine position and drape properly
Put rolled towel under right hip to tip body to the left
BIOPHYSICAL PROFILE SCORING and remove pressure of uterus on vena cava
1. Fetal breathing - at least one episode of 30secs. Instruct not to take a deep breath and hold it while the
of sustained breathing movement w/in 30mins needle is being inserted as it will shift the uterus and
2. Fetal movement - at least 3 episodes of fetal limb needle may hit placenta or fetus.
or trunk movement w/in 30mins. Inform the patient that it is not painful because
3. Fetal tone - Observation must extend and then anesthesia will be applied at the insertion site. She
flex extremities or spine at least once in 30 mins. may experience pressure sensation during the
4. Fetal heart reactivity - 2 or more heart insertion of the needle.
accelerations at least 15 beats/min Monitor FHT before, during and in 30 minutes after
5. Amniotic fluid volume - A range of amniotic fluid the test.
between 5 and 25 cm must be present Instruct patient to observe for:
-- Infection
FETAL HEART RATE -- Uterine cramping
Fetal heart sounds -- Vaginal bleeding
a. 10 – 11 wks. – ultrasound
b. 10 wks. – Doppler 3. CHORIONIC VILLI SAMPLING (CVS)
Is a transcervical or transabdominal insertion of a
Daily fetal Movement Count (Kicks Count) needle into the fetal portion of the placenta, at the
c. 18 – 20 wks. – quickening felt by the mother area of the chorion frondosum
d. 28 – 38 wks. – 10 x / hr. peaks in intensity CVS is performed at 8-12 weeks gestation under
ultrasound guidance to ensure that the fetus is
Rhythm Strip Testing – assessment of the fetal unharmed.
heart rate. Chorionic villi cells are examined to detect
▪ Average FHR – 130 beats/ min. chromosome abnormalities such as Down syndrome
▪ Average fetal moves – twice every 10 mins. - and genetic disorders such as cystic fibrosis
causes heart rate to increase Is a biopsy & analysis of chorionic villi for
Vibroacoustic Stimulation – for acoustic (sound) chromosomal analysis done at 8 to 10 weeks of
stimulation acoustic stimulator applied to the pregnancy chorion cells are located by ultrasound
mother’s abdomen to produce sharp sound (80 A thin catheter is inserted vaginally or needle biopsy
db.), startling and waking the fetus is inserted intravaginally or inserted abdominally, and
a number of chorionic cells are removed chromosone
2. AMIOCENTESIS analysis (genetic defect)
Amnion for sac and Instruct client to report bleeding, infection or leakage
kentesis for puncture. of fluid after procedure
Scheduled between the Some instances of limb reduction syndrome
14th and 16th week Less than 1% risk leading to excessive bleeding, or
Amniocentesis is the pregnancy loss
removal of fluid from Reportable s/sx:
the amniotic cavity by -- Chills or fever
needle puncture. An (infection)
ultrasound is performed first to determine the -- Uterine contraction or
safe site where the needle can be inserted. vaginal bleeding
During the procedure, the fetus is continuously (threatened
monitored by ultrasound to ensure its wellbeing. miscarriage)
Complications includes hemorrhage from the
penetration of the placenta, infection of the
amniotic fluid and puncture of the fetus.
43
4. AFP / TRIPLE SCREEN
This test involves measurement of AFP, estriol c. LATE DECELERATIONS
and HCG in maternal serum at 15-20 weeks of -- delayed decelerations until 30 to 40 seconds after the
gestation to screen for fetal structural & onset of a contraction and continue beyond the end of the
chromosomal abnormalities. contraction
Alpha-feto protein is a substance produced by -- Ominous pattern in labor (uteroplacental insufficiency) or
the liver that is present in amniotic fluid and ↓ blood flow through the intervillous spaces of the uterus
maternal serum. during contraction
Estriol is initially tested. If the result is abnormal, -- The lowest point of the deceleration (nadir) occurs near
the woman is next referred for ultrasound to the end of the contraction instead of at its peak
confirm gestational age and to evaluate for -- Occur with hypertonia or with abnormal uterine tone
neural tube defects (NTD) and other structural caused by administration of oxytocin
abnormalities. -- Stop or slow the administration of oxytocin
A low estriol, elevated HCG, and low AFP -- Change the position from supine to lateral to relieve
finding is often associated with Trisomy 21 pressure from the Vena Cava
(Down syndrome). -- Administer IVF or O2 as prescribed
High in the maternal serum (MSAFP) if the fetus -- If late decelerations persist – prepare for possible
has an open spinal or abdominal defect. prompt birth of the infant
PERIODIC CHANGES
a. ACCELERATIONS
-- temporary normal increases in FHR caused by
fetal movement or compression of the umbilical vein
during contraction
b. EARLY DECELERATIONS
-- periodic decreases in FHR resulting from pressure
of the fetal head during contractions.
-- Beginning when the contractions begins and
ending when the contractions end (mirror image)
-- Normal – late in labor
44
BACHELOR OF SCIENCE IN NURSING 2YA-11 (PHARMACOLOGY)
NCMA216 : BSN SECOND YEAR – 1ST SEMESTER PRELIM 2023
HISTORY
CU 1: INTRODUCTION TO DRUGS A. Babylonians - earliest surviving “prescriptions”
on clay tablets in 3000 B.C
B. Chinese - Recorded the Pen Tsao (great herbal)
PHARMACOLOGY
a 40 volume compendium of plant remedies dating
The study of the biological effects of chemicals.
to 2700 B.C
Drugs are chemical that are introduced into
C. Egyptians - archives of remedies on a document
the body to cause some sort of change.
known as Erb’s Papyrus in 1500 B.C
Nurses deals with pharmacotherapeutics, or
D. Pharmacologia sen Manuductio and Materia
clinical pharmacology.
Medicum - first recorded reference to the word
Some drugs effects are therapeutic or helpful
pharmacology
but others are undesirable or potentially
E. Early 1800s - chemists isolates specific
dangerous.
substances from complex mixtures
pharmacologists then study their effects in animals.
BRANCH OF PHARMACOLOGY
F. Fredrich Serturner - first isolated morphine from
opium, injected himself and three other friends with
PHARMACODYNAMICS
huge doses (100 mg)
Deals with the biochemical and physiological
effects of drugs.
DRUG
How the drug affects the body.
- are chemicals that alter physiochemical
processes in body cells. Used interchangeably with
PHARMACOKINETICS
medicines.
Absorption, distribution, biotransformation and
excretion of drugs.
NURSE RESPONSIBILITY
How the body acts on the drug.
Administering drug
Assesses for adverse drug effects
PHARMACOTHERAPEUTICS
Intervening to make the drug regimen more
How drugs maybe used in the treatment of
tolerable
disease.
Providing patient teachings about drugs and
Which drug would be most or least appropriate
/the drug regimen
to use for a specific disorder.
Monitoring and prevention of medication errors.
What dose of drug would be required.
SOURCES OF DRUG INFORMATION
PHARMACOGNOSY
Study of drugs derived for natural sources.
Drug Label
- drug labels have specific information that
TOXICOLOGY
identifies a specific drug.
Study of poisons and poisonings.
- understanding how to read a drug label is
essential.
PHARMACOVOGILANCE
Package Insert
Monitoring the effects of medical drugs after
- prepared by the manufacturer
they have been licensed for use especially in
- contains all of the chemical and study information
order to identify and evaluates previously
that led to the drug’s approval
unreported adverse reactions.
- difficult to understand and read
DRUG NAMES
Generic or Nonproprietary Name:
PHARMACY
- Name approved by the MEDICAL or
Art of preparing, compounding and dispensing
Pharmaceutical Associations in the original country
drugs. It also refers to the place where drugs
of manufacture and is adopted by all countries.
are prepared and dispensed.
E.g: Paracetamol
PHARMACIST
Brand Name or Trade Name:
A person licensed to prepare and dispense
- Name given by the manufacturer of the drug.
drugs to make up prescriptions.
E.g: Adol or Panadol or Biogesic
3. Inorganic compounds
Salts of various elements can have therapeutic
effects in the human body
E.g: aluminum fluoride, iron , gold
B. Synthetic Sources
Genetic engineering alter bacteria to produce
chemicals that are therapeutic and effective
Original prototypes
E.g: escherichia coli.
ORPHAN DRUG
- Are chemicals that are discarded Phase I
- Will not participate in the next phase
Criteria:
- Lack therapeutic activity in humans
- Too toxic
- Produce unacceptable side effects
- Teratogenic
DRUG EVALUATION
Pre-clinical Trials
- chemicals tested on laboratory animals
Phase I studies
- chemicals tested on human volunteers
Phase II Studies
- drug tried on informed patients
CU 2: PHARMACODYNAMICS C. BIOTRANSFORMATIONS
The liver is the single most important site for
biotransformation (metabolism)
PHARMACODYNAMICS
Breaks down medicationns
Is the study of effect of drugs on the body.
Helps to prevent medication from causing
Drugs act within the body to mimic the actions
adverse effect on the body
of the body’s own chemical messenger.
D. EXCRETION
RECEPTOR CELLS
Removal of drugs from the body
Receptor site reacts to certain chemicals.
Kidneys play the most important role in
The better the fit the more pronounced the
excretion of medication.
reaction will be.
Half-life is the time it takes for the amount of
Enzymes within the body are needed to
drug in the body to decrease to one-half the
breakdown the chemicals to open up the
peak level.
receptor site.
FACTORS INFLUENCING DRUGS EFFECTS
PHARMACOKINETICS
Weight
Onset of drug action
Age
Drug half-life
Gender
Timing of the peak effect
Physiological factors
Duration of drug effects
Pathological factors
Metabolism or biotransformation of the drug
Genetic factors
Site of excretion
Immunological factors
Psychological factors
Critical Concentration
Environmental factors
- amount of a drug that is needed to cause a
Drug tolerance
therapeutic effect.
Cumulative effect
Loading Dose
DRUG TO DRUG INTERACTIONS
- a higher dose than that usually used for treatment.
Can occur anytime two or more drugs are
taken together.
Dynamic Equilibrium
can occur at:
- the actual concentration that a drug reaches in
- Site of absorption
the body. Affected by:
- During distribution
a. Absorption
- During biotransformation
b. Distribution
- During excretion
c. Biotransformation
- At the time of action
d. Excretion
DRUG FOOD INTERACTIONS
Certain foods interact with drugs.
A. ABSORPTION
Drugs are best taken on an empty stomach.
Administration
Affected by route of administration
DRUG LABORATORY TEST INTERACTIONS
Oral medications affected by presence of food
Drugs may alter the results of lab testing
in the stomach.
Laboratory test may be used to monitor the
First Pass Effect
effects of other medications.
Medications are extensively metabolized by
the liver.
Dose-Response Relationship
The body’s physiologic response to changes in
B. DISTRIBUTION
drug concentration at the site of action.
Protein Binding
Potency - refers to the amount of drug needed
Blood Brain Barrier
to elicit a specific physiologic response to a
Placenta/Breast Milk
drug.
Efficacy - magnitude of effect a drug can
cause when exerting its maximal effect.
Excretion
Removal of the drug from the body. Drug is
changed into inactive form and excreted by the
body.
Routes:
- Kidney: main organ for drug
- Elimination: leave the body through urine.
- Free or unbound water soluble drugs - filtered in
the kidney
- (+) kidney disease: dose must be decreased.
d. ALLERGIES
A person's previous allergies can impact their
treatment because they might react to a drug, food, or
animal product they were exposed to before, so doctors
need to be careful when prescribing such things.
Anticholinesterase drugs for Myasthenia gravis CHOLINERGIC ANTAGONIST also being referred
include: to as anticholinergic drug or parasympatholytic. The
Edrophonium HCL (Tensilon) – short acting drugs act to block the cholinergic receptors in the
anticholinesterase drug used to diagnose the PNS. The drugs may also block some cholinergic
disease. The action lasts for 10 to 20 minutes. receptors present in the SNS.
Neostigmine, Physostigmine, Pyridostigmine –
long acting anticholinesterase drugs used for ▪ Pharmacokinetics: The drugs are well absorbed and
therapeutic purposes. The onset of action starts 20 distributed. Drugs pass the BBB, placenta and breastmilk.
to 30 minutes and may last for 3 – 6 hours. The drugs are excreted in the urine.
▪ Contraindications and Cautions: The drugs are not
ALZHEIMER’S DISEASEis a degenerative disease given to patients with known allergy to the drugs. Should
of the CNS characterized by loss of neurons in the not be used in clients with cardiovascular,gastrointestinal
CNS which may slow down impulse transmission or genitourinary conditions because
across the synapses of the CNS. One important they may exacerbate anticholinergic effect add worsen
cause of this is explained by loss of acetylcholine the conditions. Contraindicated in client with glaucoma as
receptors in the post synaptic neurons, like the drug may cause pupillary dilation and further increase
myasthenia gravis, less receptors mean lesser intraocular pressure. Caution is used to patients with
impulse transmission. So anticholinesterase drugs hepatic or urinary impairment.
that inhibit acetylcholinesterase enzyme will ▪ Adverse effects: These are associated with
increase acetylcholine effect and promote impulse anticholinergic effects of drugs such as drying o themouth,
transmission in the CNS. Can drugs for myasthenia constipation, urinary retention, tachycardia, mydriasis.
gravis be used to patients with Alzheimer’s disease? Drowsiness, confusion and insomnia are allrelated to the
The answer is no simply because those drugs CNS effects of anticholinergic drugs
cannot pass the BBB. Therefore, Alzheimer’s ▪ Examples:
disease will have its own anticholinesterase drugs. Atropine – indicated to decrease secretions, treat
bradycardia, pylorospams, ureteral colic, cause pupil
Acetylcholinesterase drugs used for Alzheimer’s disease dilation (mydriasis) indicated as preop drug for
are called Anti Alzheimer’s drugs which include: cataractextraction. Use as antidote for cholinergic crisis
Rivastigmine Dicyclomine – use for hyperactive bowel in adults
Donepezil Scopolamine – use in motion sickness, indicated to
Tacrine decrease secretion, pupil dilation
● Pharmacokinetics: These drugs are well absorbed ADRENERGIC DRUGS these drugs act to either
and distributed in the body. Drugs for myasthenia do not stimulate or block the adrenergic receptors in the
pass the BBB. The drugs are metabolized in the liver and SNS
excreted in the urine. o Adrenergic agonist – stimulate the receptors to
● Contraindications and Cautions: The drugs are not increase sympathetic effect and is also referred to as
given to those with known allergy to the drugs. The drugs sympathomimetic drugs
may exacerbate bradycardia, diarrhea and urinary o Adrenergic antagonist – block the receptors to
incontinence decrease sympathetic effect and is also referred to as
● Adverse effects: Exacerbation of parasympathetic sympatholytic drugs
effects may be seen in the patient such as bradycardia,
hypotension and incontinence Adrenergic receptors have 2 types and subtypes.
Classification is based on their actual locations in the
● NURSING CONSIDERATIONS body. Below are some adrenergic receptor sites and their
o Properly administer eye medication specific locations in the body
o Slow IV administration to avoid severe cholinergic
effectso Cholinergic agonist oral preparation must TYPES OF THE ADRENERGIC RECEPTORS
betaken with an empty stomach to decrease nausea and 1. Alpha receptors
vomiting a. Alpha 1 receptors
o Closely monitor vital signs and exacerbation of b. Alpha 2 receptors
parasympathetic effects 2. Beta receptor
o Provide safety measures a. Beta 1 receptors
o Monitor patients with Alzeimer’s disease forprogression b. Beta 2 receptors
of the disease. Drugs will not cure thedisease
o Monitor patients with Myasthenia gravis for underside
or overdose of medication
o Provide health teaching on the name of drugs, itsaction
and adverse effects to promote client’s understanding
and compliance
RECEPTORS LOCATION
Alpha 1 receptors when stimulated will
Alpha 1 receptors Vascular smooth muscles, iris,
causevasoconstriction, pupillary dilation and closure of
visceral smooth muscles like the
urinary bladder sphincter causing urinary retention. When
urinary bladder and iris
the receptors are block? What would be the
Alpha 2 receptors CNS neurons, pancreatic islets
expectedeffects?
Alpha 2 receptors in the CNS neurons when Beta 1 receptors Myocardium, Kidneys,
stimulatedwill decrease norepinephrine flow from the CNSneurons
CNS to the SNS therefore decreasing sympathetic Beta 2 receptors Visceral smooth muscles like in
response. Take note that this is the drug that stimulate the lungs, some vascular smooth
adrenergic receptors but decreasing SNS effect because muscles, CNS neurons
thereceptors being stimulated are located in the CNS. vasoconstriction to lessen congestion in the nose
Beta 1 receptors in the heart when stimulated will therefore called decongestants.
increase heart rate. When we use a drug that o Alpha 2 adrenergic agonist – Clonidine better known
blocks the receptor, what is the effect? for its brand name as Catapres acting on the CNS
Beta 2 receptorsare located in the lungs, if we use a neurons to decrease norepinephrine flow. This drug is
drug that stimulates receptors, the effect indicated for treatment of hypertension.
isbronchodilation, what is the effect if we block
thereceptor? 3. Beta specific adrenergic agonist – these drugs
specifically stimulate the beta receptors and not the
● Classifications of Adrenergic Agonist alpha receptors.
1. Alpha and Beta adrenergic
drugs( Sympathomimetic drugs ) – these ● Pharmacokinetics: well absorbed and distributed in
drugsstimulate all adrenergic receptors to enhance the body, metabolized in the liver and excreted in the
their effects. urine. The drugs pass the placenta and breastmilk, use in
● Pharmacokinetics: these drugs are rapidly absorbed, pregnancy and lactation only if benefits outweigh the
metabolized in the liver and excreted in the urine. These risks
drugs may cross the placenta and breastmilk ● Contraindications and Cautions: The drugs are
● Contraindications and Cautions: Should not be contraindicated in clients with allergy to the drugs.
given in client with allergy to these drugs and to patients Caution is used in clients with cardiovascular disease like
with pheochromocytoma as the drugs may exacerbate hypertension and tachycardia.
the signs and symptoms ● Adverse effects: These are related to the primary
● Adverse effects: These are all related to increase SNS effects of drugs which will increase sympathetic effects
response like tachycardia, hypertension, constipation, like hypertension and tachycardia.
urinary retention, pupillary dilation ● Examples
● Examples o Isoproterenol – for treatment of cardiogenic shock and
o Epinephrine – the drug of choice during CPR, heartblock in transplanted heart.
indicated for treatment of shock o Salbutamol – for treatment of obstructive respiratory
o Dobutamine – used for treatment of congestive heart disease like COPD and bronchial asthma
failure
o Dopamine – usually given for congestive heart failure ● Nursing Considerations
and cardiogenic shock o Avoid sudden withdrawal of the drug because it may
o Norepinephrine – like epinephrine, may be indicated cause rebound hypertension, arrhythmias and flushing
for cardiac arrest o Monitor vital signs especially blood pressure and heart
rate
2. Alpha specific adrenergic agonist – these drugs o Avoid comfort measures including rest
specifically stimulate only the alpha receptors and andenvironmental control to decrease CNS irritation.
not the beta receptors o Provide adequate health teaching on the name of drug,
● Pharmacokinetics: these drugs are well absorbed and prescribed dosage, effects and adverse effects to
distributed, reach peak levels in 20 to 45 minutes. These increase patient’s knowledge and
drugs are metabolized in the liver and excreted in the subsequentcompliance.
urine
● Contraindications and Cautions: these drugs are not ● Classifications of Adrenergic Antagonist Drugs
indicated to clients with allergy to the drugs, those with (Sympatholytic drugs)
hypertension and close angle glaucoma. Caution is used 1. Alpha and Beta adrenergic antagonist – these
in clients with cardiovascular disease. drugs block all adrenergic receptors
● Adverse effects: these are related to the overdose of ● Pharmacokinetics: these drugs are well absorbed and
drugs that may increase sympathetic effects like distributed in the body, metabolized in the liver and
hypertension, gastrointestinal depression excreted in the urine and the feces.
andgenitourinary effects like urinary retention ● Contraindications and Cautions: These drugs
● Examples should not be given to clients with allergy to the drugs. To
o Alpha 1 adrenergic agonist – Phenylephrine used for those with hypotension and bradycardia. Caution is used
treatment of common colds and allergy. This drug causes in clients with cardiovascular disease andobstructive lung
disorders
By: Torres & Belmonte
BACHELOR OF SCIENCE IN NURSING 2YA-11 (PHARMACOLOGY)
NCMA216 : BSN SECOND YEAR – 1ST SEMESTER PRELIM 2023
● Adverse effects: these mainly on the effects of the some beta blockers. These drugs are known teratogenic
drugs in the lungs like bronchospasm, blood in animals as it passes the placenta and breast milk
vesselscausing vasodilation and hypotension. ● Contraindications and Cautions: Contraindicated in
● Examples clients with allergy to the drugs. Caution should be usedin
o Carvedilol clients with bradycardia and heart block as well on
o Labetalol patients with obstructive lung diseases like COPD
▪ Both examples maybe indicated to clients with severe andbronchial asthma
hypertension caused by pheochromocytoma ● Adverse effects: these are related to the bradycardia
and bronchoconstriction effect of the
2. Alpha adrenergic antagonist – these drugs block drug.Gastrointestinal effects like nausea and
only the alpha receptors, specific drugs act on the alpha 1 vomiting,genitourinary symptoms may be disturbing to
and alpha 2 receptors. clients as well.
● Pharmacokinetics: these drugs are well absorbed and ● Examples
distributed, metabolized in the liver and excreted in the ● Beta adrenergic antagonists or Beta blockers
urine. o Propranolol
● Contraindications and Cautions: The drugs should o Pindolol
not be given to clients with hypotension and urinary ● Beta 1 specific adrenergic antagonists or Beta 1
incontinence blockers
● Adverse effects: related to the primary action of the o Metoprolol
drug causing vasodilation and hypotension o Atenolol
● Examples
o Phentolamine – more specific drug hypertension in ● Nursing considerations
pheochromocytoma, that will have less adverse effects o Avoid sudden withdrawal of the drug because it may
cause rebound hypertension, arrhythmias and flushing
o Monitor vital signs especially blood pressure and heart
3. Alpha 1 selective adrenergic antagonist – these rate
drugs block only the alpha receptors, specific drugs acton
the alpha receptors on the blood vessels and urinary
bladder to case vasodilation for treatment ofhypertension
and bladder emptying for treatment ofurinary retention. o Monitor ECG
Although some drugs may act in both blood vessels and o Avoid comfort measures including rest and
urinary bladder at the same time environmental control to decrease
● Pharmacokinetics: drugs are absorbed in the GIT, CNS irritation.
metabolized in the liver and excreted in the urine. o Provide adequate health teaching on the name of drug,
● Contraindications and Cautions: Contraindicated in prescribed dosage, effects and adverse effects to
clients with allergy to the drugs. This may exacerbate increase patient’s knowledge and subsequent
hypotension and urinary incontinence. Caution is used to compliance.
clients with cardiovascular disease, gastrointestinal
andgenitourinary conditions
● Adverse effects: related to the sympatholytic effect of
drugs causing hypotension and urinary incontinence. TERMINOLOGIES
● Examples Neurotransmitters
o Prazosin – indicated for treatment of hypertension = chemicals in the body acting as messengers
o Terazosin – indicated for treatment of Sympathetic Nervous System
hypertension and BPH causing urinary retention = a branch of peripheral nervous system involved in
o Doxazosin – indicated for treatment of preparing the body for stress-related activities
hypertension and BPH causing urinary retention = “ fight or flight “
o Alfuzosin indicated for treatment of BPH Parasympathetic Nervous System
o Tamsulosin – indicated for treatment of BPH = associated with returning the body to routine,day-to-day
operations
4. Beta adrenergic antagonists – these drugs block = “ rest and digest “
both beta 1 and beta 2 receptors, particularly affecting Adrenergic
both the heart and the lungs, these drugs increase heart = means “working on adrenaline (epinephrine) or
rate and bronchoconstriction of the lungs noradrenaline (norepinephrine) (or on their receptors)
5. Beta 1 specific adrenergic antagonist–these drugs Cholinergics
block specifically beta 1 receptors in the heart. = means “working on acetylcholine or on their receptors
Thesedrugs are most commonly known as beta
blockers.These drugs are indicated to clients with ADRENERGIC AGONISTS
hypertension,dysrhythmias, angina and use to support Adrenergic agonists, also called sympathomimetics,
cardiac functionin clients with congestive heart failure are drugs that mimic the effects of the SNS and are used
● Pharmacokinetics: these drugs are absorbed in the to stimulate the adrenergic receptors within the SNS. The
gastrointestinal tract and undergo hepatic metabolism. adverse effects associated with these drugs are usually
The presence of food may increase the bioavailability of also a result of sympathetic stimulation.
Community Community-
Health based Nursing 10.Counseling – establishes an interpersonal
Nursing relationships; with the intention of increasing or
Emphasis Preservation Managing enhancing their capacity for self-care and coping
and protection acute and 11.Consultation – seeks information and
of health chronic care generates optional solutions to perceived problems
Primary Community Individual and 12.Collaboration – commits two or more persons
Clients Family or an organization
13.Coalition building – develops alliances among
POPULATION-FOCUSED APPROACH AND organizations
COMMUNITY HEALTH NURSING 14.Community organizing – helps community
INTERVENTIONS groups to identify common problems or goals
Population-Focused Nursing mobilizes resources and develop and implement
Specific groups of people and focuses on health strategies
promotion and disease prevention. 15.Advocacy – pleads someone’s cause or acts
Its goal is to promote healthy communities. on someone’s behalf
16.Social marketing – utilizes commercial
PRACTICE: marketing principles for programs
1. focuses on the entire population 17.Policy development and enforcement –
2. is based on assessment of the populations’ place issues on decision makers’ agendas,
health status acquires plan of resolution.
3. considers the broad determinants of health
4. emphasizes all levels of prevention EMERGING FIELDS OF CHN IN THE
5. 5.intervenes with communities,systems, PHILIPPINES.
individuals and families HOME HEALTH CARE
This practice involves providing nursing care
CHN Practice Requires the following type of nursing care to individuals and families in their
data for scientific approach and population own places of residence mainly to minimize the
focus: effects of illness and disability.”
1. The epidemiology or body knowledge of a HOSPICE HOME CARE
particular problem and its solution Home care rendered to the terminally ill.
2. Information about community Palliative care is particularly important.
ENTREPRENURSE
17 PUBLIC HEALTH INTERVENTIONS AND To promote nurse entrepreneurship by
DEFINITIONS introducing a home health care industry.
1. Surveillance – monitors health events PURPOSE:
2. Disease and other health event investigation 1. Reduce the cost of health care for the countries
– systematically gathers and analyzes data indigent population.
regarding threats to the health of populations 2. Maximize employment opportunities.
3. Outreach – locates populations of interests or 3. Utilize the countries unemployed human
populations at risk resources.
4. Screening – identifies individuals with AIMS: public health services and the
unrecognized health risk factors achievement of the country’s Millennium
5. Case finding – identifies risk actors and Development Goals (MDG) on maternal and
connects them with resources child health.
6. Referral and follow-up – assists individuals and
families, families, groups,organizations ad Faith Community Nursing or Parish Nursing:
communities to identify and access necessary This is the practice of nursing combined with
resources spiritual care. They may work in either paid or
7. Case management – optimizes self-care unpaid positions in a variety of religious faiths.
capabilities of individuals and families.
ULASIMANG BATO
Indications: Infusion, decoction or salad for
gout and rheumatic pains; pounded plant warm
poultice for boils and abscesses. TSAANG GUBAT
Diarrhea
GUAVA Stomachache
For washing wounds
Indications: antidiarrheal and antiseptic AMPLAYA
Diarrhea – May be taken 3-4 times a day As DiabetesMellitus (Mild non-insulin dependent)
gargle and for toothache
AKAPULKO
Anti-fungal (tinea flava, ringworm, athlete’s foot
and scabies.
Anti-fungal (tinea flava, ringworm, athlete’s foot
and scabies) – Fresh, matured leaves are
pounded. Apply soap to the affected area 1-2
times a day
NIYOG-NIYOGAN
Anti-helmintic – The seeds are taken 2 hours
after supper.
Anti-helmintic
Dosage:
4. Salience
• Refers to the family’s perception and evaluation of
the problem in terms of seriousness an urgency
attention needed.
DIMENSIONS OF EVALUATION
• EFFECTIVENESS- focus is attainment of the
objectives
• EFFICIENCY- relates to cost whether in terms
ofmoney, time, effort, or materials
• APPROPRIATENESS- ability to solve or
correctexisting problem situation, a question that
involvesprofessional judgement.
• ADEQUACY- pertains to its comprehensiveness
whether all necessary activities were performed
inorder to realize the intended results.